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KARALI, ZUHAL

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KARALI

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ZUHAL

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2021 - 202311
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    Publication
    The impact of the Covid-19 pandemic in adolescents with asthma
    (Korean Acad Medical Sciences, 2021-12-20) Çekiç, Şükrü; Karali, Zuhal; Çiçek, Fatih; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, ZUHAL; ÇİÇEK, FATİH; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı; 0000-0002-9574-1842; 0000-0001-7348-7081; 0000-0001-8929-679X; JKI-5906-2023; AAH-1789-2021; L-1933-2017; CZC-9168-2022; FUI-8766-2022
    Background: The coronavirus disease 2019 (COVID-19) pandemic is affecting people at any age and there is limited information about the effect of the COVID-19 pandemic on quality of life (QoL) in adolescents with asthma. In the present study, it was aimed to assess the attitudes of adolescents with asthma toward the COVID-19 pandemic and determine the effects of the pandemic on their QoL. Methods: In total, 125 adolescents with asthma and 98 healthy adolescents participated in the present study. The questionnaire form consisted of three parts. In the first part, all the participants were asked whether they complied with the protective measures against COVID-19. The second part included questions for measuring the participants' level of concern about COVID-19, while the third part consisted of EUROHIS-QOL 8. Results: The patient and control groups were similar in terms of the female/male ratio (55/70 and 48/50, respectively) and mean participant age (14.6 +/- 2 and 15.1 +/- 1.65 years, respectively) (P = 0.459 and P = 0.062, respectively). The prevalence of COVID-19 in the patients (n = 2, 1.6%) was lower than that in the controls (n = 6, 6.1%); however, the difference was not statistically significant (P = 0.142). The total EUROHIS-QOL score was significantly lower in the patients (31.2 +/- 6.7) than in the controls (33.7 +/- 4.4) (P < 0.001). The total QoL scores of asthmatic adolescents without other allergic disease (31.4 +/- 6.7) was also lower than those of the controls (33.7 +/- 4.4) (P = 0.009). Treatment disruption was significantly more common in patients who received subcutaneous immunotherapy (n = 20, 48.8%) than in those who did not (n = 8, 9.5%) (P < 0.001). Moreover, the patients had lower EUROHIS-QOL scores in the overall QoL, general health, finance, and home domains. Conclusion: Our results indicate that the mean QoL score of asthmatic adolescents during COVID-19 pandemic is lower than in the healthy population. Disruption in their treatment was most common in patients with asthma who were receiving subcutaneous immunotherapy.
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    Publication
    Recombinase activating gene defects, phenotypic diversity
    (Wiley, 2023-12-01) Yorgun, M.; Aydıner, E. Karakoç; Özen, A.; Barıs, S.; Oğuzkaya, Y. Şadırvan; ŞADIRVAN OĞUZKAYA, YAĞMUR HAZAL; Çekiç, Şükrü; ÇEKİÇ, ŞÜKRÜ; Karalı, Zuhal; KARALI, ZUHAL; Kılıç, Sara Şebnem; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-9574-1842; 0000-0002-4730-9422
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    Publication
    Full title: The effects of health literacy on disease control in adolescents with asthma
    (Taylor & Francis Ltd, 2022-12-19) Çekiç, Şükrü; Karalı, Zühal; Canıtez, Yakup; Esmen, Selin; Ortaç, Hatice; Abdu, Selin; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, ZUHAL; CANITEZ, YAKUP; Esmen, Selin; Ortaç, Hatice; ABDU, SELİN; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi İstatistik Anabilim Dalı.; 0000-0002-9574-1842; 0000-0002-1199-1706; AAH-1789-2021; L-1933-2017; CZC-9168-2022; HKI-1858-2023; HJF-9598-2022; HKH-2991-2023; FUI-8766-2022
