Person: ERSOY, CANAN
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ERSOY
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CANAN
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Publication Effect of omega-3 polyunsaturated fatty acid supplementation on glysemic control and renal function in type 2 diabetic patients with chronic kidney disease(Oxford Universitesi, 2021-05-01) Usta, Mehmet; Ayar, Yavuz; Goksel, Gultekin; Karagoz, Isminur Saka; Ersoy, Alpaslan; Ersoy, Canan; ERSOY, CANAN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0003-4607-9220; GSE-0029-2022; O-9948-2015; AGF-0767-2022Publication Assesment of attainment of recommended TSH levels and levothyroxine compliance in differentiated thyroid cancer patients(Wiley, 2022-06-12) Yavuz, Dilek Gogas; Yazan, Ceyda D.; Hekimsoy, Zeliha; Aydın, Kadriye; Gökkaya, Naile; Ersoy, Canan; Akalın, Ayşen; Topaloğlu, Ömercan; Aydoğan, Berna I.; Dilekçi, Esra N. A.; Alphan Üç, Ziynet; Cansu, Güven B.; Özsarı, Levent; İyidir, Özlem T.; Olgun, Mehtap E.; Keskin, Lezzan; Mert, Meral; Can, Bülent; Güngör, Kaan; Galip, Tayfun; Cantürk, Zeynep; Elbuken, Gülşah; Pekkolay, Zafer; Kutbay, Nilufer O.; Yorulmaz, Göknur; Kalkan, Ahmet T.; Ünsal, Yasemin Aydoğan; Yay, Adnan; Karagün, Barış; Bozkur, Evin; ERSOY, CANAN; AYDOĞAN ÜNSAL, YASEMİN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; AAH-8861-2021; HSE-4469-2023Objective Thyroid-stimulating hormone (TSH) suppression treatment can induce signs and symptoms of hyperthyroidism and hypothyroidism due to inappropriate treatment or poor compliance to the treatment. The current study aimed to investigate TSH levels, frequency of being on target TSH, adherence to levothyroxine (LT4) suppression treatment in differentiated thyroid cancer (DTC) patients after surgery in a multicentric setting. Design and Patients This multicentric cross-sectional study was conducted at 21 medical centres from 12 cities in Turkey. DTC patients followed at least one year in the same center included in the study. Clinical data, serum TSH, free thyroxine (FT4), thyroglobulin (Tg) and anti-Tg levels were recorded during the most recent visit. Body mass index, systolic and diastolic blood pressures, pulse rate were measured. LT4 doses were recorded and doses per kilogram of bodyweight were calculated. Pill ingestion habits recorded and adherence to the therapy were evaluated using the Morisky Medication Adherence Scale and categorized as good, moderate or poor compliant based on their scores. Risk stratification forpredicting the disease persistance and/or reccurence was assessed using the American Joint Committee on Cancer-7th edition thyroid cancer staging calculator. TSH serum concentrations were classified as severe suppression (TSH < 0.01 mU/L), moderate suppression (TSH: 0.01-0.1 mU/L), mild suppression (TSHL 0.1-0.5 mU/L), euthyroid (TSH: 0.5-4 mU/L) and hypothyroid (TSH > 4 mU/L). TSH levels can also be classified as on being on target, under the target, or beyond over the target, according to the American Thyroid Association recommendations. Results A group of 1125 patients (F/M: 941/184, 50.7 +/- 11.7 years) were included in the study. The mean LT4 daily dosage was 132.4 +/- 39.6 mcg/day. TSH levels showed severe suppression in 99 (%8.8) patients, moderate suppression in 277 (%24.6) patients and mild suppression in 315 (%28) patients and euthyroid range in 332 (%29.5) patients and hypothyroid range in 97 (8.6%). TSH levels were in target in 29.2% of the patients 20.4% of the patients were undertreated, 50.4% overtreated. The daily LT4 dose and LT4 dose/kg were significantly higher in the severe suppression group (p < .001, p < .001). According to the Morisky scale, 564 patients (50.1%) were good compliant, 368 patients (32.7%) were moderate compliant, and 193 patients (17.1%) were noncompliant. Patients with poor compliance need a higher dose of LT4 compared to the good compliance group (p < .001). TSH levels of patients with good compliance were 0.67 +/- 1.96 mU/L and TSH with poor compliance was 2.74 +/- 7.47 mU/L (p < .001). TSH levels were similar in patients on fixed and alternating dosages. Conclusion In 29.2% of the DTC patients, serum TSH levels were at target levels. Remaining of the study group have TSH levels under or over treatment range, exposing the patient to medication side effects. Majorty of the study group 82.8% have good or moderate adherence to LT4 therapy. Reaching TSH targets requires simplified and applicable guidelines and following the guideline recommendations.Publication Answer regarding comment on: Risk factors and outcomes of the post-liver transplantation diabetes mellitus(Aves, 2023-01-01) Ünsal, Yasemin