Person: ÇİL, ERGÜN
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Publication Qt dispersion in epileptic children and effect of antiepileptic drugs on QT dispersion(Erciyes Üniversitesi Tıp Fakültesi, 2010-09-01) Şentürk, Ebru Tayfun; Semizel, Evren; Bostan, Özlem Mehtap; Okan, Mehmet; Çil, Ergün; TAYFUN ŞENTÜRK, EBRU; Semizel, Evren; BOSTAN, ÖZLEM MEHTAP; OKAN, MEHMET SAİT; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Nörolojisi Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; JMN-6038-2023; DQX-9595-2022; AAG-8558-2021; IMZ-1723-2023; AAG-9324-2021Purpose: Sudden death in epileptic patients may due to epilepsia or drug induced arrhythmia. The aim of this study is to identify changes of QT dispersion, as a predictive marker for arrhythmias, in children treated with antiepileptic drugs.Material and Methods: Ninety children treated with antiepileptic drugs and 30 healthy children as controls were involved in the study. Standard 12-lead surface electrocardiograms (ECG) of the study groups were evaluated before antiepileptic drug therapy and after 3 months. ECG of the control group was also reviewed at the beginning of the study and after 3 months. QT, JT and RR intervals were measured in both groups. The corrected QT (QTc) and JT (JTc) intervals were determined and QTc and JTc dispersions were measured.Results: QTc and JTc dispersion were found to be 85.8+/-16.5 ms and 79.8+/-15.6 ms respectively in patients group before the therapy and 43.3+/-8.2 ms and 40.8+/-5.6 ms in control group at the beginning (p<0.05). Even QTc dispersion were found to be significantly decreased after 3 months of therapy (80.5+/-12.9 ms), it was still significantly higher than the QTc dispersion in control group after 3 months.Conclusion: Determination of QTcd and JTcd values may be useful to predict the risk of sudden death in epileptic patients.Publication The frequency of asymptomatic urinary system abnormalities in children detected with cineurography imaging during angiocardiography(Cambridge Univ Press, 2019-02-01) Oral, Orçun; Toprak, Muhammet Hamza Hata; Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; Toprak, Muhammet Hamza Hata; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi; 0000-0001-7707-2174; 0000-0003-3516-0082; AAG-9324-2021; AAH-4421-2021; AAG-8558-2021; AAH-3865-2021; ECM-4447-2022Introduction: Diagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, and properties of urinary system anomalies accompanying heart diseases, and to find out the effectiveness of cineurographic images in detecting the urinary system anomalies. Methods: The cineurographic images of 2022 children who had undergone angiocardiography between 1995 and 2015 were retrospectively examined. Results: Urinary system anomalies were detected in 261 of the 2022 cases (12.9%). Of these 261 cases, 148 were males (56.7%), whereas 113 were females (43.3%). Among the heart diseases, the group most accompanied by urinary system anomalies was the non-cyanotic left-to-right shunted heart diseases, which was detected in 120 (39.1%) patients. Pelvicalyceal ectasia was the most common urinary system anomaly encountered and was detected in 89 patients (34.1%). Of the urinary system anomalies cases, 94 detected by cineurography were determined to be clinically severe. When the effectiveness of the cineurography was evaluated using the ultrasonography records of the patients, it was found to have 63.8% accuracy. Conclusion: Many of the patients with CHDs concomitantly have urinary system anomalies. It is possible to determine asymptomatic urinary system anomalies using cineurographic imaging during angiocardiography. This may lead to earlier treatments and improved prognosis for the patients, thus making it possible to prevent potential future problems.Publication A rare anomaly: Recurrent congenital aorto-azygos fistula after two procedure of transcatheter occlusion(Springer, 2015-10-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı; 0000-0001-7707-2174; 0000-0003-3516-0082; AAH-3865-2021; AAH-4421-2021; AAG-9324-2021; AAG-8558-2021Publication Clinical features of patients with congenital complete atrioventricular block(Galenos Yayincilik, 2007-09-01) Çil, Ergün; ÇİL, ERGÜN; Semizel, Evren; Bostan, Özlem M.