Person: MELEK, HÜSEYİN
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MELEK
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HÜSEYİN
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Publication Comparison of survival results of patients with t0 and t1-2-3 in pathological t staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment(Termedia Publishing House, 2020-01-01) Kermenli, Tayfun; Melek, Hüseyin; Bayram, Ahmet Sami; Gebitekin, Cengiz; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAE-1069-2022; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020Aim: In this study, we aimed to compare the survival results of patients who underwent neoadjuvant treatment with NSCLC between March 1997 and August 2014 and were found to have T0N0 and T1-2-3/N0.Material and methods: A hundred ninety-five patients who had complete neoadjuvant therapy, complete lung resection and lymph node dissection, and pathologically diagnosed as T0 or T1-2-3/N0, M0 were included in the study.Results: Of the 195 patients included in the study, 181 were male, 14 were female and the mean age of the patients was 57.9. The mean age of the groups was as follows: group 1: 58.1, group 2: 57.7, group 3: 59.7 and group 4: 56.8. In our series the most common complication was atelectasis (n = 19). Others were prolonged air leak (n = 16), pneumonia (n = 12), apical pleural space (n = 6), wound infection (n = 3), cardiac problems (n = 3), hematoma (n = 3), bronchopleural fistula (n = 3), empyema (n = 2), chylothorax (n = 1). The 5-year survival rate for patients in the T0N0 group was 76.3%. This rate was 71.8% in group 2, 63.6% in group 3 and 44.1% in group 4.Conclusions: Survival was found to be better in patients who underwent surgery after neoadjuvant therapy and had a complete pathological response. We believe that we can provide better results with the increase in the number of cases detected as TxN0 after the neoadjuvant treatment and prolongation of the follow-up period.Publication Lung cancer surgery in patients with a history of coronary artery bypass graft: A multicentre study(Elsevier Science, 2021-02-17) Akçam, Tevfik İlker; Samancılar, Özgür; Yazgan, Serkan; Ceylan, Kenan Can; Kocatürk, Celalettin İbrahim; Sezen, Celal Buğra; Tezel, Cağatay Salim; Gürer, Deniz; Bayram, Ahmet Sami; Melek, Hüseyin; Özkan, Berker; Ülker, Melike Güler; Kaba, Erkan; Toker, Alper; BAYRAM, AHMET SAMİ; MELEK, HÜSEYİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-1822-8153 ; 0000-0003-0684-0900 ; AAI-5039-2021 ; ABB-7580-2020Background Lung cancer surgery may be required for patients with a history of coronary artery bypass graft (CABG). In this study, we evaluated the general characteristics of patients, the difficulties experienced during and after lung cancer surgery and complications and mortality rates.Method Patients who were operated on for primary lung cancer between January 2012 and July 2017 in the participating centres were analysed retrospectively (n=7,530). Patients with a history of CABG (n=220) were examined in detail. This special group was analysed and compared with other patients operated on for lung cancer who did not have CABG (n=7,310) in terms of 30-day mortality and revision for haemorrhage.Results Of the 7,530 patients operated on for primary lung cancer, 2.9% were found to have undergone CABG. Surgical revision was required in the early postoperative period for 6.8% of those who had CABG and 3.5% in those who did not have CABG (p=0.009). Thirty-day (30-day) mortality was 4.5% in those who had CABG and 2.9% in those who did not have CABG (p=0.143). Further analysis of patients who had undergone CABG demonstrated that video-assisted thoracoscopic surgery (VATS) resulted in fewer complications (p=0.015). Patients with a left-sided left internal mammary artery (LIMA) graft had a higher number of postoperative complications (p=0.30).Conclusions Patients who had CABG suffered postoperative haemorrhage requiring a revision twice as often, and a tendency towards higher mortality (non-statistically significant). In patients with a history of CABG, VATS was demonstrated to have fewer complications. Patients with