Aydoğan; Gül, Özen Öz; Göktuğ, Mehmet Refik; Cander, Soner; Ersoy, Canan Özyardımcı; Aydemir, Ensar; Ateş, Coşkun; Ünsal, Oktay; Kıyıcı, Murat; Ertürk, Erdinç; ÖZ GÜL, ÖZEN; GÖKTUĞ, MEHMET REFİK; CANDER, SONER; ERSOY, CANAN; AYDEMİR, ENSAR; ATEŞ, COŞKUN; KIYICI, MURAT; ERTÜRK, ERDİNÇ; Tıp Fakültesi; Endokrinoloji ve Metabolizma Hastalıklar Ana Bilim Dalı; 0000-0001-8519-784X ; GBT-4320-2022; CSJ-5407-2022; CJH-1319-2022; JMT-8992-2023; AAB-6671-2022; CDO-0747-2022; FHW-0015-2022; AAJ-6536-2021Publication Differences between atypical parathyroid tumors and parathyroid adenomas in patients with primary hyperparathyroidism(Springer India, 2023-09-29) Aydemir, Ensar; AYDOĞAN ÜNSAL, YASEMİN; ÖZ GÜL, ÖZEN; AYDEMİR, ENSAR; ATEŞ, COŞKUN; Ateş, Coşkun; CANDER, SONER; Cander, Soner; Saraydaroğlu, Özlem; SARAYDAROĞLU, ÖZLEM; Ersoy, Canan; ERSOY, CANAN; Ertürk, Erdinc; ERTÜRK, ERDİNÇ; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0003-4300-2965; 0000-0003-4565-9848; 0000-0002-1332-4165; AAJ-6536-2021; AAB-6671-2022; AAA-7171-2022Atypical parathyroid tumor is a rare disease that can be challenging to distinguish from parathyroid adenoma. Atypical parathyroid tumor shows some laboratory and histopathological features with parathyroid cancer. This study attempts to compare clinical, laboratory, radiologic, and histopathological characteristics in atypical parathyroid tumor and parathyroid adenoma. This was a retrospective study based on the database of eighty-two subjects who underwent surgery for primary hyperparathyroidism at a tertiary referral center between 2010 and 2021. Forty-one patients with atypical parathyroid tumor were matched by age and gender to controls with parathyroid adenoma. Clinical, laboratory, radiologic, and characteristics were obtained from the hospital database. Forty-five (54.8%) of primary hyperparathyroidism patients were symptomatic, 36 (90%) had nephrolithiasis, 6 (15%) had fracture, and 3 (7.5%) had hypercalcemic crisis. Atypical parathyroid tumor patients present with significantly increased serum calcium, parathormone, and alkaline phosphatase levels (P < .001, all). No significant difference was observed in the results of bone mineral density, T-scores, and Z-scores. The size of adenoma was significantly greater in the atypical parathyroid tumor group (24 (8.8-70) mm vs. 12 (3.8-32) mm, P = 0.005). Our study revealed that increased preoperative serum calcium, parathormone, alkaline phosphatase concentrations, and parathyroid adenoma size on ultrasound may have predicted the atypical parathyroid tumor.Publication Knowledge, attitude, and practice towards COVID-19: Research to develop a measuring instrument(Ediciones Doyma S A, 2022-06-28) Göktaş, Olgun; Ersoy, Canan; Göktaş, Olgun; ERSOY, CANAN; Aile Sağlığı Merkezi; İç Hastalıkları Ana Bilim Dalı; AAH-8861-2021; JHW-6055-2023Objective: To evaluate the knowledge, attitudes, and behaviors of individuals about COVID-19 and to develop a valid and reliable scale that can measure these items about COVID-19 and other similar pandemic processes. Design: Methodological scale study with a quantitative approach. Participants: 415 individuals in the first phase and 367 in the retest phase. Interventions: Carried out between March 1, 2021, and April 30, 2021. Main measurements: Reliability and factor analyses were performed and validity was evaluated. In factor analysis, a scale with 4 factors and 30 questions was obtained. Confirmatory factor analysis (CFA) was applied to the factor scores of the scale. Factors were named AGeneral Culture, B-Mask, Distance and Cleanliness, C-Mental Status, and D-Way of Information. A 3-point Likert-type scoring system was created for the responses. Results: Cronbach???s alpha value was 0.894. In factor modeling, 3 of the confirmatory factor analysis fit indices were good and 4 of them were acceptable, so our model was found to be appropriate. The scale was highly reliable, according to internal and external consistency coefficients. The scale was named the Turkey COVID-19 Attitude Scale. p values < 0.05 were considered statistically significant. Conclusions: The valid and reliable Turkey COVID-19 Attitude Scale, which we developed to evaluate the knowledge, attitudes, and behaviors of individuals about COVID-19, can be used to guide research during COVID-19 and future pandemics. ?? 