Person: TÜMAY ÖZER, ELİF
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TÜMAY ÖZER
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ELİF
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Publication Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing(Taylor, 2021-06-02) Aras, Cansu; Özer, Elif Tümay; Göktalay, Gökhan; Saat, Gülbahar; Karaca, Esra; ARAS GÜL, CANSU; TÜMAY ÖZER, ELİF; GÖKTALAY, GÖKHAN; KARACA, ESRA; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0003-1777-3977; AAI-3137-2021; AAS-8480-2020; EKA-8835-2022; AAI-3137-2021; JKY-1522-2023; DPL-6507-2022Electrospun nanofibers have a natural wound healing effect due to their similarity to the extracellular matrix (ECM). Nigella sativa oil, which has therapeutic properties, is used for a wide variety of applications in traditional medicine. The aim of this study was to investigate the release characteristic and wound healing performance of Nigella sativa oil (NSO) loaded polyurethane (PU) electrospun nanofibrous mats in wound dressing applications. In addition, the antibacterial activity and cytotoxicity of the electrospun mats were studied. Analyses using a scanning electron microscope (SEM) showed that PU/NSO nanofibrous mat with an average fiber diameter of 416 +/- 66 nm were successfully fabricated. NSO was released at a maximum ratio of 30% from the electrospun mat, and the Korsmeyer-Peppas model was identified as best for determining the release mechanism. Significant antibacterial activity was observed against Staphylococcus aureus (90.26%) and Escherichia coli (95.75%). The developed PU/NSO nanofibrous mat increased the cell viability more than 100% in human umbilical vein endothelial cell line (HUVEC) cell line. The NSO loaded PU nanofibrous mat significantly promoted the wound healing process on a rat wound model, and its wound closure reached approximately 85% compared to the control groups on the 9(th) day (p < 0.01). The results indicated PU/NSO nanofibrous mat is a suitable candidate for a wound dressing.Publication Dummy molecularly imprinted polymer-based solid-phase extraction method for the determination of some phthalate monoesters in urine by gas chromatography-mass spectrometry analysis(Elsevier, 2023-11-24) Küçük, Melike; Osman, Bilgen; Özer, Elif Tumay; KÜÇÜK, MELİKE; OSMAN, BİLGEN; TÜMAY ÖZER, ELİF; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0001-8406-149X; V-1616-2019; JCP-4547-2023; JME-2199-2023A dummy molecularly imprinted polymer-based solid-phase extraction (SPE) sorbent was used for the selective extraction of some phthalate monoesters, monoethyl phthalate (MEP), monobutyl phthalate (MnBP) and mono-(2-ethylhexyl) phthalate (MEHP) in urine prior to gas-chromatography-mass spectrometry (GC-MS) analysis. Diethyl phthalate (DEP), a phthalate ester, was successfully used as a dummy template to prepare selective sorbent for MEP, MnBP, and MEHP extraction. DEP-imprinted poly(ethylene glycol dimethacrylate N-meth-acryloyl-L-tryptophan methyl ester) (DPEMT) microbeads were synthesized by suspension polymerization and characterized by Fourier Transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Brunauer Emmet Teller (BET) analysis. The critical parameters (i.e., pH, sorbent amount, ionic strength, sample volume, elution solvent) affecting the extraction performance of the DPEMT-SPE sorbent were optimized. Under optimum conditions, good linearities were obtained in the concentration range of 4 to 60 ng/mL with deter-mination coefficients (R2) of greater than 0.9959. The developed SPE method provided low limits of detection (LOD) of 0.05-1.20 ng/mL and limits of quantification (LOQ) of 0.18-4.01 ng/mL with relative standard de-viations (RSDs) of less than 8.95 % for intra-and inter-day analyses. The proposed SPE method was used to analyze phthalate monoesters in spiked urine samples, and recoveries of 97.45-109.26 % were obtained. DPEMT-SPE sorbent was reused for 15 times without any losses of performance. Consequently, a highly selective and sensitive SPE method based on a dummy molecularly imprinted polymer combined with GC-MS was suc-cessfully developed to monitor human phthalate exposure via urine samples.Publication Lead fractionation analysis in lipstick samples by inductively coupled plasma-mass spectrometry(Taylor & Francis, 2015-01-01) Yılmazcan, Özlem; Erdemir, Ümran Seven; İzgi, Belgin; Özer, Elif Tümay; Güçer, Şeref; Yılmazcan, Özlem; SEVEN ERDEMİR, ÜMRAN; İZGİ, BELGİN; TÜMAY ÖZER, ELİF; Güçer, Şeref; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0003-3243-9168; 0000-0003-0610-2019; 0000-0002-1074-3612; AAE-8564-2020; AAI-3137-2021; Q-5688-2017; JKC-4986-2023; GAV-3362-2022A new analytical approach based on fractionation was introduced for lead in lipstick samples. Different separation techniques including n-hexane, glycerol extraction, and activated carbon adsorption were used to characterize