Person: ÖZKAYA, GÜVEN
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ÖZKAYA
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GÜVEN
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Publication Peer-assisted skills learning in structured undergraduate medical curriculum: An experiential perspective of tutors and tutees(Wolters Kluwer Medknow Publications, 2022-05) Aydin, Mevlüt Okan; Kafa, İlker Mustafa; Özkaya, Güven; Alper, Züleyha; Haque, Shafiul; AYDİN, MEVLÜT OKAN; KAFA, İLKER MUSTAFA; ALPER, ZÜLEYHA; ÖZKAYA, GÜVEN; 0000-0002-8060-8803; 0000-0001-8309-0934; 0000-0002-8349-9868; AAI-3331-2021; AAG-7125-2021; ABE-2261-2020; FQT-8976-2022Background and Aims: This study aims to evaluate the implication of peer-assisted learning model adopted in students' clinical skills training from the perspective of tutees and tutors at the end of a peer-tutored clinical skills program and peer tutors themselves. Subjects and Methods: This cross-sectional study was conducted in the Faculty of Medicine, Bursa Uludag in between January and March 2018. Following the clinical skills training, a questionnaire designed to assess the views of tutees and peer tutors was filled out on a voluntary basis by 159 tutees and 43 tutors. The statistical analysis of the collected and processed data was analyzed by using IBM SPSS 23.0 statistical program. The statistical significance level was maintained as alpha = 0.05. Results: According to the Likert scale, satisfaction with the tutors and the educational environment was high in general. The 2nd term tutees provided more negative feedback compared to other terms. Among all the terms, the most positive answers were provided by the 3rd term students. Although the tutors found themselves fully skilled in communication with colleagues, there were striking differences between the tutors in the 5th and 6th terms of providing a good role model for pre-clinical terms students. Conclusion: Considering peer assisted learning (PAL)'s positive responses from this study, the adoption of PAL has been started to be used as a supplementary teaching method for the clinical skills training at the Faculty of Medicine, Bursa Uludag University. PAL is considered a successful education model since it is cost-efficient for undergraduate medical training and improves the professional skills of both teacher and learner students. It can be availed of as an alternative method in medical faculties where especially the number of academic members is insufficient.Publication Effect of rosiglitazone and insulin combination therapy on inflammation parameters and adipocytokine levels in patients with Type 1 DM(Hindawi, 2015-03-17) Güçlü, Metin; Gül, Özen Öz; Cander, Soner; Ünal, Oğuzkaan; Özkaya, Güven; Sarandöl, Emre; Ersoy, Canan; Güçlü, Metin; ÖZ GÜL, ÖZEN; CANDER, SONER; Ünal, Oğuzkaan; ÖZKAYA, GÜVEN; SARANDÖL, EMRE; ERSOY, CANAN; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0001-5082-9894; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020; AAI-1005-2021; ABI-4847-2020; AAH-8861-2021; HUR-0563-2023; IPU-7626-2023Aim. To investigate the efficacy of combined therapy of insulin and rosiglitazone on metabolic and inflammatory parameters, insulin sensitivity, and adipocytokine levels in patients with type 1 diabetes mellitus (type 1 DM). Material and Methods. A total of 61 adults with type 1 DM were randomly and prospectively assigned in open-label fashion to take insulin and rosiglitazone 4mg/day (n - 30) or insulin alone (n = 31) for a period of 18 weeks while undergoing insulin therapy without acute metabolic complications. Results. Combination therapy did not significantly improve metabolic and inflammatory parameters, insulin sensitivity, and adiponectin levels. While leptin and resistin levels decreased in both groups (group 1: resistin 6.96 +/- 3.06 to 4.99 +/- 2.64, P = 0.006; leptin 25.8 +/- 17.6 to 20.1 +/- 12.55, P = 0.006; group 2: resistin 7.16 +/- 2.30 to 5.57 +/- 2.48, P = 0.031; leptin 16.72 +/- 16.1 to 14.0 +/- 13.4, P = 0.007) Hgb and fibrinogen levels decreased only in group 1 (Hgb 13.72 +/- 1.98 to 13.16 +/- 1.98, P = 0.015, and fibrinogen 4.00 +/- 1.08 to 3.46 +/- 0.90, P = 0.002). Patients in both groups showed weight gain and the incidence of hypoglycemia was not lower. Discussion. The diverse favorable effects of TZDs were not fully experienced in patients with type 1 DM. These results are suggesting that insulin sensitizing and anti-inflammatory characteristics of TZDs were likely to be more pronounced in patients who were not totally devoid of endogenous insulin secretion.Publication Distance education perception scale for medical students: A validity and reliability study(Bmc, 2021-07-26) Özkaya, Güven; Aydın, Mevlüt Okan; Alper, Züleyha; ÖZKAYA, GÜVEN; AYDİN, MEVLÜT OKAN; ALPER, ZÜLEYHA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıp Eğitimi Anabilim Dalı; 0000-0002-8060-8803; 0000-0002-8349-9868; AAI-3331-2021; ABE-2261-2020; JJW-0446-2023Background There are major changes in education strategies as higher education institutions urgently need to adopt distance education tools and practices due to the Covid-19 pandemic. Medical education is also trying to get out of this emergency using distance education. In this study, we aimed to develop a reliable and valid scale in order to evaluate the perceptions of medical students towards distance education. Methods The students taking part in the study were in the first five