Person: UĞRAŞ, NESRİN
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UĞRAŞ
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NESRİN
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Publication The expression and relationship of adipo R1/R2 in gastric intestinal metaplasia(Wolters Kluwer Medknow Publications, 2021-04-01) Ayyildiz, T.; Erturk, B.; Dolar, E.; DOLAR, MAHMUT ENVER; Ugras, N.; UĞRAŞ, NESRİN; Dizdar, O. S.; Adim, S. B.; Yerci, O.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroentoloji Anabilim Dalı.; D-6213-2013; AAG-9177-2021Background: Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection. Aims: In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM. Materials and Methods: Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both). Results: According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.Conclusion: The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors.Publication Do morphologic characteristics play a role in nodal metastatic progression of well-differentiated pancreatic neuroendocrine tumors?(Sage Publications Ltd, 2020-07-24) Hasdemir, Seçil; HASDEMİR, SEÇİL; Ugraş, Nesrin; UĞRAŞ, NESRİN; Yerci, Omer; YERCİ, ÖMER; Tasar, Pınar; TAŞAR, PINAR; Dundar, Halit Ziya; DÜNDAR, HALİT ZİYA; Macunluoğlu, Aslı Ceren; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Bioistatistik Anabilim Dalı.; 0000-0003-1769-7484; 0000-0002-6802-5998; AAH-2716-2021Background: Pancreatic neuroendocrine neoplasms (NENs) are tumors with histopathologic and prognostic heterogeneity that pose difficulties in establishing standards for diagnosis, classification, and treatment. Among NENs, well-differentiated neuroendocrine tumors (NETs) have been classified as grade 1, 2, and 3 in the most recently released World Health Organization classification. Although well-differentiated NETs are associated with relatively better prognosis, they have a potential for malignant behavior such as extrapancreatic spread, metastasis, or recurrence. The present study aimed to evaluate clinical and histomorphologic findings of patients with well-differentiated pancreatic NETs and to identify histopathologic findings effective in predicting nodal metastatic progression. Methods: The study group consisted of 54 patients diagnosed with well-differentiated NET. All preparations and blocks of the patients were examined for the following histopathologic parameters: tumor diameter, microscopic tumor growth pattern (solid, trabecular, acinar, and mixed), cellular features (clear, eosinophilic, oncocytic, peliotic, and pseudopapillary), stromal changes (calcification, lymphocytic infiltration, and stromal hyalinization), presence of necrosis, perineural invasion, lymphovascular invasion, mitotic activity, and Ki67 proliferative index. Results: Lymph node metastasis was present in 7 patients. Lymph node metastasis was significantly associated with tumor diameter of >2 cm (p= 0.012), Ki67 proliferative index of >20% (p= 0.022), grade 3 tumors (p= 0.002), presence of dense stromal hyalinization (p= 0.034), and mild lymphocytic infiltration (p= 0.041). Conclusion: The present study revealed that the new findings such as presence of dense stromal hyalinization and absence of remarkable lymphocytic infiltration could be predictive morphologic findings for the development of lymph node metastasis.Publication Adult nesidioblastosis, diagnostic value of the selective arterial calcium stimulation test and perfusion computed tomography. A case report(Editura Acad Romane, 2015-01-01) Cander, S.; Gül, Ö. Öz; Yıldırım-Eryılmaz, N.; Uğraş, N.; Ertürk, E.; Ersoy, C.; ÖZ GÜL, ÖZEN; ERYILMAZ, NERMİN YILDIRIM; UĞRAŞ, NESRİN; ERTÜRK, ERDİNÇ; ERSOY, CANAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; AAI-1005-2021; AAH-8861-2021; AAJ-6536-2021; AAH-2716-2021; GKT-3420-2022Endogenous hyperinsulinemia was found in a 38-year-old female patient with recurrent neuroglycopenic symptoms he glucose level was 25 mg/dL, insulin 43.9 mu/mL, C-peptide,54 ng/mL). No lesion was found on imaging tests including ahanced computed tomography (CT) methods performed ith a preliminary diagnosis of insulinoma. A suspicious yperperfusion was present in the pancreatic tail on the erfusion CT examination performed after obtaining approval. he selective arterial calcium stimulation test (SACST) result as consistent with a diffuse disease in the body and tail. The atient underwent partial (75%) pancreatectomy and is now)llowed up as a diabetes patient on intensive insulin treatment the postoperative 38th month.The most common cause of endogenous yperglycemia in hypoglycemia patients is insulinoma. The oninsulinoma pancreatogenous hypoglycemia syndrome NIPHS) is rarely seen in the adult age group. Although invasive, ACST seems to be the most suitable test to differentiate diffuse r multiple disease from insulinoma and to guide the surgery hen advanced