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021Aim: Evaluation of the clinical features of the children with congenital complete atrioventricular block.Material and Methods: The hospital records of children who had been admitted to the Uludag University Pediatric Cardiology Unit between January 1994 and Nowember 2005 were reviewed retrospectively and a total of 12 patients who were diagnosed as congenital complete A-V block between this period were involved the study. Medical records of these patients were reviewed.Results; A total of 12 patients (7 male and 5 female) were involved the study. The children ranged in age from 1 day to 6 years with a mean age of 16 months and a median age of 12 months at the time of diagnosis. Seven of 12 patients were referred to our unit due to bradycardia and rhythym problem; four of them due to murmur, and the remaining one due to syncope. Intrauterine bradycardia was also detected in four of seven patients with the symptom of bradycardia. On echocardiographic examination, corrected transposition of great arteries was found in one patient, and patent ductus arteriosus in three. Totally, specific anti-Ro and anti-La antibody were detected in the mother of six patients and one of them also had the other symptoms of neonatal lupus syndrome. Mean ventricular and atrial rates of 12 patients, obtained from electrocardiography at the time of diagnosis, were 54 +/- 11 and, 116 +/- 24 respectively. Pacemaker was implanted in eight patients. The follow up period ranged from 1 months to 11 years. Age at last evaluation ranged from 6 months old to 13 years old.Conclusion: In all fetuses with bradyarrhythmias detected in utero and all fetuses of women with anti-Ro/La antibodies, serial echocardiographic monitoring is strongly advised.Publication Arterial tortuosity syndrome: 40 new families and literature review (vol 20, pg 1236, 2017)(Nature Publishing Group, 2019-08-01) Beyens, Aude; Albuisson, Juliette; Boel, Annekatrien; Al-Essa, Mazen; Al-Manea, Waheed; Bonnet, Damien; Bostan, Ozlem; Boute, Odile; Busa, Tiffany; Canham, Nathalie; Cil, Ergun; Coucke, Paul J.; Cousin, Margot A.; Dasouki, Majed; De Backer, Julie; De Paepe, Anne; De Schepper, Sofie; De Silva, Deepthi; Devriendt, Koenraad; De Wandele, Inge; Deyle, David R.; Dietz, Harry; Dupuis-Girod, Sophie; Fontenot, Eudice; Fischer-Zirnsak, Bjoern; Gezdirici, Alper; Ghoumid, Jamal; Giuliano, Fabienne; Baena, Neus; Haider, Mohammed Z.; Hardin, Joshua S.; Jeunemaitre, Xavier; Klee, Eric W.; Kornak, Uwe; Landecho, Manuel F.; Legrand, Anne; Loeys, Bart; Lyonnet, Stanislas; Michael, Helen; Moceri, Pamela; Mohammed, Shehla; Muino-Mosquera, Laura; Nampoothiri, Sheela; Pichler, Karin; Prescott, Katrina; Rajeb, Anna; Ramos-Arroyo, Maria; Rossi, Massimiliano; Salih, Mustafa; Seidahmed, Mohammed Z.; Schaefer, Elise; Steichen-Gersdorf, Elisabeth; Temel, Şehime; Uysal, Fahrettin; Vanhomwegen, Marine; Van Laer, Lut; Van Maldergem, Lionel; Warner, David; Willaert, Andy; Collins, Tom R., II; Taylor, Andrea; Davis, Elaine C.; Zarate, Yuri; Callewaert, Bert; TEMEL, ŞEHİME GÜLSÜN; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; AAG-8558-2021; AAG-9324-2021; AAG-8385-2021; AAH-4421-2021Publication Complete atrioventricular block as a complication of varicella infection in a child: Recovery with a single dose of intravenous immunoglobulin therapy(Sage Publications, 2016-06-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çetin, Benhur; Uysal, Berfin; Güney, Begüm; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Çetin, Benhur; Güney, Begüm; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-7707-2174; 0000-0002-8470-4907; 0000-0003-3516-0082; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021; AAH-4421-2021; H-2691-2017Publication Pulmonary stenosis(Galenos Yayıncılık, 2007-12-01) Çil, Ergün; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Bilim Dalı; EPX-4996-2022Pulmonary stenosis is an obstruction between the right ventricle and the pulmonary arteries. It has three different types: valvular, subvalvular and supravalvular or peripheric. It may be mild, moderate or severe according to the obstruction. Right ventricular hyperthrophy is essential and most prominent sign on oscultation is murmur and ejection click. Prognosis is generally good and most of the patients do not need any treatment or were treated by baloon valvuloplasty without surgery.Publication Role of cineangiography and renal ultrasonography in the diagnosis of urinary tract abnormalities associated with congenital heart disease(Aves, 2009-12-01) Semizel, Evren; Yazıcı, Zeynep; YAZICI, ZEYNEP; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Çil, Ergün; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; AAI-2303-2021; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021Purpose: The incidence of urinary tract anomalies (UTA) associated with congenital heart disease (CHD) is high. The aim of this study is to investigate the role of cineurography and renal ultrasonography in the diagnosis of UTA associated CHD.Patients and Method: Cineurography of the 148 patients who underwent angiography, between January 2005 and July 2005, due to CHD were evaluated. Renal ultrasonographies were also performed to these patients. Intravenous pyelography was performed to the patients who were diagnosed as UTA by renal ultrasonography and/or cineurography.Results: Urinary tract anomalies were found in 23 of 148 patients by cineurography and in 22 of 148 patients by renal ultrasonography. Thirteen patients were diagnosed as UTA by both modalities. IVP was performed to 32 patients and UTA were detected in 24 of these 32 patients. 