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AKGÜR, SUAT

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AKGÜR

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SUAT

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2018 - 201932020 - 20212
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    Publication
    Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation
    (Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023
    Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.
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    Publication
    The prevalence, clinical and pathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults: The data from tsn-gold (Turkish society of nephrology glomerular diseases) working group
    (Oxford Univ Press, 2020-06-01) Kurultak, İlhan; Güngör, Özkan; Öztürk, Savaş; Dirim, Ahmet Burak; Eren, Necmi; Yenigün, Ezgi; Dal, Elbis Ahbap; Dinçer, Mevlüt Tamer; Bora, Feyza; Akgür, Suat; Sumnu, Abdullah; Dursun, Belda; Sipahi, Savaş; Getinkaya, Hakkı; Sahin, Idris; Şahin, Garip; Yılmaz, Mürvet; Vatansever, Bülent; Aydın, Emre; Ulu, Memnune Sena; Gündoğan, Ali; ÜstOndağ, Sedat; Sayarlıoğlu, Hayriye; Şahin, Gizem Kumru; Elcioğlu, Ömer Celal; Aydın, Zeki; Selcuk, Nedim Yılmaz; Önal, Ceren; Oruç, Meriç; Küçük, Mehmet; Aktaş, Nimet; Derici, Ulver; Süleymanlar, Gültekin; AKGÜR, SUAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi; JIX-1144-2023
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    Publication
    Morning blood pressure surge in early autosomal dominant polycystic kidney disease and its relation with left ventricular hypertrophy
    (Oxford Univ Press, 2018-05-01) Yıldız, Abdulmecit; Sağ, Saim; Gül, Cuma; Can, Fatma; Oruç, Aysegül; Aydın, Mehmet; Bedir, Ömer; Akgür, Suat; Ayar, Yavuz; Güllülü, Sürneyye; Güllülü, Mustafa; Ersoy, Alparslan; YILDIZ, ABDULMECİT; Can, Fatma; ORUÇ, AYŞEGÜL; AYDIN, MEHMET AKİF; Bedir, Ömer; AKGÜR, SUAT; Ayar, Yavuz; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; ERSOY, ALPARSLAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Bölümü; 0000-0003-2467-9356; 0000-0002-0342-9692; 0000-0002-5665-7402; 0000-0003-4607-9220; 0000-0002-5665-7402; AGF-0767-2022; GSE-0029-2022; AAH-5054-2021; AAH-4002-2021; O-9948-2015; HIG-9032-2022; IBQ-9926-2023; AAJ-8220-2020; IVE-3975-2023; EJA-1761-2022; EWD-8403-2022; JGS-9425-2023
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    A rare cause of posterior reversible leukoencephalopathy after kidney transplantation
    (Frontiers Media Sa, 2019-10-01) Ersoy, Alparslan; Ersoy, Yavuz; Kır, Elif; Kaya, Ahmet; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Hakyemez, Bahattin; ERSOY, ALPARSLAN; Kır, Elif; KAYA, AHMET TUFAN; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; HAKYEMEZ, BAHATTİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-9094-9735; 0000-0002-0342-9692; AAH-5054-2021; AAI-2318-2021; AAH-4002-2021; CZH-4661-2022; JYF-5512-2024; EJA-1761-2022; JJY-8484-2023
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    Publication
    The pmp rate in all brain deaths comparison to pmp rate of donors with family permission reported in provinces connected to Bursa Region Coordination Center which has the highest pmp rate in Turkey
    (Lippincott Williams & Wilkins, 2019-11-01) Elgin, Ersin; Yıldız, Abdülmecid; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Keskin, Sahriye; Oflaz, Rafet; Selimoğlu, Kerem; Gürel, Ceyda; Arslan, İlknur; Çınar, Yavuz Selim; Ulusoy, Türkan Yılmaz; Güler, Müjgan; Dübek, Aslı Bahar; Berkant, Yasemin Geçgil; Karan, Elif; Karaca, Mert; Ersoy, Alparlan; Elgin, Ersin; Yıldız, Abdülmecid; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; Keskin, Sahriye; Oflaz, Rafet; Selimoğlu, Kerem; Gürel, Ceyda; Arslan, İlknur; Karan, Elif; KARACA, MERT; ERSOY, ALPARSLAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; 0000-0002-0342-9692; 0000-0001-6711-676X; 0000-0002-0710-0923; DXA-2790-2022; EIF-8983-2022; AAH-4002-2021; JIX-1144-2023; JJY-8484-2023; CZH-6714-2022; DJU-5362-2022; CDS-3299-2022; EWW-9090-2022; CCH-8947-2022; FDB-4488-2022; AAG-7406-2021; AAH-5054-2021