a LIMA graft who had a left-sided resection had more postoperative complications.Publication Non-small-cell lung cancer with pathological complete response after induction therapy followed by surgical resection: Which is the pattern of failure and which are the future perspectives? Reply(Oxford Univ Press Inc, 2020-08-01) Melek, Hüseyin; Özer, Erhan; Bayram, Ahmet Sami; Gebitekin, Cengiz; MELEK, HÜSEYİN; ÖZER, ERHAN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı; 0000-0003-0684-0900; 0000-0003-1822-8153; JCE-0097-2023; AAI-5039-2021; AAE-1069-2022; ABB-7580-2020; FNZ-9525-2022Publication Intercostal nerve reconstruction for severe compensatory hyperhidrosis: The gebitekin technique(Elsevier, 2021-05-20) Gebitekin, Cengiz; Melek, Hüseyin; Çetinkaya, Gamze; Özer, Erhan; Yentürk, Eylem; Sevinç, Tolga Evrim; Bayram, Ahmet Sami; GEBİTEKİN, CENGİZ; MELEK, HÜSEYİN; Çetinkaya, Gamze; ÖZER, ERHAN; YENTÜRK, EYLEM; SEVİNÇ, TOLGA EVRİM; BAYRAM, AHMET SAMİ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı; 0000-0003-0684-0900; 0000-0003-1822-8153; 0000-0002-4848-1566; JCE-0097-2023; ABB-7580-2020; JDW-2654-2023; AAE-1069-2022; AAI-5039-2021; FNZ-9525-2022; JRB-0865-2023; IGQ-1108-2023Compensatory sweating (CS) is the most common and disabling complication of endoscopic thoracic sympathectomy and represents an unmet clinical challenge. Our surgical hypothesis is to generate a parallel pathway to the damaged part of the sympathetic nerve, similar to the Kuntz nerve, by reconstructing the 2 healthy intercostal nerves, thus treating CS. Here, we present a novel videothoracoscopic technique involving bilateral intercostal nerve reconstruction in patients with severe CS after endoscopic thoracic sympathectomy.(Ann Thorac Surg 2021;111:e443-6)(c) 2021 by The Society of Thoracic SurgeonsPublication Radiotherapy in patients with trachea tumours: A retrospective study and literature review(Kare Yayınevi, 2020-01-01) Sarihan, Süreyya; Bayram, Ahmet Sami; Melek, Hüseyin; Gebitekin, Cengiz; SARIHAN, SÜREYYA; BAYRAM, AHMET SAMİ; MELEK, HÜSEYİN; GEBİTEKİN, CENGİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-4816-5798; 0000-0003-0684-0900; AAE-1069-2022; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020; AAH-4970-2021OBJECTIVEIn this study, we aimed to evaluate our patients with tracheal tumours treated with primary or adjuvant radiotherapy (RT) and to review the current literature on the subject.METHODSBetween 1998 and 2017, eight patients underwent RT. Their median age was 37 years (15-53). The diagnosis was adenoid cystic carcinoma in five patients, squamous cell carcinoma in three patients and mucoepidermoid carcinoma in one patient. Resection type was R0 (1), R1 (4), R2 (1), and biopsy (2). The median tumour size was 2.6 cm (2-5). Median 59.4 Gy RT (32.4-66.6) was given, and weekly cisplatin was administered to four patients concomitantly.RESULTSWith a median follow-up of 85 months (4-189), five patients were alive. The 5-year overall and disease-free survival rates were 83% and 67%, respectively. There was no local recurrence in any patient. In one patient who had a complete response with curative chemo-RT, dilatation was performed five times in 10 years because tracheal stenosis developed at 60 months.CONCLUSIONTrachea tumours are rare, and the primary treatment is surgery. Adjuvant RT is controversial in R0 cases. In unresectable cases, RT is the primary treatment modality. We believe that our treatment results will contribute to the literature on the subject.Publication The survival effect of resection of cranial metastatic lesions in patients with lung cancer(Elsevier Science, 2015-09-01) Deligönül, Adem; Taşkapılıoğlu, Özgür; Melek, Hüseyin; Bekar, Ahmet; Çetinkaya, Gamze; Sarihan, Süreyya; Bayram, Ahmet Sami; Gebitekin, Cengiz; Evrensel, Türkkan; DELİGÖNÜL, ADEM; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; MELEK, HÜSEYİN; BEKAR, AHMET; Çetinkaya, Gamze; SARIHAN, SÜREYYA; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; EVRENSEL, TÜRKKAN; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Tıbbi Onkoloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; 0000-0001-5472-9065; 