Person: YAZİCİ, SERKAN
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YAZİCİ
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SERKAN
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Publication Use of complementary and alternative medicine among patients with acne vulgaris and factors perceived to trigger the disease: A multicentre cross-sectional study with 1571 patients(Wolters Kluwer Medknow Publications, 2022-05-01) Kayıran, Melek Aslan; Karadağ, Ayşe Serap; Alyamaç, Gökçen; Cemil, Bengü Çevirgen; Demirseren, Düriye Deniz; Demircan, Yuhanize Taş; Aksoy, Hasan; Kılıç, Sevilay; Yüksel, Esma İnan; Kalkan, Göknur; Aksaç, Sema Elibüyük; Kutlu, Ömer; Kaksi, Sümeyye Altıntaş; Aktürk, Aysun Sıkar; Solak, Sezgi Sarıkaya; Yazıcı, Serkan; Özden, Hatice Kaya; Koska, Mahmut Can; Uzunçakmak, Tuğba Kevser; Ataseven, Arzu; Işık, Begüm; Alpsoy, Erkan; YAZİCİ, SERKAN; Tıp Fakültesi; AAH-2459-2021Background: Acne vulgaris (AV) is among the common skin diseases for which patients refer to complementary and alternative medicine (CAM). Aims and Objectives: To investigate the approaches to CAM methods and factors believed to increase the disease in 1,571 AV patients. Materials and Methods: The sociodemographic characteristics of the patients and disease severity according to the Food and Drug Administration criteria were recorded. The Cardiff Acne Disability Index (CADI) was used to assess the impact of acne on the patient's life and the history of CAM use was noted. The patients also listed the factors that they thought worsened their disease and reported their gluten-free diet experiences. Results: Of all the patients, 74.41% had a history of using CAM methods. CAM use was significantly higher in women, patients with severe AV, those with a higher CADI score and non-smokers. As a CAM method, 66.37% of the patients reported having used lemon juice. The respondents most frequently applied CAM methods before consulting a physician (43.94%), for a duration of 0-2 weeks (38.97%). They learned about CAM methods on the internet (56.24%) and considered CAM methods to be natural (41.86%). The patients thought that food (78.55%) and stress (17.06%) worsened their disease. They considered that the most common type of food that exacerbated their symptoms was junk food (63.84%) and a gluten-free diet did not provide any benefit in relieving AV (50%). Conclusion: Physicians need to ask patients about their CAM use in order to be able to guide them appropriately concerning treatments and applications with a high level of evidence.Publication A report of 13 cases of merkel cell carcinoma: Single-center experience and review of the literature(Korean Dermatological Assoc, 2019-06-01) Yazıcı, Serkan; Yazıcı, Elif Irmak; Adım, Şaduman Balaban; Başkan, Emel Bülbül; Aydoğan, Kenan; Sarıcaoğlu, Hayriye; YAZİCİ, SERKAN; Yazıcı, Elif Irmak; BALABAN ADIM, ŞADUMAN; BÜLBÜL BAŞKAN, EMEL; AYDOĞAN, KENAN; SARICAOĞLU, HAYRİYE; Tıp Fakültesi; Dermatoloji ve Zührevi Hastalıklar Ana Bilim Dalı; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-1388-2021; AAH-2459-2021; AAH-6216-2021; IHQ-3086-2023; EMN-0789-2022; DPU-8534-2022Background: There is limited data knowledge of Merkel cell carcinoma (MCC) in Turkey aside from a few case reports. Objective: The aim of this study was to describe the clinical characteristics, demographic features, therapeutic parameters, and outcome of primary cutaneous MCC cases from Turkey. Methods: Digital medical records of the 13 MCC patients who were followed-up at a tertiary referral center were retrospectively analyzed. Clinic, demographic, tumor characteristics, and survival of the patients were retrieved. Results: Most of our patients were elderly. Female predominance was noticed. The most common primary site of the tumors was the lower extremities. The overall survival was 42 months, 68% at first year, 68% at third years, and 29% at fifth years. Conclusion: This is the first largest report from Turkish population with female predominance, and lower extremity tendency.Publication Predictors of drug survival of biologic therapies in psoriasis patients (vol 45, pg 813, 2020)(Taylor & Francis, 2020-08-31) Zorlu, Özge; Başkan, Emel Bülbül; BÜLBÜL BAŞKAN, EMEL; Yazıcı, Serkan; YAZİCİ, SERKAN; Sığırlı, Deniz; SIĞIRLI, DENİZ; Budak, Ferah; BUDAK, FERAH; Sarıcaoğlu, Hayriye; SARICAOĞLU, HAYRİYE; Aydoğan, Kenan; AYDOĞAN, KENAN; Cevhertas, Laçin; Tıp