Person: YAVAŞCAOĞLU, İSMET
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YAVAŞCAOĞLU
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İSMET
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Publication Emphysematous pyelonephritis: Case report(Aves, 2005-09-01) VURUŞKAN, HAKAN; Vuruşkan, Hakan; Çalışkan, Zülküf; Çift, Ali; Kordan, Yakup; Yavaşçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Oktay, Bülent; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-9947-848X; AAH-7103-2019Introduction: Emphysematous pyelonephritis (EP) is a lethal infection which is rarely seen and is characterized by gas in intrarenal or perirenal region. The traditional treatment of EP is open surgical flowing and parenteral antibiotherapy or nephrectomy. In this study a 74 years old male patient with EP treated with percutaneous drainage catheter and comprehensive antibiotherapy because of no clinical response to antibiotherapy is presented.Publication Prognostic value of estrogen receptors in patients who underwent prostatectomy for non-metastatic prostate cancer(Spandidos Publ Ltd, 2023-02-01) Aydın, Yavuz Mert; Şahin, Ahmet Bilgehan; Dölek, Rabia; Vuruşkan, Berna Aytaç; Ocakoğlu, Gökhan; Vuruşkan, Hakan; Yavaşçaoğlu, İsmet; Coşkun, Burhan; AYDIN, YAVUZ MERT; ŞAHİN, AHMET BİLGEHAN; DÖLEK, RABİA; AYTAÇ VURUŞKAN, BERNA; OCAKOĞLU, GÖKHAN; VURUŞKAN, HAKAN; YAVAŞCAOĞLU, İSMET; COŞKUN, BURHAN; Tıp Fakültesi; Tıbbi Onkoloji Ana Bilim Dalı; 0000-0002-6287-6767; 0000-0002-7846-0870; 0000-0002-1114-6051; 0000-0002-8242-9921; AAH-9704-2021; AFP-3055-2022; HSH-9815-2023; JCO-5169-2023; AAH-5180-2021; AAM-4927-2020; EEJ-1452-2022; EFH-9523-2022; EIN-0828-2022Estrogen receptors in prostate cancer (PCa) are a subject of debate. The aim of the present study was to investigate whether estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) impact the biochemical recurrence (BCR) of non-metastatic PCa after surgery. Following the application of the exclusion criteria, data from 108 patients who underwent laparoscopic radical prostatectomy between January 2011 and December 2019 were retrospectively evaluated. A total of 36 patients with BCR constituted the BCR group. The control group was formed using the Propensity Score Matching (PSM) method with a 1:2 ratio, including parameters with well-studied effects on BCR. The median follow-up time was 74.3 (range, 30-127.5) months in the BCR group and 66.6 (range, 31.5-130) months in the control group. Pathology specimens from the two groups were immunohistochemically stained with ER alpha and ER beta antibodies. Logistic regression analysis and survival analysis were performed. No differences in clinicopathological characteristics were detected between the two groups. The patients with ER alpha(-)/ER beta(+) staining results had a significantly fewer BCRs than other patients (P=0.024). In the logistic regression analysis, patients with ER alpha(-)/ER beta(+) PCa also had a significantly lower risk of recurrence (P=0.048). In the survival analysis, the 5-year BCR-free survival rate of patients with ER alpha(-)/ER beta(+) PCa was higher than that of other patients (85.7 vs. 66.1%; P=0.031). Excluding the effects of well-studied risk factors for recurrence by the PSM method, the present study showed that ER alpha and ER beta have prognostic value for non-metastatic PCa. The 5-year BCR-free survival rate is significantly higher in patients whose PCa tissue has ER alpha(-)/ER beta(+) staining results.Publication Laparoscopic donor nephrectomy: Our preliminary results(Aves, 2010-03-01) Yavaşcaoğlu, İsmet; Doğan, Hasan Serkan; Gürsoy, Eray; Kordan, Yakup; Vuruşkan, Hakan; Oktay, Bülent; YAVAŞCAOĞLU, İSMET; Doğan, Hasan Serkan; Gürsoy, Eray; Kordan, Yakup; VURUŞKAN, HAKAN; Oktay, Bülent; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-9947-848X; ABH-5513-2020; JHZ-8017-2023; JNH-7900-2023; 0095-2022; EFH-9523-2022; DKK-2716-2022Objective: To present preliminary results of laparoscopic donor nephrectomy.Materials