Person: KIVANÇ, SERTAÇ ARGUN
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KIVANÇ
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SERTAÇ ARGUN
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Publication The biofilm formation properties of the S. epidermidis isolates obtained from conjunctiva and multi-drug resistance(Kuwait Medical Assoc, 2020-06-01) Kılıç, Volkan; Kıvanç, Merih; Kıvanç, Sertaç Argün; KIVANÇ, SERTAÇ ARGUN; Akova, Berna; AKOVA, BERNA; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0003-0995-5260; AAH-6518-2021; ABE-3033-2020Objective: Biofilm was shown on ocular abiotic surfaces such as contact lenses, intra-ocular lenses, glaucoma shunts and corneal sutures. The aim of this study is to compare success of Microtiter plate (MTP) and Congo Red Agar (CRA) methods in showing biofilm formation of S.epidermidis isolates that were obtained from conjunctiva regarding presence of icaA gene locus and multi-drug resistance.Design: InterventionalSetting: Department of Biology, Faculty of Science, Eskisehir Technical UniversitySubjects: S. epidermidis isolates obtained from conjunctivas of healthy patientsInterventions: MTP and CRA methods and antibiotic susceptibility tests were done and scanning electron microscopy was performed. Main outcome measures: Biofilm forming capacity, multidrug resistance states and bacterial adhesion of S. epidermidisResults: Nine isolates were found as strong biofilm producers with MTP and CRA methods. There were six icaA negative isolates, one of which was not a biofilm producer. From the icaA and icaD positive isolates, 13 were biofilm negative with MTP method and seven were biofilm negative with CRA method. Eighteen isolates were determined as resistant to three or more antibiotics. Ten of 18 isolates were strong biofilm producer with MTP and eight of 18 isolates were strong biofilm producer with CRA. Biofilm producer isolates were found to be resistant to antibiotics.Conclusion: It is noted that biofilm formation capacity of S. epidermidis isolates that were obtained from ocular surface were determined and multidrug resistance were estimated more successfully with MTP method. However, there is no method which can successfully detect biofilm formation capacity with 100% accuracy.Publication Antibiofilm effect of probiotic lactic acid bacteria against bacillus spp obtained from the ocular surface(Verduci Publisher, 2021-01-01) Akova, Berna; Kıvanç, Sertaç Argun; Kıvanç, Merih; AKOVA, BERNA; KIVANÇ, SERTAÇ ARGUN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; 0000-0003-0995-5260; ABE-3033-2020; AAH-6518-2021OBJECTIVE: Increasing emergence of antibiotic resistance has led to developing alternative methods to overcome this issue. The antibiotic resistance is mainly associated with formation of biofilms. Restoring healthy microbiota is one of these methods to fight the biofilm formation. In terms of this, the use of probiotics is a novel approach. In this study. we aimed at investigating the effect of exopolysaccharides (EPSs) of different lactic acid bacteria as probiotics on Bacillus spp isolated from the ocular surface, which is known to form biofilms.MATERIALS AND METHODS: Pathogenic microorganisms were cultivated in "Brain-Hearth infusion" (BHI) broth, and lactic acid bacteria were grown in "De Man, Rogosa. Sharpe" and M17 broth. Molecular identification of lactic acid bacteria was made according to the sequence information of the 16S rRNA gene region. Antimicrobial activity of lactic acid bacteria was determined by sandwich overlay method. The minimum inhibitory concentration values of the exopolysaccharides and antibiofilm activity were determined by microtitration method. For evaluating the effect of EPSs of probiotic bacteria on biofilm, the mean and standard deviations of optical density values were calculated.RESULTS: The most effective EPS against B. cereus was EPS from L. rhamnosus 24, followed by EPS from L. plantarum and L. acidophilus. The biofilm formation of all pathogenic bacteria that were exposed to probiotic bacteria except L. rhamnosus 621 and 622 and L. rhamnosus 3111 was lower than the biofilm formation of the control group.CONCLUSIONS: EPSs obtained from lactic acid bacteria have antibacterial and antibiofilm activity on pathogenic bacteria isolated from ocular surface. This study is one of the pioneer studies in restoring healthy microbiota on ocular surface with the anticipated forthcoming use of topical probiotics.Publication Evaluation of iridocorneal angle, choroidal thickness, and retinal nerve fiber layer thickness in children with a history of retinopathy of prematurity(Lippincott Williams & Wilkins, 2020-02-01) Ulusoy, Mahmut Oguz; Kal, Ali; Kivanc, Sertac Argun; KIVANÇ, SERTAÇ ARGUN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Oftalmoloji Anabilim Dalı.; AAH-6518-2021Purpose: Retinopathy of prematurity (ROP) is proliferative retinopathy affecting premature infants associated with abnormal maturation of the retinal vasculature. We