Person: TURAN, SERKAN
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TURAN
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SERKAN
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Publication Reduced cortical thicknesses of adolescents with bipolar disorder and relationship with brain-derived neurotrophic factor(Sciendo, 2023-01-01) İnal, Neslihan; Cavuşoğlu, Berrin; Ermis, Çağatay; Görmez, Vahdet; Karabay, Nuri; Turan, Serkan; TURAN, SERKAN; Tıp Fakültesi; Psikiyatri Ana Bilim Dalı; AFO-6356-2022Background: Cortical thickness (CT) and brain-derived neurotrophic factor (BDNF) were widely investigated in bipolar disorder (BD). Previous studies focused on the association between the volume of subcortical regions and neurotrophic factor levels.Objective: In this study, we aimed to evaluate the association of the CT in youth with early-onset BD with BDNF levels as a potential peripheral marker of neuronal integrity.Method: Twenty-three euthymic patients having a clinical diagnosis of BD and 17 healthy subjects as an age-matched control group with neuroimaging and blood BDNF levels were found eligible for CT measurement. A structural magnetic resonance scan (MRI) and timely blood samples were drawn.Results: Youth with BD exhibited lower cortical thickness in caudal part of left (L) middle frontal gyrus, right (R) paracentral gyrus, triangular part of R inferior frontal gyrus, R pericalcarine region, R precentral gyrus, L precentral gyrus, R superior frontal gyrus and L superior frontal gyrus when compared to healthy controls. The effect sizes of these differences were moderate to large (d=0.67-0.98) There was a significant correlation between BDNF levels with caudal part of the R anterior cingulate gyrus (CPRACG) in adolescents with BD (r=0.49, p=0.023).Conclusion: As a special region for mood regulation, the CT of the caudal part of the R anterior cingulate gyrus had a positive correlation with BDNF. Regarding the key role of CPRACG for affective regulation skills, our results should be replicated in future follow-up studies, investigating a predictive neuroimaging biomarker for the early-onset BD.Publication Exposure to violence and the presence of suicidal and self-harm behaviour predominantly in asian females: Scoping review(Springernature, 2022-08-18) Shoib, Sheikh; Khan, Sonia; Baiou, Alaa; Chandradasa, Miyuru; Swed, Sarya; Armiya'u, Aishatu Yusha'u; TURAN, SERKAN; Tıp Fakültesi; 0000-0002-3739-706X; 0000-0003-0870-9260; 0000-0002-1873-8228; 0000-0002-9983-2020; 0000-0002-6548-0629; 0000-0003-0881-1281; AFO-6356-2022; ABA-9762-2021; HKE-9636-2023; AAQ-5795-2020Background Exposure to violence is associated with psychological distress, mental disorders such as depression, and suicidal behaviour. Most of the studies are conducted in the West, with limited publications from Asia. Thus, we conducted a scoping review of studies investigating the association between experiences of violence and later suicidal ideation/attempts from Asia in the twenty-first century. Results Many studies focused on domestic violence toward women in the Southeast Asian region. Sociocultural factors such as family disputes, public shaming, dowry, lack of education opportunities, and marriage life perceptions mediated the association. Many women exposed to violence and attempted suicide suffered from mental disorders such as depression, anxiety, and post-traumatic stress. The small number of suitable studies and the possible effect of confounders on participants were limitations in the review. Future studies would have to focus on specific types of violence and ethnoreligious beliefs. Conclusion Women in Asia exposed to violence appear to have an increased risk of suicidal behaviour and mental disorders. The early screening of psychological distress with culturally validated tools is essential for preventing suicides in Asian victims of violence.Publication Public health literacy unsold during panic buying comment(Elsevier Sci Ltd, 2022-08-02) Shoib, Sheikh; Lodi, Aisha; Saleem, Amna; Armiya'u, Aishatu Yusha'u; Philip, Sharad; Turan, Serkan; TURAN, SERKAN; Tıp Fakültesi; Psikiyatri Ana Bilim Dalı; AFO-6356-2022Publication Selective serotonin reuptake inhibitors and manic switch: A pharmacovigilance and pharmacodynamical study(Elsevier, 2021-10-16) Çıray, R. Oğulcan; Halaç, Eren; Turan, Serkan; Tunçtürk, Mustafa; Özbek, Mutlu; Ermiş, Çağatay; TURAN, SERKAN; Tıp Fakültesi; Çocuk ve Ergen Psikiyatrisi Ana Bilim Dalı; 0000-0002-6548-0629; HKE-9636-2023; AFO-6356-2022Background: There is still no approved mechanism of manic switch in bipolar disorder, yet many selective serotonin reuptake inhibitors were accused for this important adverse event. Therefore, we aimed to investigate to estimate SSRI' s risk for reporting mania and elevated mood using FEARS database and investigate receptor mechanisms involved.Methods: Mania and relevant side effects approved by FDA were