Person: AKSOY, FUAT
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AKSOY
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FUAT
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Publication Liver-derived exosomes in liquid biopsies: Advantage before liver transplantation - a pilot study(Lippincott Williams & Wilkins, 2021-08-01) ; Aksoy, F.; AKSOY, FUAT; Aksoy, Seçil Ak; Tunca, B.; TUNCA, BERRİN; Kıyıcı, M.; Kaya, E.; Bursa Uludağ Üniversitesi.; 0000-0001-5808-9384; 0000-0002-1619-6680; HII-8895-2022; ADM-8457-2022Publication Tumor-derived exosomal mir-21 induces recurrence in liver cancer(Wiley, 2021-08-01) Aksoy, Fuat; Kaya, Ekrem; Dündar, Halit Ziya; Aksoy, Seçil Ak; Tunca, Berrin; AKSOY, FUAT; KAYA, EKREM; DÜNDAR, HALİT ZİYA; AKSOY, SEÇİL; TUNCA, BERRİN; Bursa Uludağ Üniversitesi.; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0002-9562-4195; ADM-8457-2022; HII-8895-2022; AAG-7319-2021; EWI-3634-2022; ABI-6078-2020Publication Cancer stem cell markers in pancreatic ductal adenocarcinoma(Oxford Univ Press, 2018-10-01) Aksoy, Fuat; Kaya, Ekrem; Egeli, Ünal; Dündar, Halit Ziya; Taşar, Pınar; Aksoy, Seçil; Özen, Yılmaz; Tunca, Berrin; Çeçener, Gülşah; Yerci, Ömer; AKSOY, FUAT; KAYA, EKREM; EGELİ, ÜNAL; DÜNDAR, HALİT ZİYA; TAŞAR, PINAR; AKSOY, SEÇİL; ÖZEN, YILMAZ; TUNCA, BERRİN; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; 0000-0002-9562-4195; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoloji Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Bölümü; 0000-0001-5808-9384; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0002-3820-424X; AAH-1420-2021; AAH-3847-2021; ADM-8457-2022; HII-8895-2022; ABI-6078-2020; AAG-7319-2021; EWI-3634-2022; IIC-9825-2023; FOQ-1792-2022; AAP-9988-2020Publication MicroRNA-21 functions as a prognosis predictor in head of pancreas tumor(Oxford Univ Press, 2018-03-01) Aksoy, Fuat; Aksoy, Savaş; Tunca, Berrin; Dündar, Halit Ziya; Sarkut, Pınar; Özen, Y.; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; AKSOY, FUAT; Aksoy, Savaş; TUNCA, BERRİN; DÜNDAR, HALİT ZİYA; Sarkut, Pınar; Özen, Y.; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; 0000-0002-9562-4195; AAH-3847-2021; HII-8895-2022; AAH-1420-2021; ABI-6078-2020; CAV-8845-2022; EWI-3634-2022; HKB-5363-2023; FOQ-1792-2022; AAP-9988-2020; AAG-7319-2021Publication Blood-based biomarkers in Afp normal/stable hepatocellular carcinoma: Diagnostic and prognostic relevance of Mir-10b for patients on liver transplant list(Elsevier Science Inc, 2022-09-01) Aksoy, Fuat; Aksoy, Seçil Ak; Dündar, Halit Ziya; Tunca, Berrin; Erçelik, Melis; Tekin, Çağla; Kıyıcı, Murat; Selimoğlu, Kerem; Kaya, Ekrem; AKSOY, FUAT; Aksoy, Seçil Ak; DÜNDAR, HALİT ZİYA; TUNCA, BERRİN; Erçelik, Melis; Tekin, Çağla; KIYICI, MURAT; Selimoğlu, Kerem; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; Bursa Uludağ Üniversitesi/İnegöl Meslek Yüksekokulu.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0003-3635-7282; 0000-0002-3760-9755; 0000-0002-9562-4195; HII-8895-2022; ADM-8457-2022; EWI-3634-2022; ABI-6078-2020; EUG-3329-2022; JIT-9986-2023; FHW-0015-2022; CDS-3299-2022; AAG-7319-2021Background. As a diagnostic criteria of hepatocellular carcinoma (HCC), the exact threshold of alpha-fetoprotein (AFP) is controversial. In additional, not all HCC tumors are AFP positive or secrete elevated amounts of AFP into the serum. However, the diagnosis of HCC is quite important on the liver transplant list. Therefore, the purpose of this study was to investigate the expression of circulating micro RNAs (miRNAs) in AFP-stable HCC patients. Thus, we aimed to determine a diagnostic biomarker in these patients.Methods. Sixteen miRNAs were evaluated using a real-time quantitative reverse transcription polymerase chain reaction system in AFP-stable HCC and AFP-trending HCC patients.Results. In our study, 46.7% (n = 28) of the patients diagnosed with HCC