    Objective: Increased health literacy (HL) improves the management of chronic diseases. Data on the HL levels of adolescents with asthma are limited. In this study, we aimed to investigate the HL levels of adolescents with asthma and the effect of HL levels on asthma control.Methods: Our research included 81 adolescents with asthma and 47 age and sex-matched controls. The validated version of the European Health Literacy Survey Questionnaire (HLS-EU-Q16) was utilized to estimate the participants' health literacy levels. In addition, the Asthma Control Test (ACT) was used to determine the degree of asthma control.Results: No significant difference between the asthmatic adolescents (n = 45, 55.6%) and the control group (n = 28, 59.6%) has been established in terms of the number of participants who were considered to have adequate HL (p = 0.658). The difference between the patient and control groups in health care, disease prevention, health promotion, and overall HL scores was determined non-significant. According to the ACT scores, the overall median HL score was significantly higher in patients with controlled asthma {34.4 (14.6:50)} than in those with uncontrolled asthma {32.3 (16.7:48.9)} (p = 0.037). It was determined that there was a difference in the distribution of controlled asthma, uncontrolled asthma, and controls in HL subgroups (poor, problematic-limited, sufficient, and perfect HL) (p = 0.002).Conclusion: The level of HL is associated with asthma control. A significant proportion of asthmatic adolescents who participated in our research displayed low HL scores. Further studies should be conducted to increase the HL levels of adolescents to achieve better asthma control.
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    A comprehensive assessment of long-term complications in patients with stevens-johnson syndrome and toxic epidermal necrolysis
    (Karger, 2023-07-26) Çekiç, Sükrü; Canıtez, Yakup; Yüksel, Hale; Gündüz, Gamze Ucan; Karalı, Zühal; Yalçınbayır, Özgür; Vural, Pınar; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; Yüksel, Hale; UÇAN GÜNDÜZ, GAMZE; KARALI, ZUHAL; VURAL, AYŞE PINAR; YALÇINBAYIR, ÖZGÜR; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerjisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk ve Ergen Psikiyatrisi Anabilim Dalı.; 0000-0002-9574-1842; 0009-0002-4004-449X; 0000-0002-5458-1686; 0000-0002-7311-5277; 0000-0001-8929-679X; L-1933-2017; AAH-1789-2021; IZZ-9492-2023; AAH-6661-2021; CZC-9168-2022; IYJ-9408-2023; GIK-1690-2022; FUI-8766-2022
    Introduction: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare severe hypersensitivity reactions that lead to epithelial sloughing. Studies investigating the chronic multisystem effects of these syndromes and assessing patients in terms of quality of life (QOL), depression, and anxiety in the pediatric population are limited. In this study, we aimed to investigate the long-term effects of these diseases from a multisystem perspective. Method: Sixteen pediatric patients diagnosed with SJS, TEN, and SJS/TEN overlap syndrome were evaluated between September 2020 and March 2021. Physical and eye examinations were performed. To evaluate QOL and psychological status, Children's Dermatology Life Quality Index (CDLQI), Screen for Child Anxiety-Related Emotional Disorders (SCARED), and Children's Depression Inventory (CDI) were conducted. The patients' general characteristics, symptoms, and examination findings at their first admission were retrospectively obtained from the hospital's electronic records. Results: Nineteen percent of the patients were female (n = 3). There were 7 patients (44%) with the diagnosis of SJS, 5 patients (31%) with TEN, and 4 patients (25%) with SJS/TEN overlap. The median follow-up time of the subjects was 6.5 years. The most common sequelae in the chronic period were skin changes (n = 13, 81%). Hyperpigmentation was the most common skin change (n = 9, 56%). In the last evaluation, 9 cases had eye involvement. In two cases, eye examination was normal in the acute phase, while ocular involvement was present in the chronic period. In 4 (50%) patients, there was height and/or weight percentile loss. Three patients' SCARED scores and 2 patients' CDI scores were high. According to the CDLQI survey, SJS, TEN, or SJS/TEN overlap syndrome had a small to moderate effect on the QOL in the 43% (n = 6) of the patients. The ANA values of 3 patients (60%) were positive at the follow-up and negative at the first admission. Conclusion: SJS, TEN, and SJS/TEN overlap syndrome may cause sequelae even after a long time of the onset of the disease. Patients' QOL and psychological status can be affected negatively. Ocular symptoms may develop in the follow-up, even without involvement in the acute period. Patients with SJS, TEN, and SJS/TEN overlap syndrome should be followed up in the chronic period and approached multidisciplinary.
