Person: GÜL SATAR, NİHAL YAŞAR
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GÜL SATAR
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NİHAL YAŞAR
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Publication Ankaferd blood stopper accelerates deep second degree burn wound healing in rats(Veterinarni A Farmaceuticka Univerzita Brno, 2018-01-01) Topal, Ayşe; Satar, Nihal Yaşar Gül; Cangül, İbrahim Taci; Oktay, M. Ayberk; İnan, Kıvanç; Ceçen, Göksen; Akarsu, E. Pınar; Can, Hakcahan; TOPAL, AYŞE; GÜL SATAR, NİHAL YAŞAR; CANGÜL, İBRAHİM TACİ; Oktay, M. Ayberk; İnan, Kıvanç; Çeçen, Göksen; Akarsu, E. Pınar; Can, Hakcahan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Bölümü; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Bölümü; 0000-0001-8537-0761; 0000-0003-0537-2113; AAK-9543-2020; AAB-4360-2021; GGO-6894-2022; FTA-8490-2022; DLW-3934-2022; FDI-9072-2022; CCC-5151-2022; CHT-0705-2022In this study, the effects of Ankaferd Blood Stopper (ABS) and silver sulphadiazine (SSD) cream on burn wound healing were investigated in rats. A total of 24 outbred, male, Sprague-Dawley rats were randomly allocated to (1) ABS, (2) SSD, and (3) control groups. Bilateral burn wounds were created near the caudal border of the scapula. Wounds in each group were treated daily with sponges soaked in ABS solution, 1% SSD cream, or saline, respectively. On days 0, 7, 14, 21, and 28, unhealed wound area was measured and biopsy samples were taken for histopathological examination (except day 0). At the end of day 28, all rats in the ABS and SSD groups had complete coverage of the wounds with granulation tissue and epithelialization, whereas wounds in the control group were not completely epithelialized. On day 7, the mean unhealed wound areas and the mean percentages of wound contraction were not significantly different among the groups. However, the mean percentage of wound contraction in the ABS and SSD groups was significantly higher than in the control group on days 14, 21, and 28. Histopathologically, wound healing was characterized by a decrease in neutrophil counts and an increase in vessel counts. Our results suggest that ABS can be successfully used for burn wound healing besides SSD.Publication Interval between injection of contrast material and positive contrast cheliography affects accurate diagnosis of diaphragmatic hernia(Veterinarni A Farmaceuticka Univerzita Brno, 2015-01-01) Şen, İsmail A.; Akgül, M. Banş; Satar, Nihal Yaşar Gül; Topal, Ayşe; Şen, İsmail A.; Akgül, M. Banş; GÜL SATAR, NİHAL YAŞAR; TOPAL, AYŞE; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı; JDD-9615-2023; EKW-0914-2022; FTA-8490-2022; GGO-6894-2022The aim of this study was to evaluate the clinical, surgical and diagnostic imaging findings in 11 cats and 3 dogs with suspected acute and chronic traumatic diaphragmatic hernia, and to compare the results of positive contrast cheliography (peritoneography) taken immediately and 5 min after the injection of contrast material. Thoracic and abdominal radiography, ultrasonography, and positive contrast cheliography of all animals were performed. Eight cases were considered as acute and six cases were considered chronic. The contrast images taken immediately after the injection of contrast material revealed the contrast material in the thoracic cavity in 8/8 acute trauma patients, but in none of the chronic cases. In 5/6 of these cases contrast material was seen in the thoracal cavity only in additional images taken after 5 min. One patient was diagnosed with PIP and excluded from the study. Twelve cases had complete resolution and one animal died during the early postoperative period. Our results suggest that positive contrast cheliography performed immediately after the injection of contrast material may not reveal chronic cases of diaphragmatic hernia and a second imaging (or imaging after 5 min) is indicated in order not to overlook chronic cases.Publication Bronchial foreign body (olive pit) in a puppy(Kafkas Üniversitesi, 2016-01-01) Salcı, Hakan; Özkan, Hakcahan; Özfirat, Eren Can; Çeşme, Hilal; Gül Satar, Nihal Yaşar; SALCI, HAKAN; Özkan, Hakcahan; Özfirat, Eren Can; Çeşme, Hilal; GÜL SATAR, NİHAL YAŞAR; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; T-4623-2019; DKG-5031-2022; IGQ-5754-2023; CIP-4415-2022; CUS-1343-2022Publication Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing(Springer, 2014-11-01) Bağdaş, Deniz; Gül, Nihal Yaşar; Topal, Ayşe; Taş, Sibel; Özyiğit, Musa Özgür; CinkIlıç, NilÜfer; Gül, Zülfiye; Etoz, Betül