Person: UZABACI, ENDER
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UZABACI
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ENDER
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Publication Her-2 positivity rate in dogs with mammary carcinoma: A systematic review and meta-analysis(Hellenic Veterinary Medical Soc, 2020-04-01) Uzabacı, Ender; UZABACI, ENDER; Özyiğit, Musa Özgür; ÖZYİĞİT, MUSA ÖZGÜR; Ercan, İlker; Arda, O.; Veteriner Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-9634-0055; 0000-0002-2382-290X; JPL-5273-2023; ABF-2367-2020; AAR-6478-2021Human epidermal growth factor receptor 2 (HER-2) plays an essential role in cell growth and survival. HER-2 overexpression occurs in 20-30% of human breast tumors and has prognostic value as it is associated with disease progression. HER-2 overexpression is also associated with tumor progression and metastasis in malignant mammary tumors of the canine. However, in the literature, different positivity classifications/scoring were used in the evaluation of HER-2 status, and there is no consensus in terms of scoring of HER-2 expression in canine mammary tumors. In this study, it was aimed to estimate the HER-2 positivity rate by evaluating the results of the study using different positivity classifications by meta-analysis. In this context, by using "HER-2 canine mammary tumor" keywords, Pubmed and Web of Science electronic databases were scanned until February 2019, and a total of 97 related studies were found. However, 20 of these studies were used for the analysis. Two different meta-analyses were performed to evaluate the HER-2 positivity status with "2+ and 3+" and "3+" scores. As a result, HER-2 positivity rates were determined at 25.87% and 25.99% for the studies using "2+/3+" scores and "3+" respectively for HER-2 positivity. Therefore, this result suggests that the rate of HER-2 positivity is similar between humans and dogs.Publication Evaluation of outlier detection method performance in symmetric multivariate distributions(Taylor & Francis, 2020-02-01) Uzabacı, Ender; Ercan, İlker; Alpu, Özlem; UZABACI, ENDER; ERCAN, İLKER; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-9634-0055; 0000-0002-2382-290X; JPL-5273-2023; ABF-2367-2020Determining outliers is more complicated in multivariate data sets than it is in univariate cases. The aim of this study is to evaluate the blocked adaptive computationally efficient outlier nominators (BACON) algorithm, the fast minimum covariance determinant (FAST-MCD) method, and the robust Mahalanobis distance (RM) method in multivariate data sets. For this purpose, outlier detection methods were compared for multivariate normal, Laplace, and Cauchy distributions with different sample sizes and numbers of variables. False-negative and false-positive ratios were used to evaluate the methods' performance. The results of this work indicate that the performance of these methods varies according to the distribution type.Publication Characterization of commercially available propolis products in Turkey based on individual phenolic compounds(Taylor & Francis, 2021-06-14) Oruç, Hasan Hüseyin; Çaycı, Meltem; Sorucu, Ali; Uzabacı, Ender; Nyandwi, Ramadhan; ORUÇ, HASAN HÜSEYİN; Çaycı, Meltem; UZABACI, ENDER; Sağlık Bilimleri Enstitüsü; Farmakoloji ve Toksikoloji Ana Bilim Dalı; 0000-0002-5399-2395; 0000-0002-3401-9186; 0000-0002-9634-0055; 0000-0003-4371-425X; JMP-9327-2023; JPL-5273-2023; GBO-2873-2022The healing properties of propolis, such as antibacterial, antiviral, antifungal, anti-inflammatory, antitumoral, antioxidant, immunomodulatory, tissue regeneration, and anti-ulcer, are due to the high content of phenolic compounds (flavonoids and phenolic acids). Therefore, propolis can potentially be used for human consumption or even for medicinal purposes. This study aimed to analyze sixteen individual phenolic compounds that have beneficial effects, determine their concentrations in local and imported raw propolis and products consumed in Turkey, and evaluate the determined results for propolis quality. A total 91 propolis samples were collected from commercial raw propolis and propolis products, which were from different provinces of Turkey and different countries, sold and used in Turkey between 2015 and 2018. Sixteen phenolic compounds were analyzed by high-performance liquid chromatography with a diode array detector system. Regardless of their origin, the results indicated that the concentrations of individual phenolic compounds varied greatly within crude, ethanol-based, water-based, and propylene glycol propolis samples analysed. There were significant differences in some individual phenolic compounds between the local and imported samples (p < 0.05). The current results showed that qualitative and quantitative analysis of commercial propolis samples for useful phenolic compounds are important and may provide quality control of propolis products.Publication Assessment of the quality of life scores of operated and unoperated patients with temporal and extra temporal lobe epilepsy and their relatives-caregivers(Kare Publ, 2018-01-01) BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Atasayar, Gülfer; Demiralay, Ahmet; Uzabacı, Ender; UZABACI, ENDER; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; 0000-0001-6739-8605; 0000-0002-9634-0055; JPL-5273-2023; JCE-6657-2023; V-7170-2017Objectives: We investigated how seizure syndromes and treatment methods correlated with the quality of life and social functioning of patients with epilepsy and their relatives-caregivers.Methods: A total of 203 patients with epilepsy and their relatives-caregivers were divided into four groups. The patients were administered the