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TAŞ, SİBEL

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TAŞ

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SİBEL

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    Publication
    Teucrium leucocladum: An effective tool for the treatment of hyperglycemia, hyperlipidemia, and oxidative stress in streptozotocin-induced diabetic rats
    (Hindawi, 2020-11-12) Bassalat, Najlaa; Taş, Sibel; Jaradat, Nidal; TAŞ, SİBEL; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü; 0000-0001-6225-774X; IUG-1724-2023
    Teucrium leucocladum is among the most used traditional medicinal plants in Palestine, which is used for the treatment of hyperglycemia and colon spasms from ancient times. Therefore, the current investigation aimed for the first time to determine the hypoglycemic, hypolipidemic, and oxidative stress inhibitory effects of the aerial parts (stem and leaves) of T. leucocladum hydrophilic (water) extract in streptozotocin- (STZ-) induced diabetic rats (65 mg/kg), given intraperitoneally at a dose of 100 mg/kg for 21 days. The rats were divided into four groups as control (C), control + T. leucocladum extract (C + TL), diabetes (D), and diabetes + T. leucocladum extract (D + TL). The antioxidant activity was analyzed using in vitro 2,2-diphenyl-1-picrylhydrazyl and in vivo methods by measuring the plasma and tissue malondialdehyde (MDA) levels using a colorimetric assay. On the other hand, glutathione peroxidase (GSH-Px), erythrocyte superoxide dismutase (SOD) enzyme levels, serum paraoxonase (PON), and arylesterase (ARE) enzyme activities were assessed by utilizing standard biochemical kits. Besides, the blood glucose and serum insulin levels were assessed by a glucometer and Rat ELISA Kit, respectively. However, the autoanalyzer was used to evaluate the lipid profile. The diabetic rat group that administered T. leucocladum extract showed the best reduction in the tissue and plasma MDA levels and an increase of insulin-releasing potentials. Besides, the serum PON and ARE activities and erythrocyte superoxide dismutase and whole blood glutathione peroxidase enzyme levels were significantly increased in all animals treated with T. leucocladum extract. The current investigation demonstrated that T. leucocladum manifests antihyperglycemic and antihyperlipidemic effects and also increased the antioxidative defense system and reduced the lipid peroxidation process in experimental diabetic rats.
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    Publication
    Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
    (Springer, 2014-11-01) Bağdaş, Deniz; Gül, Nihal Yaşar; Topal, Ayşe; Taş, Sibel; Özyiğit, Musa Özgür; CinkIlıç, NilÜfer; Gül, Zülfiye; Etoz, Betül Cam; Ziyanok, Sedef; İnan, Sevda; Turacozen, Özge; Gürün, Mine Sibel; Bağdaş, Deniz; GÜL SATAR, NİHAL YAŞAR; TOPAL, AYŞE; TAŞ, SİBEL; ÖZYİĞİT, MUSA ÖZGÜR; CinkIlıç, Nilüfer; Gül, Zülfiye; Etoz, Betül Cam; ZİYANOK DEMİRTAŞ, SEDEF; İnan, Sevda; Turacözen, Özge; GÜRÜN, MİNE SİBEL; Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi; Uludağ Üniversitesi Veteriner Fakültesi, Cerrahi Anabilim Dalı; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı; 0000-0001-6225-774X; 0000-0002-3595-6286; 0000-0002-8872-0074; 0000-0003-3878-3808; 0000-0001-8138-5851; AAG-8716-2019; AAH-4272-2021; AAF-9939-2020; ABE-6873-2020; JBJ-7162-2023; AAH-5296-2021; AAR-6478-2021; AAH-2873-2021; E-3364-2018; EOB-5882-2022; GGO-6894-2022; AAH-5296-2021
    Chlorogenic acid (CGA) is a well-known natural antioxidant in human diet. To understand the effects of CGA on wound healing by enhancing antioxidant defense in the body, the present study sought to investigate the potential role of systemic CGA therapy on wound healing and oxidative stress markers of the skin. We also aimed to understand whether chronic CGA treatment has side effects on pivotal organs or rat bone marrow during therapy. Full-thickness experimental wounds were created on the backs of rats. CGA (25, 50, 100, 200 mg/kg) or vehicle was administered intraperitoneally for 15 days. All rats were sacrificed on the 16th day. Biochemical, histopathological, and immunohistochemical examinations were performed. Possible side effects were also investigated. The results suggested that CGA accelerated wound healing in a dose-dependent manner. CGA enhanced hydroxyproline content, decreased malondialdehyde and nitric oxide levels. and elevated reduced glutathione, superoxide dismutase, and catalase levels in wound tissues. Epithelialization, angiogenesis, fibroblast proliferation, and collagen formation increased by CGA while polymorph nuclear leukocytes infiltration decreased. CGA modulated matrix metalloproteinase-9 and tissue inhibitor-2 expression in biopsies. Otherwise, high dose of CGA increased lipid peroxidation of liver and kidney without affecting the heart and muscle samples. Chronic CGA increased micronuclei formation and induced cytotoxicity in the bone marrow. In conclusion, systemic CGA has beneficial effects in improving wound repair. Antioxidant, free radical scavenger, angiogenesis, and anti-inflammatory effects of CGA may ameliorate wound healing. High dose of CGA may induce side effects. In light of these observations, CGA supplementation or dietary CGA may have benefit on wound healing.