sought to evaluate iridocorneal angle, choroidal thickness, and retinal nerve fiber layer thickness (RNFLT) of the children that have a history of ROP using spectral-domain optical coherence tomography. Patients and Methods: Fifty eyes of 28 children with a history of ROP and 46 eyes of 23 healthy school-aged children were included in this study. RNFLT, choroidal thickness, and iridocorneal angle parameters [trabecular iris angle, angle opening distance (AOD500), and trabecular iris space area (TISA500) 500 mu m from the scleral spur] were evaluated using spectral-domain optical coherence tomography. Student t test was used to compare the mean of the parameters. Correlations between the variables were investigated based on the Pearson or Spearman correlation coefficient. Results: Subfoveal (ROP: 253.98 +/- 42.5; control: 286.2 +/- 71.9; P=0.045), 500 mu m (ROP: 242.04 +/- 41.8; control: 276.7 +/- 45.3; P=0.003), 1000 mu m (ROP: 237 +/- 39.7; control: 270.15 +/- 55.93; P=0.007), and 1500 mu m (ROP: 224.16 +/- 37.5; control: 259.75 +/- 55.2; P=0.003) temporal choroidal thicknesses were significantly thinner in ROP history children. None of the RNFLT parameters and ganglion cell complex thickness were different between groups. Iridocorneal angle parameters were significantly lower in children with ROP history. (trabecular iris angle: ROP=31.35 +/- 3.9 degrees, control=35.4 +/- 4.5 degrees, P<0.001; TISA500: ROP=0.167 +/- 0.05 mm(2), control=0.21 +/- 0.05 mm(2), P=0.003; AOD500: ROP=480.96 +/- 160.4 mu m, control=542.95 +/- 161.2 mu m, P=0.035). Conclusions: ROP is associated with differences in the iridocorneal angle. Possible iridocorneal angle pathology should be a consideration in children with a history of ROP.Publication Spectral domain optical coherence tomography findings in Turkish sickle-cell disease and beta thalassemia major patients(Wolters Kluwer Medknow Publications, 2019-09-01) Ulusoy, Mahmut Oğuz; Türk, Hakan; Kıvanç, Sertaç Argun; KIVANÇ, SERTAÇ ARGUN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; AAH-6518-2021Purpose: To assess probable structural changes using spectral domain optical coherence tomography (SD-OCT) on sickle-cell disease (SCD) and beta thalassemia major (B-TM) patients, without any retinal abnormalities.Methods: This cross-sectional study included 32 B-TM, 34 SCD patients, and 44 healthy controls. One of the eyes of all participants was evaluated for SD-OCT and choroidal thickness, retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), ganglion cell complex (GCC).Results: Age, gender, and intraocular pressure (IOP) were not statistically different between the three groups. Hemoglobin (Hgb), hematocrite (Htc), and ferritin levels were not statistically different between the SCD and B-TM groups. Choroidal thickness at the subfoveal region was statistically higher in the control group (353.79 +/- 71.93) than in the B-TM (317.41 +/- 53.44) and SCD (283.21 +/- 63.27) groups. In addition, it was statistically higher in the B-TM group than the SCD group (P = 0.05). CMT did not differ among the three groups, average RNFL was only significantly thinner in SCD than in controls, and GCC thickness was significantly thinner in SCD than in controls and B-TM.Conclusion: In both diseases, we can show early structural changes even if proliferative or non-proliferative retinopathy or other ocular manifestations were not developed yet. Copyright (C) 2019, Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V.Publication Does smartphone exposure time and smartphone sar value affect ocular surface and refractive error of the dominant eye?(Assoc Research Vision Ophthalmology Inc, 2018-07-01) Kıvanç, Sertaç Argün; Akova-Budak, Berna; Ulusoy, Mahmut Ouz; Karatepe, Arzu Seyhan; Olcaysu, Osman Okan; KIVANÇ, SERTAÇ ARGUN; AKOVA, BERNA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Tıp Bilimleri/Göz Hastalıkları; 0000-0003-0995-5260; AAH-6518-2021; ABE-3033-2020Publication The effect of the linezolid and the vancomycine on biofilm production that formed on two different acrylic hydrophobic intraocular lenses(Assoc Research Vision Ophthalmology Inc, 2015-06-01) Kıvanc, Sertaç Argün; Budak, Berna Akova; Yıldız, Meral; Kıvanç, Merih; KIVANÇ, SERTAÇ ARGUN; Budak, Berna Akova; YILDIZ, MERAL; Uludağ Üniversitesi; 0000-0003-0995-5260; AAH-1885-2021; GNH-1796-2022; ABE-3033-2020; AAH-6518-2021Publication Comparison of two different evaluation methods for biofilm formation of S. epidermidis isolated from ocular surface(Assoc Research Vision Ophthalmology Inc, 2015-06-01) Budak, Berna Akova; Kıvanç, Sertaç Argün; Yıldız, Meral; Kıvanç, Merih; Güllülü, Gülay; Budak, Berna Akova; KIVANÇ, SERTAÇ ARGUN; YILDIZ, MERAL; Uludağ Üniversitesi; 0000-0003-0995-5260; AAH-1885-2021; AAH-6518-2021; ABE-3033-2020Publication Does corneal hysteresis correlate with endothelial cell density?