Person: GÖKTALAY, GÖKHAN
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GÖKTALAY
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GÖKHAN
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Publication Silymarin-loaded electrospun polycaprolactone nanofibers as wound dressing(Springer Heidelberg, 2023-03-02) Sali, Aisegkioul; Gebizli, Şebnem Düzyer; Göktalay, Gökhan; Sali, Aisegkioul; DÜZYER GEBİZLİ, ŞEBNEM; GÖKTALAY, GÖKHAN; Tıp Fakültesi; Biyomalzeme Bölümü; 0000-0003-3737-5896; 0000-0001-6261-4233; 0000-0002-1973-5344; AAH-1448-2021; AFO-0698-2022; HTA-7306-2023Herein, we fabricated silymarin (SIL)-loaded polycaprolactone (PCL) electrospun nanofiber mats containing different SIL concentrations (5, 7.5, 10%) for wound dressing applications. Solution properties, nanofiber properties and SIL presence were analyzed by viscosity measurements, SEM and FTIR, respectively. Solution viscosities were increased with increasing SIL concentrations resulting in bead-free, thicker and smooth nanofibers. The lowest contact angle was measured as similar to 92 degrees for 10% SIL-loaded sample which had the smoothest nanofibers and a more controlled and continuous SIL release with a rate of 68.29% at end of 144 h during in vitro release experiments. In vivo studies on rats were conducted on this sample and results were compared with a conventional wound dressing and a PCL nanofiber mat. In comparison, the 10% SIL-loaded sample provided more rapid and significantly greater wound healing from the first day of observation. The results confirmed the potential application of PCL/SIL electrospun nanofiber mats as wound dressing.Publication Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing(Taylor, 2021-06-02) Aras, Cansu; Özer, Elif Tümay; Göktalay, Gökhan; Saat, Gülbahar; Karaca, Esra; ARAS GÜL, CANSU; TÜMAY ÖZER, ELİF; GÖKTALAY, GÖKHAN; KARACA, ESRA; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0003-1777-3977; AAI-3137-2021; AAS-8480-2020; EKA-8835-2022; AAI-3137-2021; JKY-1522-2023; DPL-6507-2022Electrospun nanofibers have a natural wound healing effect due to their similarity to the extracellular matrix (ECM). Nigella sativa oil, which has therapeutic properties, is used for a wide variety of applications in traditional medicine. The aim of this study was to investigate the release characteristic and wound healing performance of Nigella sativa oil (NSO) loaded polyurethane (PU) electrospun nanofibrous mats in wound dressing applications. In addition, the antibacterial activity and cytotoxicity of the electrospun mats were studied. Analyses using a scanning electron microscope (SEM) showed that PU/NSO nanofibrous mat with an average fiber diameter of 416 +/- 66 nm were successfully fabricated. NSO was released at a maximum ratio of 30% from the electrospun mat, and the Korsmeyer-Peppas model was identified as best for determining the release mechanism. Significant antibacterial activity was observed against Staphylococcus aureus (90.26%) and Escherichia coli (95.75%). The developed PU/NSO nanofibrous mat increased the cell viability more than 100% in human umbilical vein endothelial cell line (HUVEC) cell line. The NSO loaded PU nanofibrous mat significantly promoted the wound healing process on a rat wound model, and its wound closure reached approximately 85% compared to the control groups on the 9(th) day (p < 0.01). The results indicated PU/NSO nanofibrous mat is a suitable candidate for a wound dressing.Publication The OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension(Elsevier, 2015-05-27) Feleder, Carlos; Yılmaz, M. Sertaç; Peng, Jianya; Göktalay, Gökhan; Millington, William R.; YILMAZ, MUSTAFA SERTAÇ; GÖKTALAY, GÖKHAN; Tıp Fakültesi; Tıbbi Farmakoloji Ana Bilim Dalı; 0000-0001-9496-1475; 0000-0002-2617-3626; AAH-1448-2021; AAH-1571-2021This study tested the hypothesis that lipopolysaccharide (LPS) lowers arterial pressure through two different mechanisms depending on the dose. Previously, we found that a low hypotensive dose of LPS (1 mg/kg) lowers arterial pressure by activating vagus nerve afferents. Here we report that hypotension evoked by high dose LPS (15 mg/kg) can be prevented by injecting lidocaine into the OVLT but not by vagotomy or inactivation of the NTS. The hypotension produced by both LPS doses was correlated with elevated extracellular norepinephrine concentrations in the POA and prevented by blocking alpha-adrenergic receptors. Thus, initiation of endotoxic hypotension is dose-related, mechanistically. (C) 2015 Elsevier B.V. All rights reserved.Publication Prepulse inhibition may predict individual vulnerability to nicotine-induced sensitization in rats(Elsevier Science Bv, 2008-08-01) Kayır, Hakan; Yavuz, Oğuzhan; Yıldırım, Muazzez; Uzbay, I. Tayfun; Goktalay, Gökhan; GÖKTALAY, GÖKHAN; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0001-6261-4233; AAH-1448-2021