2022 The Author(s). Published by Elsevier Espan??a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Publication Evaluating a physicians' perspective on the use of probiotics and vitamins against coronavirus disease(Pakistan Medical Assoc, 2022-11-01) Göktaş, Olgun; Ersoy, Canan; Göktaş, Olgun; ERSOY, CANAN; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; EXQ-8413-2022; AAH-8861-2021Objective: To evaluate the perspective of family physicians on probiotics and vitamins against coronavirus disease-2019.Methods: The cross-sectional study was conducted from June 1 to 30, 2021, after approval from the ethics review committee of Bursa Uludag University, Bursa, Turkey, and comprised family physicians of either gender working at family health centres in the country. Data was collected using an online questionnaire to measure the sociodemographic characteristics, habits, health status related to coronavirus disease-2019, and their knowledge, awareness and behaviour towards the use of probiotics and vitamins during the pandemic. Data was analysed using SPSS 25.Results: Of the 218 family physicians, 130(59.6%) were male and 88(40.4%) were female. The overall mean age was 46.82 +/- 5.85 years, mean professional experience was 22.32 +/- 8.75 years, and mean experience in family medicine was 10.14 +/- 3.51 years. The knowledge and awareness level about coronavirus disease-2019 was high 4.18 +/- 0.58, exposure to the disease 3.36 +/- 0.83 and their inclination towards the use of vitamins and probiotics 1.68 +/- 0.75 was low. Among the participants, 90(41.3%) used probiotic products and 120(55%) used drugs, such as vitamins and minerals. Vitamin C 99(45.4%) was the most commonly used supplement.Conclusion: Physicians' knowledge and awareness and a realistic scientific approach are important when recommending supplements, such as probiotics, vitamins and minerals, to individuals during the pandemic.Publication Co-existence of papillary and medullary thyroid carcinoma: Reports of three cases(Coll Physicians & Surgeons Pakistan, 2022-08-01) Calapkulu, Murat; Sagiroglu, Muhammed Fatih; Gul, Ozen Oz; ERTÜRK, ERDİNÇ; ÖZ GÜL, ÖZEN; CANDER, SONER; Cander, Soner; Saraydaroglu, Ozlem; SARAYDAROĞLU, ÖZLEM; Erturk, Erdinc; Ersoy, Canan; ERSOY, CANAN; 0000-0002-7445-2275; 0000-0002-1332-4165; ABF-6267-2020; AAJ-6536-2021Medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) are two different types of thyroid carcinoma. They have different features in terms of cellular origin, histopathology, clinical features, prevalence, and prognosis. PTC originates from follicular cells, while MTC from parafollicular cells. MTC and PTC co-existence is a rare phenomenon and occurs in less than 1% of all thyroid tumors. We report three cases with coexistent MTC and PTC in the same thyroid. The papillary component was dominant in two cases and the medullary in one case. While the first case was given radioactive iodine therapy, the third was treated with vandetanib. The second case was followed up postoperatively and did not receive treatment other than levothyroxine replacement. The co-existence of these tumors requires a different clinical approach in treatment and follow-up, depending on which type is dominant.Publication Adrenocortical carcinoma: Single center experience(Aves, 2017-12-01) Şişman, Pınar; Şahin, Ahmet Bilgehan; Peynirci, Hande; Cander, Soner; Gül, Özen Öz; Ertürk, Erdinç; Ersoy, Canan; ŞAHİN, AHMET BİLGEHAN; CANDER, SONER; ÖZ GÜL, ÖZEN; ERTÜRK, ERDİNÇ; ERSOY, CANAN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0002-7846-0870; AAI-1005-2021; AAH-8861-2021; AAJ-6536-2021; HUR-0563-2023; AAM-4927-2020Objective: Adrenocortical carcinoma is an aggressive endocrine malignancy with an annual incidence of 0.5-2 cases per million. The most important factors that determine prognosis are tumor stage at the time of diagnosis and the success of surgery. However, advanced age, large tumor size, hormone secretion, high Ki-67 index (>10%), tumor necrosis and high mitotic activity are other factors associated with poor prognosis. In the present study, we aimed to evaluate the contribution of the patient and treatment-related factors to the prognosis in adrenocortical carcinoma.Material and methods: We included 15 adrenocortical carcinoma patients who were followed in our center between 2005 and 2015. The effects of age, gender, tumor size, type of operation, postoperative resection status and adjuvant treatment on disease-free survival and overall survival were analyzed.Results: Disease-free survival was 23.32+/-3.69 months and overall survival was 36.60+/-10.78 months. Gender, tumor size, tumor stage, type of operation, hormonal activity, presence of necrosis, recurrence and development of metastasis were not found to be associated with disease-free survival and overall survival (p>0.05). Postoperatively applied adjuvant treatments including mitotane, chemotherapy and radiotherapy did not significantly affect disease-free survival in our study, but statistically significant increase in overall