Person: NAK, YAVUZ
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NAK
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YAVUZ
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Publication Evaluation of serum analytes in pregnant and non-pregnant dairy cows as indicators of pregnancy(South African Journal Of Animal Sciences, 2020-01-01) Abbas, S.; Yousaf, M. S.; Ahmad, I; Rehman, H.; Mahmood, A. K.; Ashraf, S.; Blouch, R. S.; Shahzad, A. H.; Nak, Y.; Nak, Yavuz; NAK, YAVUZ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; AAH-5494-2021This study was conducted to reveal the dynamics of haematological indicators in pregnant and nonpregnant dairy cows. Sixty multiparous healthy dairy cows were divided into four groups based on the length of time they had been pregnant, namely first, second and third trimesters, and non-pregnant (n=15 each). Blood was collected from each animal, and serum was harvested and stored at -20 degrees C for biochemical profiling. Concentrations of serum total oxidants (TOC), ceruloplasmin oxidase (CpO) and triiodothyronine (T-3) were higher (P <0.05) during the third trimester compared with non-pregnant cows. Serum arylesterase (Ary) concentration was lower (P <0.05) during the second and the third trimesters compared with the non-pregnant cows. The concentration of serum total homocysteine (tHcy) was higher (P <0.05) the third trimester compared with the first and the second trimesters. The concentrations of serum total antioxidants (TAC), paraoxonase 1 (PON1), thyroxine (T-4), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were not different in the pregnant and the non-pregnant cows. Thus, TOC, Ary, CpO, tHcy and T3 could be taken as biological markers to assess the progression of pregnancy and to develop management tools to improve health status during late gestation in dairy cows.Publication Effect of embryo quality on pregnancy outcome in recipient cows and heifers(Hellenic Veterinary Medical Soc, 2020-04-01) Kara, Uğur; Çoban, S.; Say, Erkan; Hızlı, Hatice; Mutlu, H.; Sagırkaya, H.; Ayasan, T.; Coskun, M. A.; Asarkaya, A.; Erten, H. E.; Yilmaz, I.; Yazgan, E.; Erdoğan, I. E.; Erten, Z. M.; Ergül, S.; Sert, F.; Nak, Yavuz; NAK, YAVUZ; Sağırkaya, Hakan; SAĞIRKAYA, HAKAN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Jinekoloji Anabilim Dalı.; AAH-5494-2021; AAH-8821-2021This study was performed to compare the effects of embryo quality on pregnancy outcome in recipient cows and heifers. Embryos obtained from 83 Holstein donors were used in the study. In order to synchronize the recipients, 500 mu g of cloprostenol were administered intramuscularly (i.m.), twice, at an interval of 11 days. In all recipients, one embryo was transferred to the upper 1/3 of the uterine horn ipsilateral to the ovary with the corpus luteum on the 7th day after oestrus onset (day 0). Each recipient received an i.m. injection of 5 mu g of buserelin at the time ofembryo transfer. Pregnancy examinations were performed by ultrasonography on the day 30th post-transfer. A total of 345 (262 grade 1, 64 grade 2 and 19 grade 3) fresh embryos were transferred to 171 recipient cows and 174 recipient heifers. The pregnancy rates of the recipient cows and heifers were 41.52% and 52.29%, respectively (p<0.05).The pregnancy rates achieved with first, second and third quality grade embryos were 45.16%, 25.0% and 12.5% in the cows (p<0.05), and 55.11%, 41.66% and 54.54% in the heifers (p>0.05), respectively. In conclusion, the pregnancy rates was significantly higher in heifers than in cows (p<0.05) and, the embryo quality had a significant impact on recipient pregnancy outcome (p<0.05). The effect of embryo quality on pregnancy was significant in cows (p<0.05), but not significant in heifers (p>0.05).Publication Efficacy and toxicity of doxorubicin and cyclophosphamide for the neoadjuvant treatment of