following assessments: Quality of Life in Epilepsy Inventory and the Social Functioning Scale. The patients and their relatives-caregivers were administered the Hamilton Depression and Anxiety Rating Scale. The Kruskal-Wallis Test and Mann-Whitney U Test were used for statistical analysis.Results: When the quality of life and social functioning subscales were evaluated, the patient group with resistant temporal lobe epilepsy (TLE) had the lowest scores, while the highest scores occurred in the TLE group that had undergone surgical intervention and had entered remission with medical treatment. For both patients and their relatives-caregivers, the anxiety and depression scores were the highest in the resistant TLE group and the lowest in the surgical and remission group.Conclusion: Control of seizures was the most important variable affecting the quality of life of patients with epilepsy and their relativescaregivers. Treatment plans for epilepsy patients should encompass the quality of life considerations, including measures to increase social functioning such as assessments of comorbid psychiatric conditions like anxiety and depression.Publication A survey to identify the Turkish people's approach on animal rights concept: II. Attitude analysis related to animal love, animal identification, animal ownership and eating habits(Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 2013-03-01) Özkul, Türel; Sarıbaş, Taner; Uzabacı, Ender; Yüksel, Erhan; ÖZKUL, TÜREL; UZABACI, ENDER; Veteriner Fakültesi; Tarihi & Deontoloji Ana Bilim Dalı; 0000-0002-9634-0055; 0000-0003-3966-478X; AAH-2830-2021; JPL-5273-2023The present study was undertaken to determine the Turkish people's cognitive level and perception on the concept of animal rights. For this aim, A questionnaire was developed for collecting data and was applied to participants in seven provinces which are considered to represent geographical regions of Turkey. The survey was applied by interviewing with 2016 participants individually. The responses to the questions of animal love, identification of animals, animal ownership and eating habits are grouped themselves after the evaluation of survey data and analysed statistically. As a results, positive proportion was determined by the parameters of animal love, contact with the animals at home, accepting the animals as an individual and being vegetarian (P<0.001).Publication Attitudes of turkish veterinary students towards farm animal welfare(Univ Federation Animal Welfare, 2021-08-01) Çavuşoğlu, Enver; Uzabacı, Ender; ÇAVUŞOĞLU, ENVER; UZABACI, ENDER; Veteriner Fakültesi; Zootekni Ana Bilim Dalı; 0000-0002-9018-3511; 0000-0002-9634-0055; JPL-5273-2023; ABE-4828-2020People's awareness of livestock welfare has increased in recent years and veterinarians have a critical role to play in maintaining and improving these standards. The aim of this study was to explore the attitude of veterinary students to livestock welfare and an online questionnaire was utilised to gauge the opinions of students from the Bursa Uludag University Faculty of Veterinary Medicine in Turkey. A five-point Likert scale covered judgments ranging from 'Strongly disagree' to 'Strongly agree.' Female students were found to have a higher score for questions related to the welfare of livestock than males. It was also found that students yet to undertake courses in clinical science and animal welfare, ie first and second years, gave higher scores than third, fourth and fifth years who had completed both of these. Moreover, students having owned or dealt previously with livestock provided lower animal welfare scores than their counterparts who had done neither. Seemingly, the sensitivity of veterinary students decreases during the latter stages of their education. To conclude, we suggest further investigation into the extent to which veterinary medicine education influences students' attitudes to animal welfare as they progress through the course.Publication Associations between c.2832a > g polymorphism of CAST gene and meat tenderness in cattle: A meta-analysis(Kafkas Univ, Veteriner Fakultesi Dergisi, 2022-09-01) Uzabacı, Ender; UZABACI, ENDER; Dinçel, Deniz; DİNÇEL, DENİZ; Veteriner Fakültesi; 0000-0002-9634-0055; JPL-5273-2023Genes or genetic markers related to meat quality have been studied for many years. The CAST gene is one candidate gene affecting meat tenderness in cattle. This meta-analysis aimed to examine the association of c.2832A>G polymorphism of the CAST gene and meat tenderness in cattle. According to the determined criteria, 17 studies were included in the meta-analysis, and pooled ratios of allele and genotype frequencies were calculated. In addition, the combined Warner-Braztler Shear Force values were calculated for three studies that reported these values according to genotypes for the meat tenderness feature. Heterogeneity between studies and publication bias were also tested. As a result of the meta-analysis, pooled ratios of AA, AG, and GG genotypes are 0.578, 0.342, and 0.080; pooled ratios of A and G alleles are 0.777 and 0.223. The highest pooled ratios were obtained for AA genotype and A allele. The combined Warner-Braztler shear force values were calculated as 3.707, 3.893, and 5.137 kilogram-force for AA, AG, and GG genotypes. The highest mean shear force value was obtained for the GG genotype. In conclusion, the meta-analysis results examined the relationship between c.2832A>G polymorphism of the CAST gene and meat tenderness were closer to the population parameter. This study may improve genetic selection and provide new strategies to increase meat quality in cattle.Publication Investigating academic veterinarians' knowledge of