Person: KESKİN, ABDULKADİR
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KESKİN
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ABDULKADİR
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Publication Effect of oestrous expression prior to timed artificial insemination with sexed semen on pregnancy rate in dairy cows(Wiley, 2022-11-16) Güner, Barış; Ertürk, Melih; Dursun, Mehmet; Öztürk, Buse; Yılmazbaş-Mecitoğlu, Gülnaz; Keskin, Abdulkadir; Dikmen, Serdal; Gümen, Ahmet; Yılmazbaş-Mecitoğlu, Gülnaz; KESKİN, ABDULKADİR; DİKMEN, SERDAL; GÜMEN, AHMET; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Zootekni Anabilim Dalı.; 0000-0002-5611-4993; HGP-8282-2022; AAH-3831-2021; A-5731-2018; AAH-1406-2021The objectives of the study were to determine (1) oestrous expression rate and (2) the effect of oestrous expression prior to progesterone-based Ovsynch protocol on pregnancy rate in Holstein cows. All cows (n = 917) were subjected to 7-day progesterone-based Ovsynch protocol. In this protocol, cows that expressed oestrus before (HEAT1) the scheduled second GnRH were inseminated 20 h later after the onset of oestrus without GnRH administration. Cows that expressed oestrus after the second GnRH administration (HEAT2) or did not express oestrus (NOHEAT) received fixed-timed AI. Oestrous expression was determined by using activity-rumination monitoring system and all cows were inseminated with sexed semen. Oestrous expression rate prior to FTAI was 40.5% and the majority (p < .01) of oestrous expression were in HEAT2 compared with HEAT1 in both primiparous (71.8 vs. 28.1%) and multiparous cows (69.5 vs. 30.5%). The mean interval from intravaginal device removal to the onset of oestrus was 47.4 +/- 0.9 h and 62.9 +/- 0.5 in HEAT1 and HEAT2, respectively. Primiparous cows (47.7%) had a higher (p < .01) expression rate compared with multiparous cows (37.2%). Overall pregnancy rate was 37.4% and there was two-way significant interaction between parity and oestrous expression on pregnancy rate (p < .01). Both primiparous (48.1 vs. 35.8%) and multiparous cows (47.4 vs. 28.4%) that expressed oestrus had greater (p < .01) pregnancy rate compared with cows that did not express oestrus. There was no difference in pregnancy rates of HEAT1 and HEAT2 in both primiparous (44.7 vs. 49.5%) and multiparous cows (47.2 vs. 47.6%). Pregnancy rate was not influenced (p = .21) by milk production (high or low) in both primiparous (47.6 vs. 48.6%) and multiparous (54.9 vs. 42.1%) cows that expressed oestrus, respectively. In conclusion, cows showing oestrus before or after second GnRH of the Ovsynch protocol had greater pregnancy rate than cows not showing oestrus.Publication Distributions of CYP19, ERα and PGR allele frequencies between fertile and subfertile Holstein-Friesian heifers(Kafkas Üniversitesi, 2015-11-01) Keskin, Abdulkadir; Öner, Yasemin; Yılmazbaş-Mecitoğlu, Gülnaz; Güner, Barış; Karakaya, Ebru; Elmacı, Cengiz; Gümen, Ahmet; KESKİN, ABDULKADİR; ÖNER, YASEMİN; MECİTOĞLU, GÜLNAZ; Güner, Barış; Karakaya, Ebru; ELMACI, CENGİZ; GÜMEN, AHMET; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Uludağ Üniversitesi/Ziraat Fakültesi/Hayvan Bilimleri Biyometri ve Genetik Bölümü.; 0000-0002-2904-8986; 0000-0003-2817-3221; 0000-0001-6414-6752; 0000-0003-4837-1858; 0000-0003-4819-0221; 0000-0002-3607-4365; V-7882-2019; AIF-3815-2022; ABB-3181-2020; AAH-3831-2021; AAH-1406-2021; AAG-4440-2019; AGY-3496-2022; ABG-2047-2020The aim of this study was to investigate the gene and genotype distributions of some mutations in the aromatase cytochrome P450 (CYP19), estrogen receptor alpha (ER alpha), and progesterone receptor (PGR) genes in fertile and subfertile Holstein-Friesian heifers using the PCR-RFLP method and comparing the