academic years of the medical faculty in Bursa in Turkey. At first, 57 items were determined to evaluate students' perceptions. Content validity was examined according to the assessment of the expert team. Construct validity of these items was examined by exploratory and confirmatory factor analysis. Also, Cronbach's alpha coefficients were calculated for reliability analysis. The medical students' responses were scored using a five-point Likert scale. Results When the content validity was examined, the number of items was determined to be 38 items. Construct validity of these items was examined by exploratory and confirmatory factor analysis. Because of the exploratory factor analysis performed on the responses of 429 medical students, 22 items were included in four factors. This four-factor model was applied to 286 medical students and validated by confirmatory factor analysis. Also, Cronbach's alpha coefficients were calculated for reliability analysis and values were between 0.713 and 0.930. Conclusions This study demonstrated validation and reliability of perceptions of distance education for medical students. We suggest a 22-item model with a four-factorial scale.Publication Examining the variations in the results of the hotelling T² test in case of changing baseline landmarks in the bookstein coordinates(Springer Heidelberg, 2015-06-01) Ercan, İlker; Sığırlı, Deniz; Özkaya, Güven; ERCAN, İLKER; SIĞIRLI, DENİZ; ÖZKAYA, GÜVEN; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-2382-290X; 0000-0003-0297-846X; AAA-7472-2021; A-4421-2016; ABF-2367-2020In many biological and biomedical investigations, the most effective way to analyze the forms of whole biological organs or organisms is by recording geometric locations of landmark points. If we want to compare shapes, then individuals should be translated, rotated and scaled in such a way that all of the individuals lie in a standard position and are centered. Bookstein conducted this process by choosing two landmarks as reference landmarks. Each individual is translated, rotated and scaled according to these reference landmarks. The aim of the present study was to examine the change in the p values in the case of choosing different baseline landmarks when performing the Hotelling T (2) test, which is commonly used when comparing two sample shape configurations based on Bookstein coordinates. For this purpose, the changes in the p values were investigated in shape configurations that are composed of a different number of landmarks by taking all of the possible paired landmark combinations at different variance levels and sample sizes. As a result of the present study, it was observed that with the increase in the landmark number, the number of possible baseline landmark combinations also increases and, for this reason, a substantial number of variations occur in the p values. Therefore, it is an important to decide which landmarks should be taken as reference landmarks when using the Bookstein coordinates.Publication Real-world experience of ocrelizumab in ms in the Turkish population: A single-center study(Wiley, 2022-07-01) Ceylan, D.; SARIDAŞ, FURKAN; Koç, Erdem; Turan, Orhan; Özkaya, Güven; ÖZKAYA, GÜVEN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-4893-3988; 0000-0001-5945-2317; HSB-2700-2023Publication Effects of coronavirus disease 2019 (covid-19) pandemic on the follow-up and treatment of patients with idiopathic pulmonary fibrosis: A cross-sectional multicenter study phone call survey(European Respiratory Soc Journals, 2021-09-05) Hanta, Ismail; Cilli, Aykut; Ozkaya, Guven; ÖZKAYA, GÜVEN; Coskun, N. Funda; Ursavas, Ahmet; URSAVAŞ, AHMET; Sevinc, Can; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0003-3604-8826; 0000-0002-4069-9181; AAI-3169-2021Publication Who are sleeping in sleep laboratory? A retrospective study(Turkish Neurological Soc, 2012-01-01) Emirza, Mine Ayse Altun; Bican, Aylin; BİCAN DEMİR, AYLİN; Bora, İbrahim; BORA, İBRAHİM HAKKI; Özkaya, Güven; ÖZKAYA, GÜVEN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016Objective: Aim of this study is to compare the results of gold standard in diagnosing sleep disorders polysomnography (PSG) with the physician's preliminary diagnosis and complaints of patients in our data of sleep laboratory.Material and Met hod: 656 patients who made PSG were included in the study. All of the patients' age, gender, comorbid chronic disease, complaints, preliminary diagnosis and PSG diagnosis were evaluated retrospectively.Results: In our study, the average age of patients was 56 and 43% women 57% were male. Complaints of patients were snoring, fatigue, stopped breath during sleep, insomnia, headache, daytime sleepiness, restless legs and abnormal behaviors during sleep. According to preliminary diagnoses and PSG diagnoses; Obstructive Sleep Apnea Syndrome (OSAS), narcolepsy, REM behavior disorder (RBD) reduced (p<0.05), simple snoring and insomnia increased (p<0.05), Restless Legs Syndrome (RLS) and parasomnia comply with (p>0.05). Sleep disorders in patients were accompanied by chronic diseases, hypertension (34.3%), diabetes (12.8%), Chronic Obstructive Pulmonary Disease (COPD) (1.2%), epilepsy (1,8%), Parkinson's disease (3.5%), dementia (3.2%), depression (18,4%), cardiovascular disease (13.3%) and cerebrovascular disease (4.9%).Discussion: We are offering a good clinical history and physical examination with the correct interpretation of PSG for the