Person: KAYA, EKREM
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KAYA
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EKREM
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Publication Does liver transplant improve neurological symptoms in wilson disease? report of 24 cases(Başkent Üniversitresi, 2022-11-01) Aksoy, Fuat; Arslan, İbrahim Ethem; Özgür, Taner; Dündar, Halit Ziya; Çelik, Fatih; Demir, Aylin Bican; Özbek, Sevda Erer; Kıyıcı, Murat; Özkan, Tanju Başarır; Kaya, Ekrem; AKSOY, FUAT; Arslan, İbrahim Ethem; ÖZGÜR, TANER; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; BİCAN DEMİR, AYLİN; ERER ÖZBEK, ÇİĞDEM SEVDA; KIYICI, MURAT; Özkan, Tanju Başarır; KAYA, EKREM; Tıp Fakültesi; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0002-9245-1241; 0000-0001-6739-8605; HII-8895-2022; ABD-3885-2020; AAG-7319-2021; FPE-9941-2022; EWI-3634-2022; JKN-9078-2023; KHB-9765-2024; DLN-1836-2022; FHW-0015-2022; JKL-3648-2023Objectives: Wilson disease is an inherited disorder that results in copper accumulation in the tissues with liver injury and failure. Orthotopic liver transplant is one of the treatments of choice for this disease. The aim of this study was to compare the neurological symptoms, before and after orthotopic liver transplant, of patients with liver cirrhosis due to Wilson disease, who represent a special group of patients with liver failure. Materials and Methods: Between 2007 and 2020, there were 24 patients with Wilson disease resistant to medical treatment who underwent deceased donor orthotopic liver transplant and were followed up for 1 year, 5 years, and 10 years for evaluation with neurological scoring systems. Patients were also evaluated for postoperative complications and survival. Results: Of the 24 patients evaluated, there were 13 (54.2%) female patients and 11 (45.8%) male patients, and the mean age was 34 years (range, 14-57 years). One of the patients died from early postoperative sepsis. After orthotopic liver transplant, disease scores returned to normal in 16 patients and improved in the remaining patients. Before transplant, all patients required help in their daily activities. After transplant, there were significant improvements in some symptoms, and the patients became more independent in their daily lives. Conclusions: Our study shows that orthotopic liver transplant provides significant improvement in neurological symptoms and quality of life in patients with Wilson disease.Publication Long non-coding rna hulc overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation(Wiley, 2021-08-01) Aksoy, Fuat; Kaya, Ekrem; Aksoy, Seçil Ak; Dündar, Halit Ziya; Tunca, Berrin; AKSOY, FUAT; KAYA, EKREM; Aksoy, Seçil Ak; DÜNDAR, HALİT ZİYA; TUNCA, BERRİN; Bursa Uludağ Üniversitesi; 0000-0001-5808-9384; 0000-0002-1619-6680; HII-8895-2022; ADM-8457-2022; AAG-7319-2021; EWI-3634-2022; ABI-6078-2020Publication Proteomic analysis of liver preservation solutions prior to liver transplantation(Bentham Science Publ Ltd, 2019-01-01) Coşkun, Abdurrahman; Baykal, Ahmet Tarık; Öztuğ, Merve; Kazan, Dilek; Emiroğlu, Remzi; Yılmaz, Sezai; Akgöz, Müslüm; Berber, İbrahim; Aktaş, Hikmet; Bilsel, Gökhan; Karaosmanoğlu, Kübra; Çetiner, Banu; Arslan, Cansu; Yurtsever, İlknur; Yazıcı, Cevat; Kaya, Ekrem; KAYA, EKREM; Dundar, Halit Ziya; DÜNDAR, HALİT ZİYA; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; 0000-0002-9562-4195; EWI-3634-2022; AAG-7319-2021Objective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period.Material/Methods: Samples were collected from the pre-transplant preservation mediums of 23 liver donors. For all donors, the cases involved Donation after Brain Death (DBD). 2D-PAGE and LCMSMS methodologies were used to detect the proteins and peptides from the preservation mediums.Results: A total of 198 proteins originating from the liver were detected.Conclusion: The data provide valuable insights into biomarkers that may be used to evaluate organ injury, functional status, and suitability for transplantation. Additionally, the findings could be valuable for the development of new strategies for effective preservation of solid organs prior to transplantation.Publication Is donor age an important factor in cadaveric organ donation?