locally advanced stage canine mammary tumors(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020-11-01) Shahzad, Abid Hussain; Kuruoglu, Fikriye Ecem; Özyiğit, Musa Özgür; ÖZYİĞİT, MUSA ÖZGÜR; Nak, Deniz; NAK, DENİZ; Küpeli, Zehra Avcı; Ekici, Zeynep Merve; Koca, Davut; KOCA, DAVUT; Avcılar, Talha; Nak, Yavuz; NAK, YAVUZ; Sahin, Mustafa Eren; ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Jinekoloji Anabilim Dalı.; 0000-0002-6715-8529; 0000-0003-1853-4679; 0000-0002-7962-6959; 0000-0001-7034-9644; 0000-0002-8623-8292; AAH-5494-2021; AAH-2873-2021; AAI-6709-2021; AAR-6478-2021The aim of this study was to investigate the effect and toxicity of a doxorubicin cyclophosphamide combination for neoadjuvant use in dogs with locally advanced mammary tumors. A total of 16 dogs with locally advanced mammary tumors aged 8-14 years was used in this study. Samples were taken from all the dogs via Tru-Cut biopsy and fine needle aspiration biopsy of the lymph nodes prior to neoadjuvant chemotherapy. The samples were sent to the pathology laboratory for histopathological examination. Based on the histopathology results, mammary tumors were diagnosed as adenocarcinoma (n=13), tubulopapillary carcinoma (n=2) and malignant mixed tumors (n=1). For the neoadjuvant chemotherapy, doxorubicin (25-30 mg/m(2)) and cyclophosphamide (100 mg/m(2)) were administered via slow IV injection 4 times at 3-week intervals. Clinical findings such as fever, vomiting, anorexia, lethargy, weight loss, alopecia, enteritis, hematuria, and skin ulceration and laboratory findings such as a decrease in neutropenia and hematocrit values were observed. Based on the longest diameter of the tumors before and after four weeks of chemotherapy, a complete response was detected in 2 dogs (12.5%), a partial response was observed in 9 dogs (56.25%) and the disease was stable in 5 dogs (31.25%). According to results, the toxicity, and efficacy of a doxorubicin and cyclophosphamide combination for neoadjuvant chemotherapy in dogs with locally advanced mammary tumors is acceptable, and the treatment is promising.Publication Ascorbic acid inclusion in semen extender improves the post-thawed semen quality of sahiwal cattle (Bos indicus)(Zoological Society of Pakistan, 2015-12-01) Sohail, M. U.; Shahzad, A. H.; Iqbal, S.; Shabbir, M. Z.; Iqbal, Z.; Abbas, S.; Younus, M.; Nak, D.; Nak, Y.; Arshaad, T.; NAK, DENİZ; NAK, YAVUZ; FPJ-3706-2022; AAH-5494-2021The antioxidant effects of ascorbic acid at different inclusion rates were evaluated upon semen (n=150) from mature Sahiwal cattle bulls (Bos indicus, n = 6) in summer season. The semen was diluted in Tris-citrate egg yolk extender containing different levels (0.0, 1.0, 2.0, 3.0, and 4.0 mg/mL) of ascorbic acid at 37.0 degrees C. Semen was cryopreserved at -196 degrees C in 0.5 mL French straws. Semen straws were thawed at 37 degrees C to assess the spermatozoa indices in terms of motility, viability, plasma membrane and acrosomal integrity under phase-contrast microscope. Supravital staining, hypo-osmotic swelling test and normal acrosomal reaction analysis tests were also performed for viability, plasma membrane and acrosomal integrity, respectively. The data were subjected to one way ANOVA. The results revealed significant improvement (P< 0.05) in post thaw sperm quality in terms of motility, vitality, acrosomal and plasma membrane integrity by the increasing concentrations of ascorbic acid (1.0, 2.0, 3.0, 4.0 mg/mL) in semen extender. Quality parameters were higher (P< 0.05) when 3.0 mg/mL of ascorbic acid was added in semen extender followed by 2.0 and 4.0 mg/mL. In conclusion the addition of ascorbic acid at the rate of 3.0 mg/mL in the semen extender may improve the semen quality of Sahiwal cattle bull.Publication Effect of carprofen and CIDR on pregnancy rates in dairy cattle(Wiley, 