screened in this dataset from the first quarter of 2004 to the third quarter of 2020. Disproportionality analysis were performed to estimate reporting odds ratio (ROR) and linear regressions were conducted to investigate relationship between ROR and Ki values. Receptor occupancy ratios were calculated from in vitro receptor binding profiles. The pharmacodynamical profile was extracted from the International Union of Basic and Clinical Pharmacology and the British Pharmacology Society dataset. Child and adolescent population was also investigated separately.Results: The analysis showed that the odds of a spontaneous report of mania in the FAERS database involving an SSRI were higher than the odds that such a report involved other types of drugs (ROR: 5.324 [CI: 3.773; 7.514]). The largest effect size in this estimation was found in fluvoxamine (ROR: 13.957 [CI: 10.391; 18.747]). Significant effects were found in regression analysis for Ki values of H1 and M1 receptors on ROR. Receptor occupation was not found to have an effect on ROR.Conclusion: Lower degress of Ki values on M1 and H1 may be plausible pharmacological mechanism. Further pharmacological data and clinical assessments may be important to validate this safety signal.Publication Searching the underlying mechanisms of specific learning disorder: An emotion recognition and social cognition aspect for turkish clinical youth population(Routledge Journals, Taylor & Francis Ltd, 2022-12-12) Çıray, Remzi Oğulcan; Turan, Serkan; TURAN, SERKAN; Tıp Fakültesi; 0000-0003-2864-613X; HKE-9636-2023This study aimed to investigate impairments in social cognition in youth with specific learning disorder (SLD) through a cross sectional study. Eighty six adolescents which include of 43 SLD and 43 typically developing (TD) children completed a battery of tests to analyze social cognition, emotional process and clinical psychopathological profile. SLD group performed significantly worse than healthy controls in facial ER total accuracy score (Cohen d = .77) and Stroop interference (Cohen d = .92). In individual emotion analyses, patients with SLD have a very high deficiency in recognition of angry faces (Cohen d = .89). Between-group difference was also significant for Stroop congruent and facilitation scores (Cohen d = .99). The Specific Learning Disorder Symptom Check List-Parent Form scores were significant -and only- predictor of the model which for total accuracy score of facial recognition. The results of this study supported an impairment in emotion recognition and executive functions in adolescents with SLD but causality seems still unclear.Publication Violence against the doctor in the developing countries during covid-19 pandemic. mental health linkages(Medicinska Naklada, 2021-01-01) Shoib, Sheikh; Arafat, S. M. Yasir; Gupta, Anoop Krishana; Ullah, Irfan; Turan, Serkan; Turan, Serkan; TURAN, SERKAN; Tıp Fakültesi; 0000-0002-6548-0629; HKE-9636-2023Publication Investigating the effects of age, IQ, dosing, and anthropometric measures on the treatment persistence in long-term methylphenidate use(Taylor, 2022-08-22) Tunçtürk, Mustafa; Ermiş, Çağatay; Büyüktaşkın, Dicle; Halaç, Eren; Süt, Ekin; Özkan, Oben; Gündoğan, Nazan; Unutmaz, Güldal; Çıray, R. Oğulcan; Turan, Serkan; Pekcanlar, Aynur Akay; TURAN, SERKAN; Tıp Fakültesi; Çocuk ve Ergen Psikiyatrisi Ana Bilim Dalı; 0000-0002-6548-0629; AFO-6356-2022Objectives This study aimed to determine anthropometric and clinical correlates of persistence to methylphenidate (MPH) treatment in Turkish youth with attention-deficit hyperactivity disorder (ADHD). Methods Data from medical records of 518 children and adolescents with ADHD were recorded between March 2012 and January 2022. Clinical variables of patients persistent to MPH >= 2 years were compared with those of the non-persistent group. Children and adolescent age groups were compared using Kaplan-Meier estimates for treatment drop-outs. Cox regression analysis until the treatment drop-out was implemented to calculate hazard ratios (HRs) for gender, age, full-scale IQ, and anthropometric measures. Weight, height, and body mass index (BMI) z-scores were calculated per national guidelines. Results Persistent and non-persistent study groups had similar full-scale IQ, weight, height, and BMI z-scores at treatment onset. The mean MPH dose was significantly higher in the persistent group compared to the non-persistent counterparts (31.43 +/- 10.70 vs. 24.28 +/- 9.60 mg/d, p < 0.001, d = 0.70). Compared to children, the adolescents showed earlier treatment drop-outs in males (p < 0.001) but not in females (p = 0.110). Younger age showed a positive effect on treatment persistence. Conversely, baseline BMI and IQ scores were not associated with long-term persistence. Discussion Our study demonstrated lower daily doses and older age-onset were associated with early drop-outs in MPH treatment. These findings supported the