Fakültesi; İmmünoloji Ana Bilim; 0000-0001-5555-130X; 0000-0001-6407-0962; 0000-0001-7625-9148; 0000-0002-0193-1128; 0000-0003-2287-3569; AAH-1388-2021; AAH-6216-2021; AAA-7472-2021; F-4657-2014; IZP-9398-2023; AAH-2459-2021Publication The ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2021-01-01) Tanriverdi, Ozgur; Ozsen, Mine; ÖZŞEN, MİNE; Deligonul, Adem; DELİGÖNÜL, ADEM; Yazici, Serkan; YAZİCİ, SERKAN; Cetintas, Sibel Kahraman; Yalcinkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Sahin, Ahmet Bilgehan; ŞAHİN, AHMET BİLGEHAN; Orhan, Sibel Oyucu; OYUCU ORHAN, SİBEL; Ocak, Birol; OCAK, BİROL; Evrensel, Turkkan; EVRENSEL, TÜRKKAN; Kahveci, Ramazan; KAHVECİ, RAMAZAN; Cubukcu, Erdem; ÇUBUKÇU, ERDEM; Tıp Fakültesi; Onkoloji Ana Bilim Dalı; 0000-0001-6407-0962; 0000-0002-5771-7649; 0000-0002-7846-0870; 0000-0002-0598-7284; 0000-0001-7537-1699; AAJ-8314-2021; AEC-2238-2022; AAM-4927-2020; M-2172-2015Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Since morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to improve current management strategies. The purpose of this study was to investigate the prognostic value of the Ki-67 proliferation index with respect to RFS in patients with DFSP We retrospectively analyzed data from 45 patients with DFSP. We calculated the Ki-67 proliferation index as the percentage of immunostained nuclei among the total number of tumor cell nuclei regardless of the intensity of immunostaining. We constructed univariate and multivariate Cox proportional hazards regression models to identify predictors of RFS. Among the 45 patients included in the study, 8 developed local recurrences and 2 had lung metastases (median follow-up: 95.o months; range: 5.2-412.4 months). The RFS rates at 60, 120, and 240 months of follow-up were 83.8%, 76.2%, and 65.3%, respectively. The median Ki-67 proliferation index was 14%. Notably, we identified the Ki-67 proliferation index as the only independent predictor for RFS in multivariate Cox proportional hazards regression analysis (hazard ratio = 1.106, 95% confidence interval = 1.019-1.200, p = 0.016). In summary, our results highlight the potential usefulness of the Ki-67 proliferation index for facilitating the identification of patients with DFSP at a higher risk of developing disease recurrences.Publication Clinical and demographical characteristics of familial Behcet's disease (southeast Marmara region)(Karger, 2019-01-01) Kalın, Zübeyde Ceylan; Sarıcaoğlu, Hayriye; Yazıcı, Serkan; Aydoğan, Kenan; Başkan, Emel Bülbül; SARICAOĞLU, HAYRİYE; YAZİCİ, SERKAN; AYDOĞAN, KENAN; BÜLBÜL BAŞKAN, EMEL; Tıp Fakültesi; Dermatoloji ve Zührevi Hastalıklar Ana Bilim Dalı; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-2459-2021; AAH-6216-2021; AAH-1388-2021; DQE-8993-2022Background: Familial aggregation in Behcet's disease (BD) has been reported in Turkish and Japanese populations. While the frequency of familial cases has been reported to be 2-5% worldwide, this rate reaches up to 15% in the Middle East. Objective: This study aimed to determine the incidence of familial BD cases followed in the BD polyclinic and to compare their clinical and demographic characteristics to those observed in sporadic cases. Methods: Data related to BD patients who were followed between 1995 and 2014 were collected from computerized archive records and were assessed for detailed family histories. Only first-degree relatives (brother, sister, mother, father, children) were considered to be cases of familial BD. Clinical and demographic features were retrieved. Our BD polyclinic is located in the Southeast Marmara Region in Turkey. Results: BD was detected in 36 first-degree relatives of 33 patients out of 840 patients with BD. A total of 45 patients were diagnosed as familial BD; 23 were female, and 22 were male. In our patients, the incidence of familial BD was determined to be 3.9%. The rates for HLA-B5 positivity, ocular involvement, genital ulcers, and erythema nodosum were determined to be 86.6% (26/30), 26.6%, 82.2%, and 60%, respectively. None of the patients had neurological involvement, but 2 had vascular involvement. Conclusion: This study may contribute to the epidemiological data of BD from