Person: DİLEK, KAMİL
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Publication Effects of anti-tumor necrosis factor therapy on kidney function in patients with inflammatory arthritis(Oxford Univ Press, 2013-05-01) Öztürk, Oğuzhan; Yıldız, Abdulmecit; Gül, Cuma Bülent; Dilek, Kamil; GÜL, CUMA BÜLENT; DİLEK, KAMİL; Tıp Fakültesi; 0000-0003-2467-9356; A-7063-2018; EUF-5229-2022Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication A family with IgA nephropathy and hereditary lymphoedema praecox(Wiley, 2002-05-01) Usta, M; Dilek, Kamil; Ersoy, Ahmet; Alper, E; Özbek, Serhat; Özdemir, Bülent; Filiz, G; Yavuz, M; Güllülü, Mustafa; Yurtkuran, Merih; Usta, M; DİLEK, KAMİL; Ersoy, Ahmet; Alper, E; ÖZBEK, SERHAT; ÖZDEMİR, BÜLENT; Filiz, G; Yavuz, M; GÜLLÜLÜ, MUSTAFA; Yurtkuran, Merih; Uludağ Üniversitesi Tıp Fakültesi; Nefroloji Bölümü; 0000-0003-3427-8337; 0009-0001-9179-9107; HYD-3798-2023; CNY-9323-2022; GXG-1656-2022; CCY-8570-2022; FTG-3544-2022; JHE-3353-2023; EVQ-8652-2022; HJG-9929-2022; JGS-9425-2023; GLB-5791-2022Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis worldwide. The pathogenesis is still unknown and treatment has not yet been established. Rarely it can be associated with other disorders. Its association with hereditary lymphoedema is not reported before. We report four patients, a 60-year-old father, his two sons and his daughter, with hereditary lymphoedema. The family had nine members and in four of them lymphoedema was evident. The other members had neither lymphoedema nor IgA nephropathy. This is the first report of IgA nephropathy in association with hereditary lymphoedema.Publication Efficacy of tacrolimus in patients with primary focal segmental glomerulosclerosis resistant to immunosuppressive treatments(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2011-01-01) Usta, Mehmet; Ersoy, Alparslan; Gül, Cuma Bülent; Kahvecioğlu, Serdar; Akdağ, İbrahim; Güllülü, Mustafa; Yavuz, Mahmut; Dilek, Kamil; Yurtkuran, Mustafa; ERSOY, ALPARSLAN; GÜL, CUMA BÜLENT; GÜLLÜLÜ, MUSTAFA; YAVUZ, MAHMUT; DİLEK, KAMİL; Yurtkuran, Mustafa; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0710-0923 ; 0000-0003-2467-9356; AAH-5054-2021; A-7063-2018; JGS-9425-2023; EHM-7377-2022; EUF-5229-2022; EGT-2006-2022OBJECTIVE: We investigated the efficacy and safety of tacrolimus in patients with primary focal segmental glomerulosclerosis (FSGS) resistant to treatment in this study.MATERIAL and METHODS: This prospective study included 9 patients (5 female/4 male) with FSGS resistant to steroids. Their immunosuppressive treatments except corticosteroids were stopped at least six months previously. Tacrolimus (4 mg/day) treatment was administered. The daily urinary protein excretion, serum creatinine, albumin and total cholesterol values were measured before and after treatment.RESULTS: The mean level of daily urinary protein excretion, serum creatinine and serum albumin at the baseline was 4.7 +/- 3.3 g/day, 1.2 +/- 0.6 mg/dL, and 3.5 +/- 0.7 g/dL, respectively. The daily urinary protein excretion significantly reduced from the 1st month of the treatment. At the 6th month, complete remission was achieved in 3 patients (33%) and partial remission in 2 patients (22%). 3 patients were resistant to the treatment. There was no difference in serum albumin, creatinine and cholesterol levels after the treatment when compared to the baseline levels.CONCLU SION: Tacrolimus is a safe and effective treatment in patients with FSGS resistant to treatment. However, the tendency to relapse in all patients who have complete or partial remission when the treatment was withdrawn demonstrates dependence on treatment.Publication Paricalcitol protects peritoneal membrane function in encapsulating peritoneal sclerosis(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2016-01-01) Gül, Cuma Bülent; Yıldız, Abdülmecit; Vuruşkan, Berna; Gül, Özen Öz; Oruç, Ayşegül; Aktaş, Nimet; Ersoy, Alparslan; Güllülü, Mustafa; Dilek, Kamil; Yavuz, Mahmut; Yurtkuran, Mustafa Abbas; YILDIZ, ABDULMECİT; AYTAÇ VURUŞKAN, BERNA; ÖZ GÜL, ÖZEN; ORUÇ, AYŞEGÜL; ERSOY, ALPARSLAN; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; YAVUZ, MAHMUT; Yurtkuran, Mustafa Abbas; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0002-0710-0923 ; 0000-0002-0342-9692; HIG-9032-2022; AAH-9746-2021; AAI-1005-2021; AAH-4002-2021; AAH-5054-2021; JGS-9425-2023; EUF-5229-2022; EHM-7377-2022; IPP-3337-2023OBJECTIVE: The most lethal complication of peritoneal