Person: ÖZKAYA, GÜVEN
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ÖZKAYA
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GÜVEN
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Publication Effects of coronavirus disease 2019 (covid-19) pandemic on the follow-up and treatment of patients with idiopathic pulmonary fibrosis: A cross-sectional multicenter study phone call survey(European Respiratory Soc Journals, 2021-09-05) Hanta, Ismail; Cilli, Aykut; Ozkaya, Guven; ÖZKAYA, GÜVEN; Coskun, N. Funda; Ursavas, Ahmet; URSAVAŞ, AHMET; Sevinc, Can; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; 0000-0003-3604-8826; 0000-0002-4069-9181; AAI-3169-2021Publication Assessment of oral manifestations in pediatric patients with celiac disease in relation to marsh types(Medicina Oral S L, 2023-01-01) Elbek-Çubukcu, Çiğdem; Arsoy, Hanife Ayşegül; Özkaya, Güven; ELBEK ÇUBUKÇU, ÇİĞDEM; ARSOY, HANİFE AYŞEGÜL; ÖZKAYA, GÜVEN; Tıp Fakültesi; Pedodonti Ana Bilim Dalı; 0000-0003-0297-846X; A-4421-2016; EVO-0292-2022; HQK-8183-2023experience, and oral hygiene status, and to measure salivary flow rate, salivary buffer capacity, and salivary car-iogenic microflora with Marsh types.Material and Methods: A single-blind, prospective clinical study with 62 pediatric patients diagnosed with celiac disease with 64 controls. Clinical identification of molar-incisor hypomineralization (MIH) was followed accord-ing to the European Academy of Pediatric Dentistry criteria. DMFS and dfs index were used for the caries expe-rience of each child. The clinical diagnosis of RAU was present or not. Oral hygiene was surveyed by recording the OHI-S and the CRT (R) Bacteria and Buffer Test was used to examine the cariogenic microflora of each child.Results: The prevalence of MIH was 61% and the number of recurrent aphthous ulcers were significantly higher in children with celiac disease. There was no statistically significant difference in the CD group, when DMFS, dfs, and MIH parameters were investigated according to dietary compliance. Higher dietary compliance resulted in better oral hygiene status. There was an inverse relationship between the duration of celiac diagnosis and the presence of MIH. A positive relation was found between the duration of the disease and the severity of MIH. In addition to the higher S. mutans counts, the salivary flow rate was very low in children with celiac disease, indicat-ing a positive correlation between poor dietary compliance and poorer oral hygiene.Conclusions: In children, enamel defects and recurrent mucosal lesions may be a sign of celiac disease. Higher numbers of dental caries in permanent teeth of children with celiac disease may be related to Marsh 2 type. The pediatricians and/or pediatric gastroenterologists should refer the chin with celiac disease to the pediatric dentist for the accurate treatment of intraoral manifestations of the disease itself.Publication A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009-2010 pandemic(Makerere Univ, 2015-01-01) Nermin, Kelebek Girgin; Remzi, İşçimen; Zeynep, Akoğul; İlker, Çimen; Meltem, Öner Torlar; Güven, Özkaya; Ferda, Kahveci; Halis, Akalın; KELEBEK GİRGİN, NERMİN; İŞÇİMEN, REMZİ; Akoğul, Zeynep; Çimen, İlker; Torlar, Meltem Öner; ÖZKAYA, GÜVEN; KAHVECİ, FERDA ŞÖHRET; AKALIN, EMİN HALİS; Tıp Fakültesi; Mikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı; AAH-7250-2019; FTV-1495-2022; EIE-4319-2022; JOR-4047-2023; FMO-2967-2022; EZV-3846-2022; CPT-2668-2022; EZJ-5901-2022Background: H1N1 influenza A virus infections were first reported in April 2009 and spread rapidly, resulting in mortality worldwide. The aim of this study was to evaluate patients with H1N1 infection treated in the intensive care unit (ICU) in Bursa, Turkey.Methods: Demographic characteristics, clinical features, and outcome relating to H1N1 infection were retrospectively analysed in patients treated in the ICU.Results: Twenty-three cases of H1N1 infection were treated in the ICU. The mean age of patients was 37 years range: (1782). Fifteen patients were female (65.2%). The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 19 range: (5-39). The most common symptoms were dyspnea (73.9%), fever (69.6%), and cough (60.9%). Mechanical ventilation was required for all patients. Oseltamivir and antibiotics were administered to all patients. Six (26.1%) patients died. APACHE II scores were higher in the deceased 28.5 range: [16-39] vs. 14 range: [5-28] in survivors; p = 0.013).Conclusion: When compared to the literature, the demographic, epidemiological, and clinical characteristics were similar in the cases we encountered. The mortality rate was high despite the use of appropriate treatment. We believe that the high mortality is related to higher APACHE II scores. The H1N1 virus should be considered in community acquired pneumonia, especially in younger patients presenting with severe pneumonia.Publication Examining of published articles with respect to statistical errors in medical sciences(Akad Doktorlar Yayınevi, 