Person: ERCAN, İLKER
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ERCAN
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İLKER
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Publication The risk of developing gestational diabetes mellitus in maternal subclinical hypothyroidism: A systematic review and meta-analysis(Springer Heidelberg, 2023-07-12) Dinçgez, Burcu; Ertürk, Nergis Kender; ERCAN, İLKER; Şahin, İbrahim; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-2382-290X; 0000-0002-2902-9670; AAH-5248-2020; GRY-0743-2022PurposeThe purpose of this study was to determine the association between maternal subclinical hypothyroidism (SCH) and gestational diabetes mellitus (GDM) risk.MethodsThis study is a systematic review and meta-analysis. Following PubMed, Medline, Scopus, Web of Science, and Google Scholar database search up to April 1 2021, a total of 4597 studies were identified. Studies published in English, with full text available, related to subclinical hypothyroidism in pregnancy, reporting or mentioning the incidence of GDM were included in the analysis. Following exclusion of studies, a total of 16 clinical trial were analyzed. For the risk of GDM, odds ratios (ORs) were calculated. Subgroup analyzes were performed according to gestational age and thyroid antibodies.ResultsPregnant women with SCH were at increased risk of GDM compared to women with euthyroidism, overall (OR = 1.339, 95% CI 1.041-1.724; p = 0.023). Additionally, SCH without thyroid antibodies has no significant effect on GDM risk (OR = 1.173, 95% CI 0.88-1.56; p = 0.277) and pregnant women with SCH in the first trimester were not found to be at increased risk of GDM compared to women with euthyroidism regardless of thyroid antibodies (OR = 1.088, 95%CI 0.816-1.451; p = 0.564).ConclusionsMaternal SCH in pregnancy is related to an increased risk of GDM.Publication Evaluation of the corpus callosum shape in patients with obstructive sleep apnea(Springer Heidelberg, 2021-09-28) Güneş, Aygül; Sığırlı, Deniz; Ercan, İlker; Turan Özdemir, Senem; Durmuş, Yavuz; Yıldiz, Tekin; SIĞIRLI, DENİZ; ERCAN, İLKER; Turan Özdemir, Senem; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; AAA-7472-2021; ABF-2367-2020; FPU-9468-2022Background The aim of this study was to examine whether or not there was a difference in corpus callosum shape between patients with mild to moderate and severe obstructive sleep apnea (OSA) compared with patients who have simple snoring.Methods The landmark coordinate data was obtained from the mid-sagittal magnetic resonance imaging (MRI) images of 70 patients who underwent polysomnography. For comparisons, mild and moderate OSA groups were combined and analyses were performed on three groups; simple snoring/control group, mild or moderate OSA group, and severe OSA group.Results The corpus callosum shape of controls was significantly different from that of the severe OSA group. The most prominent deformities were observed in the genu and rostral body of the corpus callosum for the patients with severe OSA. No significant difference was found between mild/moderate OSA group and simple snoring group in terms of global corpus callosum shape.Conclusion The data demonstrated that severe OSA patients have structural changes in the corpus callosum and deformities may vary as the severity of disease changes.Publication Evaluation of outlier detection method performance in symmetric multivariate distributions(Taylor & Francis, 2020-02-01) Uzabacı, Ender; Ercan, İlker; Alpu, Özlem; UZABACI, ENDER; ERCAN, İLKER; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-9634-0055; 0000-0002-2382-290X; JPL-5273-2023; ABF-2367-2020Determining outliers is more complicated in multivariate data sets than it is in univariate cases. The aim of this study is to evaluate the blocked adaptive computationally efficient outlier nominators (BACON) algorithm, the fast minimum covariance determinant (FAST-MCD) method, and the robust Mahalanobis distance (RM) method in multivariate data sets. For this purpose, outlier detection methods