Person: SAPAN, NİHAT
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Publication Cftr mutations unidentified in cftr2 database and their phenotypic characteristics: Data from cystic fibrosis registry of Turkey(European Respiratory Soc Journals Ltd, 2020-09-07) Cinel, Güzin; Dogru, Deniz; Çakir, Erkan; Eyüboğlu, Tuğba Şişmanlar; Çobanoğlu, Nazan; Pekcan, Sevgi; Yalçın, Ebru; Kiper, Nural; Sen, Velat; Sen, Hadice Selimoğlu; Ercan, Ömür; Keskin, Özlem; Eltan, Sevgi Bilgiç; Al Shadfan, Lina Muhammed; Yazan, Hakan; Altıntaş, Derya Ufuk; Sasihüseyinoğlu, Şenay; Cokugras, Haluk; Atabek, Ayşe Ayzıt; Gürsoy, Tuğba Ramaşlı; Aslan, Ayşe Tana; Bingol, Aysen; Başaran, Abdurrahman Erdem; Özdemir, Ali; Köse, Mehmet; Hangül, Melih; Emiralioğlu, Nagehan; Tuğcu, Gökçen; Yüksel, Hasan; Yılmaz, Özge; Orhan, Fazıl; Aydın, Zeynep Gokçe Gayretli; Topal, Erdem; Tamay, Zeynep; Can, Demet; Bal, Cem Murat; Çaltepe, Gönül; Özçelik, Uğur; Sapan, Nihat; SAPAN, NİHAT; Çekiç, Sükrü; ÇEKİÇ, ŞÜKRÜ; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-9574-1842; L-1933-2017; FUI-8766-2022Publication The prevalence of reactions related to insect (hymenoptera) stings in children(Galenos Yayınevi, 2020-12-10) Canıtez, Yakup; Sapan, Nihat; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Anabilim Dalı.; 0000-0001-8929-679X; 0000-0002-7601-8392; CJQ-2060-2022; FUI-8766-2022INTRODUCTION: There has a few number of studies in children that looked for the prevalence of reactions caused by insect (hymenoptera) stings. This study was planned with the aim of investigating the prevalence of systemic, large local and local reactions due to hymenoptera stings in the general population in children.MATERIALS and METHODS: In this study, four different schools in Bursa city center and its villages were selected for research by random sampling method. A total of 3243 children in the 6-15 age group were evaluated using the questionnaire method in the study.RESULTS: Of the children, 1714 (52.9%) were boys and 1529 (47.1%) were girls. The mean age was 9.80.0,04 years. The number of children who were stung at least once in their lifetime was 1992 (61.4%), and the number of children who were stung in the last 12 months was 711 (21.9%). The frequency of reactions due to hymenoptera stings in the study population (lifetime prevalences), systemic reaction in 9 children (0.3%), large local reaction in 19 children (0.6%), local reaction in 1964 children (60.5%) were found. There were higher numbers of lifetime hymenoptera sting and rates of systemic or large local reactions in boys compared to girls (p<0,001, p<0,05, p<0,01 respectively).CONCLUSIONS: In our region, children between the ages of 6-15 frequently encounter hymenoptera stings. Since reactions due to hymenoptera stings occur at certain rates, it would be appropriate to consider these data in terms of defining possible reactions and approach.Publication Retrospective evaluation of cases with cow's milk allergy(Bursa Uludağ Üniversitesi, 2021-12-01) Efe, Hülya Poyraz; Canıtez, Yakup; Sapan, Nihat; Efe, Hülya Poyraz; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Anabilim Dalı; 0000-0001-8929-679X; 0000-0002-2226-7035; 0000-0002-7601-8392; AAH-1789-2021; CPN-6371-2022; FUI-8766-2022Introduction: Cow's milk allergy (CMA) is described as immunological reaction against to one or more milk proteins. It is known that CMA which affects about 1-3% of the general population is the most commonly seen food allergy in infants and children. It is well known that a tolerance develops and prognosis is better during the first three years of the life. In the present study, we aimed to investigate the natural course of cases diagnosed with CMA and to determine the factors which have impact on the tolerance development.Materials and Methods: Medical records of cases who have been followed for CMA were retrospectively reviewed. Gender, age at first symptom, breastfeeding duration, family atopy history, multiple food allergies, concomitant allergic diseases, inhalant allergy sensitivity and clinical manifestation of cases were assessed. Also, prick test results, milk-specific IgE, casein-specific IgE and the reactions that developed during food challenge test were evaluated.Results: The age at first