Person: MECİTOĞLU, ZAFER
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MECİTOĞLU
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ZAFER
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Publication Evaluation of metabolic profiles of saanen goats in the transition period(Hellenic Veterinary Medical Soc, 2020-04-01) Akkaya, F.; Kandemir, C.; Şentürk, S.; Mecitoglu, Z.; MECİTOĞLU, ZAFER; Kasap, S.; Ertunç, S.; Veteriner Fakültesi; 0000-0002-2465-9913; 0000-0002-5557-121X; AAH-1677-2021; AAH-5069-2021Healthy Saanen goats (n=30) in periparturient period were used in the present study. Blood samples were collected 21, 14 and 7 days before parturition, at the time of birth and postpartum days 7, 14 and 21. Non-esterified fatty acids (NEFA), betahydroxy butyric acid (BHBA), Total protein (TP), albumin (ALB), blood urea nitrogen (BUN), creatinine (CREA) aspartate amino transferase (AST), gamma glutamyl transferase (GGT), sorbitol dehydrogenase (SDH), glucose (GLU), cholesterol (CHOL), triglyceride (TG), calcium (Ca), phosphorus (P), and magnesium (Mg) levels were evaluated. During the study period, NEFA, SDH, CREA levels increased and CHOL and TG levels decreased at time of parturition. When the changes of parameters in prepartum and postpartum period were compared, the concentrations of NEFA, CHOL, GLU, TG, Ca were higher (p <0.001) in prepartum period;however BHBA, Mg, ALB, GGT, AST, TP, P, BUN, SDH and CREA concentrations were detected to be higher (p <0.001) in postpartum period. Metabolic Profile Test based on biochemical parameters evaluated in our study would be beneficial for diagnosis, prevention and control of diseases such as pregnancy toxemia, hypocalcemia, infertility in goats.Publication Effects of daily propylene glycol drenching during the Ovsynch protocol on fertility and metabolic parameters in lactating dairy cows(Wiley, 2023-06-18) Çakırcalı, Rabia; Karakaya-Bilen, Ebru; Güner, Barış; Mecitoğlu, Zafer; Ortaç, Cihan Tolga; Keskin, Abdulkadir; Orman, Abdulkadir; Gümen, Ahmet; Çakirçalı, Rabia; MECİTOĞLU, ZAFER; Ortaç, Cihan Tolga; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GÜMEN, AHMET; Veteriner Fakültesi; Jinekoloji Ana Bilim Dalı; 0000-0001-9138-4422 ; 0000-0002-5557-121X ; DWK-3046-2022; AAH-1677-2021; JLZ-4927-2023; AAH-3831-2021; AAG-9134-2021; AAH-1406-2021Negative energy balance (NEB) caused by restricted feed intake leads to body condition loss (BCS), increased metabolic stress and reduced fertility in dairy cows. Propylene glycol (PG) is a precursor of ruminal propionate for gluconeogenesis used to increase metabolic adaptation to the early postpartum period. The aim of this study was to determine the effects of daily drenching of PG during the fixed-time artificial insemination (FTAI) protocol on beta-hydroxybutyric acid (BHBA), glucose, adiponectin, insulin-like growth factor-1 (IGF1) concentrations, follicle size and pregnancy rate in dairy cows. Cows (n = 148) were randomly divided into two groups and received either 300 mL of PG (PG-OVS, n = 76) or 300 mL of water (CON- -OVS, n = 72) each day of the Ovsynch protocol (GnRH-7 days-PGF2a-56 hours-GnRH-16-18-hour FTAI) between days 57 +/- 3 to 67 +/- 3 postpartum for the first service. Body condition scores (14 days before expected calving, at calving, on days 21 and 42 postpartum) were recorded. Blood samples were collected days 7 +/- 3, 21 +/- 3 postpartum, at the beginning of the Ovsynch (days 57 +/- 3) and at the time of FTAI (days 67 +/- 3) for measurements of BHBA, glucose, adiponectin and IGF1 concentrations. Ultrasonographic examinations were done to measure follicle size at the beginning of Ovsynch and FTAI and to determine pregnancy on days 30 and 60 following FTAI. There were no differences (p >.05) in glucose, adiponectin and IGF1 concentrations between the groups during the study. Although there was no difference ( p >.05) in BHBA concentrations on postpartum day 7 +/- 3, 21 +/- 3 and 57 +/- 3 between the groups, BHBA concentrations at the time of insemination was lower (p <.05) in the PG-OVS group (0.72 +/- 0.03 mmol/L) than in the CON-OVS group (0.81 +/- 0.03 mmol/L). Follicle sizes at the beginning of Ovsynch (PG-OVS, 14.5 +/- 0.48 