were compared for multivariate normal, Laplace, and Cauchy distributions with different sample sizes and numbers of variables. False-negative and false-positive ratios were used to evaluate the methods' performance. The results of this work indicate that the performance of these methods varies according to the distribution type.Publication Seasonal influenza vaccine awareness and factors affecting vaccination in Turkish society(Professional Medical Publications, 2022-03-01) Can, Fatma Ezgi; Yakar, Burkay; Göktaş, Olgun; ERCAN, İLKER; Akalin, Emin Halis; AKALIN, EMİN HALİS; Aile Sağlığı Merkezi; Tıbbi Mikrobiyoloji Ana Bilim Dalı; 0000-0002-2382-290X; 0000-0001-7530-1279; AAU-8952-2020; JSL-7718-2023Objective: Influenza vaccine reduces the burden of seasonal influenza and related complications. Potential vaccination barriers need to be identified to raise awareness and increase acceptance. We aimed to investigate the rates of seasonal influenza vaccination and the knowledge, opinions, and behaviours prevalent in Turkish society. Methods: The study among seven regions in Turkey was conducted from October-November 2018 in 28 family health centres, using a cross-sectional, descriptive design. The knowledge, opinions, and behaviours of participants regarding the influenza vaccine were obtained by family physicians through face-to-face interviews with participants. Results: A total of 3,492 people aged 10-97 years age range (median: 50 years) were included in the study. Over half of the participants (59.9%, n = 2093) were female. It was found that the percentage of participants who never received the influenza vaccine was 78.4%; only 13.4% were occasionally vaccinated, and 8.1% received regular annual vaccination. Influenza vaccination rates were higher in married people (p < 0.001), women (p = 0.005), patients with chronic lung and cardiovascular disease (p < 0.001), those over 65 years /nursing home residents (p < 0.001). Awareness of the vaccine's benefit was higher in the group at high risk of influenza (p < 0.001). Conclusion: The rate of regular vaccination against influenza every year was insufficient, at 8.1%. Individuals' insensitivity, insufficient knowledge, and attitudes toward influenza vaccination is a serious health problem for Turkish society. Barriers to influenza vaccination can be reduced by good communication between family physicians and their patients.Publication IGF-1 and GH alterations in lambs with intestinal inflammation(TÜBİTAK, 2021-01-01) Temizel, Ethem Mutlu; Karakuş, Adil Ömer; Kavukcu, Fatih; Küçükşen, Duygu Udum; Ercan, İlker; TEMİZEL, ETHEM MUTLU; Karakuş, Adil Ömer; Kavukcu, Fatih; Küçükşen, Duygu Udum; ERCAN, İLKER; Veteriner Fakültesi; Biyokimya Ana Bilim Dalı; 0000-0002-6834-0808; 0000-0002-2382-290X; ECV-4083-2022; FBQ-7974-2022; JJZ-4815-2023; JJM-7084-2023; ABF-2367-2020Insulin-like growth factor-1 (IGF-1) acts on the development of internal organs such as the small intestine and muscle in all animal species. Similar to IGF-1, GH is also essential for growth and is an effective hormone on intestinal development during neonatal period. The aim of this study was to investigate the effects of diarrhea on IGF-1 and GH hormones in lambs with intestinal inflammation up to 63 days of age. The study material consisted of 15 healthy and 15 diarrheic lambs. Blood and fecal samples were collected on the first day of life and on the 7th, 14th, 21st, 35th, 49th and 63rd postnatal days consecutively. Diarrhea was observed on 6 animals on the 7th day and 9 animals on 14th day visitation. IGF-1 showed statistically significant differences (P < 0.01) between diarrheic and healthy animals on all measurement days. A significant association was found between the cut-off values determined after ROC analysis of the 7th day (Sens: 93.33%, Spec: 66.67%, P = 0.004) and 14th day (Sens: 73.33%, Spec: 80%, P = 0.0002) values of IGF-1 and diarrhea. Considering 14th day of IGF-1, a logistic regression analysis was performed, the risk of diarrhea is OR = 7.00 times higher if the concentration of the parameter