Person: YAVUZ, MAHMUT
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
YAVUZ
First Name
MAHMUT
Name
7 results
Search Results
Now showing 1 - 7 of 7
Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Retrospective evaluation of the factors affecting etiology and prognosis of adult acute kidney injury(Galenos Yayıncılık, 2020-06-01) Göçken, Abdulkadir; Ayar, Yavuz; Yavuz, Mahmut; Yabacı, Ayşegül; YAVUZ, MAHMUT; Yabacı, Ayşegül; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Bilim Dalı.; CAJ-5024-2022; EHM-7377-2022Aim: Acute kidney injury (AKI) is still an important cause of morbidity and mortality. Several factors are effective in its frequency, etiology, prognosis and mortality. In our study, we aimed to demonstrate the etiology and prognostic factors of AKI.Methods: A total of 272 patients diagnosed with AKI, who were hospitalized in the nephrology department between January 2011 and December 2015, were included in the study. In addition to the demographic characteristics of patients, clinical and laboratory findings were evaluated retrospectively.Results: Forty-seven point four percent of patients were female and 52.6% were male. The mean age of the patients was 61.6 years, the mean length of hospital stay was 13.3 days, the number of hemodialysis sessions was 1.24 and the mortality rate was 4.8%. The need and number of hemodialysis sessions were significantly higher in older patients (>65 years). The need and number of hemodialysis sessions were higher in the renal AKI group (48.7%, 1.9). The length of hospital-stay was longer and mortality rate was higher in patients with renal AKI compared to the other groups (16.4 days, 8.8%). Mortality rate, length of hospital-stay, and number of hemodialysis sessions were found to be increased significantly in patients with infection (42%).Conclusion: Etiology and accompanying infection in AKI are the most important factors affecting mortality. In addition, anemia and advanced age increase the length of hospital stay and the need for hemodialysis.Publication The relationship between severity of interstitial fibrosis and anemia in patient with primary glomerulonephritis: The data from TSN-gold working group(Oxford Univ Press, 2020-06-01) Cebeci, Egemen; Turgutalp, Kenan; Öztürk, Savaş; Özlük, Yasemin; Bek, Sibel Gökçay; Şumnu, Abdullah; Seyahi, Nurhan; Yavuz, Mahmut; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Sakaci, Tamer; Şahin, Garip; Tokgöz, Bülent; Şahin, Gülizar Manga; Bozacı, Ilter; Dursun, Belda; Sipahi, Savaş; Kayalar, Arzu Özdemir; Süleymanlar, Gültekin; Ulu, Memnune Sena; Güzel, Fatma Betül; Kutlay, Sim; Parmaksız, Ergün; Koz, Süleyman; Kurultak, İlhan; Selçuk, Nedim Yılmaz; Yildırım, Yaşar; Gürsu, Meltem; Çavdar, Caner; Timuçin, Meryem; Aydın, Zeki; Oygar, Deren; Kahvecioğlu, Serdar; Kibar, Müge Uzerk; Torun, Dilek; Taymez, Dilek Güven; Küçük, Mehmet; Demir, Serap; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altintepe, Lüftullah; Koç, Mehmet; Azak, Alper; Odabaş, Ali Rıza; Yılmaz, Zülfikar; Paydaş, Saime; YAVUZ, MAHMUT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; EHM-7377-2022Publication The relationship between visfatin and carotid atherosclerosis in patients with advanced chronic kidney disease(Oxford Univ Press, 2015-05-01) Ayar, Yavuz; Ersoy, Alparslan; Sayılar, Emel Işıktaş; Yıldız, Abdülmecit; Pektaş, Fatih; Tüysüz, Özlem; Yavuz, Mahmut; Topal, Naile Bolca; Dirican, Melahat; Arslan, Ismail; Ateş, Çiğdem Aksu Coşkun; Ayar, Yavuz; ERSOY, ALPARSLAN; Sayılar, Emel Işıktaş; YILDIZ, ABDULMECİT; Pektaş, Fatih; Tüysüz, Özlem; YAVUZ, MAHMUT; BOLCA TOPAL, NAİLE; Dirican, Melahat; Arslan, İsmail; Ateş, Çiğdem Aksu Coşkun; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-1539-9216; HIG-9032-2022 ; O-9948-2015; AAI-2327-2021; W-2575-2017; GSE-0029-2022; AGF-0767-2022; AAH-5054-2021; JDU-0150-2023; ECR-6289-2022; EHM-7377-2022; ESK-6562-2022; JML-0742-2023; IIU-0465-2023Publication Clinical significance of genetic in patients