Person: UDUM, DUYGU
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UDUM
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DUYGU
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Publication Ovarian follicle dynamics and hormonal changes during early pregnancy in saanen goats(Czech Academy Agricultural Sciences, 2020-01-01) Doğan, İbrahim; Toker, Mehmed Berk; Alcay, Selim; Küçükşen, Duygu Udum; DOĞAN, İBRAHİM; TOKER, MEHMED BERK; ALÇAY, SELİM; UDUM, DUYGU; 0000-0003-1976-1814; 0000-0003-4033-9749; A-2794-2014; R-8366-2018; CBC-7350-2022; FGX-3813-2022This study is aimed at describing the ovarian follicular dynamics, corpora lutea and their hormonal control during early pregnancy in Saanen goats. The ovaries of pregnant goats (n = 10) were monitored daily for follicles (>= 2 mm) and corpora lutea by transrectal ultrasound over the 35 days after mating. Blood samples were collected by jugular venipuncture at the time of ultrasonography and were analysed for the concentrations of oestradiol (E-2) and progesterone (P-4), inhibin, FSH (follicle-stimulating hormone) and LH (luteinizing hormone). The pattern of follicular growth was characterised by five (n = 2; 20 %), six (n = 5; 50 %) and seven (n = 3; 30 %) follicular waves during early pregnancy. The first corpora lutea (size 6.8 +/- 0.4 mm, mean + SEM) were detected at 5.0 +/- 0.3 days after the mating with a maximum diameter (12.2 +/- 0.3 mm) observed on day 24.0 +/- 1.1 of pregnancy. The dominant follicle diameter of waves 1 and 4, and the duration of waves 1-4 and 7 were maximal during the early pregnancy period (P < 0.05). In addition, the inter-wave interval of the 5 waves was significantly (P < 0.05) longer compared to the six and seven inter-wave intervals (7.0 +/- 0.1, 5.8 +/- 0.1 and 5.0 +/- 0.2 days, respectively). Although the number of small and medium-sized follicles did not differ with the days post-breeding, the number of large-sized follicles in the same period significantly decreased between 16 and 26 days and was negatively correlated with the period of pregnancy (P < 0.05). The plasma LH and E-2 concentrations were negatively correlated with the P-4 concentration. The inhibin concentrations were negatively correlated with FSH, but positively correlated with the number of large-sized follicles. These results indicate that ovarian follicular growth during the first 35 days of pregnancy in goats was characterised by a wave-like pattern and there was a close relationship between the number of FSH peaks and the number of follicular waves.Publication Determination of the relationships between serum amyloid A, serum calprotectin and fecal calprotectin in healthy and infectious diarrheic calves and their diagnostic significances as inflammatory markers(Elsevier Sci Ltd, 2023-10-11) Karakuş, Adil Ömer; Temizel, Ethem Mutlu; Udum, Duygu; Karakuş, Adil Ömer; TEMİZEL, ETHEM MUTLU; UDUM, DUYGU; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Veteriner Biyokimya Anabilim Dalı.; 0000-0001-7052-1694; JSG-9381-2023; ECV-4083-2022; AAH-5167-2021In this study, serum amyloid A (SAA), serum calprotectin (SCalp) and fecal calprotectin (FCalp) levels were investigated in neonatal calves with infectious diarrhea. Total of 70 calves were divided into E. coli, C. parvum, C. parvum + viral, viral and control groups. Clinical parameters were recorded on days 0 and 7, post treatment. On these days, blood and stool samples were also taken. SAA, SCalp and FCalp levels were measured with commercial ELISA kits. Mean SAA levels on day 0 were measured as 0.54 (0.16-2.18) ng/ml and 38.40 (8.28-83.96) ng/ml for the diarrhea and healthy group, respectively (P < 0.001). Statistically significant difference was also obtained between the diarrhea [68.02 ng/ml 46.66-101.67] and control [24.05 ng/ml 11.92-56] groups in terms of SCalp levels on day 0 (P < 0.001). Cut-off value of SCalp to distinguish E. coli originated diarrhea from viral diarrhea was found to be 70.969 ng/ml (Sens: 94%). FCalp levels on day 0 were 93.08 (22.17-122.88) ng/ml and 87.01 +/- 3.33 ng/ml in the diarrhea and healthy groups, respectively (P = 0.04). Cut-off concentration of FCalp was found to be 91.804 ng/ml (P = 0.0057). In addition, as a result of the logistic regression analysis, FCalp's ability to identify animals with diarrhea was found to be 6.316 times (P = 0.009) higher. The highest levels of SCalp and FCalp measured on day 0 were found among E. coli group. As a result, the importance of FCalp and SCalp in diagnosing the status of infectious diarrhea in calves for the first time in the veterinary literature is emphasized.Publication Erythrocyte potassium, sodium and GSH concentrations of Saanen and Turkish hair breeds of goats(Zoological Soc Pakistan, 2008-01-01) Aydın, Cenk; Doğrutekin, Deniz; Udum, Duygu; Çetin, Meltem; AYDIN, CENK; Doğrutekin, Deniz; UDUM, DUYGU; Çetin, Meltem; Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-3090-0099; 0000-0001-7052-1694; AAH-5167-2021; DWC-5118-2022; ESX-0896-2022; HQE-4960-2023Biochemical variation of three genetic markers, namely erythrocyte potassium (K-e), erythrocyte sodium (Na-c) and erythrocyte glutathione (GSH) in sixty Saanen and Turkish Hair Goats was analysed. The potassium and sodium concentrations were determined by flame photometry. The level of GSH in erythrocytes was determined by the DTNB method. The frequencies of the mentioned loci have been calculated and compared with some of the goat breeds studied so far by other authors. Our results indicated that there were bimodal distributions in K-e and GSH concentrations in Saanen goat breeds, whereas there was only GSH polymorphism in Turkish Hair Goats. The distribution of K-e concentrations Suggested the presence of high-K/low-K (HK/LK) polymorphism, based on the predetermined dividing value of 50 meq/L of K-e concentration in erythrocytes of Saanen Goats. Both types are shown to be controlled genetically by an autosomal locus with two alleles HK and LK, with HK being dominant over LK. While majority of the Turkish Hair Goat population (93%) had low (GSH(h)) or 'deficient' erythrocyte GSH concentrations (<50 mg/100 mL erythrocyte), Saanen breeds (93%) had high (GSH H) erythrocyte GSH levels. Relationships between the parameters were also evaluated. In Saanen Goats, erythrocyte K-e and Na-e values exhibited positive correlation with the total monovalent cation concentrations (K-e + Na-e) while in Turkish Hair Goats only K-e value showed correlation with the same monovalent cations.