is above the cut-off value. ROC analysis also showed significant cut-off values for GH on 14th day. In terms of sensitivity, the highest value was IGF-1's 7th day value, therefore it can be preferred for the determination of intestinal inflammation in cases with diarrhea. As a general evaluation, it is seen that the highest performance was given by the 7th day IGF-1 values according to the Youden's J index. In conclusion, elevations in IGF-1 and GH concentrations may be associated with intestinal inflammation. The inducing effect of the inflammatory response on IGF-I and GH may strengthen the relationship between the two parameters.Publication Evaluation of the predictive role of anterior uterocervical angle in preterm labor in twin gestation through meta-analysisy? Anterior uterocervical angle and preterm labor in twin gestation(Elsevier Masson, Corp Off, 2022-05-10) Dinçgez, Burcu; Yenigül, Nefise Nazlı; Ercan, İlker; ERCAN, İLKER; Uzunoğlu, Arda; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; ABF-2367-2020; IAK-9330-2023Multiple gestations are high-risk pregnancies with increased obstetric and perinatal risks. Preterm labor occurs in about half of twin pregnancies. Thus, prediction of the time of delivery and prevention of premature birth are very important in multiple gestations. Anterior uterocervical angle is a successful tool that has been used in the prediction of preterm labor in recent years. However there is only limited data about this issue for twin pregnancies in the literature. Here, we aimed to demonstrate the relationship between uterocervical angle and preterm labor in twin pregnancies more clearly and reliably with this meta-analysis. In this context, "twin gestation, uterocervical angle, cervical angle, angle, cervix, cervical, preterm and preterm labor" keywords were used and PubMed, Medline, ClinicalKey, Scopus, Science Direct, Web of Science, and Google Scholar database were searched between 1 January 2010 and 27 December 2020. Finally, a total of three studies were included in the analysis. Here, we found that uterocervical angle was associated with a higher risk of preterm delivery in the overall effect.Publication Examining of published articles with respect to statistical errors in medical sciences(Akad Doktorlar Yayınevi, 2015-01-01) Ercan, İlker; Karadeniz, Pınar G.; Cangür, Şengül; Özkaya, Güven; Demirtaş, Hakan; ERCAN, İLKER; Karadeniz, Pınar G.; ÖZKAYA, GÜVEN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0003-0297-846X; A-4421-2016; ABF-2367-2020; CXZ-6919-2022Researchers who do not have adequate statistical knowledge commit a wide range of critical errors with regard to the design, execution,analysis, presentation and interpretation of their studies. The aim of the present work is to examine the statistical errors of scientific articles. Cross sectional study. Methods: Ninety-five articles published in either Science Citation Index (SCI) or (Science Citation Index-Expanded) SCI-E journals, 122 articles published in non-SCI or non-SCI-E journals were included in this study. The articles were chosen from among those indexed in the PubMed and Bioline databases between the years 2004 and 2010, inclusively. A total of 217 articles had at least one statistical error. The most frequently encountered statistical error was "errors in summarizing data" for articles published in the journals indexed in SCI or SCI-E, as well as non-SCI or non-SCI-E journals. For errors involving "use of an incorrect test" and "statistical symbol errors", there was a statistically significant difference between articles published in journals indexed in SCI or SCI-E and non-SCI or non-SCI-E journals; this difference favored the former. Some action should be taken by researchers and editors to prevent the introduction of statistical errors into scientific publications. Researchers (i) should have a basic statistical knowledge, (ii) should consult a biostatistician at the planning, analyzing, interpreting and reporting stages of a study. Furthermore, editors should send studies that have been submitted