Person: DÜNDAR, HALİT ZİYA
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DÜNDAR
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HALİT ZİYA
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Publication Clinical features and short-term outcomes of bariatric surgery in morbidly obese patients: Institutional experience at a rural hospital(Mary Ann Liebert, Inc, 2021-03-01) Şenol, Kazım; Ferhatoğlu, Murat Ferhat; Kocaeli, Aysen Akkurt; Dündar, Halit Ziya; Kaya, Ekrem; ŞENOL, KAZIM; DÜNDAR, HALİT ZİYA; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı; 0000-0002-9562-4195; FVY-2168-2022; EWI-3634-2022; AAG-7319-2021Objective: To prospectively evaluate the postoperative morbidity, mortality, and weight loss evolution of patients who underwent a bariatric procedure during 1 year of follow-up.Methods: Since July 2016, a total of 101 patients' data have been prospectively registered in a database. Comorbidities, operating time, hospital stay, early and late complications rate, and weight loss evolution after 1 year of follow-up were recorded.Results: The mean age was 38.41 +/- 11.05 years with a mean body mass index (BMI) of 49.02 +/- 5.89 kg/m(2) (range 38-67). Laparoscopic sleeve gastrectomy (LSG) was performed in 93 patients (92.07%) and Roux-en-Y gastric bypass (RNYGB) in 8 patients (7.92%). Thirty-day morbidity rate was 7.92% (8/101). Within a mean 9.32 +/- 2.25 (range 1-19) months follow-up time, mean percent of the excess of weight loss of 1st, 6th, and 12th months were 22.7 +/- 6.1, 67.2 +/- 11.2, and 81.4 +/- 10.5, respectively. Diabetes (n = 38, 37.6%), hypertension (n = 13, 12.9%), and obstructive sleep apnea (n = 5, 4.9%) were resolved in 76%, 68.4%, and 100% of the patients, respectively (p < 0.001).Conclusions: LSG and RNYGB are safe and highly effective, particularly in patients with a BMI >50 kg/m(2). Both techniques have been presented with better clinical outcomes regarding significant comorbidity resolution in the early evolution of weight loss.Publication Proteomic analysis of liver preservation solutions prior to liver transplantation(Bentham Science Publ Ltd, 2019-01-01) Coşkun, Abdurrahman; Baykal, Ahmet Tarık; Öztuğ, Merve; Kazan, Dilek; Emiroğlu, Remzi; Yılmaz, Sezai; Akgöz, Müslüm; Berber, İbrahim; Aktaş, Hikmet; Bilsel, Gökhan; Karaosmanoğlu, Kübra; Çetiner, Banu; Arslan, Cansu; Yurtsever, İlknur; Yazıcı, Cevat; Kaya, Ekrem; KAYA, EKREM; Dundar, Halit Ziya; DÜNDAR, HALİT ZİYA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0002-9562-4195; EWI-3634-2022; AAG-7319-2021Objective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period.Material/Methods: Samples were collected from the pre-transplant preservation mediums of 23 liver donors. For all donors, the cases involved Donation after Brain Death (DBD). 2D-PAGE and LCMSMS methodologies were used to detect the proteins and peptides from the preservation mediums.Results: A total of 198 proteins originating from the liver were detected.Conclusion: The data provide valuable insights into biomarkers that may be used to evaluate organ injury, functional status, and suitability for transplantation. Additionally, the findings could be valuable for the development of new strategies for effective preservation of solid organs prior to transplantation.Publication Covid-19 in liver transplant recipients: A national cohort(Elsevier, 2021-07-01) Kabaçam, Gökhan; Turan, İlker; Kiyici, Murat; Ellik, Zeynep Melekoğlu; Dolu, Süleyman; Dayanğaç, Murat; Arı, Derya; Gökçe, Dilara Turan; Yıldırım, Abdullah Emre; Gençdal, Genco; Harputluoğlu, Murat; Kartal, Aysun; Demiray, Emine Kübra Dindar; Gündüz, Feyza; Ergenç, İlkay; Efe, Cumali; Sümer, Hale Gökcan; Kayhan, Meral Akdoğan; Gülşen, Murat Taner; Akyıldız, Murat; Arıkan, Çiğdem; Karademir, Sedat; Balcı, Deniz; Dündar, Ziya; Akarsu, Mesut; Günşar, Fulya; Karasu, Zeki; İdilman, Ramazan; KIYICI, MURAT; DÜNDAR, HALİT ZİYA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; FHW-0015-2022; JHK-0911-2023Publication Do morphologic characteristics play a role in nodal metastatic progression of well-differentiated pancreatic neuroendocrine tumors?(Sage Publications Ltd, 2020-07-24) Hasdemir, Seçil; HASDEMİR, SEÇİL; Ugraş, Nesrin; UĞRAŞ, NESRİN; Yerci, Omer; YERCİ, ÖMER; Tasar, Pınar; TAŞAR, PINAR; Dundar, Halit Ziya; DÜNDAR, HALİT ZİYA; Macunluoğlu, Aslı Ceren; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Bioistatistik Anabilim Dalı.; 0000-0003-1769-7484; 0000-0002-6802-5998; AAH-2716-2021Background: Pancreatic neuroendocrine neoplasms (NENs) are tumors with histopathologic and prognostic heterogeneity that pose difficulties in establishing standards for diagnosis, classification, and treatment. Among NENs, well-differentiated neuroendocrine tumors (NETs) have been classified as grade 1, 2, and 3 in the most recently released World Health Organization classification. Although well-differentiated NETs are associated with relatively better prognosis, they have a potential for malignant behavior such as extrapancreatic spread, metastasis, or recurrence. The present study aimed to evaluate clinical and histomorphologic findings of patients with well-differentiated pancreatic NETs and to identify histopathologic findings effective in predicting