Person: KAFA, İLKER MUSTAFA
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KAFA
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İLKER MUSTAFA
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Publication Preventive effects of maternal CDP-choline, administered either alone or in combination with a steroid, on lung injury in a neonatal rat model of hyperoxia(Springernature, 2019-09-01) Koç, Cansu; Cansev, Mehmet; Alkan, Tülin; Kafa, İlker Mustafa; Çetinkaya, Merih; KOÇ, CANSU; CANSEV, MEHMET; ALKAN, TÜLİN; KAFA, İLKER MUSTAFA; Tıp Fakültesi; 0000-0001-8309-0934; AAA-4754-2022; M-9071-2019; AAH-1792-2021; AAG-7125-2021Publication Peer-assisted skills learning in structured undergraduate medical curriculum: An experiential perspective of tutors and tutees(Wolters Kluwer Medknow Publications, 2022-05) Aydin, Mevlüt Okan; Kafa, İlker Mustafa; Özkaya, Güven; Alper, Züleyha; Haque, Shafiul; AYDİN, MEVLÜT OKAN; KAFA, İLKER MUSTAFA; ALPER, ZÜLEYHA; ÖZKAYA, GÜVEN; 0000-0002-8060-8803; 0000-0001-8309-0934; 0000-0002-8349-9868; AAI-3331-2021; AAG-7125-2021; ABE-2261-2020; FQT-8976-2022Background and Aims: This study aims to evaluate the implication of peer-assisted learning model adopted in students' clinical skills training from the perspective of tutees and tutors at the end of a peer-tutored clinical skills program and peer tutors themselves. Subjects and Methods: This cross-sectional study was conducted in the Faculty of Medicine, Bursa Uludag in between January and March 2018. Following the clinical skills training, a questionnaire designed to assess the views of tutees and peer tutors was filled out on a voluntary basis by 159 tutees and 43 tutors. The statistical analysis of the collected and processed data was analyzed by using IBM SPSS 23.0 statistical program. The statistical significance level was maintained as alpha = 0.05. Results: According to the Likert scale, satisfaction with the tutors and the educational environment was high in general. The 2nd term tutees provided more negative feedback compared to other terms. Among all the terms, the most positive answers were provided by the 3rd term students. Although the tutors found themselves fully skilled in communication with colleagues, there were striking differences between the tutors in the 5th and 6th terms of providing a good role model for pre-clinical terms students. Conclusion: Considering peer assisted learning (PAL)'s positive responses from this study, the adoption of PAL has been started to be used as a supplementary teaching method for the clinical skills training at the Faculty of Medicine, Bursa Uludag University. PAL is considered a successful education model since it is cost-efficient for undergraduate medical training and improves the professional skills of both teacher and learner students. It can be availed of as an alternative method in medical faculties where especially the number of academic members is insufficient.Publication Hopelessness among medical students caused due to covid-19 pandemic linked educational hiatus: A case study of Bursa Uludag University, Türkiye(MDPI, 2023-02-01) Aydın, Mevlüt Okan; Özkaya, Güven; Kafa, İlker Mustafa; Haque, Shafiul; Alper, Züleyha; AYDİN, MEVLÜT OKAN; ÖZKAYA, GÜVEN; KAFA, İLKER MUSTAFA; ALPER, ZÜLEYHA; Tıp Fakültesi; Tıp Eğitimi Ana Bilim Dalı; 0000-0002-8060-8803; 0000-0003-0297-846X; 0000-0001-8309-0934; A-4421-2016; ABE-2261-2020; AAI-3331-2021; AAG-7125-2021The COVID-19 pandemic has caused disruptions in medical education, leading to feelings of hopelessness among students regarding their medical careers. However, effective institutional crisis-response approaches can mitigate these feelings of hopelessness. This study evaluated changes in the levels of hopelessness among Turkish medical students due to interruptions in their education caused by the pandemic between March and July 2020, using the Beck Hopelessness Scale in three selected periods. A statistical survey was conducted with a total of 3580 participants in three different periods to study the impact of various contributing