Turkey. (C) 2019 S. Karger AG, BaselPublication Retrospective analysis of the forty-six patients with bullous pemphigoid followed-up in our clinic(Deri Zuhrevi Hastaliklar Dernegi, 2016-01-01) Yazıcı, Serkan; BÜLBÜL BAŞKAN, EMEL; YAZİCİ, SERKAN; Başkan, Emel Bülbül; Tunalı, Şükran; Aydoğan, Kenan; AYDOĞAN, KENAN; Sarıcaoğlu, Hayriye; SARICAOĞLU, HAYRİYE; Tıp Fakültesi; Deri ve Zührevi Hastalıkları Ana Bilim Dalı; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-1388-2021; AAH-6216-2021; AAH-2459-2021Background and Design: Bullous pemphigoid (BP) is an autoimmune disease characterised by widespread itchy plaques and subepithelial blisterings and usually affects the elderly population. Due to the chronic nature of the disease, to prevent the side effects of chronic steroid treatment, adjuvant immunosuppressive (mycophenolate mofetil, azathioprine, methotrexate) and anti-inflammatory (tetracycline, nicotinamide, dapsone) agents may be used. In this study, we retrospectively evaluated the clinical and demographic characteristics and applied treatments of 46 patients with the diagnosis of BP and compared with literature data.Materials and Methods: We retrospectively evaluated the records of 46 patients who received clinical and histopathological diagnosis of BP and followed up in our clinic between 2006 and 2013.Results: Of the 46 patients, 22 were female and 24 male. The mean age of onset was 69.54 years (range: 18-105). The duration of the lesion ranged from 1 week to 10 months with a median duration of 8 weeks. The most frequent comorbid chronic disease was hypertension detected in 28 (60.8%) patients. Only four patients had a history of malignancy before the onset of the disease. Nineteen patients (42%) used more than 5 agents for comorbid diseases. Thirty-two patients (69.5%) used systemic corticosteroids alone and ten (22%) patients needed additional adjuvant therapies.Conclusion: BP is a major cause of morbidity in the elderly population receiving multiple drug treatment. To avoid the side effects of steroid therapy, especially in patients with severe disease, short-term use of additional immunosuppressive agents appears to be safe and effective.Publication Is there any association between mycosis fungoides and Th-1,Th-2 cytokines and transforming growth factor-beta 1 gene polymorphisms?(Deri Zuhrevi Hastaliklar Dernegi, 2018-01-01) Yazıcı, Serkan; YAZİCİ, SERKAN; Aydoğan, Kenan; AYDOĞAN, KENAN; Sarıcaoğlu, Hayriye; SARICAOĞLU, HAYRİYE; BÜLBÜL BAŞKAN, EMEL; Tunalı, Şükran; Tıp Fakültesi; Dermatoloji Ana Bilim Dalı; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-2459-2021; AAH-1388-2021; AAH-6216-2021Background and Design: Cytokines are considered to play a crucial role in the development of mycosis fungoides (MF). Cytokine production is under genetic control and allelic variations of cytokine genes are associated with lower or higher production of cytokines. The aim of this study was to determine any possible cytokine gene polymorphisms that may be a risk factor for the development or progression of MF.Materials and Methods: Genotyping of interferon-gamma (IFN-gamma)+874, interleukin (IL)-10-1082, IL-6-174, transforming growth factor-beta 1 (TGF-beta 1), codon 10 and codon 25, and tumor necrosis factor-alpha (TNF-alpha)-308 was undertaken in 55 Turkish patients with MF and compared to 50 healthy controls. Polymerase chain reaction (PCR)-restriction fragment length polymorphism was applied for IFN-gamma+874, IL-10-1082, IL6-174 and TNF-alpha-308 gene polymorphisms. TGF-beta 1 was genotyped by direct DNA sequencing of PCR amplified gene products for codon 10 and codon 25 polymorphisms.Results: Genotype distributions showed no significant difference between the patients and the controls for any of the five investigated cytokines. There was no significant difference between advanced stage and early stage cases and healthy controls.Conclusion: None of the studied cytokine gene polymorphisms are risk factors for the development or progression of MF in the Turkish population, however, further studies are needed.Publication Factors related to omalizumab drug survival and treatment responses in chronic urticaria(Karger, 2022-08-29) Hasal, Eda; SARICAOĞLU, HAYRİYE; Bülbül Başkan, Emel; BÜLBÜL BAŞKAN, EMEL; YAZİCİ, SERKAN; Yazıcı, Serkan; Aydoğan, Kenan; AYDOĞAN, KENAN; Tıp