2015-01-01) Ercan, İlker; Karadeniz, Pınar G.; Cangür, Şengül; Özkaya, Güven; Demirtaş, Hakan; ERCAN, İLKER; Karadeniz, Pınar G.; ÖZKAYA, GÜVEN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0003-0297-846X; A-4421-2016; ABF-2367-2020; CXZ-6919-2022Researchers who do not have adequate statistical knowledge commit a wide range of critical errors with regard to the design, execution,analysis, presentation and interpretation of their studies. The aim of the present work is to examine the statistical errors of scientific articles. Cross sectional study. Methods: Ninety-five articles published in either Science Citation Index (SCI) or (Science Citation Index-Expanded) SCI-E journals, 122 articles published in non-SCI or non-SCI-E journals were included in this study. The articles were chosen from among those indexed in the PubMed and Bioline databases between the years 2004 and 2010, inclusively. A total of 217 articles had at least one statistical error. The most frequently encountered statistical error was "errors in summarizing data" for articles published in the journals indexed in SCI or SCI-E, as well as non-SCI or non-SCI-E journals. For errors involving "use of an incorrect test" and "statistical symbol errors", there was a statistically significant difference between articles published in journals indexed in SCI or SCI-E and non-SCI or non-SCI-E journals; this difference favored the former. Some action should be taken by researchers and editors to prevent the introduction of statistical errors into scientific publications. Researchers (i) should have a basic statistical knowledge, (ii) should consult a biostatistician at the planning, analyzing, interpreting and reporting stages of a study. Furthermore, editors should send studies that have been submitted to their journal to a biostatistician during the review process.Publication Risk factors for and clinical outcomes of infections caused by extended-spectrum-β-lactamase-producing escherichia coli in children: Results of a 5 year study(Aves Yayıncılık, 2009-03-01) Çelebi, Solmaz; Yüce, Necla; Çakır, Deniz; Hacımustafaoğlu, Mustafa; Özkaya, Güven; ÇELEBİ, SOLMAZ; Yüce, Necla; Çakır, Deniz; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; ÖZKAYA, GÜVEN; Tıp Fakültesi; Biyostatistik Ana Bilim Dalı; Çocuk Enfeksiyon Hastalıkları Bilim Dalı; 0000-0002-7056-0615; 0000-0003-4646-660X; 0000-0003-0297-846X; JHN-1091-2023; JKN-1212-2023; GQP-2135-2022; CTG-5805-2022; A-4421-2016Aim: The prevalence of extended-spectrum beta lactamase (ESBL) producing bacterial pathogens, particulary in intensive care units, has been increasing worldwide. The aim of this study was to define the risk factors and clinical outcomes associated with ESBL-producing Escherichia coli (E. coli) infections in children.Material and Method: We conducted a case-control study between January 1, 2004 and December 31, 2008 at the Uludag University Pediatric Clinic. All patients with ESBL-producing E. coli infections were compared to patients with non-ESBL-producing E. coli infections. Risk factors analyzed included prior antibiotic use, underlying diseases, invasive medical devices, and other demographic characteristics.Results: E. coli infections were diagnosed in 136 of the 8879 patients hospitalized in our center between January 1, 2004 and December 31, 2008 (overall incidence, 15.3 per 1,000 admissions). The mean age of patients was 55.4+/-52.6 months (3 days-18 years) and 60% were female. The prevalence of ESBL-producing isolates among E. coli was found to be 54.4%. Sixtyeight percent of the E. coli infections were nosocomial. In this study, risk factors for ESBL-producing E. coli infections included pediatric intensive care unit stay, nosocomial infection, therapy with broad-spectrum antibiotics, prolonged exposure to broad-spectrum antibiotics, prolonged hospitalization, use of immunosuppressant medications, blood transfusion, presence of a central venous catheter and total parenteral nutrition (p< 0.05). The mortality rate of E. coli infection was found to be 16.9%. Predisposing factors associated with mortality were; presence of septic shock, congenital heart disease, nosocomial infection, presence of ESBL-producing E. coli infections, pediatric intensive care unit stay, therapy with broad-spectrum antibiotics, prolonged exposure to broad-spectrum antibiotics, prolonged hospitalization, neutropenia, presence of central venous catheter and mechanical ventilation (p<0.05).Conclusion: In this study, the prevalence of ESBLproducing isolates among E. coli was 54.4%. The mortality (24.3%) for the patients in the ESBL group was significantly higher than the mortality for the patients in the non-ESBL group (8%) (p<0.05).Publication Examining the variations in the results of the hotelling T² test in case of changing baseline landmarks in the bookstein coordinates(Springer Heidelberg, 2015-06-01) Ercan, İlker; Sığırlı, Deniz; Özkaya, Güven; ERCAN, İLKER; SIĞIRLI, DENİZ; ÖZKAYA, GÜVEN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-2382-290X; 