Cam; Ziyanok, Sedef; İnan, Sevda; Turacozen, Özge; Gürün, Mine Sibel; Bağdaş, Deniz; GÜL SATAR, NİHAL YAŞAR; TOPAL, AYŞE; TAŞ, SİBEL; ÖZYİĞİT, MUSA ÖZGÜR; CinkIlıç, Nilüfer; Gül, Zülfiye; Etoz, Betül Cam; ZİYANOK DEMİRTAŞ, SEDEF; İnan, Sevda; Turacözen, Özge; GÜRÜN, MİNE SİBEL; Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi; Uludağ Üniversitesi Veteriner Fakültesi, Cerrahi Anabilim Dalı; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı; 0000-0001-6225-774X; 0000-0002-3595-6286; 0000-0002-8872-0074; 0000-0003-3878-3808; 0000-0001-8138-5851; AAG-8716-2019; AAH-4272-2021; AAF-9939-2020; ABE-6873-2020; JBJ-7162-2023; AAH-5296-2021; AAR-6478-2021; AAH-2873-2021; E-3364-2018; EOB-5882-2022; GGO-6894-2022; AAH-5296-2021Chlorogenic acid (CGA) is a well-known natural antioxidant in human diet. To understand the effects of CGA on wound healing by enhancing antioxidant defense in the body, the present study sought to investigate the potential role of systemic CGA therapy on wound healing and oxidative stress markers of the skin. We also aimed to understand whether chronic CGA treatment has side effects on pivotal organs or rat bone marrow during therapy. Full-thickness experimental wounds were created on the backs of rats. CGA (25, 50, 100, 200 mg/kg) or vehicle was administered intraperitoneally for 15 days. All rats were sacrificed on the 16th day. Biochemical, histopathological, and immunohistochemical examinations were performed. Possible side effects were also investigated. The results suggested that CGA accelerated wound healing in a dose-dependent manner. CGA enhanced hydroxyproline content, decreased malondialdehyde and nitric oxide levels. and elevated reduced glutathione, superoxide dismutase, and catalase levels in wound tissues. Epithelialization, angiogenesis, fibroblast proliferation, and collagen formation increased by CGA while polymorph nuclear leukocytes infiltration decreased. CGA modulated matrix metalloproteinase-9 and tissue inhibitor-2 expression in biopsies. Otherwise, high dose of CGA increased lipid peroxidation of liver and kidney without affecting the heart and muscle samples. Chronic CGA increased micronuclei formation and induced cytotoxicity in the bone marrow. In conclusion, systemic CGA has beneficial effects in improving wound repair. Antioxidant, free radical scavenger, angiogenesis, and anti-inflammatory effects of CGA may ameliorate wound healing. High dose of CGA may induce side effects. In light of these observations, CGA supplementation or dietary CGA may have benefit on wound healing.Publication Tarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats(Arquivo Brasileiro Medicina Veterinaria Zootecnia, 2022-01-01) İpek, Volkan; Özfırat, E. C.; ÖZFIRAT, NEVZAT; Topal, A.; Satar, N. Y. G.; GÜL SATAR, NİHAL YAŞAR; Pamukçular, O.; Uçkan, E. M.; Akkoç A.; AKKOÇ, AHMET; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; 0000-0002-5090-7917; 0000-0001-5874-7797The aim of this study was to investigate the anti-inflammatory effect of alcoholic extract of Tarantula cubensis alcoholic extract (TCAE) in experimentally induced inflammation in rats. Fifty-four adult Sprague-Dawley male rats were randomly divided into nine groups. Paw edema was induced by 0.2mL subplantar (s.p.) injection of 1% carrageenan (CAR) into the right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) (10mg/kg, p.o.) or TCAE at different doses (1, 10 or 100 mu g/kg) injected s.c. for systemic or s.p. for local anti-inflammatory effect. Saline was used as control. Changes in paw thickness, volume, and weight were calculated as percentages. Formalin-fixed paws were used for histopathological examination. We detected that TCAE applied s.c. at 10 mu g/kg and 100 mu g/kg doses resulted in thinner paw thickness, lower paw volume, and lower paw weights four hours after the induction of inflammation when compared with the INDO group (p<0.05). The paw edema inhibitory effect of TCAE applied at a dose of 10 mu g/kg, s.c. was 68% when compared with the INDO which had an inhibitory effect of 56%. These results were verified with similar histopathological findings. The anti-inflammatory feature of 10 mu g/kg of TCAE given systematically was similar to the effects of INDO. Our results suggest that TCAE has anti-inflammatory effects by reducing edema and decreasing inflammatory reaction. These results may be attributed to the inhibition of the production of proinflammatory mediators. Thus, TCAE may be considered as a potential anti-inflammatory agent for treating acute inflammatory conditions.