Person: TEMİZEL, ETHEM MUTLU
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TEMİZEL
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ETHEM MUTLU
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Publication IGF-1 and GH alterations in lambs with intestinal inflammation(TÜBİTAK, 2021-01-01) Temizel, Ethem Mutlu; Karakuş, Adil Ömer; Kavukcu, Fatih; Küçükşen, Duygu Udum; Ercan, İlker; TEMİZEL, ETHEM MUTLU; Karakuş, Adil Ömer; Kavukcu, Fatih; Küçükşen, Duygu Udum; ERCAN, İLKER; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-6834-0808; 0000-0002-2382-290X; ECV-4083-2022; FBQ-7974-2022; JJZ-4815-2023; JJM-7084-2023; ABF-2367-2020Insulin-like growth factor-1 (IGF-1) acts on the development of internal organs such as the small intestine and muscle in all animal species. Similar to IGF-1, GH is also essential for growth and is an effective hormone on intestinal development during neonatal period. The aim of this study was to investigate the effects of diarrhea on IGF-1 and GH hormones in lambs with intestinal inflammation up to 63 days of age. The study material consisted of 15 healthy and 15 diarrheic lambs. Blood and fecal samples were collected on the first day of life and on the 7th, 14th, 21st, 35th, 49th and 63rd postnatal days consecutively. Diarrhea was observed on 6 animals on the 7th day and 9 animals on 14th day visitation. IGF-1 showed statistically significant differences (P < 0.01) between diarrheic and healthy animals on all measurement days. A significant association was found between the cut-off values determined after ROC analysis of the 7th day (Sens: 93.33%, Spec: 66.67%, P = 0.004) and 14th day (Sens: 73.33%, Spec: 80%, P = 0.0002) values of IGF-1 and diarrhea. Considering 14th day of IGF-1, a logistic regression analysis was performed, the risk of diarrhea is OR = 7.00 times higher if the concentration of the parameter is above the cut-off value. ROC analysis also showed significant cut-off values for GH on 14th day. In terms of sensitivity, the highest value was IGF-1's 7th day value, therefore it can be preferred for the determination of intestinal inflammation in cases with diarrhea. As a general evaluation, it is seen that the highest performance was given by the 7th day IGF-1 values according to the Youden's J index. In conclusion, elevations in IGF-1 and GH concentrations may be associated with intestinal inflammation. The inducing effect of the inflammatory response on IGF-I and GH may strengthen the relationship between the two parameters.Publication Immune response of cattle to botulinum type C and D toxoid administered on three occasions(Univ Agriculture, Fac Veterinary Science, 2015-01-01) Mecitoğlu, Zafer; Temizel, Ethem Mutlu; Özyigit, Özgür; Akgül, Gülşah; Kennerman, Engin; MECİTOĞLU, ZAFER; TEMİZEL, ETHEM MUTLU; ÖZYİĞİT, MUSA ÖZGÜR; Akgül, Gülşah; KENNERMAN, ENGİN; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı; AAH-1677-2021; ECV-4083-2022; GLP-3036-2022; CBU-1718-2022; FDU-5862-2022The aims of the present study were to investigate the antibody response of cows from an outbreak region to vaccination with a bivalent botulinum toxoid (Type C and D) on three occasions and to investigate the antibody response to vaccination with the botulinum toxoid in the presence of anti-BoNT antibodies. Twenty-two cows from an outbreak region and 10 cows from a farm without a history of botulism were used in this study. Blood samples were collected before each vaccination and three weeks after the third vaccination (days 0, 21, 42 and 63). The level of anti-BoNT/C antibodies steadily increased after each vaccination (0.471 +/- 0.04, 0.566 +/- 0.03 and 0.663 +/- 0.04, respectively); however, the levels of anti-BoNT/ D antibodies were not significantly different after the second and third vaccinations (0.377 +/- 0.03, 0.493 +/- 0.03 and 0.465 +/- 0.03, respectively). Post vaccination antibody responses of animals found positive and negative for anti-BoNT antibodies at the beginning of the study were similar. The results of the present study indicated that vaccination of cattle with botulinum toxoid on three occasions is recommended, particularly in outbreaks that are suspected to be caused by BoNT/C and that presence of naturally acquired antibodies against BoNT did not interfere with post vaccination immune response.Publication Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia(Elsevier, 2015-04-01) Temizel, Ethem Mutlu; Batmaz, Hasan; Keskin, Abdülkadir; Orman, Abdülkadir; Gençoğlu, Hıdır; Çatık, Serkan; Topal, Onur; TEMİZEL, ETHEM