0000-0003-0297-846X; AAA-7472-2021; A-4421-2016; ABF-2367-2020In many biological and biomedical investigations, the most effective way to analyze the forms of whole biological organs or organisms is by recording geometric locations of landmark points. If we want to compare shapes, then individuals should be translated, rotated and scaled in such a way that all of the individuals lie in a standard position and are centered. Bookstein conducted this process by choosing two landmarks as reference landmarks. Each individual is translated, rotated and scaled according to these reference landmarks. The aim of the present study was to examine the change in the p values in the case of choosing different baseline landmarks when performing the Hotelling T (2) test, which is commonly used when comparing two sample shape configurations based on Bookstein coordinates. For this purpose, the changes in the p values were investigated in shape configurations that are composed of a different number of landmarks by taking all of the possible paired landmark combinations at different variance levels and sample sizes. As a result of the present study, it was observed that with the increase in the landmark number, the number of possible baseline landmark combinations also increases and, for this reason, a substantial number of variations occur in the p values. Therefore, it is an important to decide which landmarks should be taken as reference landmarks when using the Bookstein coordinates.Publication Co-plot method: A research on tobacco control in the european region(Prex Spa, 2015-01-01) Cangür, Şengül; Ercan, İlker; Özkaya, Güven; ERCAN, İLKER; ÖZKAYA, GÜVEN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-2382-290X; 0000-0003-0297-846X; A-4421-2016; ABF-2367-2020BACKGROUND: The aim of this study is to introduce the uncommonly used Co-Plot method which is called the multivariate graphical analysis and to apply this method to a data set including tobacco control in European region.METHODS: This study uses the data from the World Health Organization database according to Human Development Index of European countries. It takes into account variables such as smoking prevalence in young people and adults, the proportion of smoking-related deaths and domestic legislations cases pertaining to tobacco products and analyses the data using the Co-Plot method.RESULTS: Results of the study demonstrated that smoking prevalence and restrictions on advertising of tobacco products were highly negatively correlated. The proportion of deaths associated with smoking-related diseases increased parallel to the increase in the smoking prevalence in young people and adults. Norway, France and Finland have enforced legal limitations on direct and indirect advertising, and thus there has been a decline in smoking prevalence among young people and adults. In some countries, including Ireland, Italy and Serbia, the prevalence of smoking among the young has decreased due to the new or increased legal restrictions on the sale distribution of tobacco products. The governments in the Czech Republic, Kazakhstan, Estonia, Croatia, the Netherlands, Belgium, and Poland have placed restrictions on direct and indirect advertising. The distribution of other causes-related deaths and lung cancer-related deaths are high.CONCLUSION: The restrictions on tobacco products were tightened in time with the increased prevalence of smoking and proportion of smoking-related deaths. It can be said that the significant relationships identified in this study have even more pertinence in developed countries. Consequently, Co-Plot method has enabled deeper data interpretations of the relationships between the countries and the variables in this study.Publication Distance education perception scale for medical students: A validity and reliability study(Bmc, 2021-07-26) Özkaya, Güven; Aydın, Mevlüt Okan; Alper, Züleyha; ÖZKAYA, GÜVEN; AYDİN, MEVLÜT OKAN; ALPER, ZÜLEYHA; Tıp Fakültesi; Tıp Eğitimi Ana Bilim Dalı; 0000-0002-8060-8803; 0000-0002-8349-9868; AAI-3331-2021; ABE-2261-2020; JJW-0446-2023Background There are major changes in education strategies as higher education institutions urgently need to adopt distance education tools and practices due to the Covid-19 pandemic. Medical education is also trying to get out of this emergency using distance education. In this study, we aimed to develop a reliable and valid scale in order to evaluate the perceptions of medical students towards distance education. Methods The students taking part in the study were in the first five academic years of the medical faculty in Bursa in Turkey. At first, 57 items were determined to evaluate students' perceptions. Content validity was examined according to the assessment of the expert team. Construct validity of these items was examined by exploratory and confirmatory factor analysis. Also, Cronbach's alpha coefficients were calculated for reliability analysis. The medical students' responses were scored using a five-point Likert scale. Results When the content validity was examined, the number