(Int Scientific Literature, 2015-04-29) Akova-Budak, Berna; Kıvanç, Sertaç Argün; AKOVA, BERNA; KIVANÇ, SERTAÇ ARGUN; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0003-0995-5260; AAH-6518-2021; ABE-3033-2020Background: Our aim was to determine if there is a correlation between corneal biomechanical properties, endothelial cell count, and corneal pachymetry in healthy corneas.Material/Methods: Ninety-two eyes of all subjects underwent complete ocular examination, including intraocular pressure measurement by Goldmann applanation tonometer, objective refraction, and slit-lamp biomicroscopy. Topographic measurements and corneal pachymetry were performed using a Scheimpflug-based (Pentacam, Oculus, Germany) corneal topographer. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with an Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Buffalo, NY). Endothelial cell count measurement was done using a specular microscope (CellChek, Konan, USA).Results: Right eye values of the subjects were taken for the study. The mean CH was 11.5 +/- 1.7 mmHg and the mean CRF was 11.2 +/- 1.4 mmHg. Mean intraocular pressure was 15.3 +/- 2.3 mmHg. The mean endothelial cell count was 2754 +/- 205 cells/mm(2). No correlation was found between biomechanical properties of cornea and endothelial cell count. There was a significant positive correlation between CH, CRF, and corneal thickness (p<0.001; r=0.79).Conclusions: The corneal biomechanical properties significantly correlated with corneal thickness. We found no correlation between CH and CRF with the endothelial cell density in normal subjects.Publication Is ciliary muscle affected in migraine patients with aura and without aura?(Int Scientific Information, 2015-01-02) Kıvanç, Sertaç Argün; Ulusoy, Mahmut Oğuz; Akova-Budak, Berna; Olcaysu, Osman Okan; Özcan, Muhammed Emin; KIVANÇ, SERTAÇ ARGUN; AKOVA, BERNA; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0003-0995-5260; AAH-6518-2021; ABE-3033-2020Background: The aim of this study was to compare spherical equivalents (SE) and spherical equivalents with cycloplegic (CSE) values of migraine patients with and without visual aura, with those patients without migraine complaints.Material/Methods: We included patients over the age of 18 years, who had 20/20 uncorrected vision, and who did not have ocular pathology in their examination. The patients were divided into 3 groups: Group 1: 86 eyes of 43 migraine patients without aura, Group 2: 38 eyes of 19 migraine patients with aura, and Group 3: 60 eyes of 30 patients without migraine. Spherical equivalents and spherical equivalents with cycloplegic from the auto-refractometrical values of the patients were compared.Results: The mean age of the migraine and control patients was 34.2 +/- 8.3 and 33.6 +/- 10.8 years, respectively. Forty-three (69%) of 62 migraine patients had migraine without aura and 19 (31%) had migraine with aura. The right and left eyes of the patients were evaluated together and a significant correlation was found between the groups. To evaluate the impact of cycloplegia in patients, SE and CSE values were obtained and differences between these values were evaluated. It was found that the change in Group 2 patients was significantly lower than the change in Group 3 patients (p=0.024).Conclusions: We found that the cycloplegic spherical equivalents values of our patients with aura were lower than control patients. We need further studies to reveal whether migraine with aura is the trigger or the result of those attacks.Publication Association of birth parameters with refractive status in a sample of caucasian children aged 4-17 years(Hindawi, 2015-01-01) Akova Budak, Berna; Kıvanç, Sertaç Argün; Olcaysu, Osman Okan; AKOVA, BERNA; KIVANÇ, SERTAÇ ARGUN; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; 0000-0003-0995-5260; ABE-3033-2020; AAH-6518-2021Purpose. To investigate the association of birth parameters with refractive status in different age groups of Caucasian children. Materials and Methods. This cross-sectional study included 564 eyes of 282 children aged 4 to 17 years. All children underwent complete ophthalmologic examination. The children were divided into three groups according to their refractive status (emmetropia, myopia, and hyperopia), ages (4-7, 8-9, 10-12, and 13-17), and appropriateness for gestational age, respectively. Results. The mean age of the children was 9.2 +/- 2.8 (age range 4-17 years). The mean spheric equivalent was +0.3 +/- 1.7 (range: (-10.0)(+10.0) diopters). The mean birth weight and gestational age were 2681.1 +/- 930.8 grams (750-5000 grams) and 37.2 +/- 3.7 weeks (25-42 weeks). According to multinominal logistic regression analysis, children with myopia were more likely to have higher birth weights than emmetropic children (OR: 1.0, 95% CI: 1.000-1.001, and P = 0.028). The hypermetropes were found to be significantly small for gestational age between 13 and 17 years of age. Conclusion. Birth weight and appropriateness for gestational age as birth parameters may have an impact on development of all types of refractive errors. The hypermetropic children tended to be small for gestational age.