notion that effective dosing strategies at younger ages could increase the sustainability of the treatment with MPH in the Turkish population.Publication Circulating c1q complement/tnf-related protein (ctrp)-13 levels in obese children and its relationship with metabolic disorders(Karger, 2021-09-01) Erbas, Ibrahim Mert; Paketci, Ahu; Sisman, Ali Riza; Demir, Korcan; Bober, Ece; Abaci, Ayhan; Turan, Serkan; TURAN, SERKAN; Tıp Fakültesi; Psikiyatri Ana Bilim Dalı; 0000-0002-8334-2422; 0000-0001-8828-0892; 0000-0002-1812-0321; HKE-9636-2023Publication Psychometric properties of the clinician affective reactivity index for assessment of irritability in a clinical sample of Turkish children and adolescents(Sciendo, 2022-01-01) Turan, Serkan; Ermiş, Çağatay; Eray, Şafak; Yavuz, Büşra Ece; Uzman, Simge; Özbek, Mutlu Muhammed; Tunçtürk, Mustafa; Ciray, Remzi Oğulcan; İnal, Neslihan; TURAN, SERKAN; Tıp Fakültesi; AFO-6356-2022Background: No clinician-oriented scale exists to assess irritability in Turkey. This pilot study aimed to evaluate the psychometric properties of the Turkish version of The Clinician Affective Reactivity Index (CL-ARI).Metho: A total of 116 children and adolescents aged between 10 to 17 years (14.1 +/- 2.1 years) were recruited from the psychiatric outpatient clinics. The participants completed a set of scales (Strengths and Difficulties Questionnaire [SDQ], Affective Reactivity Index [ARI], Revised Child Anxiety and Depression Scale, Swanson, Nolan, and Pelham, Version IV Scale). Diagnostic interviews were administered to confirm psychiatric diagnoses. Cronbach's alpha was calculated to assess internal consistency. Discriminant validity was further tested using independent sample t-test and Receiver Operating Characteristic curves. Interrater reliability was tested using intraclass correlation coefficients (ICC). Convergent validity was also tested using Pearson's correlation.Results: Cronbach's alpha values of CL-ARI were 0.919 total score, 0.842 for the temper outbursts score, 0.861 for the irritable mood score, and 0.840 for the impairment score. ICC values for interrater reliability were high for the temper outbursts (r = 0.993), the irritable mood (r = 0.993), the impairment (r = 0.917), and the total score (r = 0.991). In the sample, there was a high level of correlation between the self-report ARI-child/parent form and the CL-ARI total and subscale scores. Likewise, moderate-high level of correlations were found between the behavioral SDQ child/parent forms and the CL-ARI total and subscale scores.Conclusions: This is the Turkish validation of the CL-ARI, a dedicated interview and rating scale to assess irritability in the clinical sample. The results of this study suggest that the Turkish version of CL-ARI has adequate internal consistency and interrater reliability, and sufficient convergent and discriminant validity to be used in research settings.Publication Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: An explorative analysis on symptom dimensions(Taylor & Francis Ltd, 2022-12-27) Tunçtürk, Mustafa; Ermis, Çağatay; Büyüktaşkın, Dicle; Turan, Serkan; Sağlam, Yeşim; Alarslan, Sezen; Güler, Duru; Sut, Ekin; Unutmaz, Güldal; Güzel, Ayse Beste; Canbek, Ozge Atay; Inal, Neslihan; Karacetin, Gul; Hazell, Philip; TURAN, SERKAN; Tıp Fakültesi; Çocuk ve Ergen Psikiyatrisi Ana Bilim Dalı; 0000-0002-6548-0629 ; AFO-6356-2022ObjectiveThis study sought to compare pre-intervention patient characteristics and post-intervention outcomes in a naturalistic sample of adolescent inpatients with treatment-resistant psychotic symptoms who received either electroconvulsive therapy (ECT) or clozapine.MethodsData of adolescents with schizophrenia/schizoaffective disorder receiving ECT or clozapine were retrospectively collected from two tertiary-care psychiatry-teaching university hospitals. Subscale scores of the Positive and Negative Symptom Scale (PANSS) factors were calculated according to the five-factor solution. Baseline demographics, illness characteristics, and post-intervention outcomes were compared.ResultsThere was no significant difference between patients receiving ECT (n = 13) and clozapine (n = 66) in terms of age, sex, and the duration of hospital stay. The ECT group more commonly had higher overall illness and aggression severity. Smoking was less frequent in the clozapine group. Baseline resistance/excitement symptom severity was significantly higher in the ECT group, while positive, negative, affect, disorganisation, and total symptom scores were not. Both interventions provided a significant reduction in PANSS scores with large effect sizes.ConclusionBoth ECT and clozapine yielded high effectiveness rates in adolescents with treatment-resistant schizophrenia/schizoaffective disorder. Youth receiving ECT were generally more activated than those who received clozapine.
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