Person: SARANDÖL, EMRE
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SARANDÖL
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EMRE
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Publication Evaluation of percentage recovery together with modified reference range in hyperprolactinemia(Walter De Gruyter Gmbh, 2020-02-01) Dirican, Melahat; Açıkgöz, Hacer Ebru; Sarandöl, Emre; SARANDÖL, EMRE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; AAG-6985-2021; ABE-1716-2020Objective: Macroprolactinemia is an important cause of hyperprolactinemia. The aim of this study was to examine the added value of the consideration of modified reference range in determination of macroprolactinemia and true hyperprolactinemia.Materials and methods: Three hundred and ninety patients with high and 131 with normal prolactin (PRL) levels were included in this study. PRL had been analyzed before and after polyethylene glycol precipitation (postPEG PRL). Recovery percentage (R%) <40% and >60% had been reported as macroprolactinemia and true hyperprolactinemia, respectively. Post-PEG PRL levels were evaluated according to the modified reference range obtained from those of the normoprolactinemic subjects.Results: According to the R% criterion; macroprolactinemia had been detected in 24.9% and true hyperprolactinemia in 67.4% of hyperprolactinemic patients. When the data were evaluated considering the post-PEG PRL levels according to the modified reference range; 13 (13.4%) of the 97 macroprolactinemia reports would be considered as true hyperprolactinemia and 6 (2.3%) of the 263 true hyperprolactinemia reports would be changed as macroprolactinemia.Conclusion: Discrimination capacity of R% criterion for true hyperprolactinemia and macroprolactinemia is limited, and we suggest that, in accordance with R% criterion, laboratory reports should include the post-PEG PRL levels along with the modified reference range.Publication Which frequency is better for pediatric shock wave lithotripsy? Intermediate or low: A prospective randomized study(Springer, 2021-04-22) Kaygısız, Onur; Çiçek, Mehmet Çağatay; Mert, Ahmet; Akesen, Selcan; Sarandöl, Emre; Kılıçarslan, Hakan; KAYGISIZ, ONUR; ÇİÇEK, MEHMET ÇAĞATAY; AKESEN, SELCAN; SARANDÖL, EMRE; KILIÇARSLAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-9790-7295; 0000-0002-0471-5404; 0000-0003-4236-3646; 0000-0002-2593-7196; L-9439-2019; HGM-5995-2022; ELR-9087-2022; DXM-3644-2022; FGY-3115-2022Purpose Shock wave lithotripsy (SWL) is the first option in the treatment of pediatric kidney stones; however, optimal frequency is still uncertain. The aim of this study was to compare low frequency [60 shocks per minute (SWs/min)] and intermediate frequency [90 SWs/min] in terms of lithotripsy success, complications, cardiac arrhythmia, anesthesia time, secondary procedures, and efficiency quotient (EQ) in children. Methods Seventy-eight consecutive children who received SWL for radiopaque renal stones between July 2016 and January 2020 were randomly divided into two groups: Group 60 (SWL frequency: 60 SWs/min) and Group 90 (SWL frequency: 90 SWs/min). After exclusion (remaining 71 children), Group 60 (n = 38) and Group 90 (n = 33) were compared using univariate analysis. Results The median age of children (37 girls, 34 boys) was 5 (1-16) years. Patient demographics and stone features were similar between the groups. Success rate after the last SWL session was 81.6% (n = 31) for Group 60 and 87.9% (n = 29) for Group 90 (p = 0.527). Stone-free rate after the first, second, and third sessions was 42.1%, 18.4%, and 21.1% for Group 60 and 48.5%, 27.3%, and 12.1% for Group 90, respectively. Additional treatment rate was similar between the groups. In Group 60, the EQ was 57.83, and it was 64.07 in Group 90. Median total anesthesia time was significantly longer in Group 60 (74.5 min) than in Group 90 (32 min; p < 0.001). Conclusion Intermediate frequency and low-frequency pediatric SWL have similar success rates; however, intermediate-frequency SWL has a shorter anesthesia time.Publication The effect of different antihypertensive treatment protocoles on oxidant-antioxidant systems in type 2 diabetic patients with microalbuminuria and