0000-0003-4816-5798; 0000-0003-0684-0900; AAI-5039-2021; ABX-9081-2022; AAH-4970-2021; AAE-1069-2022; JDW-2654-2023; AAJ-1027-2021; JCE-0097-2023; ABB-8161-2020; ABB-7580-2020Publication Cricothyroidotomy performed by seldinger method in the management postoperative sputum retention and atelectasis after lung resection(Bayçınar Medikal Yayın, 2015-01-01) Melek, Hüseyin; Çetinkaya, Gamze; Erol, Mehmet Muharrem; Kaya, Fatma Nur; Bayram, Ahmet Sami; MELEK, HÜSEYİN; Çetinkaya, Gamze; Erol, Mehmet Muharrem; KAYA, FATMA NUR; BAYRAM, AHMET SAMİ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı; 0000-0003-0684-0900; 0000-0002-4848-1566; JDW-2654-2023; AAI-5039-2021; ABB-7580-2020; KHE-8874-2024; CXE-4995-2022Mini-tracheotomy is a safe and effective method in the prevention and treatment of postoperative sputum retention and atelectasis. It can be applied under general anesthesia or local anesthesia. Minitracheotomy-related complications are usually preventable and are rare. In this article, we present the outcomes of Mini-Trach II (R) Portex Seldinger kit application technique under the guidance of rigid bronchoscopy in patients with atelectasis and sputum retention after lung resection.Publication Can thoracic sympathetic nerve damage be reversed?(Georg Thieme Verlag, 2015-12-01) Erol, M. Muharrem; Salcı, Hakan; Melek, Hüseyin; İlhan, Tuncay; Özfiliz, Nesrin; Bayram, Ahmet Sami; Gebitekin, Cengiz; Erol, M. Muharrem; SALCI, HAKAN; MELEK, HÜSEYİN; İLHAN, TUNCAY; ÖZFİLİZ, NESRİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji Anabilim Dalı.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAI-5039-2021; AAE-1069-2022; AAH-2756-2021; JCE-0097-2023; AAH-8859-2021; ABB-7580-2020; T-4623-2019; KHE-8874-2024Background Function of the thoracic sympathetic chain (TSC) reportedly recovers after surgical clips are removed. Hence, this study was designed to study nerve regeneration after unclipping the TSC.Methods The bilateral TSCs of six goats were studied; the goats were separated into three groups (groups I, II, and III) during excision, clipping, and unclipping. During surgery, the TSCs were excised with a scalpel in group I and clipped in groups II and III. In group III, the clips were removed 1 month postoperatively and observed for possible nerve healing for 1 month. All TSCs were examined histologically following en block resection at 1 month postoperatively in groups I and II and at 2 months postoperatively in group III.Results Inflammation in nerve sections was noted following clip removal. Furthermore, there was significant degeneration and cell infiltration in the nerve fibers of the clipped regions. The Schwann cells around the peripheral nerve endings in the unclipped regions facilitated nerve transmission by reconstitution of myelin.Conclusion Clipping the TSC can cause histologic degeneration; however, histologic nerve regeneration occurs after unclipping.Publication Diagnostic value of cervical mediastinoscopy: Report of 506 cases(European Respiratory, 2013-09-01) Erol, Mehmet; Melek, Hüseyin; Bayram, Ahmet; Kermenli, Tayfun; Coşkun, Funda; Akyıldız, Elif; Gebitekin, Cengiz; Erol, Mehmet; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; Kermenli, Tayfun; COŞKUN, NECMİYE FUNDA; AKYILDIZ, ELİF ÜLKER; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Kliniği; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Patholoji Bölümü; 0000-0003-0684-0900; 0000-0002-7371-4026; 0000-0003-3604-8826; AAE-1069-2022; AAD-1271-2019; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020; KHO-7454-2024; A-6612-2019; IAV-7890-2023Publication Diagnostic value of video-assisted thoracoscopic lung biopsy on diagnosis of diffuse parenchymal lung dissease(European Respiratory, 2013-09-01) Bayram, Ahmet Sami; Melek, Hüseyin; Erol, Mehmet Muharrem; Coşkun, Funda; Akyıldız, Elif Ülker; Gebitekin, Cengiz; BAYRAM, AHMET SAMİ; MELEK, HÜSEYİN; Erol, Mehmet Muharrem; COŞKUN, NECMİYE FUNDA; AKYILDIZ, ELİF ÜLKER; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Bölümü; 0000-0003-0684-0900; 0000-0003-3604-8826; JCE-0097-2023; AAE-1069-2022; AAI-5039-2021; ABB-7580-2020; AAD-1271-2019; KHE-8874-2024; JHY-9777-2023