factors, such as socio-economic status, family problems, health problems, and lack of working environment, on the levels of hopelessness in conjunction with active COVID-19 cases and the effect of institutional interventions for the continuation of medical education during the pandemic. The analysis revealed a direct relationship between contributing factors and hopelessness scores at the end of the selected three periods. Additionally, active COVID-19 cases and institutional crisis-response strategies were found to be indirectly associated with students' hopelessness. An increase in students' hopelessness was found to be related to an increase in active COVID-19 cases in the country, a lack of continuing education practices, and the role of contributing factors. Conversely, a decrease in hopelessness was associated with effective institutional crisis-response strategies. These findings suggest that educational settings dealing with practical subjects should prioritize preparedness for crisis situations.Publication Usability of dental pulp visibility and tooth coronal index in digital panoramic radiography in age estimation in the forensic medicine (vol 134, pg 381, 2020)(Springer, 2020-05-01) Gök, Ertuğrul; Fedakar, Recep; Mustafa Kafa, İlker; FEDAKAR, RECEP; KAFA, İLKER MUSTAFA; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0001-8309-0934; AAH-6287-2021; AAG-7125-2021Publication Glutamatergic activation of A1 and A2 noradrenergic neurons in the rat brain stem(Medicinska Naklada, 2019-07-10) Gök-Yurtseven, Duygu; Kafa, İlker M.; Minbay, Zehra; Eyigör, Özhan; GÖK YURTSEVEN, DUYGU; KAFA, İLKER MUSTAFA; MİNBAY, FATMA ZEHRA; EYİGÖR, ÖZHAN; Fen Bilimleri Enstitüsü; Histoloji Bölümü ve Embriyoloji Bilim Dalı; 0000-0001-8309-0934; 0000-0003-3463-7483; AAW-4867-2021; AAG-7125-2021; ABE-5128-2020; ABC-1475-2020Aim To analyze the effects of glutamatergic agonists and antagonists on the activation of the A1 and A2 noradrenergic neurons localized in caudal ventrolateral medulla and nucleus tractus solitarii, respectively.Methods Rats were injected with glutamatergic agonists - kainic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or N-methyl-D-aspartic acid (NMDA), and the brain sections were prepared for immunohistochemistry. Before agonist injections, antagonists - 6-cyano-7-nitroquinoxaline-2,3-dione or dizocilpine were administered. The expression of c-Fos, as the neuronal activation marker, and tyrosine hydroxylase (TH), as the marker of noradrenergic neurons was assessed with dual immunohistochemistry. The percentage of c-Fos-positive noradrenergic neurons relative to all TH-positive neurons in the respective areas of the brain stem was calculated.Results All three glutamatergic agonists significantly increased the number of the c-Fos-positive noradrenergic neurons in both the A1 and A2 area when compared with control animals. Kainic acid injection activated about 57% of TH-positive neurons in A1 and 40% in A2, AMPA activated 26% in A1 and 38% in A2, and NMDA 77% in A1 and 22% in A2. The injections of appropriate glutamatergic antagonists greatly decreased the number of activated noradrenergic neurons.Conclusion Our results suggest that noradrenergic neurons are regulated and/or activated by glutamatergic system and that these neurons express functional glutamate receptors.Publication Anti-apoptotic and anti-oxidant effects of systemic uridine treatment in an experimental model of sciatic nerve injury(Türk Nöroloji Derneği, 2021-01-01) Khezri, Marzieh Karimi; Turkkan, Alper; Khezri, Marzieh Karimi; Koç, Cansu; KOÇ, CANSU; Salman, Berna; SALMAN, BERNA; Levent, Pinar; Cakir, Aysen; Kafa, Ilker Mustafa; Cansev, Mehmet; Bekar, Ahmet; ÇAKIR, AYŞEN; KAFA, İLKER MUSTAFA; CANSEV, MEHMET; BEKAR, AHMET; Tıp Fakültesi; Fizyoloji Ana Bilim Dalı; 0000-0002-6097-5585; 0000-0001-8309-0934; 0000-0003-2918-5064; AAA-4754-2022; ABX-9081-2022; A-6819-2018AIM: To investigate the anti-apoptotic and anti-oxidant effects of systemic uridine treatment in a rat model of sciatic nerve injury.MATERIAL and METHODS: Thirty-two