Kişi: ŞİMŞEK, ABDURRAHMAN
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ABDURRAHMAN
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ŞİMŞEK
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Yayın Sadece Metadata The age-dependent role of Th22, Tc22, and Tc17 cells in the severity of pneumonia in COVID-19 immunopathogenesis(Wiley, 2021-08) Şimşek, Abdurrahman; Çağan, Eren; Kızmaz, Muhammed Ali; Dombaz, Fatma; Tezcan, Gülçin; Asan, Ali; Demir, H. İbrahim; Bal, S. Haldun; Ermiş, Diğdem Yoyen; Demirdöğen, Ezgi; Heper, Yasemin; Akalın, E. Halis; Oral, Haluk Barbaros; Budak, Ferah; ŞİMŞEK, ABDURRAHMAN; TEZCAN, GÜLÇİN; BAL, SALİH HALDUN; DEMİRDÖĞEN, EZGİ; BUDAK, FERAH; HEPER, YASEMİN; AKALIN, EMİN HALİS; Kızmaz, Muhammed Ali; Dombaz, Fatma; YÖYEN ERMİŞ, DİĞDEM; ORAL, HALUK BARBAROS; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-8850-0269; 0000-0001-5334-7911; 0000-0001-7288-3250; 0000-0002-5956-8755; 0000-0002-7400-9089; 0000-0001-7625-9148; AAG-7381-2021; HKN-2347-2023; DWR-5356-2022; KBR-5535-2024; GYL-2038-2022; AAH-9812-2021; CTY-9474-2022; AAU-8952-2020; IZP-9398-2023; K-7285-2012; AAH-3843-2020Yayın Sadece Metadata Relationship of exosome profile with acute and chronic inflammation in brucellosis(Wiley, 2021-08-01) Şimşek, Abdurrahman; Kızmaz, Muhammed Ali; Ellergezen, Pınar Hız; Bal, Salih Haldün; Bozkurt, Tuğçe; Akalın, Emin Halis; Oral, Haluk Barbaros; Yılmaz, Özer; Budak, Ferah; ŞİMŞEK, ABDURRAHMAN; Kızmaz, Muhammed Ali; Ellergezen, Pınar Hız; BAL, SALİH HALDUN; Bozkurt, Tuğçe; AKALIN, EMİN HALİS; ORAL, HALUK BARBAROS; YILMAZ, ÖZER; BUDAK, FERAH; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon ve Klinik Mikrobiyolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0001-8850-0269; 0000-0001-5334-7911; 0000-0001-5144-091X; 0000-0001-7530-1279; 0000-0003-0463-6818; 0000-0001-7625-9148; IZP-9398-2023; K-7285-2012; AAG-7381-2021; HKN-2347-2023; AAU-8952-2020; F-4657-2014; CPH-1647-2022; KBR-5535-2024; KLE-8588-2024; EHB-5539-2022Yayın Sadece Metadata The prevalence of hla-b*57 serotype associated with hypersensitivity reactions in the treatment of hiv i̇nfection in the Turkish population(Bentham Science, 2023-01-01) Kizmaz, Muhammed Ali; Simsek, Abdurrahman; ŞİMŞEK, ABDURRAHMAN; Aymak, Figen; Akalin, Emin Halis; AKALIN, EMİN HALİS; Budak, Ferah; BUDAK, FERAH; Oral, Haluk Barbaros; ORAL, HALUK BARBAROS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Immunoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0001-7530-1279; 0000-0003-0463-6818; 0000-0001-7625-9148; HKN-2347-2023; K-7285-2012Objectives The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish population and to provide new perspectives to physicians starting abacavir therapy in HIV patients.Background Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions in some patients. These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele. High-resolution HLA-B*57:01 scanning has a time and cost disadvantage compared with low-resolution HLA-B*57 scanning. Before starting abacavir treatment, we will discuss whether high-resolution scanning is more beneficial in individuals who are positive on HLA-B*57 screening. This is the study with the largest cohort to investigate the prevalence of HLA-B*57 in Turkey.Methods The results of 25 thousand 318 people who applied to Bursa Uludag University Faculty of Medicine, Department of Immunology for HLA-B* typing were scanned.Results In our study, the HLA-B*57 serotype was detected in 827 (3.3%) individuals.Conclusion Considering these results, it can be assumed that the prevalence of HLA-B*57:01 in Turkey is lower than 3.3%. Instead of a high-resolution HLA-B*57:01 scan in all patients starting abacavir therapy, a high-resolution HLA-B*57:01 scan might be of greater benefit in patients who are positive on a low-resolution HLA-B*57 scan.