with C3 glomerulopathies(Oxford Univ Press, 2017-05-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Berdeli, Afig; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; Ersoy, Alparslan; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; ERSOY, ALPARSLAN; Uludağ Üniversitesi; 0000-0002-0342-9692; 0000-0002-4791-8367; 0000-0002-0710-0923; AAH-4002-2021; AAH-5054-2021; HIG-9032-2022; EHM-7377-2022; EUF-5229-2022; CTG-8811-2022; AAH-5054-2021Publication Arm circumference: Its importance for dialysis patients in the obesity era(Springer, 2013-08-01) Akpolat, Tekin; Kaya, Coskun; Utaş, Cengiz; Arınsoy, Turgay; Taskapan, Hulya; Erdem, Emre; Yılmaz, M. Emin; Ataman, Rezzan; Bozfakioglu, Semra; Özener, Cetin; Karayaylalı, İbrahim; Kazancıoğlu, Rumeyza; Camsarı, Taner; Ersoy, Fevzi; Duman, Soner; Ateş, Kenan; Yavuz, Mahmut; YAVUZ, MAHMUT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.The purposes of this study were to investigate the association between arm circumference and body mass index (BMI) and to discuss problems, mainly arm circumference and cuff size mismatch, that could affect the reliability of home blood pressure monitoring (HBPM) among peritoneal dialysis (PD) and hemodialysis (HD) patients.525 PD and 502 HD patients from 16 centers were included in the study. A two-part questionnaire was used to gather information from the participants. Arm circumferences were categorized into four groups according to the British Hypertension Society cuff size recommendations.Mean BMI and arm circumference of all participants were 25.0 kg/m(2) and 27.6 cm, respectively. There was a significant correlation between BMI and arm circumference. The mean BMI and arm circumference values were higher in PD patients than in HD patients. Requirement of a large-sized adult cuff was more common among PD patients compared to HD patients (14 % vs 8 %, p = 0.002).Since HBPM is a useful tool for clinicians to improve BP control, nephrologists should be aware of the problems related to HBPM in dialysis patients and take an active role to increase the reliability of HBPM.Publication An enflammatory marker in chronic renal failure patients: Visfatin(Galenos Yayıncılık, 2015-09-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Yavuz, Mahmut; Arslan, İsmail; Aksu, Çiğdem; Ateş, Coşkun; Pektaş, Fatih; Tüysüz, Özlem; Topal, Naile Bolca; Dirican, Melahat; Ayar, Yavuz; Sayılar, Emel Işıktaş; YAVUZ, MAHMUT; Arslan, İsmail; Aksu, Çiğdem; ATEŞ, COŞKUN; Pektas, Fatih; Tüysüz, Özlem; BOLCA TOPAL, NAİLE; Dirican, Melahat; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biokimya Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-1539-9216; 0000-0003-4565-9848; AGF-0767-2022; W-2575-2017; EHM-7377-2022; JML-0742-2023; HPQ-6488-2023; CDO-0747-2022; JDU-0150-2023; ECR-6289-2022; AAI-2327-2021; ESK-6562-2022Aim: Visfatin is a cytokine released from adipose tissue, especially in enflammation. In our study, we tried to show the relationship of visfatin levels with chronic renal failure (CRF) as an enflammatory marker.Methods: We included 50 CRF patients (28 male, 22 female) who attended Uludag University Nephrology Clinic and 31 healthy volunteers (13 male, 18 female). Visfatin levels and biochemical parameters, such as parathyroid hormone (PTH), lipid parameters, albumin, C-reactive protein (CRP), creatinine, urea, immunoglobulins, etc. were examined.Results: In CRF patients, visfatin levels were found to be significantly increased (p<0.001) and albumin, hemoglobin, body mass index (BMI) and high density lipoprotein (HDL) cholesterol levels were decreased (p<0.001). Triglycerides (p=0.003), CPR (p=0.005), procalcitonin (p<0.001), IgG3 (p=0.003), and ferritin (p<0.001) levels were significantly higher in patient group than in control group as an enflammatory marker.Conclusion: CRF is an independent enflammatory process. Visfatin levels in patients with chronic renal failure patients are determined to be high as an indicator of enflammation.