dialysis is encapsulating peritoneal sclerosis (EPS), which develops as a result of epithelio-mesenchymal transformation (EMT) and known fibrotic processes. Paricalcitol has previously been shown to inhibit both EMT and fibrosis. We investigated the effect of paricalcitol on EPS.MATERIAL and METHODS: Forty non-uremic albino Wistar rats divided into four groups of equal numbers. The first group was administered 2 mL saline intraperitoneally (IP) and the second group was administered 2 mL of 200 gram chlorhexidine gluconate (CG) (0.1%) dissolved in saline and ethanol (15%) IP. The treatment groups received CG for three weeks in addition to subcutaneous paricalcitol at a dose of 0.2 mcg/kg/day to the third group and 0.4 mcg/kg/day to the fourth group. A one-hour peritoneal equilibration test was performed with 25 mL 3.86% PD solution at the end of the study. Peritoneal membrane and intracardiac blood samples were obtained.RESULTS: D/P urea was significantly low in both treatment groups when compared to group 2 (p<0.05). Paricalcitol co-treatment recovered ultrafitration failure and peritoneal membrane thickness was better paricalcitol groups but there was no statistically significant difference between the groups. Serum calcium, phosphorus and parathyroid hormone levels were similar in all groups.CONCLUSION: Paricalcitol can be effective in the protection of peritoneal functions.Publication Lower gastrointestinal tract hemorrhage due to ectopic pancreatic tissue in a renal transplant recipient: : A case report(Elsevier, 2002-06-01) Ersoy, Alpaslan; Yavuz, M; Tokyay, R; Yerci, Ömer; Kıyıcı, Murat; Usta, M; Güllülü, Mustafa; Dilek, Kamil; Oktay, B; Yurtkuran, Merih; ERSOY, ALPARSLAN; Yavuz, M; Tokyay, R; YERCİ, ÖMER; KIYICI, MURAT; Usta, M; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; Oktay, B; Yurtkuran, M.; Uludağ Tıp Fakültesi; Tıp Fakültesi; Nefroloji Bölümü; 0000-0002-3208-6211; AAH-5054-2021; AAI-4213-2021; IHY-2104-2023; DZX-1258-2022; EIS-5114-2022; GGE-6952-2022; JGS-9425-2023; EUU-1912-2022; FRV-0139-2022; EGT-2006-2022Publication Modified histopathological classification with age-related glomerulosclerosis for predicting kidney survival in ANCA-associated glomerulonephritis(Springer, 2022-09-25) Aydın, Mehmet Fethullah; Yıldız, Abdülmecit; Oruç, Ayşegül; Vuruşkan, Berna Aytaç; Akgür, Suat; Ayar, Yavuz; Güllülü, Mustafa; Dilek, Kamil; Yavuz, Mahmut; Ortaç, Hatice; Ersoy, Alparslan; Aydın, Mehmet Fethullah; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; AYTAÇ VURUŞKAN, BERNA; Ortaç, Hatice; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-0342-9692 ; 0000-0002-5665-7402 ; AAJ-8220-2020; HIG-9032-2022; AAH-4002-2021; EEJ-1452-2022; JGS-9425-2023; EUF-5229-2022; EHM-7377-2022; HJF-9598-2022; CPX-5894-2022Background The histopathological classification of ANCA-GN divides patients into four groups based on signs of glomerular injury. However, this classification did not consider age-related glomerulosclerosis. In this study, we aimed to compare the prediction of renal survival between Berden's ANCA-GN histopathological classification and ANCA-GN histopathological classification modified with age-related glomerulosclerosis. Methods Between January 2004 and December 2019, 65 patients diagnosed with ANCA-GN were enrolled. Demographic, laboratory, and histopathologic findings were retrospectively analyzed. Renal survival analyses were compared according to classical and modified ANCA-GN histopathological classifications. Multivariate Cox regression analysis for the factors affecting renal survival was performed. Results In Berden's ANCA-GN histopathological classification, 15 patients were in the focal group, 21 in the crescentic, 21 in the sclerotic, and 8 in the mixed group. The ANCA-GN histopathological classification model generated statistically significant predictions for renal survival (p = 0.022). When the histopathological classification was modified with age-related glomerulosclerosis, eight of the nine patients previously classified in the sclerotic group were classified in the mixed and one in the crescentic groups. Modification of histopathological classification with age-related glomerulosclerosis increases the statistical significance in renal survival analysis (p = 0.009). The multivariate Cox regression analysis showed that the disease-related global sclerotic glomeruli percentage and serum creatinine level were significant independent factors. Conclusion Modification of Berden's