symptom was mean 4 +/- 2,3 months. Twenty-two percent of patients had a positive family history of atopy and 30% had multiple food allergies. There were concomitant allergic disorders in 58% of patients. Skin (93.8%), gastrointestinal system (GIS) (24.7%) and respiratory system (18.5%) symptoms were most commonly seen. The percentage of tolerance development by the years was determined as 41% for the first year, 64% for the second year and 75% for the third year. Milk-specific IgE level at the time of diagnosis (p=0.010) and asthma presence (p=0.010) were found significant risk factors for persistent CMA.Conclusion: Clinical parameters and allergy tests may help to predict the prognosis of CMA. Milk-specific IgE level at the time of diagnosis is the risk factor for persistent CMA.Publication Knowledge levels of mothers of asthmatic children about asthma(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2020-01-01) Çekiç, Şükrü; ÇEKİÇ, ŞÜKRÜ; Canıtez, Yakup; CANITEZ, YAKUP; Küçüker, Hakan; KÜÇÜKER, HAKAN; Karali, Yasin; KARALI, YASİN; Çiçek, Fatih; ÇİÇEK, FATİH; Sapan, Nihat; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017Objective: Compliance of the family with asthma treatment is one of the main factors determining the success of treatment. This study aimed to investigate the knowledge level of the mothers with asthmatic children about symptoms, diagnosis and treatment of asthmaMethod: A questionnaire consisting of 42 questions was used in the study. The questionnaire was composed of questions prepared by us and adapted from a validated asthma knowledge level questionnaire. Each correct answer was evaluated as 2.38 points. Those receiving 67.7 points above were considered sufficient.Results: 323 mothers of children with asthma were included in the study. None of the mothers answered all the questions correctly among. The total mean score of the mothers was 57.8 +/- 11.9 (median: 58.5, minimum: 26.8, maximum: 87.8). The median scores of the mothers who graduated from university (median: 65.9, minimum: 36.6, maximum: 85.4) was higher than those who graduated from primary school (median: 53.7, minimum: 29.3, maximum: 87.8), middle school (median: 58.5, minimum: 29.3, maximum: 78) and high school (median: 61, minimum: 26.8, maximum: 80.5) (p<0.001, p<0.001 and p=0.003). The median score of working mothers (median: 65.9, minimum: 34.1, maximum: 87.8) was higher than those who were housewives (median: 56.1, minimum: 26.8, maximum: 87.8) (p<0.001). The median score of mothers who breastfed for more than six months (median: 61, minimum: 29.3, maximum: 87.8) was higher compared to those who breastfed less than six months (median: 56.1, minimum: 26.8, maximum: 85.4) (p=0.005).Conclusion: Education levels of the mothers and being a working mother were significant factors affecting the level of asthma knowledge among mothers.Publication The effect of allergen immunotherapy on the development of new sensitization in children(Aves, 2021-07-01) Çekiç, Şükrü; Canıtez, Yakup; Çiçek, Fatih; Ocakoğlu, Gökhan; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; ÇİÇEK, FATİH; OCAKOĞLU, GÖKHAN; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı; 0000-0002-9574-1842; 0000-0002-1114-6051; 0000-0001-8929-679X; 0000-0001-7348-7081; L-1933-2017; AAH-5180-2021; AAH-1789-2021; JKI-5906-2023; FUI-8766-2022Aim: The protective effect of allergen immunotherapy against a new allergic sensitization is controversial. This study aimed to investigate the effect of allergen immunotherapy on new allergic sensitization in children.Materials and Methods: The study included 50 patients who received immunotherapy for at least 3 years, and whose skin prick tests were repeated at intervals of at least 3 years (31 patients for house dust mite immunotherapy, 19 patients for pollen immunotherapy), and 69 controls with similar characteristics.Results: The number of patients who developed a new sensitization was similar both in the groups of patients who received house dust mite and pollen immunotherapy, and the control group. There was no significant difference between the first and last skin prick tests of the patients who received house dust mite and pollen immunotherapy; however, in the control groups, a significant