the lipid fraction, polar and aromatic components of the samples. Additionally, artificial saliva and food stimulant extractions were used for the risk assessment studies. Trace metal levels in fractions were determined by inductively coupled plasma-mass spectrometry. Method validation parameters in the total element determinations were defined in terms of detection limits, accuracy, and precision. The limits of detection and quantification were 0.02 and 0.07mgkg(-1) for Pb; whereas the repeatability and reproducibility of the results based on percent relative standard deviation were 3.0% and 7.2% for lead, respectively.Publication Preparation and characterization of latanoprost-loaded pva nanofibers as an ocular drug delivery system for glaucoma treatment(Taylor & Francis As, 2023-05-15) Karaca, Esra; KARACA, ESRA; Cesur, Merve İlkay Altuntuğ; Osman, Bilgen; OSMAN, BİLGEN; KANMAZ, DİLAYDA; TÜMAY ÖZER, ELİF; Baykara, Mehmet; BAYKARA, MEHMET; Tıp Fakültesi; Oftalmoloji Ana Bilim Dalı; 0000-0001-8406-149X; 0000-0002-5555-1649; 0000-0003-1777-3977; HSI-3968-2023; AAS-8480-2020In this study, latanoprost-loaded polyvinyl alcohol (PVA/LAT) nanofibers were developed as an ocular drug delivery system for glaucoma treatment. The nanofibers were constructed via electrospinning and crosslinked by glutaraldehyde. The characterization studies were conducted by scanning electron microscopy, Fourier Transform infrared spectroscopy, Brunauer, Emmett, and Teller analyses, water contact angle measurements, and also swelling and degradation studies. The PVA/LAT nanofibers crosslinked with 0.5% glutaraldehyde solution for 20 min had a cumulative release of 52% for 23 days. The results demonstrated that the PVA/LAT nanofibers have a usage potential as an ocular drug delivery system for glaucoma treatment.Publication Adsorptive removal of 4-hydroxybenzoic acid via cross-linked polymeric microbeads: Analysis of isothermal, kinetic and thermodynamic parameters(Taylor & Francis Inc, 2023-05-26) Özer, Elif Tumay; Osman, Bilgen; KÜÇÜK, MELİKE; OSMAN, BİLGEN; TÜMAY ÖZER, ELİF; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0001-8406-149X; JCP-4547-2023In this study, the performance of cross-linked microbeads prepared through suspension polymerization was investigated for removal of 4-hydroxybenzoic acid (4-HBA) from aqueous solution. Adsorption studies were conducted at different pHs (2.0-8.0), temperatures (282-308 K) and initial 4-HBA concentrations (1-500 mg/L). The maximum 4-HBA adsorption was 49.05 +/- 2.89 mg/g at pH 2.0 (282 K). The adsorption data obeyed to the Langmuir isotherm model. The modified Ritchie second-order and the pseudo second-order kinetic model fitted the adsorption data. The 4-HBA adsorption capacity did not significantly change after 10 consecutive usages. Gibbs free energy changes of the adsorption were calculated as -24.372, -28.431 and -29.093 kJ/mol for 282, 298 and 308 K, respectively. The microbeads were also used for the removal of 4-HBA from spiked river water samples. The removal efficiencies of 43.2% to 68.8% and RSDs of 0.49% to 4.78% demonstrated the usability of the microbeads in application.Publication Biosorption of tetracycline antibiotics by Lactarius deliciosus biomass(Taylor & Francis Inc, 2023-10-06) Sarıkaya, Aslı Göcenoğlu; OSMAN, BİLGEN; GÖÇENOĞLU SARIKAYA, ASLI; Osman, Bilgen; TÜMAY ÖZER, ELİF; Özer, Elif Tumay; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0002-7161-7003; 0000-0001-8406-149X; AAC-6901-2020In this study, Lactarius deliciosus biomass was used as a biosorbent for the biosorption of three tetracycline antibiotics, chlortetracycline (CTC), doxycycline (DC), and tetracycline (TC), from aqueous solution. The biomass was characterized by Fourier Transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The effect of biosorbent amount (0.01-0.1g), pH (3.0-8.0), initial antibiotic concentration (30-300 mg/L for CTC and DC, and 5-50 mg/L for TC), contact time (2-120 min), and temperature (7 degrees C, 16 degrees C, 25 degrees C) were investigated. The maximum biosorption amount of CTC, DC, and TC was 216.4 +/- 4.2 mg/g (pH 4.0), 121.2 +/- 6.2 mg/g (pH 3.0), and 23.2 +/- 2.1 mg/g (pH 7.0) at 25 degrees C, respectively. The biosorption amount of tetracyclines decreased with increasing temperature demonstrating that the biosorption processes were exothermic. The biosorptions of tetracyclines were favorable with negative Delta G degrees values for all temperatures. CTC and DC biosorption processes were well fitted to the pseudo-second-order kinetic and Freundlich isotherm models. TC biosorption data obeyed the pseudo-first-order kinetic model. Tap and drinking water samples spiked with tetracyclines were used as real samples for biosorption. The results showed that L. deliciosus biomass could be effectively used as a biosorbent for tetracycline antibiotics with high adsorption capacities.