ANCA-GN histopathological classification model with age-related glomerulosclerosis may increase the statistical significance of the histopathological classification model.Publication Demographic and clinical characteristics of patients with autosomal dominant polycystic kidney disease: A single center experience(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2016-01-01) Yıldız, Abdulmecit; Sağ, Saim; Oruç, Ayşegül; Ayar, Yavuz; Gül, Bülent; Aktaş, Nimet; Aydın, Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Güllülü, Mustafa; Dilek, Kamil; YILDIZ, ABDULMECİT; Sağ, Saim; ORUÇ, AYŞEGÜL; Ayar, Yavuz; Aydın, Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0002-5665-7402; AAJ-8220-2020; AGF-0767-2022; AAW-9185-2020; AAH-5054-2021; O-9948-2015; GSE-0029-2022; AAH-4002-2021OBJECTIVE: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We presented the ADPKD patients who were not undergoing replacement therapy.MATERIAL and METHODS: According to the Turkish Nephrology Society Cystic Kidney Disease Working Group online database, patients with ADPKD were questioned for age, sex, smoking, level of education, hypertension (HT), hematuria, history of urinary stones, urinary infections, and extrarenal history of any cysts. Patients who had undergone kidney replacement therapy and who had a glomerular filtration rate (GFR) less than 30 ml/min were excluded.RESULTS: A total of 93 patients (41 +/- 13 years, 44 female, 49 male) were included. 47% of the patients were current smokers and 72% were on at least one antihypertensive drug. The average GFR was 92 +/- 29 ml/min, and the microalbumin-to-creatinine ratio on spot urine was 18 mg/g. Apart from patients who had kidney cysts, 35% had a history of a liver cyst, 25% had kidney stones and 14% had macroscopic hematuria.CONCLUSION: HT and smoking are frequently seen in early phase of ADPKD. These risk factors have a negative effect on the development of cardiovascular disease and renal prognosis in these patients. Overall, this study showed that aggressive care must be ensured to control these risk factors.Publication A case of behcet's disease concomitant with kaposi's sarcoma(Wolters Kluwer Medknow Publications, 2010-06-01) Erdem, Hatice; Hacıoğlu, Şenay Yıldız; Sarıcaoğlu, Hayriye; Dilek, Kamil; Adım, Şaduman Balaban; Erdem, Hatice; Hacıoğlu, Şenay Yıldız; SARICAOĞLU, HAYRİYE; DİLEK, KAMİL; BALABAN ADIM, ŞADUMAN; Tıp Fakültesi; Dermatol Ana Bilim Dalı; HIZ-7238-2022; ICQ-8894-2023; DPU-8534-2022; EUF-5229-2022; EMN-0789-2022Iatrogenic Kaposi's sarcoma is a subtype of Kaposi's sarcoma (KS), which is a vascular malignant tumor and is seen in organ transplant recipients and in patients receiving immunosuppressive therapy due to other reasons. Iatrogenic KS can develop after corticosteroid or immunosuppressive drug therapy due to systemic lupus erythematosus, rheumatoid arthritis, polymyositis, dermatomyositis, polymyalgia rheumatica and Beh double dagger et's disease, generally with ocular involvement. Our case was a 44-year old male patient. Colchicine and prednisolone were administered for his mucocutaneous findings and polyarthritis. In the seventh month of the therapy, four symmetric, brown-red coloured, asymptomatic macules developed on the inner surface of his left foot. In histopathologic specimens; CD34 positive, atypical spindle cells with swollen nuclei formed bundles and vascular spaces filled with erythrocytes. The patient was diagnosed as KS histopathologically and clinically. HHV-8 DNA was positive with PCR. Regression was observed in the lesions after the cessation of corticosteroid treatment. This case is presented because he was the only case with iatrogenic Kaposi's sarcoma among our Behcet's disease patients receiving corticosteroids or immunosuppressive therapies.Publication Goodpasture's syndrome initially presenting with alveolar hemorrhage(Aves, 2007-12-01) Ursavaş, Ahmet; URSAVAŞ, AHMET; Dilek, Kamil; DİLEK, KAMİL; Kahveci, Serdar; Uzarslan, Esra; Gözü, R. Oktay; Tıp Fakültesi; Romatoloji Ana Bilim Dalı; AAI-3169-2021Goodpasture's syndrome is characterized by rapidly progresive glomerulonephritis, presence of deposited and circulating anti-glomerular basement membrane (GBM) antibodies which often accompanied by lung haemorrhage. The antigen target in Goodpasture's syndrome is the alpha 3 chain of type IV collagen. Heamoptysis may be the initial symptom. We present a case of Goodpasture's syndrome presented with diffuse alveolar heamorrhage.