increase in sensitivity to tree pollens (n = 2, 5.4%; n = 8, 21.6%) and weed pollens (n = 7, 26.9%; n = 14, 53.8%) was detected (P = .031 and P = .039). While allergen sensitivities in the first tests of the pollen immunotherapy group and the control group were similar, weed pollen sensitivity was significantly higher in the last tests of the control group (n = 14, 53.8%; n = 4, 21.1%, P = .027). It was determined that the presence of weed pollen sensitization (OR: 8.1, 95% CI: 1.5-42.4) and having asthma (OR: 3.5, 95% CI:1.3-10.8) increases the risk of new sensitization in all groups.Conclusion: Allergen immunotherapy has been found to protect against new sensitization to tree and weed pollens. However, this effect was insignificant in the multivariate analysis. Weed pollen sensitization and the presence of asthma are related to the development of new sensitization.Publication Proven food-induced acute urticaria and predictive factors for definitive diagnosis in childhood(Karger, 2021-02-18) Aydoğan, Metin; Topal, Erdem; Uysal, Pınar; Acar, Hazal Cansu; Cavkaytar, Özlem; Demirkale, Zeynep Hızlı; Aydoğmuş, Çiğdem; Yakıcı, Nalan; Aydemir, Sezin; Akkelle, Emre; Şimşek, Işıl Eser; Kaplan, Fatih; Arga, Mustafa; Yücel, Esra; Çoğurlu, Mujde Tuğba; Erdoğan, Mehmet Sarper; Tamay, Zeynep; Güler, Nermin; Yeşil, Yakup; Çekiç, Şükrü; Sapan, Nihat; Çokuğraş, Haluk; Kıykım, Ayça; Günaydın, Nursen Ciğerci; Tuncel, Tuba; Orhan, Fazıl; Özdemir, Öner; Özdemir, Cevdet; ÇEKİÇ, ŞÜKRÜ; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji ve İmmünoloji Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017; FUI-8766-2022Background: Urticaria can be the only sign of a food allergy or can be seen together with other signs and symptoms of a food allergy. Objective: To determine the demographic, etiologic, and clinical features of food-induced acute urticaria in childhood. Methods: Patients suspected of food-induced acute urticaria were included in this prospective cross-sectional multicenter study. Results: Two hundred twenty-nine urticaria cases were included in this study. Seventeen patients who did not meet the inclusion criteria of the study were excluded. Of the 212 included cases, 179 (84.4%) were diagnosed with definitive food-induced acute urticaria. The most common foods causing acute urticaria were cow's milk, hen's eggs, and nuts in 56.4, 35.2, and 19% of cases, respectively. The positive predictive value of a history of milk-induced acute urticaria together with a milk-specific IgE >5 kU/L for cow's milk-induced acute urticaria was 92% (95% CI: 81-96%). A history of cow's milk-induced and/or hen's egg-induced acute urticaria was consistent with a definitive diagnosis of food-induced urticaria (Chen's kappa: 0.664 and 0.627 for milk and eggs, respectively). Urticaria activity scores were higher in patients with food-induced acute urticaria (p = 0.002). Conclusion: Cow's milk, hen's eggs, and nuts were the most common allergens in the etiology of childhood food-induced acute urticaria. Although the urticaria activity score provides guidance for diagnosis, an oral food challenge is often essential for the definitive diagnosis of a patient with a history of food-induced acute urticaria.Publication The impact of the Covid-19 pandemic in adolescents with asthma(Korean Acad Medical Sciences, 2021-12-20) Çekiç, Şükrü; Karali, Zuhal; Çiçek, Fatih; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, ZUHAL; ÇİÇEK, FATİH; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı; 0000-0002-9574-1842; 0000-0001-7348-7081; 0000-0001-8929-679X; JKI-5906-2023; AAH-1789-2021; L-1933-2017; CZC-9168-2022; FUI-8766-2022Background: The coronavirus disease 2019 (COVID-19) pandemic is affecting people at any age and there is limited information about the effect of the COVID-19 pandemic on quality of life (QoL) in adolescents with asthma. In the present study, it was aimed to assess the attitudes of adolescents with asthma toward the COVID-19 pandemic and determine the effects of the pandemic on their QoL. Methods: In total, 125 adolescents with asthma and 98 healthy adolescents participated in the present study. The questionnaire form consisted of three parts. In the first part, all the participants were asked whether they