had stable/normal AFP levels. We detected that high expression of miR-24, miR-10b and the low expression of miR-143 were independently and significantly associated with HCC in AFP-stable compared with AFP trending (P <.05). Additionally, we demonstrated that the overexpression of miR-10b was associated with poor disease-free survival in HCC (P = 0.001).Conclusions. Although more clinical validations are needed for the diagnosis of HCC, our current results indicate that the coexistence of high expression of miR-10b and miR-24 may help clinicians adjust in the diagnosis of HCC in patients who are on the liver transplant list but awaiting biopsy for the diagnosis of HCC.Publication Effect of locoregional treatments in hepatocellular carcinoma: What are the pathologic/radiologic Milan Criteria?(Başkent Üniversitesi, 2023-10-01) Aksoy, Fuat; Dündar, Halit Ziya; Çelik, Fatih; Öngen, Gökhan; Nas, Ömer Fatih; Sağlam, Kutay; Gürlüler, Ercüment; Kıyıcı, Murat; Kaya, Ekrem; AKSOY, FUAT; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; ÖNGEN, GÖKHAN; NAS, ÖMER FATİH; SAĞLAM, KUTAY; GÜRLÜLER, ERCÜMENT; KIYICI, MURAT; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; EWI-3634-2022; JYY-5340-2024; FQR-8472-2022; JJS-3965-2023; JSD-3843-2023; FHW-0015-2022; JSF-3184-2023Objectives: Milan criteria is the most commonly used criteria for patients with hepatocellular carcinoma awaiting liver transplant. The effects of locoregional therapy on downstaging or bridging before liver transplant on survival remain controversial. Considering that the tumor size may change with locoregional therapy and formalin fixation after explantation, we aimed to evaluate the effects of locoregional therapy on radiological and pathological Milan criteria and survival.Materials and Methods: Demographic data, etiology, preoperative alpha-fetoprotein value, Child-Pugh and Model for End-Stage Liver Disease-Na scores, status of being inside or outside of radiological Milan criteria, status of being inside or outside of Milan criteria in explant (pathological Milan criteria), and the locoregional therapy types and combinations were evaluated for their effects on inclusion in Milan criteria and survival.Results: During the study period, 396 patients underwent liver transplant at our center, with 97 because of cirrhosis and hepatocellular carcinoma. When we viewed patients according to preoperative radiologic evaluations, 67.9% were within Milan criteria and 32.1% were outside. When we viewed according to explant (pathological) evaluations, 80.7% of patients were within Milan criteria. Among 97 patients, 71 (73.2%) had locoregional therapy (22 [30.9%] for downstaging, 49 [69.0%] for bridging to transplant), and 12 patients (12.3%) were within Milan criteria on explant examination while outside of Milan criteria before LT. One-year, 3-year, and 5-year survival rates were 80.7%, 76.1%, and 71.6%, respectively. Conclusions: As a result of radiological evaluations, in patients who were outside of Milan criteria and underwent locoregional therapy, explant pathology within Milan criteria had a positive effect on survival; however, after locoregional therapy, there was no significant effect on survival in patients who were still outside of Milan criteria.Publication Recurrent hepatocellular carcinoma after liver transplantation: Identifying the high-risk patient using the expression profiles of emt-associated lncrnas(Frontiers Media Sa, 2019-10-01) Aksoy, Seçil Ak; Aksoy, Fuat; Dündar, Haliz Ziya; Tunca, Berrin; Taşar, Pınar; Uğraş, Nesrin; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; Aksoy, Seçil Ak; AKSOY, FUAT; Dündar, Haliz Ziya; TUNCA, BERRİN; TAŞAR, PINAR; UĞRAŞ, NESRİN; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; AAH-8540-2021; AAG-7319-2021; AAP-9988-2020; ABI-6078-2020; AAH-1420-2021; AAH-2716-2021; HII-8895-2022; EGD-8703-2022; IIC-9825-2023Publication