Person: YILDIZ, MERAL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
YILDIZ
First Name
MERAL
Name
7 results
Search Results
Now showing 1 - 7 of 7
Publication Anti-tumor necrosis factor treatment in the management of pediatric noninfectious uveitis: Infliximab versus adalimumab(Mary Ann Liebert, Inc, 2021-01-28) Uçan Gündüz, Gamze; Yalçınbayır, Özgür; Çekiç, Şükrü; Yiıdız, Meral; Kılıç, Sara Şebnem; UÇAN GÜNDÜZ, GAMZE; YALÇINBAYIR, ÖZGÜR; ÇEKİÇ, ŞÜKRÜ; YILDIZ, MERAL; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Alerji ve Klinik İmmünoloji; 0000-0002-5458-1686; 0000-0002-7311-5277; 0000-0002-9574-1842; 0000-0001-8571-2581; AAH-1885-2021; AAH-6625-2021; AAH-6661-2021; IYJ-9408-2023; AAH-1658-2021; JAC-9459-2023; L-1933-2017Purpose: Management of uveitis displays a particular challenge in childhood. This study aims to compare the efficacy and safety of infliximab (IFX) and adalimumab (ADA) in pediatric noninfectious uveitis that were refractory to conventional immunosuppresives.Methods: This retrospective single-center study included 33 patients who were treated with anti-tumor necrosis factor (TNF) agents (16 with IFX and 17 with ADA). Patients had diverse etiologies, including juvenile idiopathic arthritis, idiopathic uveitis, and Behcet's disease. Demographic characteristics, systemic diagnosis, findings of the ophthalmological examination, control of ocular inflammation, response to treatment, and the rate of clinical remission were studied.Results: Fourteen (87.5%) patients receiving IFX and 10 (58.8%) patients receiving ADA achieved response to treatment during the follow-up (P = 0.118). The agents were discontinued with complete clinical remission in 6 (37.5%) patients receiving IFX and in 2 (11.8%) patients receiving ADA (P = 0.118). Baseline visual acuities and parameters of inflammation improved significantly in both groups after anti-TNF therapy.Conclusion: Both IFX and ADA are safe and effective for pediatric noninfectious uveitis.Publication The effect of the linezolid and the vancomycine on biofilm production that formed on two different acrylic hydrophobic intraocular lenses(Assoc Research Vision Ophthalmology Inc, 2015-06-01) Kıvanc, Sertaç Argün; Budak, Berna Akova; Yıldız, Meral; Kıvanç, Merih; KIVANÇ, SERTAÇ ARGUN; Budak, Berna Akova; YILDIZ, MERAL; Uludağ Üniversitesi; 0000-0003-0995-5260; AAH-1885-2021; GNH-1796-2022; ABE-3033-2020; AAH-6518-2021Publication Comparison of two different evaluation methods for biofilm formation of S. epidermidis isolated from ocular surface(Assoc Research Vision Ophthalmology Inc, 2015-06-01) Budak, Berna Akova; Kıvanç, Sertaç Argün; Yıldız, Meral; Kıvanç, Merih; Güllülü, Gülay; Budak, Berna Akova; KIVANÇ, SERTAÇ ARGUN; YILDIZ, MERAL; Uludağ Üniversitesi; 0000-0003-0995-5260; AAH-1885-2021; AAH-6518-2021; ABE-3033-2020Publication Investigation of tnf-alpha gene (g308a) and gstp1 gene (ile105val) polymorphisms in Turkish patients with retinopathy of prematurity(Tubitak Scientific & Technological Research Council Turkey, 2015-01-01) Karkucak, Mutlu; Türe, Mehmet; Yıldız, Meral; ÖZMEN, AHMET TUNCER; YILDIZ, MERAL; Gülten, Emine Tuna; Sığırlı, Deniz; SIĞIRLI, DENİZ; Özmen, Ahmet Tuncer; Yakut, Tahsin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genetik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Oftalmoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; AAH-1885-2021; AAA-7472-2021Background/aim: Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor- alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism.Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction- restriction fragment length polymorphism method was used. In statistical analysis the significance level was determined as P < 0.05.Results: When the patient and control groups were compared in terms of TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, no statistically significant difference was found (P > 0.05).Conclusion: In our study, no correlation was identified between TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms and susceptibility for development of ROP. Further studies are required with more cases of ROP patients and other gene polymorphisms that could be related.Publication Herpes zoster ophthalmicus and lateral rectus palsy in an elderly patient(Karger, 2011-01-01) Yalçınbayır, Özgür; Yıldız, Meral; Gündüz, Gamze Ucan; Gelişken, Öner; YALÇINBAYIR, ÖZGÜR; YILDIZ, MERAL; UÇAN GÜNDÜZ, GAMZE; Gelişken, Öner; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0002-7311-5277; 