distributions between groups. A total of 106 heifers were included the study, and the heifers that became pregnant after the first artificial insemination (n=51) were used as a fertile group. Heifers (n=55) with equal and more than 3 AIs were accepted as a subfertile heifers. Blood samples from all of the heifers were obtained for DNA isolation. While two alleles and three genotypes were found at the PGR and ER alpha loci, two alleles and two genotypes were detected at the CYP19 locus. The A allele and AA genotype, G allele and GG genotype, and C allele and CT genotype were found to be predominant in CYP19, ER alpha and PGR, respectively. According to the chi-square test (chi(2)), two of the groups investigated were in Hardy-Weinberg equilibrium for all gene loci. There were no differences detected in allele or genotype frequencies between the fertile and subfertile heifers.Publication Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats(Ankara Univ Press, 2022-01-01) Kibar, Murat; Aytmirzakizi, Ayperi; Öztürk, Zeynep; KESKİN, ABDULKADİR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.; AAH-3831-2021The aim of this study was to investigate the impact of the general anesthetic drug ketamine and premedication agents medetomidine and xylazine, and their reversal by atipamezole, on monitored anesthesia care values and ocular parameters such as intraocular pressure, horizontal pupillar diameter, and Schirmer tear test in cats. A randomized, single-blinded study was conducted. Twenty intact female cats (weiging between 2.2 and 3.6 kg, and 0.5 to 5.5 years of age) referred for ovariohysterectomy (OHE) procedure by the owners at regular intervals over 4 months were included in the study. The cats were randomly divided into two groups containing 10 animals in each group. The cats were premedicated with medetomidine 80 mg/kg intramuscular in group 1 while the cats in the 2nd group were premedicated with xylazine hydrochloride 2 mg/kg intramuscular. After the OHE procedure was ended, anesthesia regimes were reversed by using atipamezole 200 mg/kg intramuscularly. Monitoring of respiration rate, heart rate, mean arterial pressure, peripheral arterial oxygen saturation, and body temperature were conducted using a patient monitor at T0, T1, T2, T3, and T4 time points. Both groups showed declines in intraocular pressure and increases in horizontal pupil diameter after anesthesia induction (T0 vs. T1, all, P<0.05); however, the chancing and recovery pattern of intraocular pressure and horizontal pupil diameter showed intergroup difference. In conclusion, xylazine/ketamine is more effective than medetomidine/ketamine in attenuating the intraocular pressure, increasing the horizontal pupil diameter, and alteration the monitored anesthesia care response in the general anesthesia.Publication Mammary hyperplasia in a pregnant queen(Australian Small Animal Veterinary Assoc, 2008-06-01) Keskin, Abdulkadir; Yılmazbaş, Gülnaz; Şimşek, Gözde; Seyrek-İntas, Kamil; KESKİN, ABDULKADİR; Yılmazbaş, Gülnaz; Şimşek, Gözde; Seyrek-İntas, Kamil; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; 0000-0003-2817-3221; AAH-7292-2019; AAH-3831-2021; AAG-4440-2019; DRG-7451-2022Mammary hyperplasia producing severe swelling and ulceration of the mammary glands occurred during late gestation in a 10-month-old queen. Inguinal and caudal abdominal mammary glands and the left cranial abdominal mammary gland were asymmetrically and diffusely enlarged. Mammary gland skin was ulcerative and necrotic, and milk was leaking from the affected areas. To prevent mastitis the queen received topical antibacterial and anti-inflammatory drugs and systemic antibacterial and antiprolactin drugs. At the end of the first week following parturition, the majority