2015-09-01) Pancarcı, S. M.; Abay, M.; Güngör, O.; Nak, Yavuz; Bekyürek, T.; Alparslan, A.; NAK, YAVUZ; AAH-5494-2021Publication Serum and milk progesterone concentrations with regard to milk yield and cyclicity in cows during progesterone administration(Wiley, 2015-02-01) Pancarcı, S. M.; Nak, Yavuz; Yıldız, O.; Aksit, H.; Alparslan, A. D.; NAK, YAVUZ; Uludağ Üniversitesi; AAH-5494-2021Publication Effect of butylated hydroxytoluene on post-thawed semen quality of beetal goat buck, capra hircus(Zoological Soc Pakistan, 2015-02-01) Iqbal, Z.; Ijaz, A.; Aleem, M.; Shahzad, A. H.; Sohail, M. U.; Nak, Deniz; Nak, Yavuz; Abbas, S.; NAK, DENİZ; NAK, YAVUZ; Uludağ Üniversitesi/Tıp Fakültesi/Doğum ve Jinekoloji Bölümü; AAH-5494-2021; FPJ-3706-2022Present study was conducted to evaluate the effect butylated hydroxytoluene (BHT) on post-thawed semen quality of Beetal goat buck semen. Semen was obtained from six bucks using artificial vagina and cryopreserved in tris egg yolk extender and semen quality was assessed on the basis of post-thaw sperm motility, viability, plasma membrane integrity, and acrosomal membrane status. Ejaculates were pooled and extended to the concentration of 2 x 10(9) spermatozoa per mL in tris egg yolk extender (300 mOsmol/L). Tris egg yolk extender containing various concentrations of BHT (0.0, 2.0 and 5.0 mM) was prepared. French straws (0.5 mL) were manually filled with semen, gradually cooled from 39 degrees C to 4 degrees C and finally, cryopreserved in liquid nitrogen at -196 degrees C. Five straws from each treatment [BHT (0.0, 2.0 and 5.0 mM)] were thawed and evaluated under phase-contrast microscope (40 x) for sperm motility, whereas sperm viability, plasma membrane integrity and acrosomal integrity were assessed by the supravital staining, hypo-osmotic swelling test (HOST) and normal acrosomal reaction, respectively. The results showed that only acrosomal integrity was improved (P < 0.05) by the addition of BHT in semen extender. Motility was suppressed (P < 0.05) by increasing BHT concentration. The maximum motility of sperm was achieved with 0.0 mM BHT. The HOST response and viability of spermatozoa were increased by addition of 2 and 5 mM BHT, but this increment was not statistically significant. In conclusion, the addition of BHT to semen extender can partially improve semen quality of Beetal goat.Publication Sry-negative xx sex reversal in an english cocker spaniel: A case report(Czech Academy Agricultural Sciences, 2015-01-01) Shahzad, A. H.; Nak, D.; NAK, DENİZ; Gülten, T.; Karkucak, M.; Yılmaz, R.; Nak, Y.; NAK, YAVUZ; Şimşek, G.; Bursa Uludağ Üniversitesi/Veterinerlik Fakültesi; 0000-0002-0944-2230; 0000-0002-8623-8292; ABG-8940-2020; AAH-5494-2021A SRY-negative XX male describes a female karyotype with testicular tissue resulting from abnormal gonadal development. In such cases male gonad formation takes place in the absence of a Y chromosome which supports the hypothesis that some other genes are also responsible for testicular development. The present case report describes a one-year-old dog brought to the hospital with a complaint of no oestrus cycle. Apparently normal masculine bitch had an enlarged clitoris with an os on radiograph. A gonado-hysterectomy was performed. Instead of ovarian structures both testicular masses were present and a normal complete bicornuate uterus with a normal cervix was observed. The histology of both gonads showed two testes, each with its ductus deferens and the uterus with typical histological structure. Cytogenetic evaluation of peripheral blood lymphocytes revealed a female with a normal karyotype (78, XX). Polymerase chain reaction (PCR) analysis of genomic DNA showed that the SRY gene was absent.Publication Investigation of relationships between serum lactate, acute phase proteins, pro/antiinflammatory cytokine levels, and metritis formation in holstein dairy heifers(Tubitak