radiological imaging methods are inadequate " detect the presence of insulinoma. Regarding perfusion CT, would be more appropriate to wait for comparative data to put forward in a more consistent manner. When no response an be obtained to medical treatment in NIPHS, partial/total ancreatectomy is the most appropriate treatment option as enables recovery from the hypoglycemic episodes despite ading to a significant condition like diabetes.Publication Evaluation of cystic lesions of the pancreas based on clinicopathologic parameters(Carbone Editore, 2015-01-01) Atalay, Fatma Öz; Uğras, Nesrin; Aytaç, Berna; Yerci, Ömer; ÖZ ATALAY, FATMA; UĞRAŞ, NESRİN; AYTAÇ VURUŞKAN, BERNA; YERCİ, ÖMER; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-9746-2021; AAH-2716-2021; JHC-4482-2023; EGD-8703-2022Aims: To identify demographic, histopathologic and immunohistochentical features of pancreatic cystic lesions, which could assist diagnosis of neoplastic ones.Materials and methods: Sixty-seven cystic lesions from pancreatic resections between 2001 and 2013 were studied. Patient demographics and cyst location and size were recorded. Forty-sir specimens with adjacent non-lesional parenchyma were evaluated for pancreatic intraepithelial neoplasia (PanIN). Neoplastic cysts were immunohistochemically tested for ki67, p53, and progesterone receptor. Ten high-power fields were examined to determine ki67 proliferative index (PI; average percentage of nuclear staining) and p53 status (<1% stained nuclei indicating negative). Presence/absence of progesterone receptor (PR)-positive nuclei in pericystic stromal cells Was recorded.Results: Eighteen (26.9%) of the 67 lesions were non-neoplastic and 49 (73.1%) were neoplastic. Serous cystadenomas (SCAs) were most common (n=23: 34.3%), and 59 (88%) of the patients were women. Mean ages for the mucinous cystic neoplasm (MCN) and SCA subgroups were 46.7 and 64.6 years, respectively, and these lesions tended to be in the pancreatic tail and head, respectively. ki67 PI was higher for non-invasive MCNs with high-grade dysplasia than low-grade dysplasia (20% vs. 4-6%, respectively). No neoplasms were p53-positive. Only MCNs were PR-positive. SCA was the lesion most frequently associated with PanIN.Conclusion: Age of patient and the location of cyst are distinctive features in neoplastic pancreatic cysts. Diameter of the cyst gives an idea about the malignancy potential of the lesions. In MCNs. considering the increased risk of multiple foci of varying degrees of dysplasia, ki67 proliferative index is useful as well as the adequate sampling of the cyst for the accurate diagnosis of these foci, particularly when the presence or degree of it cannot he adequately assessed in hematoxylin and eosin (HE)-stained sections.Publication Prognostic value of p53 protein expression in giant cell tumor of bone(Vesalius Univ Medical Publ, 2015-12-01) Yalçınkaya, Ulviye; Uğraş, Nesrin; Kabul, Selva; Ocakoğlu, Gökhan; Bilgen, Muhammed S.; YALÇINKAYA, ÜLVİYE; UĞRAŞ, NESRİN; KABUL, SELVA; Bilgen, Muhammed S.; Ocakoğlu, Gökhan; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji ve Pediatrik Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi Anabilim Dalı.; 0000-0002-1114-6051; AAH-2716-2021; AAH-8924-2021; HLG-6346-2023; AAH-5180-2021; CAH-9737-2022; ELH-9133-2022Giant cell tumor of bone (GCTB) is a benign tumor with a tendency for local recurrence. GCTB may cause lung metastases, and secondary malignant GCTB is rare. Its histological appearance does not predict local aggressiveness and/or the metastatic potential of the tumor. We aimed to investigate the prognostic value of the Ki-67 proliferative index and p53 protein expression in GCTB in predicting local recurrence, lung metastasis, and malignant transformation. We retrospectively reviewed 42 cases of GCTB. The p53 expression was positive in 20 cases. We used 10% as a cut-off value for p53 expression. In 10 cases, there were local recurrences. Lung metastases were found in three cases and malignant transformation was found in one case with classical GCTB located in the sacrum three years following diagnosis. The Ki-67 index was higher in cases with recurrence, but this difference was not statistically significant. Of the recurrent cases, two had no p53 staining while eight had moderate-to-strong staining. The staining was usually weakly positive in the non-recurrent cases. In conclusion, we believe that p53 may be used as a marker for the biological behavior of GCTB.Publication Malignant glomus tumor with oncocytic features: An unusual presentation of dysphagia(Wiley, 2015-07-01) Uğras, Nesrin; Yerci, Ömer, I.; Yalçınkaya, Ulviye; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; UĞRAŞ, NESRİN; YERCİ, ÖMER; YALÇINKAYA, ÜLVİYE; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; 0000-0002-9600-9418; AAH-8924-2021; AAH-2716-2021; JIO-2609-2023; JII-0241-2023; JGW-0566-2023; GCS-6830-2022; JIV-8745-2023Glomus