Outcome of split liver transplantation vs living donor liver transplantation: A systematic review and meta-analysis(Baishideng Publishing Group Inc, 2023-07-27) Garzali, İbrahim Umar; Akbulut, Sami; Aloun, Ali; Naffa, Motaz; Aksoy, Fuat; AKSOY, FUAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0001-5808-9384; HII-8895-2022BACKGROUNDThe outcomes of liver transplantation (LT) from different grafts have been studied individually and in combination, but the reports were conflicting with some researchers finding no difference in both short-term and long-term outcomes between the deceased donor split LT (DD-SLT) and living donor LT (LDLT).AIMTo compare the outcomes of DD-SLT and LDLT we performed this systematic review and meta-analysis.METHODSThis systematic review was performed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The following databases were searched for articles comparing outcomes of DD-SLT and LDLT: PubMed; Google Scholar; Embase; Cochrane Central Register of Controlled Trials; the Cochrane Database of Systematic Reviews; and Reference Citation Analysis (https://www.referencecitationanalysis.com/). The search terms used were: "liver transplantation;" "liver transplant;" "split liver transplant;" "living donor liver transplant;" "partial liver transplant;" "partial liver graft;" "ex vivo splitting;" and "in vivo splitting."RESULTSTen studies were included for the data synthesis and meta-analysis. There were a total of 4836 patients. The overall survival rate at 1 year, 3 years and 5 years was superior in patients that received LDLT compared to DD-SLT. At 1 year, the hazard ratios was 1.44 (95% confidence interval: 1.16-1.78; P = 0.001). The graft survival rate at 3 years and 5 years was superior in the LDLT group (3 year hazard ratio: 1.28; 95% confidence interval: 1.01-1.63; P = 0.04).CONCLUSIONThis meta-analysis showed that LDLT has better graft survival and overall survival when compared to DD-SLT.Publication Evaluation of the trend of biochemical functions in the early period after cadaveric liver transplantation(Elsevier Science Inc, 2023-06-28) Aksoy, Fuat; Gürlüler, Ercüment; Çelik, Fatih; Şen, Murat; Balkan, Eyüp Anıl; Dündar, Halit Ziya; Kaya, Ekrem; AKSOY, FUAT; GÜRLÜLER, ERCÜMENT; ÇELİK, FATİH; ŞEN, MURAT; BALKAN, EYÜP ANIL; DÜNDAR, HALİT ZİYA; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; AAG-7319-2021; JYY-5340-2024; JEX-7100-2023; IZR-9309-2023; EWI-3634-2022Background. Monitoring biochemical parameters to detect early complications after liver transplantation (LT) is important. Thus, we aimed to investigate parameter trends indicating liver function in patients who did not develop complications after cadaveric LT. Methods. A total of 266 cadaveric LT operations performed by a single center between 2007-2022 were included in the study. Patients with any early complications were excluded from the study. During the first 15 days, the parameters reflecting the patients' liver integrity and synthesis functions were evaluated. All parameters studied were evaluated at the same time of day and by a single laboratory. Results. Regarding synthesis functions, the coagulation parameters (prothrombin time and international normalized ratio) peaked on the first day and then decreased. Regarding tissue hypoxia, there was no significant change in lactate values. Total and direct bilirubin values also decreased after peaking on the first day. No significant change was observed in albumin, another liver synthesis value. Conclusions. Although an increase in aspartate aminotransferase, alanine aminotransferase, total and direct bilirubin, prothrombin time, and international normalized ratio, which was especially seen on the first day, is considered normal, values that do not decrease after the second day or lactate values that increase gradually should be a warning in terms of possible early complications.