(Aves, 2018-09-01) Dündar, Halit Ziya; Oflaz, Rafet; Çınar, Yavuz Selim; Sarkut, Pınar; Özkan, Ömer Faruk; Kaya, Ekrem; DÜNDAR, HALİT ZİYA; Oflaz, Rafet; Çınar, Yavuz Selim; Sarkut, Pınar; KAYA, EKREM; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; AAG-7319-2021; JIK-5424-2023; DJU-5362-2022; JJX-5826-2023; HKB-5363-2023Introduction: Our liver transplantion center has determined that the organ donation rate is low in young donors. The goal of study was to investigate whether this observation was valid and the causes for rejecting organ donation among family members of young donors.Methods: The brain death declaration and organ donation rates were analyzed during the study period. The relationship between the organ donation and donor's age was investigated, and factors related to refusing organ donation were also analyzed. A questionnaire including 10 questions was prepared for family members of brain-dead patients, who rejected organ donation. The study was conducted by phone, and conversations were recorded.Results: Including the years between 2011 and 2015, there was a total of 750 brain death declarations, and 508 of the patients did not approve organ donation. The donor rate under 30 years was lower as compared to the elderly patients (23.8% vs. 32.9%, p=0.026). The most common reasons for refusing organ donation were religious in nature and the anxiety about the corruption of bodily integrity. Sixty-two percent of family members who refused organ donation declared that they would have accepted organ donation if the donor declared accepting organ donation when he or she was alive.Conclusion: For family members of patients who deceased at young ages emotional attitudes are very important about the decision of organ donation. The testament of person about organ donation is the most important factor affecting the decision of family members.Publication Clinical features and short-term outcomes of bariatric surgery in morbidly obese patients: Institutional experience at a rural hospital(Mary Ann Liebert, Inc, 2021-03-01) Şenol, Kazım; Ferhatoğlu, Murat Ferhat; Kocaeli, Aysen Akkurt; Dündar, Halit Ziya; Kaya, Ekrem; ŞENOL, KAZIM; DÜNDAR, HALİT ZİYA; KAYA, EKREM; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; 0000-0002-9562-4195; FVY-2168-2022; EWI-3634-2022; AAG-7319-2021Objective: To prospectively evaluate the postoperative morbidity, mortality, and weight loss evolution of patients who underwent a bariatric procedure during 1 year of follow-up.Methods: Since July 2016, a total of 101 patients' data have been prospectively registered in a database. Comorbidities, operating time, hospital stay, early and late complications rate, and weight loss evolution after 1 year of follow-up were recorded.Results: The mean age was 38.41 +/- 11.05 years with a mean body mass index (BMI) of 49.02 +/- 5.89 kg/m(2) (range 38-67). Laparoscopic sleeve gastrectomy (LSG) was performed in 93 patients (92.07%) and Roux-en-Y gastric bypass (RNYGB) in 8 patients (7.92%). Thirty-day morbidity rate was 7.92% (8/101). Within a mean 9.32 +/- 2.25 (range 1-19) months follow-up time, mean percent of the excess of weight loss of 1st, 6th, and 12th months were 22.7 +/- 6.1, 67.2 +/- 11.2, and 81.4 +/- 10.5, respectively. Diabetes (n = 38, 37.6%), hypertension (n = 13, 12.9%), and obstructive sleep apnea (n = 5, 4.9%) were resolved in 76%, 68.4%, and 100% of the patients, respectively (p < 0.001).Conclusions: LSG and RNYGB are safe and highly effective, particularly in patients with a BMI >50 kg/m(2). Both techniques have been presented with better clinical outcomes regarding significant comorbidity resolution in the early evolution of weight loss.Publication Blood-based biomarkers in Afp normal/stable hepatocellular carcinoma: Diagnostic and prognostic relevance of Mir-10b for patients on liver transplant list(Elsevier Science Inc, 2022-09-01) Aksoy, Fuat; Aksoy, Seçil Ak; Dündar, Halit Ziya; Tunca, Berrin; Erçelik, Melis; Tekin, Çağla; Kıyıcı, Murat; Selimoğlu, Kerem; Kaya, Ekrem; AKSOY, FUAT; Aksoy, Seçil Ak; DÜNDAR, HALİT ZİYA; TUNCA, BERRİN; Erçelik, Melis; Tekin, Çağla; KIYICI, MURAT; Selimoğlu, Kerem; KAYA, EKREM; İnegöl Meslek