MUTLU; BATMAZ, HASAN; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GENÇOĞLU, HIDIR; Çatık, Serkan; TOPAL, ONUR; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; 0000-0001-9138-4422; 0000-0002-1933-7354; 0000-0003-1991-8957; HJZ-4775-2023; AAH-1712-2021; AAH-3831-2021; AAG-9134-2021; S-8278-2017; ECV-4083-2022; CHM-0716-2022The effect of administration of butaphosphan and cyanocobalamin on the prophylaxis of pregnancy toxaemia in ewe was investigated. Moreover, the effects of these compounds on body weight gain and biochemical metabolism of pregnant ewe was assessed. A total of 59 pregnant Kivircik crossbred ewes were used in this study. Group I (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 1-week intervals. Group II (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 3-day intervals. Group III (n: 15) was administered 0.9% NaCl three times before delivery at 1-week intervals. Group IV (n: 14) was administered 0.9%NaCI three times before delivery at 3-day intervals. Six blood samples Were taken from each ewe four times before delivery and two times after delivery. Haematological and biochemical analyses were performed.The levels of BHB and NEFA in groups administered butaphosphan and cyanocobalamin were noticeably lower but there were no statistically significance. Elevated BHB (>0.8 mmol/L), subclinical pregnancies toxaemia were identified in 56.66% in test groups and 72.41% in control groups in all ewes and this was higher in the ewes bearing multiple pregnancies 71.42 in test groups and 82.35% in control groups. Subclinical pregnancy toxaemia in pregnant ewes with twins or triplets is lower than the levels for the control groups, despite the greater lamb counts and weights of the ewes in test groups.Based on our results, it was concluded that the butaphosphan and cyanocobalamin combination could be used as an alternative treatment for the prevention of pregnancy toxaemia. (C) 2015 Elsevier B.V. All rights reserved.Publication Evaluation of glutaraldehyde coagulation test and colostrum brix refractometer compared with snap foal igg test in neonatal foals(Wiley, 2023-10-01) Babaeski, Serdar; Kasap, Sevim; KENNERMAN, ENGİN; KASAP, SEVİM; Kennerman, Engin; ORMAN, ABDÜLKADİR; Orman, Abdulkadir; TEMİZEL, ETHEM MUTLU; Yıldırım, Kübra Nur; YILDIRIM, KÜBRA NUR; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; 0000-0001-9138-4422; AAG-9134-2021Background: Prompt diagnosis of passive transfer failure in the neonatal period is important for early treatment.Objectives: To compare the diagnostic performance of serum glutaraldehyde coagulation test (GCT) and colostrum BRIX% for failure to transfer passive immunity (FTPI) diagnosis with the results of SNAP foal test and to evaluate the results of serum GCT and colostrum BRIX% measurements in foals with diarrhoea in the 0-1 month period.Study design: In vitro experiments.Methods: Excess serum and colostrum (n: 298) from samples collected from newborn foals and their dams for clinical purposes were used. Foals were classified as FTPI positive (IgG < 8 g/L) or negative (IgG >= 8 g/L) using the SNAP foal test. We compared the sensitivity and specificity of serum GCT and colostrum BRIX % for diagnosing FTPI in all foals and in the sub-group of foals which developed diarrhoea within the first month of life was noted. The relationships between the results of the serum GCT and colostrum BRIX% and diarrhoea in foals with and without FTPI were evaluated.Results: Serum GCT and colostrum BRIX % were statistically significantly different (p < 0.05) between the foals without FTPI and with FTPI classified according to the SNAP test. Using a cut-off value for serum GCT of >10, sensitivity was 100% (95% CI 92.9%-100%) and specificity 100% (98.3%-100%) while with a cut-off value of <= 24, with colostrum BRIX% of <= 24 sensitivity was 92% (80.9%-97.8%), and specificity was 98% (95.3-99.3). In the sub-group of foals without FTPI using a colostrum BRIX% cut-off value of <= 26 the sensitivity for prediction of diarrhoea in the 0-1 month period was only 72.4% (52.8-87.3, p < 0.001) with specificity 54.3% (47.6-61.1) but the test performance was not robust (ROC AUC 0.61).Main limitations: The number of repeated measurements in the evaluation of serum GCT, and colostrum BRIX% was low. More clinical problems could be examined.Conclusions: The serum GCT, and colostrum BRIX%, both economical and practical to use in the field, gave results comparable with the SNAP foal IgG test. The ability to accurately predict diarrhoea in the first month of life with these tests was limited.