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GÜNEŞ, MESUT ERTAN

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    New antibacterial agent: Nanobubble ozone stored in liposomes: The antibacterial activity of nanobubble ozone in liposomes and their thymol solutions
    (Taylor, 2021-03-30) Alkan, Perihan Erkan; Güneş, Mesut Ertan; Özakın, Cüneyt; Sabancı, Ahmet Ümit; ERKAN ALKAN, PERİHAN; GÜNEŞ, MESUT ERTAN; ÖZAKIN, CÜNEYT; Bursa Uludağ Üniversitesi/Sağlık Hizmetleri Meslek Yüksekokulu; Bursa Uludağ Üniversitesi/Teknik Bilimler Meslek Yüksekokulu/Gıda İşleme Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Mikrobiyoloji Anabilim Dalı; 0000-0002-8837-3375; 0000-0002-9347-8307; 0000-0001-5428-3630; AAK-4470-2021; JHZ-5366-2023
    Ozone is a highly effective oxidant. In its gaseous form, ozone is not a stable compound; however, stability and effectiveness are sustained for a long period, when stored in vegetable oils. In this study, solutions are prepared containing a combination of ozone nanobubbles, vegetable oils and emulsifiers. Throughout the study, the antibacterial effectiveness and stability of ozone nanobubble carried in liposomes and their solutions with thymol are tested on strains of Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922). Findings of the study suggest that the stability range of the ozone nanobubbles carried in liposomes extend to a 1-year period. In addition, the antibacterial effectiveness of this structure, both with and without thymol, is tested to be substantially high on the sample bacteria. These ozone structures/solutions can be stored at +4 degrees for an extended period of time compared to ozone's possible stability range as a sole trioxygen molecule. Results of the study highlight the possibility of extending the storage/stability range even further.
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    Nanoparticle liposomes: A new strategy in bacterial infections
    (Doc Design Informatics, 2021-08-01) Erkan Alkan, Perihan; Güneş, Mesu Ertan; Özakın, Cüneyt; Sabancı, A. Ümit; ERKAN ALKAN, PERİHAN; GÜNEŞ, MESUT ERTAN; ÖZAKIN, CÜNEYT; Bursa Uludağ Üniversitesi/Sağlık Hizmetleri Meslek Yüksekokulu; Bursa Uludağ Üniversitesi/Teknik Bilimler Meslek Yüksekokulu; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Klinik Mikrobiyoloji Anabilim Dalı; 0000-0002-8837-3375; 0000-0002-9347-8307; AAK-4004-2021; AAK-4470-2021; JRO-4525-2023
    Objective: In our study, a nanoparticle liposome molecule with patent application number TR201804452A2 was used, and the Minimum Inhibitor Concentration (MIC) was found to be 1562 ppm. According to the ASTMF 1980 standard, it has been determined that the nanoparticle liposome solution kept at 37 days and 55 degrees C in return for one-year stability preserves its effectiveness. Our study aimed to show that the newly developed solution maintains its effectiveness for a long time.Methods: CLSI M07-A10 (Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Tenth ed. Approved Standard) standard test method of the nanoparticle liposome solution developed with a technique different from the standard ozonation mechanisms, and antibacterial tests were performed by modifying the contact time and the MIC value of the solution, and its effect on time has been determined. For the stability test of the nanoparticle liposome solution, it was kept at 55 degrees C for 37 days in return for one-year stability according to the ASTM F 1980 standard.Results: MIC of nanoparticular ozone solution CLSI M07-A10 standard test method for S. aureus (ATCC 25923) and E. coli (ATCC 25922) strains by modifying contact time It was determined as 1.562 ppm. For S. aureus (ATCC 25923), at the end of the first hour, it was determined that the activity started at 2000 and 1750 ppm nanoparticle liposome solution concentration. For E. coli (ATCC 25922) it was determined that the activity started at the 10th minute at 2000 ppm nanoparticular ozone solution concentration. The solution was still effective at the end of one year according to the ASTM F 1980 standard in terms of effectiveness.Conclusions: As a result, the nanoparticle liposome solution, a new product, does not lose its stability and effectiveness for a long time, contrary to what is known. Although the half-life of gaseous ozone is as short as 20 minutes, the stability in the nanoparticle liposome solution has been determined as at least one year. Since nanoparticle liposome solution is a natural and slow-release product, it is thought that it can create a barrier in mucosal membranes in regions such as the nose, throat, eye and ear with solutions to be prepared in appropriate doses thus preventing bacteria from settling.