mm; CON-OVS, 14.3 +/- 0.59 mm) and FTAI (PG-OVS, 17.8 +/- 0.52 mm; CON-OVS, 17.7 +/- 0.42 mm) were not different ( p <.05). Pregnancy rate of the cows in the PG-OVS group (46.1%, 35/76) was higher (p =.05) than in the CON-OVS group (30.6%, 22/72) on day 30 following FTAI. In conclusion, decreasing serum BHBA concentrations at the time of FTAI by means of daily drenching of PG during the Ovsynch protocol, increased the pregnancy rate at first service in lactating dairy cows. On the other hand, blood glucose was not related with pregnancy rates in our study, probably as a result of our sampling time and more rapid fluctuations of blood glucose concentrations when compared to BHBA.Publication Evaluation of serum choline along with, some biochemical and clinical parameters in cattle suffering from with botulism(Pakistan Agricultural Scientists Forum, 2021-02-01) Batmaz, Hasan; Mecitoğlu, Zafer; Koç, Cansu; Kaya, Fatih; Topal, Onur; Cansev, Mehmet; BATMAZ, HASAN; MECİTOĞLU, ZAFER; KOÇ, CANSU; KAYA, FATİH; TOPAL, ONUR; CANSEV, MEHMET; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0002-6097-5585; 0000-0001-8820-1509; 0000-0002-1933-7354; 0000-0003-2918-5064; M-9071-2019; AAA-4754-2022; IXN-7700-2023; S-8278-2017; HXD-1722-2023; FQB-3477-2022Botulism is a disease of cattle that causes significant impact due to its high mortality rate. The aim of the present study is to evaluate serum choline levels as well as clinical and biochemical parameters of cattle suspected to be suffering from botulism and to compare the results with healthy cattle and also to compare the results of survivors and fatalities. Thirteen botulism suspected and eleven healthy cattle were used. Total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), calcium, phosphorus, magnesium and potassium levels were measured from the sera of botulism and control cattle by colorimetric method using an autoanalyser. Choline levels were analyzed using HPLC. Dysphagia, decreased tongue strength weak anal reflexes, tongue and tail paralysis and locomotion disorders were the main clinical findings observed in suspected botulism cases. Botulinum toxin analysis of ruminal fluid samples were positive in two cattle from one herd. AST, ALT, potassium and choline levels were higher in cattle suffering from suspected botulism cases and choline levels were positively correlated with albumin and total protein levels. Three animals from botulism group survived. Clinical findings were milder, animals were not recumbent and choline levels were lower in survivors. Clinical findings of the three animals that recovered were milder, animals were not recumbent and choline levels were lower in survivors. It was observed that clinical findings such as decreased tongue strength and anal reflexes, dysphagia, tail paralysis, and locomotion disorders are important for diagnosis of botulism In conclusion, cattle with milder clinical signs and lower choline have a higher chance of survival.Publication Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning(Wiley, 2022-09-27) Kaçar, Yiğit; Mecitoğlu, Zafer; Batmaz, Hasan; KAÇAR, YİĞİT; MECİTOĞLU, ZAFER; BATMAZ, HASAN; Veteriner Fakültesi; İç Hastalıkları Ana Bilim Dalı; AAH-4972-2021; FQB-3477-2022; HXD-1722-2023This study aimed to investigate the effect of using menbutone in addition to ammonium molybdate on liver enzymes in sheep naturally poisoned with copper. Merino lambs (n = 30), naturally poisoned with copper and which also had high liver enzyme levels, were divided into two groups, each with 15 lambs. The AM + MEN group received ammonium molybdate and menbutone and the AM group received only ammonium molybdate solution. Both groups received 1.7% ammonium molybdate solution (1 mL per 10 kg body weight [BW]) subcutaneously on 0, 2nd and 4th days of the study. Menbutone (Genabil (R), Boehringer Ingelheim, Germany) was administered intramuscularly at a dose of 10 mg/kg BW on days 0 and 2, in addition to ammonium molybdate in the AM + MEN group. Blood samples were collected on days 0 and 7, and aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT) and creatinine levels were evaluated. Over 7 days, AST levels decreased from 351.04 +/- 63.50 IU/L to 286.40 +/- 55.68 