complied with the protective measures against COVID-19. The second part included questions for measuring the participants' level of concern about COVID-19, while the third part consisted of EUROHIS-QOL 8. Results: The patient and control groups were similar in terms of the female/male ratio (55/70 and 48/50, respectively) and mean participant age (14.6 +/- 2 and 15.1 +/- 1.65 years, respectively) (P = 0.459 and P = 0.062, respectively). The prevalence of COVID-19 in the patients (n = 2, 1.6%) was lower than that in the controls (n = 6, 6.1%); however, the difference was not statistically significant (P = 0.142). The total EUROHIS-QOL score was significantly lower in the patients (31.2 +/- 6.7) than in the controls (33.7 +/- 4.4) (P < 0.001). The total QoL scores of asthmatic adolescents without other allergic disease (31.4 +/- 6.7) was also lower than those of the controls (33.7 +/- 4.4) (P = 0.009). Treatment disruption was significantly more common in patients who received subcutaneous immunotherapy (n = 20, 48.8%) than in those who did not (n = 8, 9.5%) (P < 0.001). Moreover, the patients had lower EUROHIS-QOL scores in the overall QoL, general health, finance, and home domains. Conclusion: Our results indicate that the mean QoL score of asthmatic adolescents during COVID-19 pandemic is lower than in the healthy population. Disruption in their treatment was most common in patients with asthma who were receiving subcutaneous immunotherapy.Publication Omalizumab treatment in childhood chronic urticaria(Wiley, 2018-08-01) Çekiç, Şükrü; Karali, Yasin; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, YASİN; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri ve Alerji Bölümü; 0000-0002-9574-1842; L-1933-2017; FFS-1974-2022; CJQ-2060-2022; FUI-8766-2022Publication Evaluation of the patients diagnosed with stevens johnson syndrome and toxic epidermal necrolysis: A single center experience(Aves, 2016-09-01) Çekiç, Şükrü; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; SAPAN, NİHAT; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı,/Çocuk Alerji Bilim Dalı; 0000-0002-9574-1842; 0000-0001-8929-679X; AAH-1789-2021; L-1933-2017Aim: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years.Material and Methods: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludag University School of Medicine were included in this study. Clinical findings, laboratory tests and response to treatments were evaluated via electronic files.Results: Two of the patients had Stevens-Johnson syndrome, four had Stevens-Johnson syndrome/toxic epidermal necrolysis overlap, and five had toxic epidermal necrolysis. The median period for drug usage was 10 days (2-44 days). Herpes simpleks virus IgM antibody was detected two patients. The median healing time was 38 days 26-94 days). Maculopapular eruptions and oral mucositis were seen in all patients. Vesicul or bullae, epidermal detachment and ocular involvement in 10 of patients. Wound care, H1 antihistamine and methyl prednisolon were used in all patients, intravenous immunoglobulin were used in 7 patients and cyclosporine in 1 patient. Sequel lesions developed in 2 of the patients and there was no death.Conclusion: Anticonvulsants, antibiotics and non steroid anti-inflammatory drugs play a major role in the etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis. Anticonvulsants are associated with severe disease. The patients with proper wound care and treatment with immunosuppressive drugs can be recovered without or with minimal sequelae.Publication Airborne pollen grains of Turkey(Bilimsel Tip Yayinevi, 2009-01-01) Bıçakçı, Adem; BIÇAKÇI, ADEM; CANITEZ, YAKUP; Altunoğlu, Mustafa Kemal; Bilişik, Aycan; Çelenk, Sevcan; ÇELENK, SEVCAN; SAPAN, NİHAT; Sapan, Nihat; Malyer, Hulusi; MALYER, HULUSİ; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-6333-3123; 0000-0003-4925-8902; O-1244-2018; K-2981-2012In this evaluation, the results of aeropalynological studies carried out for 49 regions of Turkey have been assessed. The most common and greatest amounts of pollens in the atmosphere of Turkey were Cupressaceae, Pinus and Gramineae. The highest amount for pollen grains was recorded between March and June.
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