stage 1 hypertension(Oxford Univ Press, 2015-05-01) Ersoy, Alparslan; Erek, Müge; Ersoy, Canan; Sarandöl, Emre; Yıldız, Abdülmecit; ERSOY, ALPARSLAN; Erek, Müge; ERSOY, CANAN; SARANDÖL, EMRE; YILDIZ, ABDULMECİT; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; AAH-5054-2021; ABE-1716-2020; AAH-8861-2021; EWD-8165-2022; HIG-9032-2022Publication Effect of rosiglitazone and insulin combination therapy on inflammation parameters and adipocytokine levels in patients with Type 1 DM(Hindawi, 2015-03-17) Güçlü, Metin; Gül, Özen Öz; Cander, Soner; Ünal, Oğuzkaan; Özkaya, Güven; Sarandöl, Emre; Ersoy, Canan; Güçlü, Metin; ÖZ GÜL, ÖZEN; CANDER, SONER; Ünal, Oğuzkaan; ÖZKAYA, GÜVEN; SARANDÖL, EMRE; ERSOY, CANAN; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0001-5082-9894; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020; AAI-1005-2021; ABI-4847-2020; AAH-8861-2021; HUR-0563-2023; IPU-7626-2023Aim. To investigate the efficacy of combined therapy of insulin and rosiglitazone on metabolic and inflammatory parameters, insulin sensitivity, and adipocytokine levels in patients with type 1 diabetes mellitus (type 1 DM). Material and Methods. A total of 61 adults with type 1 DM were randomly and prospectively assigned in open-label fashion to take insulin and rosiglitazone 4mg/day (n - 30) or insulin alone (n = 31) for a period of 18 weeks while undergoing insulin therapy without acute metabolic complications. Results. Combination therapy did not significantly improve metabolic and inflammatory parameters, insulin sensitivity, and adiponectin levels. While leptin and resistin levels decreased in both groups (group 1: resistin 6.96 +/- 3.06 to 4.99 +/- 2.64, P = 0.006; leptin 25.8 +/- 17.6 to 20.1 +/- 12.55, P = 0.006; group 2: resistin 7.16 +/- 2.30 to 5.57 +/- 2.48, P = 0.031; leptin 16.72 +/- 16.1 to 14.0 +/- 13.4, P = 0.007) Hgb and fibrinogen levels decreased only in group 1 (Hgb 13.72 +/- 1.98 to 13.16 +/- 1.98, P = 0.015, and fibrinogen 4.00 +/- 1.08 to 3.46 +/- 0.90, P = 0.002). Patients in both groups showed weight gain and the incidence of hypoglycemia was not lower. Discussion. The diverse favorable effects of TZDs were not fully experienced in patients with type 1 DM. These results are suggesting that insulin sensitizing and anti-inflammatory characteristics of TZDs were likely to be more pronounced in patients who were not totally devoid of endogenous insulin secretion.Publication Serum fetuin-a levels for the detection and evaluation of the left ventricular systolic heart failure(Elsevier, 2013-10-29) Keçebaş, Mesut; Güllülü, Sümeyye; Sağ, Saim; Açıkgöz, Ebru; Besli, Feyzullah; Şentürk, Tunay; Kaderli, Aysel Aydın; Özdemir, Bülent; Baran, İbrahim; Sarandöl, Emre; Aydınlar, Ali; Keçebaş, Mesut; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Sağ, Saim; Açıkgöz, Ebru; Besli, Feyzullah; ŞENTÜRK, TUNAY; Kaderli, Aysel Aydın; ÖZDEMİR, BÜLENT; Baran, İbrahim; SARANDÖL, EMRE; AYDINLAR, ALİ; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı; 0000-0002-6206-8700; C-1517-2017; ABE-1716-2020; AAW-9185-2020; AAI-6632-2021; JKQ-3658-2023; JGR-6552-2023; CBS-6076-2022; DXE-4816-2022; CXL-7581-2022; JHE-3353-2023; CDA-1396-2022Publication The effects of the renin-angiotensin-aldosterone system blockers on serum ischemia-modified albumin levels in autosomal dominant polycystic kidney disease(Springer London Ltd, 2022-01-23) Ermurat, Selime; Güllülü, Mustafa; Sarandöl, Emre; GÜLLÜLÜ, MUSTAFA; SARANDÖL, EMRE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Klinik Biyokimya Anabilim Dalı.; JGS-9425-2023; DXM-3644-2022Background Among one of the common hereditary causes of chronic kidney disease is autosomal-dominant polycystic kidney disease (ADPKD), and its incidence rate is reported as one between 500 and 1.000 individuals. The most common complications of ADPKD are hypertension (HT) and end-stage renal disease (ESRD). HT occurring in the early stage of ADPKD leads to deteriorations in renal function. Aims It was aimed to investigate the ischemia-modified albumin (IMA) levels and the effect of renin-angiotensin-aldosterone system (RAAS) blockers on serum IMA levels in patients with ADPKD. Methods One hundred and fifteen patients were included