of the mammary glands had regressed significantly with complete regression 14 days later.Publication Effects of daily propylene glycol drenching during the Ovsynch protocol on fertility and metabolic parameters in lactating dairy cows(Wiley, 2023-06-18) Çakırcalı, Rabia; Karakaya-Bilen, Ebru; Güner, Barış; Mecitoğlu, Zafer; Ortaç, Cihan Tolga; Keskin, Abdulkadir; Orman, Abdulkadir; Gümen, Ahmet; Çakirçalı, Rabia; MECİTOĞLU, ZAFER; Ortaç, Cihan Tolga; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GÜMEN, AHMET; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Zootekni Bölümü.; 0000-0001-9138-4422 ; 0000-0002-5557-121X ; DWK-3046-2022; AAH-1677-2021; JLZ-4927-2023; AAH-3831-2021; AAG-9134-2021; AAH-1406-2021Negative energy balance (NEB) caused by restricted feed intake leads to body condition loss (BCS), increased metabolic stress and reduced fertility in dairy cows. Propylene glycol (PG) is a precursor of ruminal propionate for gluconeogenesis used to increase metabolic adaptation to the early postpartum period. The aim of this study was to determine the effects of daily drenching of PG during the fixed-time artificial insemination (FTAI) protocol on beta-hydroxybutyric acid (BHBA), glucose, adiponectin, insulin-like growth factor-1 (IGF1) concentrations, follicle size and pregnancy rate in dairy cows. Cows (n = 148) were randomly divided into two groups and received either 300 mL of PG (PG-OVS, n = 76) or 300 mL of water (CON- -OVS, n = 72) each day of the Ovsynch protocol (GnRH-7 days-PGF2a-56 hours-GnRH-16-18-hour FTAI) between days 57 +/- 3 to 67 +/- 3 postpartum for the first service. Body condition scores (14 days before expected calving, at calving, on days 21 and 42 postpartum) were recorded. Blood samples were collected days 7 +/- 3, 21 +/- 3 postpartum, at the beginning of the Ovsynch (days 57 +/- 3) and at the time of FTAI (days 67 +/- 3) for measurements of BHBA, glucose, adiponectin and IGF1 concentrations. Ultrasonographic examinations were done to measure follicle size at the beginning of Ovsynch and FTAI and to determine pregnancy on days 30 and 60 following FTAI. There were no differences (p >.05) in glucose, adiponectin and IGF1 concentrations between the groups during the study. Although there was no difference ( p >.05) in BHBA concentrations on postpartum day 7 +/- 3, 21 +/- 3 and 57 +/- 3 between the groups, BHBA concentrations at the time of insemination was lower (p <.05) in the PG-OVS group (0.72 +/- 0.03 mmol/L) than in the CON-OVS group (0.81 +/- 0.03 mmol/L). Follicle sizes at the beginning of Ovsynch (PG-OVS, 14.5 +/- 0.48 mm; CON-OVS, 14.3 +/- 0.59 mm) and FTAI (PG-OVS, 17.8 +/- 0.52 mm; CON-OVS, 17.7 +/- 0.42 mm) were not different ( p <.05). Pregnancy rate of the cows in the PG-OVS group (46.1%, 35/76) was higher (p =.05) than in the CON-OVS group (30.6%, 22/72) on day 30 following FTAI. In conclusion, decreasing serum BHBA concentrations at the time of FTAI by means of daily drenching of PG during the Ovsynch protocol, increased the pregnancy rate at first service in lactating dairy cows. On the other hand, blood glucose was not related with pregnancy rates in our study, probably as a result of our sampling time and more rapid fluctuations of blood glucose concentrations when compared to BHBA.Publication Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia(Elsevier, 2015-04-01) Temizel, Ethem Mutlu; Batmaz, Hasan; Keskin, Abdülkadir; Orman, Abdülkadir; Gençoğlu, Hıdır; Çatık, Serkan; Topal, Onur; TEMİZEL, ETHEM MUTLU; BATMAZ, HASAN; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GENÇOĞLU, HIDIR; Çatık, Serkan; TOPAL, ONUR; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; 0000-0001-9138-4422; 0000-0002-1933-7354; 