tumors in the gastrointestinal tract are unusual, as the previous series in the literature have been mainly limited to the stomach. Less than 10 cases of esophageal glomus tumors have been described in the literature. Oncocytic glomus tumors are a recently identified, rare variant of the glomus tumor. We report a 47-year-old female who presented with an approximately 3-month history of dysphagia and weight loss. Upper gastrointestinal endoscopy showed a black-purple, hypervascular, protruding lesion measuring approximately 65mm at the 37th cm of the esophagus. The patient underwent an Ivor Lewis operation via open thoracotomy. The resected specimen had a protuberant, ulcerated mass measuring 80x35mm in the posterior wall of the esophagus. Based on the histopathological, immunohistochemical and electron microscope findings, the final diagnosis was a malignant glomus tumor with oncocytic features. To our knowledge, this is the first report of a malignant glomus tumor with oncocytic features in an esophageal location.Publication Histopathological changes of neoadjuvant chemoradiation and relation with the pre-treatment tumor stage in rectal carcinoma(Gazi Univ, Fac Med, 2017-01-01) Özgün, Gonca; ÖZ ATALAY, FATMA; Ugraş, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-7188-6115; AAH-2716-2021Objective: Neoadjuvant chemoradiotherapy has considered one of the standard treatment modalities for locally advanced rectal cancers. Chemoradiotherapy has a variety of different effects and responses on tumor, tumor bed and peritumoral tissues. The purpose of the present study was to evaluate the stromal responses in tumor bed between the different treatment modalities and different clinical T stages.Methods: Fifty-seven consecutive patients with median age of 62.4 years were treated for rectal adenocarcinoma between January 2005 and July 2012 in Uludag University Medical Faculty. Twenty-three of the patients were treated with neoadjuvant chemoradiation therapy and following surgery, 34 patients treated with surgery only.Results: When we compared the stromal responses in the tumor bed between the two different treatment modalities, the amount of fibrosis and intensity of inflammatory cell infiltration were found considerably marked. The existence of calcification, hemosiderin-laden macrophages and mucin lakes were found also significant marked. There was no difference found in between the patients with different clinical stages which were received neoadjuvant CRT.Conclusion: The stromal response in the tumor bed increases with the neoadjuvant chemoradiotherapy but the excess of the response doesn't have any relation with the clinical T stage.Publication Early-stage colon cancer with high malat1 expression is associated with the 5-fluorouracil resistance and future metastasis(Springer, 2022-07-06) Öztürk, Ersin; Aksoy, Seçil Ak; Tunca, Berrin; TUNCA, BERRİN; Erçelik, Melis; Tezcan, Gulcin; TEZCAN, GÜLÇİN; Çeçener, Gülşah; ÇEÇENER, GÜLŞAH; UĞRAŞ, NESRİN; YILMAZLAR, AHMET TUNCAY; Yerci, Omer; YERCİ, ÖMER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-1619-6680; 0000-0002-5956-8755; 0000-0001-8593-5101; 0000-0002-3820-424X; ADM-8457-2022; AAH-3843-2020Background This study aimed to investigate the role of long noncoding RNA (LncRNA) expression profiles to predict relapse and 5-FU response in patients with stage I/II colon cancer (CC). Methods and Results The expression level of 15 LncRNA was analyzed in stage I/II colon tumors of 126 CC patients. To confirm the findings in-vitro, 5FU-resistant HT29 cells were generated by subjecting HT-29 cells to the increasing concentrations of 5FU for 6 months. The 5FU resistance was observed in WST-1 and Annexin V analyses. The colony formation and wound healing assays were assessed to determine the metastatic properties of the cells. Expression levels of LncRNAs and mRNA of EMT-related genes were determined by RT-PCR. The role of LncRNA on metastasis and 5FU sensitivity were confirmed in pcDNA3.0-PTENP1 and si-MALAT1 expressed 5FU-resistant HT29 cell lineages. Results High MALAT1 (p = 0.0002) and low PTENP1 (p = 0.0044) expressions were significantly associated with 5-FU resistance and tumor relapse in stage I/II CC. The invasiveness and colony-forming characteristics of 5-FU-resistant cell lineages were higher as compared to the parent HT-29. Moreover, the expression of MALAT1 (p = 0.0009) was increased while the expression of PTENP1 (p = 0.0158) decreased in 5FU-resistant-HT-29 cells. Si-MALAT1 treatment increased cell sensitivity to 5FU, whereas it decreased invasive behaviors of 5 FU-resistant-HT-29 cells. Conclusion MALAT1 may be a biomarker in predicting recurrence in early-stage CC. Our findings suggest that a cell-based therapy to target MALAT1 could be established for these patients to prevent metastasis and 5-FU resistance.