and methods: The results of 18 transperitoneal laparoscopic donor nephrectomy performed between March 2008 and April 2009 in our clinic were presented. Nephrectomy side was right in one patient and left in the rest.Results: Nine patients were male and 9 were female, and the mean age was of 56 (range 42-73) years. All of the cases were succesfully completed laparoscopically. Mean operation time was 155 +/- 37 (range 90-240) min and mean follow-up period was 6.3 (range 1-12) months. Mean warm ischemia period was 175 +/- 57 (range 90-320) sec. Mean postoperative hospital stay was 2.8 +/- 0.7 (range 2-4) days. No intraoperative and postoperative complications occured. Two transplantation patients were reoperated because of ureteral complications.Conclusion: Laparoscopic donor nephrectomy is effective and safe with graft survival results comparable to open approach in addition to well known advantages such as decreased postoperative pain, shorter hospital stay and recovery period, and better esthetic appearence.Publication Detection of vesico-ureteric reflux in renal transplant recipients by colour doppler urosonograpy(Aves, 2005-09-01) Vuruskan, Hakan; VURUŞKAN, HAKAN; Çift, Ali; Oktay, Bülent; Bolca, Naile; BOLCA TOPAL, NAİLE; Kordan, Yakup; Yavasçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-9947-848X; AAH-7103-2019Introduction: In this study, we evaluated the vesico-ureteric reflux (VUR) in renal transplant recipients by using color Doppler urosonography (CDU).Materials and Methods: Among 149 renal transplant recipients, 42 (27 men, 15 women) who accepted to take part were included to the study. The mean age and duration of post-transplant follow-up of the patients were 35.1+/-1.39 years (15-55) and 63.6+/-7.2 months (7-170), respectively. In all patients, ureterovesical anastomosis and antireflux submucosal tunnel were performed with Lich-Gregoir technique without using ureteral stent. Urinary system was assessed in all patients with CDU without any contrast enhancing agent by the same radiologist. During CDU, patients were asked to make Valsalva maneuver when their bladders were full with urine and were evaluated for reflux. The patients' ureteric jets were first investigated in transverse and then in longitudinal plane by observing distal ureteric segment and ureteral orifice. The flows coming towards the transducer were coded red in color while those moving away from the transducer were coded blue in color. During observation of the distal ureteric segment; detection of red color was regarded as reflux. The patients, in whom reflux was detected by CDU, were reassessed by voiding cystouretrography (VCUG).Results: Among 42 patients who underwent CDU, 7 patients (16.7%) were diagnosed to have VUR. In all patients, the diagnosis of CDU detected VUR was confirmed by VCUG. In 4 patients (57.2%) low grade and in 3 patients (42.9%) intermediate grade reflux was found by using CDU. None of the patients had high grade reflux. In 3 patients (42.9%) grade 2, in 3 patients (42.9%) grade 3, in 1 patient (14.2%) grade 4 reflux were observed during evaluation of these patients by VCUG. Since VCUG is an invasive procedure and the patients who were determined not to have VUR by CDU had no urinary tract infection history in the follow-up they did not undergo VCUG.Conclusion: CDU is a non-invasive and effective method for the diagnosis and follow-up of VUR in renal transplant recipients.Publication Single center experience with laparoscopic adrenalectomy on a large clinical series: Lessons learned from 273 cases: A retrospective cohort study(Kuwait Medical Association, 2022-12) Çelen, Sinan; Günseren, Kadir Ömur; Vuruşkan, Hakan; Acımış, Nurhan Meydan; Kordan, Yakup; Yavaşcaoğlu, İsmet; GÜNSEREN, KADİR ÖMÜR; VURUŞKAN, HAKAN; YAVAŞCAOĞLU, İSMET; Tıp Fakültesi; Üroloji Bölümü; ITO-9188-2023; EFH-9523-2022; EIN-0828-2022Objectives: We aim to evaluate the risk of laparoscopic adrenalectomy (LA) for large adrenal tumors and the risk of learning curve.Design: Single centre, retrospective studySetting: Uludag University, Bursa, TurkeySubjects: A study in a large patient population (N=273) who underwent LA between 2006 and 2017.Interventions: The patients were divided into two study groups according to tumour size as estimated by pathologic specimen maximum diameter, Group A (less than 5cm) and group B (larger than 5cm). In addition, to evaluate learning curve of LA, the patients were divided into two groups according to time interval: the first period was 2006 to 2011, and the second period 2012-2017.Main outcome measures: To evaluate the risk of learning curve and tumour sizeResults: There was no statistical difference between the two groups for per-operative and postoperative complications according to tumour size <5 or >= 5 cm, and there was statistical difference between the two groups for operation time, length of hospital stay; but no statistical difference for postoperative complications according to time interval.Conclusion: LA in large adrenal masses (5 cm or larger) is not associated with longer operative time, increased blood loss and longer hospital stay, without affecting perioperative morbidity, Hence, the size of an adrenal mass should not be the only factor in determining whether LA or not. Besides, learning curve may affect outcomes of LA.Publication Laparoscopic extraperitoneal radical prostatectomy: Our first experiences(Aves, 2005-09-01) Oktay, Bülent; Vuruskan, Hakan; VURUŞKAN, HAKAN; Yavasçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Kordan, Yakup; Çalışkan, Zülküf; Öztürk, Murat; ÖZTÜRK, MURAT; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-9947-848X; 0000-0002-0668-8075Introduction: Laparoscopic radical prostatectomy is a relatively new and contemporary approach in the surgical management of localized prostate cancer. We report our preliminary results after 6 procedures.Materials and Methods: We performed laparoscopic extraperitoneal radical prostatectomy (LERP) in 6 patients between January and June in 2004. Clinical stage, serum PSA, Gleason score, operating time, surgical and medical complications, estimated blood loss, transfusion rate, hospital stay and catheterization times were recorded. The pathologic stage (1997 TNM classification), status of surgical margins and continence were noted.Results: There was no conversion and reintervention. The mean operation time was 320 minutes. The mean blood loss was 178.3 ml. The mean hospital stay was 4.5 days. There were no major complications. Subileus occurred in one patient and resolved spontaneously. The mean catheterization time was 13.3 days. 2 of 6 patients had positive surgical margins at the urethra. 4 of 6 patients were continent after a median followup period of 3 months.Conclusion: LERP as a minimally invasive procedure seems to offer the same early oncological and surgical results as conventional open radical prostatectomy. Long and gradual learning curve of this procedure is its main disadvantage.Publication Clinical course of angiomyolipom in our cases(Aves, 2006-03-01) VURUŞKAN, HAKAN; Çalışkan, Zülküf; Vuruşkan, Hakan; Kordan, Yakup; Sökmen, Ali; Yavaşcaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Oktay, Bülent; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-9947-848XIntroduction: The aim of the study is to determine the factors that affect the clinical course of angiomyolipomas (AML)Materials and Methods: Between January 1992 and November 2003, 24 patients were diagnosed clinically and radiologically to have angiomyolipoma. They were followed prospectively for a mean of 4.6 years (range: 2-11 years). Patients were divided into 3 groups; Group 1: Patients with a solitary lesion, Group2: Patients with multiple lesions associated with tuberous sclerosis and Group 3: Patients with multiple lesions having no tuberous sclerosis. According to the size of the lesion (lesions <4 cm and lesions >4cm) patients were also subdivided into 2 groups. The lesions were followed regularly every 6 month with ultrasonography. These 3 groups were compared in terms of symptoms, size and the percentage of the growth of the lesion.Results: The median age of the patients was 43 (31-59). 