survival was observed in patients getting adjuvant treatments (p=0.006).Conclusion: Adrenocortical carcinoma has poor prognosis and short overall survival, and in its clinical course, recurrence and development of metastasis can be commonly observed even after complete resection of the tumor. Therefore, the patients should be evaluated carefully while determining the surgical procedure during the preoperative period, and the operation and post-operative follow-up should be performed in experienced centers. However, due to the positive effects of adjuvant treatments on survival, all patients should be evaluated postoperatively for the necessity of adjuvant treatments, especially mitotane.Publication Comparison of the effects of medical and surgical treatments in giant prolactinoma: A single-center experience(Springer, 2021-07-08) Hakyemez, Bahattin; Cander, Soner; CANDER, SONER; Oz Gul, Ozen; ÖZ GÜL, ÖZEN; Eylemer, Eda; Gunes, Elif; Hakyemez, Bahattin; HAKYEMEZ, BAHATTİN; Gullulu Boz, Elif; GÜLLÜLÜ BOZ, SAİDE ELİF; Yilmazlar, Selcuk; YILMAZLAR, SELÇUK; Ersoy, Canan; ERSOY, CANAN; Tıp Fakültesi; AAA-3274-2019Purpose Giant prolactinomas, which have extremely large sizes and high prolactin (PRL) values, are rarely seen. Although medical therapy is effective, surgical treatment is more frequently applied due to slightly lower response rates and compression symptoms. This study aimed to compare the medical and surgical treatment results in giant prolactinomas. Methods Thirty-nine patients who were followed up in our center for giant prolactinoma were included in the study, and the response rates of the patients were evaluated after the medical and surgical treatments. The treatment responses were compared in terms of tumor volume, PRL level, visual field, and pituitary function. Results The outcomes of the 66 treatment periods (medical n = 42; surgical n = 24) in 39 patients (mean age, 47.2 years; men, 89.7%) were evaluated. The most common presentations were hypogonadism and visual defects. The mean longest tumor diameter at diagnosis was 52.2 +/- 11.8 mm, and the median PRL levels were 5000 ng/mL. PRL level normalization was achieved in 69% with medical therapy, and a curative response was obtained in only two patients with surgery. Tumor volume reduction was 67% (no cure) in the medical and 75% (13% cure) in the surgical groups (p = 0.39). Improvement of visual field was 70.8% in the medical and 84.2% in the surgical group (p = 0.12). Conclusion In our study, it was observed that medical therapy was effective and safe in patients with giant prolactinomas. The use of surgical treatment should be limited to prolactinomas with compression or post-resistance to medical treatment in serious cases.Publication Re-training of type 2 diabetic patients for better adherence to diabetes care plan in oral anti-diabetics and plus insulin treatment groups(Aves, 2015-06-01) Cander, Soner; Gül, Özen Öz; Gül, Cuma Bülent; Yavaş, Sibel; Ersoy, Canan; ÖZ GÜL, ÖZEN; ERSOY, CANAN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; AAI-1005-2021; AAH-8861-2021Purpose: This prospective observational single-centre study was designed to evaluate the effect of patient re-training for better adherence to regular self-monitoring of blood glucose (SMBG), standard diabetic diet and exercise program in ambulatory patients with type 2 diabetes mellitus (T2DM) receiving oral anti-diabetic (OAD) and OAD plus insulin treatments.Material and Method: In this study, we enrolled a total of 61 patients with T2DM in whom ongoing therapy with OAD (n=34) and OAD+insulin (n=27) failed to achieve adequate glycemic control. The patients were educated for lifestyle behavior, adherence to diet and exercise therapy, close monitoring with SMBG without change in their ongoing drugs and dosing. Changes in glycemic parameters, serum lipids and anthropometrics at the end of 3rd month were compared between the treatment groups.Results: During the course of the study, a significant decrease in the body weight and fat were observed in OAD (p<0.001 and p=0.002) and OAD+insulin groups (p=0.044 and p=0.008, respectively). A significant decrease in the HbA1c % (6.1%; 8.2% to 7.6%) was observed in the overall population (p<0.001) as well as in OAD (p=0.011) and OAD+ insulin (p=0.001) groups. A significant decrease was noted in the post-prandial capillary blood glucose levels in only OAD+insulin group.Discussion: Re-training approach with close follow-up and frequent SMBG seems to be important factors for the maintenance of achieved glycemic control. In our study, the effect of diabetes education on postprandial capillary blood glucose levels was more pronounced in OAD+ insulin group.