as ADPKD (n = 50), HT (n = 35), and healthy control (HC) groups (n = 30). Patients with ADPKD and HT were divided into two subgroups as RAAS blocker-users and non-users. Results Serum IMA levels were detected as 0.42 (0.17-0.80) in ADPKD and 0.28 (0.04-0.51) in HT and 0.36 (0.22-0.56) in HC groups as absorbance units (ABSU), and the highest serum IMA level was seen in Group ADPKD. Serum IMA levels were 0.33 +/- 0.14 in RAAS blocker-users and 0.41 +/- 0.11 ABSU in non-users with ADPKD. Serum IMA levels were witnessed to be significantly lower in RAAS blocker-users in Groups ADPKD (p = 0.038) and HT (p = 0.004), compared to non-users. Given basal and 6-month values of those with ADPKD, the levels of serum IMA within 6 months were significantly lower (p = 0.002). Conclusions We consider that serum IM levels should be assessed in oxidative stress (OS)-related conditions, such as ADPKD, and RAAS blockers may be effective in reducing serum IMA levels in ADPKD and HT patients.Publication Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features(Sage Publications Ltd, 2012-04-01) Kotan, Zeynep; Sarandöl, Emre; Kırhan, Emine; Özkaya, Güven; Kırlı, Selçuk; SARANDÖL, EMRE; Kırhan, Emine; ÖZKAYA, GÜVEN; KIRLI, SELÇUK; Uludağ Üniversite/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversite/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversite/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020; DBC-8927-2022; CZU-1387-2022Objective: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. Methods: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. Results: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. Conclusions: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.Publication Effects of vitamin C supplementation on oxidative stress and serum paraoxonase/arylesterase activities in patients on long-term hemodialysis(Soc Espanola Nefrologia Dr Rafael Matesanz, 2023-09-01) Sarandöl, Emre; Erdinç, Selda; Şenol, Emel; Ersoy, Alparslan; Sürmen-Gura, Esma; SARANDÖL, EMRE; Erdinç, Selda; Şenol, Emel; ERSOY, ALPARSLAN; Sürmen-Gura, Esma; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0001-7377-9682; JVN-0414-2024; AAG-7327-2021; JKC-3379-2023; DSA-1108-2022; CPX-5894-2022Background: Oxidative stress increases oxidizability of apolipoprotein-B containing lipoproteins and decreases paraoxonase (PON) activity in hemodialysis (HD) patients and plays an important part in the development of atherosclerotic cardiovascular diseases. In HD patients, plasma ascorbic acid (AA) levels are decreased either due to the loss by hemodialysis membranes or due to malnutrition and contribute to the imbalance of antioxidant defense mechanisms. We hypothesized that long-term ascorbic acid (AA) supplementation recovers oxidizability of lipoproteins in HD patients by reinforcing PON activity. Methods: Twenty-nine adult patients were treated with 100 mg and 500 mg AA at the end of each HD session thrice a week for two consecutive 16 weeks-periods, respectively. Blood samples were obtained before the first HD session and prior to the first HD sessions following the 100 mg AA-supplemented and the 500 mg AA-supplemented periods. Results: PON activities were significantly increased after 100 mg (p < 0.05) and 500 mg AA (p < 0.001) supplementation periods compared to the basal level. Apo-B lipoprotein oxidizability (Delta-MDA) was significantly decreased after 500 mg AA supplementation compared to both basal (p < 0.05) and 100 mg AA supplementation periods (p < 0.05). Plasma AA concentrations were negatively correlated with Delta-MDA levels (R = -0.327; p < 0.01). Conclusion: Our results suggest that long-term parenteral 500 mg AA supplementation improves PON activity alleviating apo B-containing lipoproteins oxidizability in HD patients. (c) 2021 Sociedad Espanola de Nefrolog ' ia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).Publication Relationship between prohepcidin and cardiovascular risk markers in end stage renal failure patients(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2013-01-01) Arabul, Mahmut; Kahvecioğlu, Serdar; Eren, Mehmet