13 patients in group 1, 1 patient in group 2 and 4 patients in group 3 had lesions <4 cm and 1 patient in group 1, 2 patients in group 2 and 3 patients in group 3 had lesions >4 cm. In 3 patients from group 2 and 2 patients from group 3 the lesions were bilateral. 7 cases out of 24 (29.1%) were diagnosed incidentally. Patients were found to have 8 different symptoms which were observed 37 times among all patients. The most common symptom, abdominal and flank pain, was observed in 54.1 % (13 patients) of patients. In patients with lesions <4 cm the prevalence of these symptoms were 16.2% (6), 2.7% (1), 5.4% (2) and in patients with lesions >4 cm were 8.1% (3), 37.8% ( 14), 29.7% (11) in group1, 2 and 3 respectively. Considering the growth of the lesions; in group 1with lesions <4 cm only 1 patient out of 13 showed 0.6 cm (18.1%) growth during follow-up. Similarly 1 patient of group1 with lesion >4 cm showed no increase in size of the lesion. In group 2 all patients showed an increase in size of the lesions, which was 1 cm (33.3%) in the group with the lesion <4 cm (1 patient) and 4.6 +/- 3.4 cm (41.8%) in the group with the lesion >4 cm (2 patients). Among group 3 patients with the lesions <4 cm, 3 of 4 showed a mean increase in the diameter of previous lesion of 0.9 +/- 4.2 cm (28.1%), while in 1 patient the lesion remained unchanged. Similarly in group 3 patients with the lesions >4 cm, 2 out of 3 showed a mean increase of 1.8 +/- 5.3 cm (33.3%), while 1 remained unchanged.Conclusion: In AML patients the most important factors which determine the lesion to grow and be symptomatic are the size, the number (multiplicity) of the lesions and the presence of tuberous sclerosis.Publication Laparoscopic ureterolithotomy; an equally effective and a sensible alternative to flexible ureterorenoscopy in the management of large ureteral stones in terms of effectivity and cost(Iniestares, S.a., 2021-07-01) Demir, Aslan; Günseren, Kadir Ömür; GÜNSEREN, KADİR ÖMÜR; Çicek, Mehmet Çağatay; ÇİÇEK, MEHMET ÇAĞATAY; Yavasçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Kılıçarslan, Hakan; KILIÇARSLAN, HAKAN; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0001-8673-3093; 0000-0002-0471-5404; 0000-0001-8673-3093; ABC-9924-2020; HGM-5995-2022; JIT-9412-2023; EIN-0828-2022OBJECTIVES: We aimed to understand whether laparoscopic ureterolithotomy (LU) is a good alternative to flexible ureterorenoscopic lithotripsy (FURS) by comparing these techniques concerning cost-effectiveness.METHODS: We analysed 79 patients with upper ureteral stones larger than 1.5 cm underwent FURS or LU concerning cost-effectiveness analysis. The data including age, body mass index (BMI), stone size, operation time, hospitalisation time, complications and stone-free rates of 15th day and 3rd months. We audited the costs of FURS and LU and compared them concerning cost-effectiveness.RESULTS: There was not any statistically significant difference between the two groups with regard to age, BMI, stone size, stone-free rates at the 3rd month, and complication rates, (p>0.05).The operation times were statistically lower in the FURS than in the LU (61.5 +/- 24.3 min and 140.9 +/- 49.1 min, respectively, p<0.05). The stone-free rate at the 15th day was lower in the FURS group than in the LU group (31 (81.6%) and 41 (100%), respectively, p<0.05) (Table I).However, this statistical difference disappears at 3 months (p>0.05). The mean costs of FURS and LU were $194.2 +/- 12.4 and $179.2 +/- 58.5, respectively (p<0.001).CONCLUSION: FURS is equally effective to LU in terms of stone-free rates. The cost of FURS is higher statistically than LU. FURS is shown as the first choice for the upper ureteral stones larger than 10 mm in size, if the laparoscopic experience is in high-level situations in that clinic, LU