Yüksekokulu; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0003-3635-7282; 0000-0002-3760-9755; 0000-0002-9562-4195; HII-8895-2022; ADM-8457-2022; EWI-3634-2022; ABI-6078-2020; EUG-3329-2022; JIT-9986-2023; FHW-0015-2022; CDS-3299-2022; AAG-7319-2021Background. As a diagnostic criteria of hepatocellular carcinoma (HCC), the exact threshold of alpha-fetoprotein (AFP) is controversial. In additional, not all HCC tumors are AFP positive or secrete elevated amounts of AFP into the serum. However, the diagnosis of HCC is quite important on the liver transplant list. Therefore, the purpose of this study was to investigate the expression of circulating micro RNAs (miRNAs) in AFP-stable HCC patients. Thus, we aimed to determine a diagnostic biomarker in these patients.Methods. Sixteen miRNAs were evaluated using a real-time quantitative reverse transcription polymerase chain reaction system in AFP-stable HCC and AFP-trending HCC patients.Results. In our study, 46.7% (n = 28) of the patients diagnosed with HCC had stable/normal AFP levels. We detected that high expression of miR-24, miR-10b and the low expression of miR-143 were independently and significantly associated with HCC in AFP-stable compared with AFP trending (P <.05). Additionally, we demonstrated that the overexpression of miR-10b was associated with poor disease-free survival in HCC (P = 0.001).Conclusions. Although more clinical validations are needed for the diagnosis of HCC, our current results indicate that the coexistence of high expression of miR-10b and miR-24 may help clinicians adjust in the diagnosis of HCC in patients who are on the liver transplant list but awaiting biopsy for the diagnosis of HCC.Publication Internal versus external biliary drainage in malignant biliary obstructions: Is there a difference in the rate of infection?(Sage Publications Ltd, 2023-08-23) Öngen, Gökhan; Nas, Ömer Fatih; Hacıkurt, Kadir; Dündar, Halit Ziya; Özkaya, Güven; Kaya, Ekrem; Hakyemez, Bahattin; ÖNGEN, GÖKHAN; NAS, ÖMER FATİH; ÖZKAYA, GÜVEN; KAYA, EKREM; HAKYEMEZ, BAHATTİN; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; 0000-0002-3425-0740 ; 0000-0002-9562-4195; FQR-8472-2022; JJS-3965-2023; IVU-2672-2023; AAG-7319-2021; AAI-2318-2021Background: Percutaneous biliary drainage is a frequently used method to provide biliary decompression in patients with biliary obstruction.Purpose: To investigate the between drainage type and infection risk in patients treated with internal-external and external biliary drainage catheterization for malignant biliary obstruction.Material and Methods: A total of 410 patients with malignant biliary obstruction who underwent internal-external or external biliary drainage catheterization between January 2012 and October 2016 were retrospectively evaluated. We investigated the correlation between percutaneous biliary drainage technique and infection frequency by evaluating patients with clinical findings, bile and blood cultures, complete blood counts, and blood biochemistry.Results: There was no statistically significant difference between the selected patient groups (internal-external or external biliary drainage catheter placed) in terms of age, sex, primary diagnosis, receiving chemotherapy, catheter sizes, and outpatient-patient status. After catheterization, catheter-related infection was observed in 49 of 216 (22.7%) patients with internal-external and 18 of 127 (14.2%) patients with external biliary drainage catheters, according to the defined criteria. There was no difference in infection rate after the biliary drainage in the two groups (P > 0.05). There was also no difference concerning frequently proliferating microorganisms in bile cultures.Conclusion: Internal-external biliary drainage catheter placement does not bring an additional infection risk for uninfected cholestatic patients whose obstruction could be passed easily in the initial drainage.Publication Effect of locoregional treatments in hepatocellular carcinoma: What are the pathologic/radiologic Milan Criteria?