Scientific & Technological Research Council Turkey, 2023-01-01) Koca, Davut; ÖZYİĞİT, MUSA ÖZGÜR; Avcılar, Talha; NAK, DENİZ; Nak, Yavuz; Şahin, Mustafa Eren; Nak, Deniz; Özyiğit, Musa Özgür; NAK, YAVUZ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Jinekoloji Anabilim Dalı.; 0000-0001-7034-9644; 0000-0002-7962-6959The main purpose of this investigation was to identify and suggest suitable early screening inflammatory markers for the early diagnosis of uterine infections such as acute septic metritis (ASM) in the Holstein heifers. In addition, to achieve the above-mentioned aim, the objectives of the present study were tried to determine the relationship between blood serum lactate, acute phase proteins (APPs), pro/anti inflammatory cytokine levels, and metritis formation in Holstein heifers. For this purpose, 250 Holstein heifers which were 11-13 months old, were chosen as the study material. After heifers were conceived, blood serum samples were collected at the 8th and 4th weeks before the parturition. In the postpartum period, animals with ASM (n = 15) and healthy animals (n = 15) were identified, and blood serum samples were taken. Lactate, serum amyloid-A (SAA), haptoglobin (Hp), Interleukin-1beta (IL-1 (3), IL-6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF -& alpha;) levels were measured from these collected blood serum samples. Acute-phase proteins, lactate, and pro and anti inflammatory cytokine levels of healthy and animals with ASM were statistically compared. Heifers with metritis had a significantly greater concentration of IL-6 and SAA versus healthy heifers in the prepartum 8th week. In addition, it was determined that IL-6, IL-1(3, IL-10, TNF-& alpha;, and SAA levels were significantly higher in the 4th week before parturition in the ASM group than those of the healthy group. When all these findings are evaluated together, this study suggested that IL-6, and IL-10, can be used as early biomarkers in the prepartum preliminary diagnosis of postpartum important inflammatory processes such as ASM.Publication Evaluation of some systemic inflammatory biomarkers in canine malignant mammary tumors [i](Kafkas Univ, Veteriner Fakultesi Dergisi, 2023-09-01) Koca, Davut; Ekici, Zeynep Merve; Özyiğit, Musa Özgür; ÖZYİĞİT, MUSA ÖZGÜR; Nak, Deniz; NAK, DENİZ; Avcı Küpeli, Zehra; Kuruoğlu, Fikriye Ecem; Avcılar, Talha; Gümüş, Oğulcan; Nak, Yavuz; NAK, YAVUZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-6715-8529; 0000-0002-7962-6959; 0000-0001-7034-9644The aim of this study is to investigate whether neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), albumin-to-globulin ratio (AGR), and prognostic nutritional index (PNI) parameters could be used as biomarkers for canine malignant mammary tumors (MMTs), and the changes in these parameters according to different tumor (T), lymph node (N), and metastasis (M) stages (TNM I-II-III, TNM IV, TNM V) and the number of affected mammary glands (single, multiple). Thirty-seven with MMT and 20 healthy dogs were used in this study. Complete blood count and biochemistry analysis were performed in all dogs. Tumor material is removed by tru-cut and sent to the pathology laboratory for diagnosis. NLR, PLR, and SII values increased, and LMR and PNI values decreased in dogs with MMT. Median NLR values increased and median LMR and PNI values decreased as the TNM stage progressed. In dogs with a single MMT, median NLR, and PLR values were found to be lower than in dogs with multiple MMTs, and median LMR, SII, AGR, and PNI values were higher. The present results indicated that NLR, LMR, PLR, SII, and PNI parameters could be used as biomarkers for canine MMT. Also, NLR, LMR, PLR, SII, PNI, and AGR parameters may be valuable biomarkers that reveal the degree of systemic immune response according to different TNM stages and the number of affected mammary glands.