to their journal to a biostatistician during the review process.Publication Comparison of quantitative ultrasonography with dual energy absorptiometry and investigation of the correlation between quantitative ultrasonography parameters(Springer, 2004-04-01) Altan, Lale; Bingöl, Ü; Kumaş, F. F; Ercan, İlker; Yurtkuran, Merih; ALTAN İNCEOĞLU, LALE; Bingöl, Ü; Kumaş, F. F; ERCAN, İLKER; Yurtkuran, Merih; Tıp Fakültesi; Atatürk Rehabilitasyon Merkezi; AAH-1652-2021; EMT-7521-2022; FJP-3640-2022; EUN-5017-2022; EGT-2006-2022Publication A retrospective epidemiological study of 385 burn patients hospitalized during 6 years in bursa(Springer, 2005-09-01) Özbek, Serhat; KAHVECİ, RAMAZAN; ÖZGENEL, GÜZİN YEŞİM; ÖZBEK, SERHAT; Özcan, Mesut; AKIN, SELÇUK; Akın, Selçuk; ERCAN, İLKER; Ercan, İlker; Karaca, Kemal; Tıp Fakültesi; Plastik ve Rekonstruktif Cerrahi Ana Bilim Dalı; 0000-0002-2382-290X; AAG-4626-2019; AAH-5064-2021; AAH-5441-2021A retrospective analysis of 385 consecutive admissions to a regional burns unit in a period of 6 years is presented. The majority were flame burns, followed by scalds. The male to female ratio was 3: 1. More than half of the patients were adults (more than the age of 16 years) and most of the injuries occurred at home. In the group of patients under 2 years of age, scalds were the leading cause of burns and among them hot tea spill was the most common reason. Many of the electrical burns occurred at the workplace and at home were resulted from inappropriate close location of high voltage lines to constructions and houses, and inappropriate use of paint thinner was found to be an important cause for flame burns occurred at the work place. The mean hospitalization time was 27.1 days and the overall mortality rate was 14% (n=54). In this paper, regional characteristics of some etiologic factors, together with some descriptive analysis in burn injury and some preventive measures are presented.Publication Knowledge and attitudes towards antibiotics use and an examination on patient's unrealistic health symptoms in Turkey(Modestum Ltd, 2022-04-01) Ahmadian, Robab; Uncu, Yeşim; Ercan, İlker; Toluk, Özlem; Ahmadian, Robab; UNCU, YEŞİM; ERCAN, İLKER; Toluk, Özlem; Tıp Fakültesi; Aile Hekimliği Ana Bilim Dalı; 0000-0003-1550-639X; 0000-0002-2382-290X; 0000-0001-6495-0839; AAL-6835-2021; D-9597-2016; ABF-2367-2020; AAE-5602-2019Background: This study aimed to assess the attitudes and knowledge of adult individuals about antibiotics. Since in Turkey, antibiotics are not sold without a prescription, it was also investigated whether Turkish people compelled physicians to prescribe antibiotics by showing unrealistic symptoms.Methods: A self-administered cross-sectional survey involving 1,057 respondents was conducted using a validated questionnaire. The questionnaire was prepared in four sections. The first section included attitude assessment and a five-point Likert scale has collected information. In the second section, knowledge questions examined participants' knowledge about antibiotics with Three-point Likert scale. The third section contained a sensitive question, and using the crosswise model was indirectly asked whether the participant has forced the physician to prescribe an antibiotic. The reliability test results for the attitude scale showed the a-value of Cronbach was 0.767, and KR-21 reliability for the knowledge scale was 0.713. Test-retest reliability coefficients for attitude scale was r=0.697, the coefficients for knowledge scale was r=0.887.Results: Turkish people's awareness about antibiotics is insufficient but at an acceptable level. The public is aware that antibiotics rapidly develop resistance when used widely and incorrectly. Nevertheless, %17 of them resort to showing unrealistic symptoms to force the physician to prescribe antibiotics.Conclusion: To conclude, Turkish people's knowledge and attitudes about antibiotics are insufficient but acceptable. However, a noticeable rate of patients resorts to showing unrealistic symptoms to force the physician to prescribe antibiotics.