nodal metastatic progression. Methods: The study group consisted of 54 patients diagnosed with well-differentiated NET. All preparations and blocks of the patients were examined for the following histopathologic parameters: tumor diameter, microscopic tumor growth pattern (solid, trabecular, acinar, and mixed), cellular features (clear, eosinophilic, oncocytic, peliotic, and pseudopapillary), stromal changes (calcification, lymphocytic infiltration, and stromal hyalinization), presence of necrosis, perineural invasion, lymphovascular invasion, mitotic activity, and Ki67 proliferative index. Results: Lymph node metastasis was present in 7 patients. Lymph node metastasis was significantly associated with tumor diameter of >2 cm (p= 0.012), Ki67 proliferative index of >20% (p= 0.022), grade 3 tumors (p= 0.002), presence of dense stromal hyalinization (p= 0.034), and mild lymphocytic infiltration (p= 0.041). Conclusion: The present study revealed that the new findings such as presence of dense stromal hyalinization and absence of remarkable lymphocytic infiltration could be predictive morphologic findings for the development of lymph node metastasis.Publication Tumor-derived exosomal mir-21 induces recurrence in liver cancer(Wiley, 2021-08-01) Aksoy, Fuat; Kaya, Ekrem; Dündar, Halit Ziya; Aksoy, Seçil Ak; Tunca, Berrin; AKSOY, FUAT; KAYA, EKREM; DÜNDAR, HALİT ZİYA; AKSOY, SEÇİL; TUNCA, BERRİN; Bursa Uludağ Üniversitesi.; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0002-9562-4195; ADM-8457-2022; HII-8895-2022; AAG-7319-2021; EWI-3634-2022; ABI-6078-2020Publication Cancer stem cell markers in pancreatic ductal adenocarcinoma(Oxford Univ Press, 2018-10-01) Aksoy, Fuat; Kaya, Ekrem; Egeli, Ünal; Dündar, Halit Ziya; Taşar, Pınar; Aksoy, Seçil; Özen, Yılmaz; Tunca, Berrin; Çeçener, Gülşah; Yerci, Ömer; AKSOY, FUAT; KAYA, EKREM; EGELİ, ÜNAL; DÜNDAR, HALİT ZİYA; TAŞAR, PINAR; AKSOY, SEÇİL; ÖZEN, YILMAZ; TUNCA, BERRİN; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; 0000-0002-9562-4195; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoloji Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Bölümü; 0000-0001-5808-9384; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0002-3820-424X; AAH-1420-2021; AAH-3847-2021; ADM-8457-2022; HII-8895-2022; ABI-6078-2020; AAG-7319-2021; EWI-3634-2022; IIC-9825-2023; FOQ-1792-2022; AAP-9988-2020Publication MicroRNA-21 functions as a prognosis predictor in head of pancreas tumor(Oxford Univ Press, 2018-03-01) Aksoy, Fuat; Aksoy, Savaş; Tunca, Berrin; Dündar, Halit Ziya; Sarkut, Pınar; Özen, Y.; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; AKSOY, FUAT; Aksoy, Savaş; TUNCA, BERRİN; DÜNDAR, HALİT ZİYA; Sarkut, Pınar; Özen, Y.; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; 0000-0002-9562-4195; AAH-3847-2021; HII-8895-2022; AAH-1420-2021; ABI-6078-2020; CAV-8845-2022; EWI-3634-2022; HKB-5363-2023; FOQ-1792-2022; AAP-9988-2020; AAG-7319-2021Publication Acute kidney injury after orthotopic liver transplantation.(Wiley-blackwell, 2013-06-01) İŞÇİMEN, REMZİ; İşçimen, Remzi; Gülcü, Barış; Girgin, Nermin; KELEBEK GİRGİN, NERMİN; Sarkut, Pınar; Dündar, Ziya; DÜNDAR, HALİT ZİYA; Kaya, Ekrem; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi; AAI-8104-2021; HKP-2533-2023; AAH-7250-2019; AAG-7319-2021Publication Is donor age an important factor in cadaveric organ donation?(Aves, 2018-09-01) Dündar, Halit Ziya; Oflaz, Rafet; Çınar, Yavuz Selim; Sarkut, Pınar; Özkan, Ömer Faruk; Kaya, Ekrem; DÜNDAR, HALİT ZİYA; Oflaz, Rafet; Çınar, Yavuz Selim; Sarkut, Pınar; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; AAG-7319-2021; JIK-5424-2023; DJU-5362-2022; JJX-5826-2023; HKB-5363-2023Introduction: Our liver transplantion center has determined that the organ donation rate is low in young donors. The goal of study was to investigate whether this observation was valid and the causes for rejecting organ donation among family members of young donors.Methods: The brain death declaration and organ donation rates were analyzed during the study period. The relationship between the organ donation and donor's age was investigated, and factors related to refusing organ donation were also analyzed. A questionnaire including 10 questions was prepared for family members of brain-dead patients, who rejected organ donation. The study was conducted by phone, and conversations were recorded.Results: Including the years between 2011 and 2015, there was a total of 750 brain death declarations, and 508 of the patients did not approve organ donation. The donor rate under 30 years was lower as compared to the elderly patients (23.8% vs. 32.9%, p=0.026). The most common reasons for refusing organ donation were religious in nature and the anxiety about the corruption of bodily integrity. Sixty-two percent of family members who refused organ donation declared that they would have accepted organ donation if the donor declared accepting organ donation when he or she was alive.Conclusion: For family members of patients who deceased at young ages emotional attitudes are very important about the decision of organ donation. The testament of person about organ donation is the most important factor affecting the decision of family members.