(Başkent Üniversitesi, 2023-10-01) Aksoy, Fuat; Dündar, Halit Ziya; Çelik, Fatih; Öngen, Gökhan; Nas, Ömer Fatih; Sağlam, Kutay; Gürlüler, Ercüment; Kıyıcı, Murat; Kaya, Ekrem; AKSOY, FUAT; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; ÖNGEN, GÖKHAN; NAS, ÖMER FATİH; SAĞLAM, KUTAY; GÜRLÜLER, ERCÜMENT; KIYICI, MURAT; KAYA, EKREM; Tıp Fakültesi; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; EWI-3634-2022; JYY-5340-2024; FQR-8472-2022; JJS-3965-2023; JSD-3843-2023; FHW-0015-2022; JSF-3184-2023Objectives: Milan criteria is the most commonly used criteria for patients with hepatocellular carcinoma awaiting liver transplant. The effects of locoregional therapy on downstaging or bridging before liver transplant on survival remain controversial. Considering that the tumor size may change with locoregional therapy and formalin fixation after explantation, we aimed to evaluate the effects of locoregional therapy on radiological and pathological Milan criteria and survival.Materials and Methods: Demographic data, etiology, preoperative alpha-fetoprotein value, Child-Pugh and Model for End-Stage Liver Disease-Na scores, status of being inside or outside of radiological Milan criteria, status of being inside or outside of Milan criteria in explant (pathological Milan criteria), and the locoregional therapy types and combinations were evaluated for their effects on inclusion in Milan criteria and survival.Results: During the study period, 396 patients underwent liver transplant at our center, with 97 because of cirrhosis and hepatocellular carcinoma. When we viewed patients according to preoperative radiologic evaluations, 67.9% were within Milan criteria and 32.1% were outside. When we viewed according to explant (pathological) evaluations, 80.7% of patients were within Milan criteria. Among 97 patients, 71 (73.2%) had locoregional therapy (22 [30.9%] for downstaging, 49 [69.0%] for bridging to transplant), and 12 patients (12.3%) were within Milan criteria on explant examination while outside of Milan criteria before LT. One-year, 3-year, and 5-year survival rates were 80.7%, 76.1%, and 71.6%, respectively. Conclusions: As a result of radiological evaluations, in patients who were outside of Milan criteria and underwent locoregional therapy, explant pathology within Milan criteria had a positive effect on survival; however, after locoregional therapy, there was no significant effect on survival in patients who were still outside of Milan criteria.Publication Recurrent hepatocellular carcinoma after liver transplantation: Identifying the high-risk patient using the expression profiles of emt-associated lncrnas(Frontiers Media Sa, 2019-10-01) Aksoy, Seçil Ak; Aksoy, Fuat; Dündar, Haliz Ziya; Tunca, Berrin; Taşar, Pınar; Uğraş, Nesrin; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; Aksoy, Seçil Ak; AKSOY, FUAT; Dündar, Haliz Ziya; TUNCA, BERRİN; TAŞAR, PINAR; UĞRAŞ, NESRİN; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; KAYA, EKREM; Tıp Fakültesi; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; AAH-8540-2021; AAG-7319-2021; AAP-9988-2020; ABI-6078-2020; AAH-1420-2021; AAH-2716-2021; HII-8895-2022; EGD-8703-2022; IIC-9825-2023Publication Turkish HPB surgery association consensus report on hepatic cystic echinococcosis (HCE)(Türk Cerrahi, 2022-06-01) Özturk, Gürkan; Uzun, Mehmet Ali; Özkan, Ömer Faruk; Kayaalp, Cüneyt; Tatlı, Faik; Eren, Suat; Aksungur, Nurhak; Çökert, Ahmet; Bostanci, Erdal Birol; Oter, Volkan; Kaya, Ekrem; Taşar, Pınar; KAYA, EKREM; TAŞAR, PINAR; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; 0000-0002-2378-0666; 0000-0002-9562-4195; AAG-7319-2021; IIC-9825-2023Objective: Cystic Echinococcosis (CE) is one of the important problems of the Eurasian region. We aimed to prepare a consensus report in order to update the treatment approaches of this disease. This study was conducted by Turkish HPB Surgery Association.Material and Methods: This study was conducted with the modified Delphi model. For this purpose, we conducted a three-stage consensus-building approach.Results: Six topics, including diagnosis, medical treatment, percutaneous treatment, surgical treatment, management of complications and posttreatment follow-up and recurrences in HCE were discussed.Conclusion: The expert panel made recommendations for every topic.
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