adult male rats were equally randomized to Sham, Control, U100, and U500 groups. Sham rats received a sham operation by exposing the right sciatic nerve without transection, while those in the Control, U100, and U500 groups underwent right sciatic nerve transection followed by immediate primary anostomosis. Sham and Control groups received saline (0.9% NaCl) injections intraperitoneally (i.p.), while U100 and U500 groups received 100 mg/kg and 500 mg/kg uridine injections (i.p.), respectively, once a day for 7 days after the surgery. Rats in all the groups were sacrificed on the eighth day; sciatic nerve samples were analyzed for apoptosis by Western Blotting and for oxidation parameters including myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) by Enzyme-Linked Immunosorbent Assay (ELISA).RESULTS: Uridine treatment at the dose of 500 mg/kg significantly decreased as apoptosis determined by Caspase-3/Actin ratio and exhibited significant anti-oxidant effects as determined by decreased levels of MPO and MDA as well as increased levels of SOD, GPx, and CAT compared to controls. Uridine at 100 mg/kg was only found to decrease the Caspase-3/Actin ratio, although it significantly decreased MDA and increased CAT levels compared to controls.CONCLUSION: Treatment with uridine reduces apoptosis and oxidation in a rat model of sciatic nerve injury dose-dependently. Thus, uridine may be beneficial in peripheral nerve regeneration by exhibiting anti-apoptotic and anti-oxidant effects.Publication Uridine treatment improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury(Turkish Neurosurgical Soc, 2022-01-01) Khezri, Marzieh Karimi; Türkkan, Alper; KOÇ, CANSU; Salman, Berna; SALMAN, BERNA; Levent, Pınar; Çakır, Aysen; ÇAKIR, AYŞEN; CANSEV, MEHMET; KAFA, İLKER MUSTAFA; Bekar, Ahmet; BEKAR, AHMET; Tıp Fakültesi; Farmaoloji Ana Bilim Dalı; 0000-0002-6097-5585; 0000-0001-8309-0934; 0000-0003-2918-5064; A-6819-2018; ABX-9081-2022AIM: To investigate the regenerative potential and long-term functional effects of uridine treatment in a rat model of sciatic nerve injury.MATERIAL and METHODS: Male Sprague-Dawley rats were randomized to receive sham surgery plus saline (Sham group), right sciatic nerve transection and primary repair plus saline (Control group), right sciatic nerve transection, and primary repair plus 500 mg/kg uridine (Uridine group). Saline or uridine was injected intraperitoneally (i.p.) for seven days, and the rats were monitored for 12 weeks after surgery. We evaluated electrophysiological and functional recovery using electromyography (EMG) and sciatic functional index (SFI) at six and 12 weeks, respectively. At 12 weeks, rats were decapitated and their right sciatic nerves were examined in macroscopic and histomorphologic manners.RESULTS: Functional evaluation by SFI and sciatic nerve conduction velocity analyzed by EMG both decreased in the Control group but recovered in the Uridine group 12 weeks after surgery. Additionally, upon experiment completion, Uridine treatment was observed to enhance nerve adherence, separability scores, and the number of myelinated axons.CONCLUSION: These results reveal that short-term Uridine treatment provides morphological and electrophysiological benefits, which are represented by long-term functional improvement in a rat model of sciatic nerve injury. These findings validate and extend our knowledge on Uridine's regenerative effects in peripheral nerve injuries.Publication Morphological investigation of protective effects of CDP-choline on liver and small intestine in an experimental sepsis model in rats(Soc Chilena Anatomia, 2022-12-01) Tihan, Necdet Deniz; Sak, Nazan Güner; Cini, Nilgün Tuncel; Yavaş, Senem Esin; Duman, Uğur; Ersoy, Semiha; Kafa, İlker Mustafa; Sak, Nazan Güner; Yavaş, Senem Esin; ERSOY, SEMİHA; KAFA, İLKER MUSTAFA; Tıp Fakültesi; Anatomi Ana Bilim Dalı; 0000-0002-4946-555X; 0000-0001-8309-0934; HNN-1671-2023; HNK-7641-2023; HNJ-7044-2023; AAG-7125-2021Fifty male Wistar albino rats were divided into 5 groups; Group 1 as a sham group. Group 2 as