Fakültesi; Dermatoloji Ana Bilim Dalı; 0000-0001-6310-5107; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-6216-2021Introduction: This study aimed to evaluate factors affecting drug survival and treatment response in patients with chronic urticaria treated with omalizumab in clinical practice. Methods: This study included 386 patients with chronic urticaria. Demographic characteristics, clinical features, laboratory parameters, and omalizumab treatment data were analyzed retrospectively. The 7-day urticaria activity score (UAS7) and urticaria control test (UCT) were used to assess disease severity and treatment responses. Results: Well-controlled disease (UAS7 <= 6) was achieved in 59.3% of patients at a median of 2 months. Complete response was significantly higher in patients treated with omalizumab for >= 12 months (p < 0.001). Family history of asthma (p = 0.01) was less frequent, and disease duration (p = 0.041) was shorter in patients with well-controlled disease. Total treatment duration was longer in patients with relapse (p < 0.001) and serum Helicobacter pylori IgA positivity (p = 0.029). Discussion/Conclusion: Treatment response is better in patients treated with omalizumab for >= 12 months. However, prolonged treatment does not prevent relapse. Our findings suggest that continuous or intermittent therapy is an appropriate alternative treatment option in patients with severe chronic urticaria; however, continuous therapy can be preferred to maintain the patient's quality of life.Publication Internalized stigma in hidradenitis suppurativa: A multicenter cross-sectional study(Karger, 2023-01-26) Bilgiç, Aslı; Karaman, Bilge Fettahlıoğlu; Demirseren, Duriye Deniz; Çınar, Levent; Kaçar, Nida; Ermertcan, Aylin Türel; Başkan, Emel Bülbül; Güven, Münevver; Yazıcı, Serkan; Akbulut, Tuğba Özkök; Uçmak, Derya; Ataseven, Arzu; Temiz, Selami Aykut; Engin, Burhan; Aktürk, Aysun Sıkar; Sarıcaoğlu, Hayriye; Özden, Müge Güler; Özdemir, Hilal; Mammadlı, Kifayet; Durmaz, Koray; Gülbaşaran, Fatmagül; Kılınç, Fadime; Özden, Hatice Kaya; Gönülal, Melis; Balcı, Didem Didar; Cemil, Bengü Çevirgen; Solak, Sezgi Sarıkaya; Selçuk, Leyla Baykal; Yavuz, Göknur Özaydın; Yavuz, Ibrahim Halil; Dönmez, Levent; Alpsoy, Erkan; BÜLBÜL BAŞKAN, EMEL; YAZİCİ, SERKAN; SARICAOĞLU, HAYRİYE; Tıp Fakültesi; Dermatoloji ve Zührevi Hastalıklar Ana Bilim Dalı; CEB-8268-2022; AAH-2459-2021; DPU-8534-2022Background: Hidradenitis suppurativa (HS) causes significant physical, social, and psychological burdens. Internalized stigma, acceptance of negative attitudes and stereotypes of society regarding a person's illness, has not been studied previously in HS. Objectives: The objective of this study was to investigate the internalized stigma state of HS patients and identify the factors affecting it. Methods: This multicenter, prospective, cross-sectional study included 731 patients. Internalized Stigma Scale (ISS), Hurley staging, Physician Global Assessment, Dermatology Life Quality Index (DLQI), Skindex-16, Beck Depression Inventory-II (BDI-II), and Visual Analog Scale (VAS)-pain score were used in the study. Results: The mean ISS value (57.50 +/- 16.90) was comparable to the mean ISS values of studies in visible dermatological and various psychiatric diseases. A significant correlation was found between the mean values of ISS and all disease activity scores, quality of life measures, BDI-II, and VAS-pain scores. Obesity, family history, low education and income level, vulva/scrotum involvement and being actively treated are significant and independent predictive factors for high internalized stigma in multivariate analysis. Conclusions: HS patients internalize society's negative judgements, which may create a profound negative effect on access to health care. Therefore, in addition to suppressing disease activity, addressing internalized stigma is fundamental for improving health care quality.Publication Keloid formation following ear piercing through the transitional zone(Elsevier Science Inc, 2023-06-30) Zorlu, Özge; Yazıcı, Serkan; Adım, Şaduman Balaban; Zorlu, Özge; YAZİCİ, SERKAN; BALABAN ADIM, ŞADUMAN; Tıp Fakültesi; Dermatoloji ve Zührevi Ana Bilim Dalı; 0000-0001-5555-130X; 0000-0001-6407-0962; IAL-9735-2023; EHG-3420-2022; EMN-0789-2022