Ali; Üstündağ, Yasemin; Sarandöl, Emre; Kaderli, Aysel; Emre, Türker; Doğan, İbrahim; Güllülü, Mustafa; Kaderli, Aysel; SARANDÖL, EMRE; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı; IDI-7594-2023; JGS-9425-2023; ABE-1716-2020OBJECTIVE: The leading cause of death in patients with end-stage renal disease (ESRD) is cardiovascular disease. Prohepcidin, which is the precursor of hepcidin is a peptide hormone produced by the liver, and appears to be the master regulator of iron homeostasis in humans. High prohepcidin levels may contribute to progression of cardiovascular disease in end-stage renal insufficiency patients. However, any such association remains poorly understood. The purpose of the present study was to investigate the relationship between prohepcidin and cardiovascular risk markers in end-stage renal failure patients.MATERIAL and METHODS: Twenty-two chronic hemodialysis patients, 21 chronic peritoneal dialysis patients, and 16 healthy controls were included in the present study. The levels of serum prohepcidin (the precursor form of hepcidin), high sensitivity C-reactive protein (hs-CRP), troponin-T (TT), and cystatin C (CC) were determined using commercial kits. The left ventricular mass index (LVMI) was estimated using echocardiography.RESULTS: The levels of the CVD risk markers TT, CC, and prohepcidin differed, with statistical significance, between the patient and control groups. Prohepcidin level was significantly associated with CC concentration (beta=0.855, R2=0.73, p<0.001), TT level (beta=0.456, R2=0.20, p=0.002), and the LVMI (beta=0.435, R2=0.19, p=0.003). However, no significant association between prohepcidin level and hs-CRP concentration was evident (beta=0.124, R2=0.015, p<0.42).CONCLUSION: Our data suggest that the prohepcidin level can serve as a biomarker of cardiovascular disease. This level is closely associated with the cardiovascular risk markers of CC and TT concentrations, as well as the LVMI.Publication Acute effects of different types of exercises on peripheral neurotrophic factors and cognitive functions in veteran athletes(Springernature, 2023-12-12) Birinci, Yakup Zühtü; Sağdilek, Engin; Taymur, İbrahim; Budak, Ersin; Beyaz, Aylin; Vatansever, Şerife; Pancar, Serkan; Topçu, Hüseyin; Sarandöl, Emre; Şahin, Şenay; Birinci, Yakup Zühtü; SAĞDİLEK, ENGİN; BEYAZ, AYLİN; SARANDÖL, EMRE; Topçu, Hüseyin; Şahin, Şenay; Vatansever, Şerife; Bursa Uludağ Üniversitesi/Spor Fakültesi/Antrenörlük Eğitimi Bölümü.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyofizik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-5670-7166 ; JUJ-2351-2023; AAH-4397-2021; JUJ-6778-2023; CEW-0665-2022; JUL-3582-2023; JUK-3929-2023; AEE-5817-2022PurposeDespite the clear relationship between exercise and brain health, our knowledge on the cellular and molecular mechanisms that trigger such benefits is still limited. We investigated the acute effects of aerobic running (physical exercise, PE), chess (cognitive exercise, CE), and table tennis (PE + CE) exercises on serum brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and irisin levels and cognitive functions in veteran male athletes.Methods10 table tennis athletes (TT), ten long-distance runners (LR), ten chess players (CP) between the ages of 50-65 performed 40 min of exercise sessions in their own branches while ten sedentary controls (SC) rested. Before and immediately after exercise, blood samples were obtained, and cognitive function tests [Stroop (ST), Trail Making A/B (TMT A/B), and Mental Rotation (MR), respectively] were conducted.ResultsBDNF and irisin levels increased in the TT group post-exercise (p < 0.05). TT and LR groups showed better TMT A-B, ST, and MR performances post-exercise (p < 0.05), whereas the CP group showed better TMT B and MR performances (p < 0.05). The percent change in BDNF levels in the TT group was greater than CP and SC groups (p < 0.05) whereas there were no significant differences between groups in cognitive test performances.ConclusionOur findings indicate that performing any routine exercise by veteran athletes has acute beneficial effects on cognitive functions. Table tennis is effective in elevating serum BDNF and irisin levels without additive effect in serum neurotrophic factors and cognitive test performances compared to aerobic running.