a control group, Group 3 as 100 mg/kg CDP-choline administered group, Group as 200 mg/kg CDP-choline administered group, and Group 5 as sepsis group. The sepsis model was performed by ligating and perforating the caecum of rats. Liver and small intestine tissues were assessed either histologically or quantitatively and qualitatively. There was a significant difference between the sepsis and CDP-choline groups for liver and intestinal damage evaluated in tissue samples. (p <0.001). CDP-choline treatment partially improved dose-dependent the clinical parameters of sepsis and septic shock, reversed micro-anatomical damage caused by sepsis.Publication Anthropometric measurements of femur and tibia on the byzantine skeletons of nicea remains (13th century a.d.)(Moravian Museum, 2005-01-01) ARI, İLKNUR; ŞENDEMİR, ERDOĞAN; Sendemir, Erdoğan; KAFA, İLKER MUSTAFA; Kafa, İlker Mustafa; Tıp Fakültesi; Anatomi Ana Bilim Dalı; 0000-0001-8309-0934; 0000-0001-9699-4342; AAG-7125-2021; AAA-9892-2021Skeletal anthropometric measurements to reveal regional diversity between different populations or within the same one are beneficial for understanding temporary evolutionary and developmental progress relevant to our species.Our material consisted of 26 femurs (13 left, 13 right) and 60 tibias (30 left, 30 right) of male Byzantine skeletons (13th century) excavated at Nicea in Turkey, between 1981 and 1985. Twelve osteometric parameters for femurs and five for tibias were taken into account. Indices of platymeria and platycnemia were derived and compared with other studies. Non-paired t-tests were used to compare left and right. No noticeable difference was found for femurs. Anteroposterior diameter at the nutrient foramen of tibias showed minimal difference between the left and right. The platymeric index was eumeric (mean = 86). Our material indicates the existence of eurycnemia with respect to tibial flattening (mean = 74).Publication The surface and intracranial location of asterion(Lippincott Williams & Wilkins, 2019-11-01) Babacan, Serdar; BABACAN, SERDAR; Yıldız-Yılmaz, Meriç; Kafa, İlker Mustafa; KAFA, İLKER MUSTAFA; Coşkun, İhsaniye; COŞKUN, İHSANİYE; Tıp Fakültesi; Anatomi Ana Bilim Dalı; 0000-0002-7410-7738; 0000-0001-8309-0934; 0000-0001-6484-7153; AAG-7125-2021; ABF-7082-2020; AAH-5390-2021Background: Asterion is identified as the connection point of sutura parietomastoidea, sutura occipitomastoidea, and sutura lamb doidea. The location of asterion, which is primarily preferred as a landmark during posterolateral surgical approach for intracranial operations, shows many variables. The aim of this study was to identify the surface location of the asterion and determine the distances between intracranial anatomical structures and asterion.Methods: At this present study, 11 hemicraniums (22 asterion points), situated at the laboratory of Department of Anatomy, Faculty of Medicine, Bursa Uludag University, were used. The asterion points which the sesamoid bone located were classified as type I and the ones which sesamoid bone did not locate were classified as type II. According to the proximity of asterion with sinus transversus, 3 groups were classified. About 19 parameters were measured related to asterion. The obtained data were analyzed in SPSS 22.Results: As a result of findings, while sesamoid bone was seen at 7 asterion points (type I), at 15 points sesamoid bone was not detected (type II) (respectively, 31.81%, 68.19%). It was identified that 15 asterion points were at the surface, 5 ones were average 3.42 +/- 2.52 nun over, 2 ones average 3.21 +/- 2.26 nun below of the projection of sinus transversus. Statistically significance was not seen between the measurements taken from left and right sides.Discussion and Conclusion: Asterion is an important landmark for the retrosigmoid approaches. The surface and intracranial location of the asterion and proximity with dural sinuses are important for surgeons not to cause fatal subdural hematomas during the approaches using "Burr Hole" technic in neurochirurgie operations.