of items was determined to be 38 items. Construct validity of these items was examined by exploratory and confirmatory factor analysis. Because of the exploratory factor analysis performed on the responses of 429 medical students, 22 items were included in four factors. This four-factor model was applied to 286 medical students and validated by confirmatory factor analysis. Also, Cronbach's alpha coefficients were calculated for reliability analysis and values were between 0.713 and 0.930. Conclusions This study demonstrated validation and reliability of perceptions of distance education for medical students. We suggest a 22-item model with a four-factorial scale.Publication Peer-assisted skills learning in structured undergraduate medical curriculum: An experiential perspective of tutors and tutees(Wolters Kluwer Medknow Publications, 2022-05) Aydin, Mevlüt Okan; Kafa, İlker Mustafa; Özkaya, Güven; Alper, Züleyha; Haque, Shafiul; AYDİN, MEVLÜT OKAN; KAFA, İLKER MUSTAFA; ALPER, ZÜLEYHA; ÖZKAYA, GÜVEN; 0000-0002-8060-8803; 0000-0001-8309-0934; 0000-0002-8349-9868; AAI-3331-2021; AAG-7125-2021; ABE-2261-2020; FQT-8976-2022Background and Aims: This study aims to evaluate the implication of peer-assisted learning model adopted in students' clinical skills training from the perspective of tutees and tutors at the end of a peer-tutored clinical skills program and peer tutors themselves. Subjects and Methods: This cross-sectional study was conducted in the Faculty of Medicine, Bursa Uludag in between January and March 2018. Following the clinical skills training, a questionnaire designed to assess the views of tutees and peer tutors was filled out on a voluntary basis by 159 tutees and 43 tutors. The statistical analysis of the collected and processed data was analyzed by using IBM SPSS 23.0 statistical program. The statistical significance level was maintained as alpha = 0.05. Results: According to the Likert scale, satisfaction with the tutors and the educational environment was high in general. The 2nd term tutees provided more negative feedback compared to other terms. Among all the terms, the most positive answers were provided by the 3rd term students. Although the tutors found themselves fully skilled in communication with colleagues, there were striking differences between the tutors in the 5th and 6th terms of providing a good role model for pre-clinical terms students. Conclusion: Considering peer assisted learning (PAL)'s positive responses from this study, the adoption of PAL has been started to be used as a supplementary teaching method for the clinical skills training at the Faculty of Medicine, Bursa Uludag University. PAL is considered a successful education model since it is cost-efficient for undergraduate medical training and improves the professional skills of both teacher and learner students. It can be availed of as an alternative method in medical faculties where especially the number of academic members is insufficient.Publication Effect of rosiglitazone and insulin combination therapy on inflammation parameters and adipocytokine levels in patients with Type 1 DM(Hindawi, 2015-03-17) Güçlü, Metin; Gül, Özen Öz; Cander, Soner; Ünal, Oğuzkaan; Özkaya, Güven; Sarandöl, Emre; Ersoy, Canan; Güçlü, Metin; ÖZ GÜL, ÖZEN; CANDER, SONER; Ünal, Oğuzkaan; ÖZKAYA, GÜVEN; SARANDÖL, EMRE; ERSOY, CANAN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0001-5082-9894; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020; AAI-1005-2021; ABI-4847-2020; AAH-8861-2021; HUR-0563-2023; IPU-7626-2023Aim. To investigate the efficacy of combined therapy of insulin and rosiglitazone on metabolic and inflammatory parameters, insulin sensitivity, and adipocytokine levels in patients with type 1 diabetes mellitus (type 1 DM). Material and Methods. A total of 61 adults with type 1 DM were randomly and prospectively assigned in open-label fashion to take insulin and rosiglitazone 4mg/day (n - 30) or insulin alone (n = 31) for a period of 18 weeks while undergoing insulin therapy without acute metabolic complications. Results. Combination therapy did not significantly improve metabolic and inflammatory parameters, insulin sensitivity, and adiponectin levels. While leptin and resistin levels decreased in both groups (group 1: resistin 6.96 +/- 3.06 to 4.99 +/- 2.64, P = 0.006; leptin 25.8 +/- 17.6 to 20.1 +/- 12.55, P = 0.006; group 2: resistin 7.16 +/- 2.30 to 5.57 +/- 2.48, P = 0.031; leptin 16.72 +/- 16.1 to 14.0 +/- 13.4, P = 0.007) Hgb and fibrinogen levels decreased only in group 1 (Hgb 13.72 +/- 1.98 to 13.16 +/- 1.98, P = 0.015, and fibrinogen 4.00 +/- 1.08 to 3.46 +/- 0.90, P = 0.002). Patients in both groups showed weight gain and the incidence of hypoglycemia was not lower. Discussion. The diverse favorable effects of TZDs were not fully experienced in patients with type 1 DM. These results are suggesting that insulin sensitizing and anti-inflammatory characteristics of TZDs were likely to be more pronounced in patients who were not totally devoid of endogenous insulin secretion.