differential diagnosis can be made true, accurate diagnoses and appropriate treatment modalities in our patients.Publication Comparison of central corneal thickness measured by ultrasound pachymetry, corneal topography, spectral domain- optical coherence tomography, and non-contact specular microscopy(Elsevier, 2023-04-12) Ulutaş, Hafize Gökben; Hamidi, Nagihan Amuk; Özkaya, Güven; ÖZKAYA, GÜVEN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016Background: This study aims to investigate the compatibility of central corneal thickness (CCT) measurements obtained with spectral-domain optical coherence tomography (SD-OCT), Scheimpflug-Placido-based corneal topography (CT), non-contact specular microscopy (NCSM), and ultrasonic pachymetry (UP). These four corneal measurement techniques have not been compared in a single study on these many subjects. Methods: CCT was measured in 185 eyes of 185 volunteers with each of the four devices by a single observer. CCTs from Optovue (R) iVue SD-OCT, Sirius corneal topography, NonconRobo NCSM, and Accutom UP devices were recorded. Compatibility between devices was evaluated with intraclass correlation coefficient (ICC) and Bland-Altman plots. Pairwise comparisons were performed using the Bonferroni test. Measurement differences between devices were analyzed with the Pearson correlation coefficient. Results: Of the 185 volunteers, 103 were men, and 82 were women. Their mean age was 48.55 +/- 16.6 (18-70) years. Mean CCT values measured by UP, CT, OCT, and NCSM were 546.77 +/- 39.2, 535.29 +/- 39.2, 526.49 +/- 39.05, 505.15 +/- 46.1 mu m, respectively. Statistically significant differences were found between the mean CCT values obtained from the paired devices (p <0.001). The highest difference between pairs was found between UP and NCSM (43.63 +/- 1.8 mu m; CI 38.74 to 48.5 mu m; p <0.001), while the lowest difference was found between OCT and CT (7.3 +/- 1.5 mu m; 95%CI 3.1 to 11.6 mu m; p <0.001). In pairwise comparisons of four devices, the highest ICC value was between UP and CT (ICC: 0.899, 95%CI 0.759-0.947; p <0.001). Conclusion: Despite the high correlation between measurements obtained from different methods, notable differences in CCT values exist, rendering devices non-interchangeable. Therefore, alternative brands of the same device may yield different outcomes.Publication Assessment of oral manifestations in pediatric patients with celiac disease in relation to marsh types(Medicina Oral S L, 2023-01-01) Elbek-Çubukcu, Çiğdem; Arsoy, Hanife Ayşegül; Özkaya, Güven; ELBEK ÇUBUKÇU, ÇİĞDEM; ARSOY, HANİFE AYŞEGÜL; ÖZKAYA, GÜVEN; Bursa Uludağ Üniversitesi/Diş Hekimliği Fakültesi/Pedodonti Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Gastroenteroloji, Hepatoloji ve Beslenme Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016; EVO-0292-2022; HQK-8183-2023experience, and oral hygiene status, and to measure salivary flow rate, salivary buffer capacity, and salivary car-iogenic microflora with Marsh types.Material and Methods: A single-blind, prospective clinical study with 62 pediatric patients diagnosed with celiac disease with 64 controls. Clinical identification of molar-incisor hypomineralization (MIH) was followed accord-ing to the European Academy of Pediatric Dentistry criteria. DMFS and dfs index were used for the caries expe-rience of each child. The clinical diagnosis of RAU was present or not. Oral hygiene was surveyed by recording the OHI-S and the CRT (R) Bacteria and Buffer Test was used to examine the cariogenic microflora of each child.Results: The prevalence of MIH was 61% and the number of recurrent aphthous ulcers were significantly higher in children with celiac disease. There was no statistically significant difference in the CD group, when DMFS, dfs, and MIH parameters were investigated according to dietary compliance. Higher dietary compliance resulted in better oral hygiene status. There was an inverse relationship between the duration of celiac diagnosis and the presence of MIH. A positive relation was found between the duration of the disease and the severity of MIH. In addition to the higher S. mutans counts, the salivary flow rate was very low in children with celiac disease, indicat-ing a positive correlation between poor dietary compliance and poorer oral hygiene.Conclusions: In children, enamel defects and recurrent mucosal lesions may be a sign of celiac disease. Higher numbers of dental caries in permanent teeth of children with celiac disease may be related to Marsh 2 type. The pediatricians and/or pediatric gastroenterologists should refer the chin with celiac disease to the pediatric dentist for the accurate treatment of intraoral manifestations of the disease itself.Publication Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features(Sage Publications Ltd, 2012-04-01) Kotan, Zeynep; Sarandöl, Emre; Kırhan, Emine; Özkaya, Güven; Kırlı, Selçuk; SARANDÖL, EMRE; Kırhan, Emine; ÖZKAYA, GÜVEN; KIRLI, SELÇUK; Uludağ Üniversite/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversite/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversite/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020; DBC-8927-2022; CZU-1387-2022Objective: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. Methods: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. Results: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. Conclusions: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.