biostatistics: A web-based survey(Ankara Üniversitesi, 2015-01-01) Ocakoğlu, Gökhan; Ercan, İlker; Kaya, Mehmet Onur; Uzabacı, Ender; Can, Fatma Ezgi; OCAKOĞLU, GÖKHAN; ERCAN, İLKER; UZABACI, ENDER; Can, Fatma Ezgi; Veteriner Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-1114-6051; 0000-0002-2382-290X; 0000-0002-9634-0055; JPL-5273-2023; HLG-6346-2023; AAH-5180-2021; JSL-7718-2023; ABF-2367-2020The primary aim of our study, web-based survey, is to gain an understanding of veterinarians' statistical knowledge and how it varies by focus area. The secondary aim is to address the following question: when should biostatistics be taught in veterinary education? A total of 155 veterinarians from 41 countries participated in this study. The results indicate that while veterinarians place an emphasis on biostatistics education, the majority state that biostatistics education should be taken both at the undergraduate and postgraduate level and the participants also believe that taking a biostatistics course is useful for their occupation. In biostatistics education, the topic of sampling, which plays a significant role at the planning stage of any study, should be considered particularly important. A biostatistics education should also emphasize the necessity of consulting to a biostatistician when planning a study.Publication Effects of probiotic supplementation on broiler growth performance: A meta-analysis of randomised controlled trials(Csiro Publishing, 2023-03-10) Uzabacı, Ender; Yıbar, Artun; UZABACI, ENDER; YIBAR, ARTUN; Veteriner Fakültesi; Biyometri Bölümü; 0000-0002-9634-0055; 0000-0001-9510-5734; ABE-9200-2022; JPL-5273-2023Context. The effects of probiotics on broilers' growth and productivity performance have been reported in many scientific studies, and different results have been found. Aim. This study aimed to assess the effects of probiotics on broiler growth performance via meta-analysis. Methods. In this study, the PubMed database was searched with the keywords "broiler' and "probiotic' and it was determined that 60 of 605 studies were suitable. Average daily gain and feed conversion ratio were used as performance parameters. Publication bias was evaluated with Egger's and Begg's tests. The trim and fill method was applied when even one of these tests was significant. Heterogeneity among studies was assessed using the Cochran Q test. The random effect model was used to estimate effect sizes if heterogeneity was statistically significant; otherwise, the fixed-effect model was used. In addition to evaluating all studies, subgroup analyses were performed depending on study duration, probiotic strain, and the probiotic content. Key results. According to the meta-analysis results, there was a significant difference between the probiotic and control groups in studies lasting 35 days in terms of average daily gain (P = 0.005) and feed conversion ratio (P = 0.002). But only the average daily gain (P < 0.001) value was different between the groups in studies lasting 42 days. According to the probiotic strain, significant differences were found between the probiotic and control groups in terms of both growth parameters examined in studies using mono-strain and multi-strain probiotics. A significant difference was found between the probiotic and control groups in average daily gain values in studies where probiotics containing lactic acid bacteria (LAB) and clostridia were used. Conclusion. In conclusion, this study is a current research that examined the effects of probiotic use in broilers in detail according to more than one factor. Implication. In this study, articles in the PubMed database were examined. The sample size of the study can be increased by scanning other databases with the same keywords.Publication Epworth sleepiness scale and polysomnographic evaluation of dysthymic women with chronic insomnia(Turkish Neurological Soc, 2010-01-01) BİCAN DEMİR, AYLİN; Bican, Aylin; Kotan, Ozan Vahap; Bora, Ibrahim; BORA, İBRAHİM HAKKI; Akkaya, Cengiz; AKKAYA, CENGİZ; Carkungöz, Ender; UZABACI, ENDER; Kırlı, Selçuk; KIRLI, SELÇUK; Tıp Fakültesi; Pskiyatri Ana Bilim DalıObjective: In patients with dysthymic disorder (DD), sleep problems are assessed as a part of their depressive state, and different treatable conditions, such as other primary sleep disorders, are often skipped. We aimed to determine symptoms related to daytime sleepiness and polysomnographic findings in dysthymic women with chronic insomnia and to find out whether or not there is an accompanying sleep disorder. We suggest that pathologies that can lead to sleep problems in dysthymic patients should be searched, and to this end, application of the Epworth sleepiness scale (ESS) and polysomnography examination should be used much more frequently.Patients and Methods: We included 20 female dysthymic patients with complaints of chronic sleep problems who had been under follow-up at Uludag University Hospital Psychiatry Outpatient Clinic for at least the last two years. Twenty healthy female volunteers, aged 18-65 years, were included in the study as the control group. ESS and polysomnography examination were applied in all patients.Results: When patients with DD and healthy controls were compared, significant differences in ESS scores and ratios of sleep phases were determined between groups. DD patients had higher ESS scores and higher ratios of rapid eye movements (REM), non-REM-1 (Stage 1), non-REM-2 (Stage 2) phases and lower ratios of slow wave sleep (Stage 3 + Stage 4).Conclusion: The findings of our study suggest that there are structural sleep changes in dysthymic patients, but no direct connection between sleep variables and depressive states is evident.