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KESKİN, ABDULKADİR

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KESKİN

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ABDULKADİR

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    Publication
    Distributions of CYP19, ERα and PGR allele frequencies between fertile and subfertile Holstein-Friesian heifers
    (Kafkas Üniversitesi, 2015-11-01) Keskin, Abdulkadir; Öner, Yasemin; Yılmazbaş-Mecitoğlu, Gülnaz; Güner, Barış; Karakaya, Ebru; Elmacı, Cengiz; Gümen, Ahmet; KESKİN, ABDULKADİR; ÖNER, YASEMİN; MECİTOĞLU, GÜLNAZ; Güner, Barış; Karakaya, Ebru; ELMACI, CENGİZ; GÜMEN, AHMET; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Uludağ Üniversitesi/Ziraat Fakültesi/Hayvan Bilimleri Biyometri ve Genetik Bölümü.; 0000-0002-2904-8986; 0000-0003-2817-3221; 0000-0001-6414-6752; 0000-0003-4837-1858; 0000-0003-4819-0221; 0000-0002-3607-4365; V-7882-2019; AIF-3815-2022; ABB-3181-2020; AAH-3831-2021; AAH-1406-2021; AAG-4440-2019; AGY-3496-2022; ABG-2047-2020
    The aim of this study was to investigate the gene and genotype distributions of some mutations in the aromatase cytochrome P450 (CYP19), estrogen receptor alpha (ER alpha), and progesterone receptor (PGR) genes in fertile and subfertile Holstein-Friesian heifers using the PCR-RFLP method and comparing the distributions between groups. A total of 106 heifers were included the study, and the heifers that became pregnant after the first artificial insemination (n=51) were used as a fertile group. Heifers (n=55) with equal and more than 3 AIs were accepted as a subfertile heifers. Blood samples from all of the heifers were obtained for DNA isolation. While two alleles and three genotypes were found at the PGR and ER alpha loci, two alleles and two genotypes were detected at the CYP19 locus. The A allele and AA genotype, G allele and GG genotype, and C allele and CT genotype were found to be predominant in CYP19, ER alpha and PGR, respectively. According to the chi-square test (chi(2)), two of the groups investigated were in Hardy-Weinberg equilibrium for all gene loci. There were no differences detected in allele or genotype frequencies between the fertile and subfertile heifers.
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    Publication
    Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia
    (Elsevier, 2015-04-01) Temizel, Ethem Mutlu; Batmaz, Hasan; Keskin, Abdülkadir; Orman, Abdülkadir; Gençoğlu, Hıdır; Çatık, Serkan; Topal, Onur; TEMİZEL, ETHEM MUTLU; BATMAZ, HASAN; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GENÇOĞLU, HIDIR; Çatık, Serkan; TOPAL, ONUR; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; 0000-0001-9138-4422; 0000-0002-1933-7354; 0000-0003-1991-8957; HJZ-4775-2023; AAH-1712-2021; AAH-3831-2021; AAG-9134-2021; S-8278-2017; ECV-4083-2022; CHM-0716-2022
    The effect of administration of butaphosphan and cyanocobalamin on the prophylaxis of pregnancy toxaemia in ewe was investigated. Moreover, the effects of these compounds on body weight gain and biochemical metabolism of pregnant ewe was assessed. A total of 59 pregnant Kivircik crossbred ewes were used in this study. Group I (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 1-week intervals. Group II (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 3-day intervals. Group III (n: 15) was administered 0.9% NaCl three times before delivery at 1-week intervals. Group IV (n: 14) was administered 0.9%NaCI three times before delivery at 3-day intervals. Six blood samples Were taken from each ewe four times before delivery and two times after delivery. Haematological and biochemical analyses were performed.The levels of BHB and NEFA in groups administered butaphosphan and cyanocobalamin were noticeably lower but there were no statistically significance. Elevated BHB (>0.8 mmol/L), subclinical pregnancies toxaemia were identified in 56.66% in test groups and 72.41% in control groups in all ewes and this was higher in the ewes bearing multiple pregnancies 71.42 in test groups and 82.35% in control groups. Subclinical pregnancy toxaemia in pregnant ewes with twins or triplets is lower than the levels for the control groups, despite the greater lamb counts and weights of the ewes in test groups.Based on our results, it was concluded that the butaphosphan and cyanocobalamin combination could be used as an alternative treatment for the prevention of pregnancy toxaemia. (C) 2015 Elsevier B.V. All rights reserved.