may be a suitable alternative to FURS, especially for challenging cases.Publication The differences between the right and left side laparoscopic donor nephrectomy outcomes: A comparative analysis of single-center outcomes(Kare, 2021-02-26) Günseren, Kadir Ömür; Çiçek, Mehmet Çağatay; Aydın, Yavuz Mert; Özmerdiven, Çağdaş Gökhun; Yavaşcaoğlu, İsmet; GÜNSEREN, KADİR ÖMÜR; ÇİÇEK, MEHMET ÇAĞATAY; AYDIN, YAVUZ MERT; YAVAŞCAOĞLU, İSMET; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0001-8673-3093; 0000-0002-0471-5404; 0000-0002-6287-6767; AFP-3055-2022; ABC-9924-2020; HGM-5995-2022; EIN-0828-2022Objective: This study aimed to compare the right and left side laparoscopic donor nephrectomy (LDN) outcomes of a single center.Materials and Methods: The outcomes of patients who underwent LDN in our clinic between 2008 and 2020 were evaluated retrospectively. Two groups were consisted according to the side of the donor kidney. The gender, age, body mass index, duration of operation, amount of bleeding, warm ischemia time, drain removal time, and duration of hospitalization and complications were compared between groups.Results: A total of 314 patients were included in the study. Sixty-six patients underwent right LDN and 248 underwent left LDN. There was no difference between groups in terms of age, duration of operation, amount of bleeding, warm ischemia time, and complications (p>0.05). However, drain removal time and duration of hospitalization were longer in the left LDN group (p<0.05).Conclusions: The right LDN had similar intraoperative outcomes with the left LDN. However, failure on meticulous dissection of the lymphatic structures during left LDN might cause chylous drainage and prolonged hospitalization time.Publication Laparoscopic radical cystectomy: Uludag University experience(Aves, 2009-09-01) Yavaşcaoğlu, İsmet; Gökcen, Kaan; Doğan, Hasan Serkan; Kordan, Yakup; Aytaç, Berna; Vuruşkan, Hakan; Oktay, Bülent; YAVAŞCAOĞLU, İSMET; Gökcen, Kaan; Doğan, Hasan Serkan; Kordan, Yakup; AYTAÇ VURUŞKAN, BERNA; VURUŞKAN, HAKAN; Oktay, Bülent; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-9947-848X; ABH-5513-2020; AAH-9746-2021; EIN-0828-2022; JMX-6994-2023; GAF-0095-2022; EFH-9523-2022; DKK-2716-2022Objective: To present the experience of our clinic on laparoscopic radical cystectomy (LRC).Materials and methods: Twenty-three patients who underwent laparoscopic radical cystectomy, lymphadenectomy and urinary diversion between May 2006 and April 2009 were included. Twenty-two patients were male and one was female. Mean age of patients was 61.5 (40-75) years.Results: Mean total operative time was 388 (270-510) minutes, whereas mean time for laparoscopic cystectomy and lymph node dissection was 225 (180-310) minutes. Simultaneous nephroureterectomy was performed in two patients. Ileal conduit was performed in 20 patients as urinary diversion and orthotopic neobladder was constructed in 3. Mean blood loss was 130 mL (40-300) and intraoperative blood transfusion was not necessary in any of the patients. Mean postoperative hospitalization was 11.1 (7-24) days. No intraoperative complication was experienced and conversion to open surgery has never happened. Superficial wound infection and dehiscence have happened in 2 patients and prolonged ileus was encountered in 1 patient. Histological examination revealed organ confined (pT0/pT1/pT2/pT3a) disease in 21 (91.3%), extravesical (pT3b/pT4) disease in 2 (8.7%), and lymph node involvement in 4 (17%) patients. Four patients with lymph node involvement, 1 patient with squamous cell cancer, and 1 patient with neuroendocrin carcinoma received adjuvant chemotherapy. Within a mean time period of 13.1 (1-26) months, 95.6% (22/23) of patients, including patients who were given adjuvant chemotherapy, were alive. No port site metastasis has been reported during the follow-up period.Conclusion: Our clinical experience confirms that LRS can be performed safely without compromising the oncological principles.