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ÇİNKILIÇ, NİLÜFER

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ÇİNKILIÇ

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NİLÜFER

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2015 - 20202
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    Publication
    In vitro evaluation of electrospun polysaccharide based nanofibrous mats as surgical adhesion barriers
    (Ege Univ, 2020-01-01) Şafak, Şerife; Vatan, Özgür; VATAN, ÖZGÜR; Cinkılıç, Nilufer; ÇİNKILIÇ, NİLÜFER; Karaca, Esra; KARACA, ESRA; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Tekstil Anabilim Dalı.; 0000-0002-7687-3284; 0000-0002-3595-6286; 0000-0003-1777-3977; AAH-5296-2021; O-7508-2015; AAS-8480-2020; ISV-0209-2023
    Post-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.
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    Genotoxic and cytotoxic effects of the aglepristone, a progesteron antagonist, in mid-gestation pregnancy termination in rabbits
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2015-03-01) Vatan, Özgür; Bağdaş, Deniz; Çinkılıç, Nilüfer; Wehrend, Axel; Özalp, Gözde Rabia; VATAN, ÖZGÜR; Bagdas, Deniz; ÇİNKILIÇ, NİLÜFER; ÖZALP, RABİA GÖZDE; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; 0000-0002-7687-3284; 0000-0002-3595-6286; 0000-0003-4694-6937; ISV-0209-2023; O-7508-2015; AAH-5296-2021; AAE-3607-2019; EOB-5882-2022
    Aglepristone is an antiprogestin using for pregnancy termination in veterinary medicine. The information about side effects of aglepristone is limited. The aim of the study was to investigate cytotoxicity and genotoxicity of aglepristone in mid-gestation pregnancy termination in rabbits. Fifteen New Zealand White rabbits were used and pregnant does were randomly divided into three groups. Group I (n=5) was treated with saline as the control. The does in group II (n=5) and group III (n=5) were treated with aglepristone (10 mg/kg) on 15th day and 15th-16th days of pregnancy, respectively. The rabbits were sacrificed by guillotine 24 h after last treatment. Bone marrow and blood samples were immediately collected. Cytotoxic and genotoxic potential were tested by micronucleus and Comet assays. No genotoxicity and cytotoxicity were found in micronucleus test with single aglepristone administration. In contrast, two consecutive treatments of aglepristone showed high genotoxic and cytotoxic effects on bone marrow in animals. While comet assay of blood samples did not show any significant difference between groups; the results from comet assay of bone marrow cells showed the single injection of aglepristone did not induce any DNA damage but two injections group increased the DNA damage.