0000-0003-1991-8957; HJZ-4775-2023; AAH-1712-2021; AAH-3831-2021; AAG-9134-2021; S-8278-2017; ECV-4083-2022; CHM-0716-2022The effect of administration of butaphosphan and cyanocobalamin on the prophylaxis of pregnancy toxaemia in ewe was investigated. Moreover, the effects of these compounds on body weight gain and biochemical metabolism of pregnant ewe was assessed. A total of 59 pregnant Kivircik crossbred ewes were used in this study. Group I (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 1-week intervals. Group II (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 3-day intervals. Group III (n: 15) was administered 0.9% NaCl three times before delivery at 1-week intervals. Group IV (n: 14) was administered 0.9%NaCI three times before delivery at 3-day intervals. Six blood samples Were taken from each ewe four times before delivery and two times after delivery. Haematological and biochemical analyses were performed.The levels of BHB and NEFA in groups administered butaphosphan and cyanocobalamin were noticeably lower but there were no statistically significance. Elevated BHB (>0.8 mmol/L), subclinical pregnancies toxaemia were identified in 56.66% in test groups and 72.41% in control groups in all ewes and this was higher in the ewes bearing multiple pregnancies 71.42 in test groups and 82.35% in control groups. Subclinical pregnancy toxaemia in pregnant ewes with twins or triplets is lower than the levels for the control groups, despite the greater lamb counts and weights of the ewes in test groups.Based on our results, it was concluded that the butaphosphan and cyanocobalamin combination could be used as an alternative treatment for the prevention of pregnancy toxaemia. (C) 2015 Elsevier B.V. All rights reserved.Publication Comparison of the impacts of medet omidi ne/ke tamin e and medetomidine/propofol anesthesia and their reversal by atipamezole on echocardiographic values in dogs(Aves, 2022-09-01) Kibar, Murat; Aytmirzakizi, Ayperi; Öztürk, Zeynep; Keskin, Abdulkadir; KESKİN, ABDULKADİR; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.; 0000-0003-1791-1401The reaction of the cardiovascular system to anesthetics can be various and different, based on dosing, the experimental model, and agent sele-ction. A few studies have compared the effects of different anesthetic agents used for trans-thoracic echocardiography on cardiac functions in dogs; however, none of these studies examined the effects of different anesthetic regimes and their reversal by atipamezole echoc ardio graph icall y. The aim of this study was to investigate, visualize, and clarify in vivo both the short-term echocardiographic impacts of medet omidi ne-ke tamin e and medet omidi ne-pr opofo l anesthesia regimes and their reversal in dogs. Twenty sexually intact female dogs (weighing between 5.7 and 14.5 kg and 0.5-3 years of age) referred for ovariohysterectomy procedure from a local shelter at regular intervals over 3 months were included in the study. Echocardiographic measurements of the two-dimensional guided M-mode echocardiography were conducted with the dogs positioned in right lateral recumbence. Both groups showed declines in interventricu-lar septum percent, left ventricular diameter percent, and left ventricular ejection fraction after anesthesia induction (baseline vs. T1, all, p < .05); nevertheless, the reduction and starting pattern of interventricular septum percent, left ventricular diameter percent, and left ventricular ejection fra-ction presented important intergroup distinction. The echocardiographic values were affected significantly after anesthesia with medet omidine- ketamin e and medet omidi ne-pr opofo l; atipamezole can be useful for return to baseline values quickly and safely in dogs after abdominal sur-gery such as ovariohysterectomy.