IU/L in the AM group (P > 0.05) and from 425.00 +/- 119.25 IU/L to 240.83 +/- 29.62 IU/L in the AM + MEN group (P <= 0.05). GGT levels decreased from 121.16 +/- 15.88 IU/L to 110.39 +/- 10.13 IU/L in the AM group (P > 0.05) and 124.52 +/- 15.50 to 98.60 +/- 9.08 IU/L in the AM + MEN group (P <= 0.05). Based on these findings, the use of menbutone, in addition to ammonium molybdate, has significantly reduced the level of liver enzymes.Publication Immune response of cattle to botulinum type C and D toxoid administered on three occasions(Univ Agriculture, Fac Veterinary Science, 2015-01-01) Mecitoğlu, Zafer; Temizel, Ethem Mutlu; Özyigit, Özgür; Akgül, Gülşah; Kennerman, Engin; MECİTOĞLU, ZAFER; TEMİZEL, ETHEM MUTLU; ÖZYİĞİT, MUSA ÖZGÜR; Akgül, Gülşah; KENNERMAN, ENGİN; Veteriner Fakültesi; Dahiliye Ana Bilim Dalı; AAH-1677-2021; ECV-4083-2022; GLP-3036-2022; CBU-1718-2022; FDU-5862-2022The aims of the present study were to investigate the antibody response of cows from an outbreak region to vaccination with a bivalent botulinum toxoid (Type C and D) on three occasions and to investigate the antibody response to vaccination with the botulinum toxoid in the presence of anti-BoNT antibodies. Twenty-two cows from an outbreak region and 10 cows from a farm without a history of botulism were used in this study. Blood samples were collected before each vaccination and three weeks after the third vaccination (days 0, 21, 42 and 63). The level of anti-BoNT/C antibodies steadily increased after each vaccination (0.471 +/- 0.04, 0.566 +/- 0.03 and 0.663 +/- 0.04, respectively); however, the levels of anti-BoNT/ D antibodies were not significantly different after the second and third vaccinations (0.377 +/- 0.03, 0.493 +/- 0.03 and 0.465 +/- 0.03, respectively). Post vaccination antibody responses of animals found positive and negative for anti-BoNT antibodies at the beginning of the study were similar. The results of the present study indicated that vaccination of cattle with botulinum toxoid on three occasions is recommended, particularly in outbreaks that are suspected to be caused by BoNT/C and that presence of naturally acquired antibodies against BoNT did not interfere with post vaccination immune response.Publication Evaluation of passive transfer in goat kids with Brix refractometer and comparison with other semiquantitative tests(TÜBİTAK, 2019-01-01) Batmaz, Hasan; Kaçar, Yiğit; Topal, Onur; Mecitoğlu, Zafer; Gümüşsoy, Kadir Semih; Kaya, Feyyaz; BATMAZ, HASAN; KAÇAR, YİĞİT; TOPAL, ONUR; MECİTOĞLU, ZAFER; Kaya, Feyyaz; Veteriner Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0002-1933-7354; 0000-0001-8820-1509; AAH-4972-2021; AAH-1712-2021; IXN-7700-2023; AAH-1677-2021; S-8278-2017The aim of this study was to evaluate the passive transfer (PT) status of goat kids by Brix refractometry and compare the results with other semiquantitative tests (total protein - TP, glutaraldehyde coagulation test - GCT, and gamma-glutamyltransferase - GGT) and immunoglobulin G (IgG). The study was conducted on 75 goat kids born from 47 Saanen goats. The blood samples were collected from the kids on day 0 (presuckling) and on the 1st, 2nd, and 3rd days after birth. The Brix% and TP concentrations were measured with refractometers, and GGT activity was measured using a dry chemistry system. The duration of the GCT was determined in the first 60 min. The serum IgG concentration was measured by goat IgG ELISA kit. On the 1st and 2nd days, serum Brix% in the kids was measured as 9.33 +/- 0.17% and 9.17 +/- 0.14%, respectively. In the 1st and 2nd day serum samples of the kids, IgG was 817.76 +/- 37.34 mg/dL and 1173.29 +/- 47.81 mg/dL, respectively, and GGT was 1298.07 +/- 133.29 IU/L and 692.26 +/- 79.86 IU/L, respectively. The Brix refractometer was found to be more sensitive for detection of PT status in kids on the first and second days after birth, such as TP and GCT, whereas GGT, as an early indicator of PT, was useful only on the first day after birth. We conclude that the Brix refractometer could be used to determine the PT status in goat kids and Brix measurements lower than 8.6%, 9.2%, and 9.3% indicate failure of PT in 1-, 2-, and 3-day-old kids, respectively.