8 cincurograms yielded false-positive and 9 cincurograms yielded false-negative results. Ultrasonography produced 2 false negative results. Cineurography was able to show 62% of UTA accurately.Conclusion: Both cineurography and renal ultrasonography can be used to image the UTA associated CHD. The postangiocardiographic cineurogram appears to be a cost-effective, easy 188 and useful method of screening for silent UTA in children with CHD.Publication Syncope in children: Is rhythm holter monitoring necessary?(Galenos Yayincilik, 2016-12-01) UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Bostan, Özlem Mehtap; Çetinkaya, Fatma; Çil, Ergün; ÇİL, ERGÜN; Deniz, Tuba; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; AAG-8558-2021; AAG-9324-2021; AAH-3865-2021; AAH-4421-2021Introduction: Holter monitoring (HM) is usually used in patients with syncope when etiology cannot be explained with history, physical examination and electrocardiography (ECG). In this study the objective was to evaluate the diagnostic value of HM in children with syncope.Materials and Methods: Databases were collected retrospectively by analyzing the HM results of 3.122 pediatric patients between 2010-2014. Gender, age at diagnosis, detailed clinical history, physical examination, 12-lead electrocardiographic and echocardiographic results were noted using standardized form.Results: The study included 323 patients with syncope with a mean age of 13.21+/-3.67. There were 199 female and 124 male patients in this study. Among all patients 284 (87.9%) had normal HM results, while 11 (3.4%) patients had abnormal Holter studies that consider to explain as syncope. Three of 11 patients with abnormal Holter results diagnosed through ECG before HM, hence, the diagnostic value of HM was calculated as 2.4%. In contrast, diagnostic value of HM in patients with positive family history was found to be 16.6%. In this study, 7 patients were considered to have long QT syndrome according to their HM findings.Conclusions: Detailed clinical history has a great value in children with syncope. As a result, HM has low diagnostic value if the patients are not in high risk group. However, HM was considered to be important because of concealed long QT syndrome especially if the patient had positive family history and exercise related syncope.Publication Cardiac involvement in costello syndrome: Evaluation of six cases(Galenos Yayıncılık, 2013-08-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Semizel, Evren; Akaltun, Filiz; Üner, Gülcan; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Akaltun, Filiz; Üner, Gülcan; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; CCJ-6951-2022; AAG-8558-2021; AAH-4421-2021; AAG-9324-2021; GHF-4123-2022Introduction: Costello syndrome is probably an autosomal dominant inherited disorder that is characterized by postnatal growth retardation, developmental delay, coarse facies, loose skin, nonprogressive cardiomyopathy and friendly behavior. The aim of this study was to evaluate a variety of clinical findings and cardiac involvement of six patients diagnosed as Costello syndrome.Materials and Methods: Six cases that had a typical features of Costello syndrome admitted to pediatric cardiology department due to cardiac murmur between 2002-2013 years were evaluated. Their complaints, clinical findings, treatments and clinical courses were examined.Results: Three of the patients were male and the mean age of patients was 34 +/- 12 months (7 months to 11 years). All of the cases had coarse faces, deep palmar and plantar creases, hypertelorism, epicanthal folds, depressed nasal bridges and cardiac murmur at auscultation. Congenital heart disease was found in all patients. Five patients had pulmonary stenosis and balloon pulmonary valvuloplasty was performed in 3 of these patients. Atrial septal defect was detected in 3 patients and 1 of the patient had hypertrophic cardiomyopathy. Mental retardation was found in 2 patients.Conclusions: Costello syndrome must be keep in mind in all patients with psychomotor retardation, coarse faces, sparse hairs, deep palmar and plantar creases, phenotypical features resembling a storage disease especially in association with pulmonary stenosis and hypertrophic cardiomyopathy.