0000-0002-5458-1686; HPH-3842-2023; AAH-6661-2021; KBU-8934-2024; EXE-4887-2022Acquired palsy of the lateral rectus presents with horizontal diplopia and has a broad differential. Herpes zoster ophthalmicus-(HZO) related cranial nerve palsy is a transient and self-limiting condition. Systemic antiviral treatment is administered in order to prevent sight-threatening complications. In suspected cases, zosteriform rash should be questioned. One should keep in mind that acquired esotropia in the elderly may sometimes present following HZO.Publication Demographics of the open-globe injuries in pediatric age group in northwest Turkey(Galenos Yayincilik, 2016-12-01) KIVANÇ, SERTAÇ ARGUN; Kıvanç, Sertaç Argün; Budak, Berna Akova; Özmen, Ahmet Tuncer; ÖZMEN, AHMET TUNCER; Yıldız, Meral; YILDIZ, MERAL; Çevik, Mediha Tok; Hamidi, Nagihan Amuk; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Oftalmoloji Anabilim Dalı.; 0000-0003-0995-5260; AAH-1885-2021; AAH-6518-2021; ABE-3033-2020Introduction: Our aim was to investigate the pattern of open globe injury and assess the effect of age on different parameters of open globe injury in pediatric patients.Materials and Methods: The medical records of the patients under 18 years old who had open-globe injury were retrospectively reviewed. Age, gender, the cause of the trauma, presence of intraocular foreign body and the extent of the ocular damage were recorded.Results: The study was comprised of 79 patients (23 female, 56 male) with a mean age of 7.7+/-4.4 (range: 2-18 years). Thirty-nine patients were injured with a blunt tip object, 27 with a sharp object and one has rupture with trauma. Thirty-five injuries occurred outside and 45 at home. The season in which most of the injuries took place was summer (32%). Seventy-five percent of the injuries were noted in 11 years and under. The mean age subject to blunt tip object injury, organic body injury and outdoor injury was significantly higher compared to that of with sharp object, inorganic body injury and indoor injury.Conclusions: The open globe-injury rates in Northwest Turkey is found to be higher in smaller age groups. Making the parents aware of the danger and consequences of the trauma and avoiding the easily accessible sharp objects may decrease the trauma rates.Publication The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity(Turkish Pediatrics Assoc, 2017-03-01) ÖZKAN, HİLAL; Dorum, Bayram Ali; Yılmaz, Cansu Canbolat; Köksal, Nilgün; YILDIZ, MERAL; Yıldız, Meral; Özmen, Ahmet Tuncer; ÖZMEN, AHMET TUNCER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-2823-8454; AAH-1885-2021; AAG-8393-2021; A-5375-2017Aim: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide.Material and Methods: We prospectively studied newborn infants born at a postmenstrual age of < 32 weeks and birth weights < 1 500 gr, between January 1st, 2015, and December 31st, 2015. A total of 40 infants were enrolled in the study. The retinal examination time was determined in accordance with the American Academy of Pediatrics recommendations for retinopathy of prematurity screening and follow-up. Retinopathy of prematurity was classified according to the international classification of retinopathy of prematurity. Serum Insulin like growth factor 1 levels were measured serially in blood samples on the 1st, 3rd, 7th, 21st, and 28th day.Results: Among the 40 infants, 11 (27.5%) constituted the retinopathy of prematurity group and 29 comprised the non-retinopathy of prematurity group. In the retinopathy of prematurity group, the mean gestational age and birth weight was significantly lower. The demographic features of the study cohort were similar. The duration of mechanical ventilation was significantly greater in the retinopathy of prematurity group compared with the non-retinopathy of prematurity group (p=0.036). In terms of neonatal morbidities such as respiratory distress syndrome, intraventricular hemorrhage, bronchopulmonary dysplasia, patent ductus arteriosus, and necrotizing enterocolitis, no differences were detected between the groups. The mean serum insulin-like growth factor-1 levels in retinopathy of prematurity group were significantly lower than those in the non-retinopathy of prematurity group at each time point (1st, 3rd, 7th, 21st, and 28th day of postnatal life) (p=0.001).Conclusions: This study demonstrated the low serum insulin-like growth factor-1 levels was associated with retinopathy of prematurity development.