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    The evaluation of local and systemic reactions to subcutaneous house dust mite allergen immunotherapy
    (Galenos Publ House, 2022-06-15) Canitez, Yakup; CANITEZ, YAKUP; Karali, Zuhal; KARALI, ZUHAL; ÇEKİÇ, ŞÜKRÜ; SAPAN, NİHAT; Şadırvan, Yağmur Hazal; ŞADIRVAN OĞUZKAYA, YAĞMUR HAZAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; L-1933-2017
    Objective: Allergen -specific immunotherapy is an effective treatment method that enables the development of immunotolerance against allergens in allergic rhinitis, asthma, and venom allergy. This study investigated the local and systemic reactions during subcutaneous house dust mite allergen immunotherapy. Methods: Injection -related local and systemic reactions of 45 patients who received subcutaneous mite immunotherapy were evaluated retrospectively. Results: Forty-five children, 15 (33.3%) females and 30 (66.4%) male were included in the study. A total of 582 injections were administered. A local reaction was observed in 23 (3.94%) of all injections and the systemic reaction was observed in only 1 (0.17%) injection. Sixteen (37.7%) of the children had local reactions during the immunotherapy process and 1 (2.2%) had a systemic reaction. Conclusion: Although subcutaneous mite immunotherapy is a safe treatment, it should only be applied in centers with appropriate emergency equipment and trained healthcare professionals due to possible systemic reactions.
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    Publication
    Evaluation of patients with pediatric behcet's disease: A tertiary center experience
    (BMJ Publishing Group, 2022-06-01) Karalı, Zuhal; Çekiç, Şükrü; Çakır, İ.; Kılıç, Sabriye Senem; KARALI, ZUHAL; ÇEKİÇ, ŞÜKRÜ; Çakır, İ.; Kılıç, Sabriye Senem; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri İmmünoloji ve Romatoloji Bölümü; CZC-9168-2022; CIO-5200-2022; HXT-7953-2023; FEK-8430-2022
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    Immunological and neurocognitive functions in digeorge syndrome
    (Wiley, 2023-12-01) Karalı, Z.; Çekiç, S.; Karalı, Y.; Kılıç, S. S.; KARALI, ZUHAL; ÇEKİÇ, ŞÜKRÜ; KARALI, YASİN; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-9574-1842; CZC-9168-2022; GBO-8694-2022; IMT-6140-2023; ISC-9139-2023
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    Compliance with follow-up and adherence to Immunoglobulin Treatment in patients with primary immunodeficiency during The Pandemic
    (Springer/Plenum Publishers, 2022-04-01) Karalı, Zühal; Çekiç, Şükrü; Oğuzkaya, Yağmur; Kılıç, Sara Şebnem; KARALI, ZUHAL; ÇEKİÇ, ŞÜKRÜ; ŞADIRVAN OĞUZKAYA, YAĞMUR HAZAL; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-9574-1842; 0000-0001-8571-2581; L-1933-2017; AAH-1658-2021; CZC-9168-2022; DKN-7999-2022
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    Monitoring of immunoglobulin treatment compliance of patients with an inborn error of immunity during the pandemic
    (Wiley, 2023-10-01) KARALI, YASİN; KARALI, ZUHAL; Karalı, Zuhal; Çekiç, Şükrü; ÇEKİÇ, ŞÜKRÜ; Kılıç, Sara Şebnem; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0002-9574-1842; 0000-0001-8571-2581; AAH-1658-2021
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    Neurological involvement in primary immunodeficiencies
    (Springer/plenum Publishers, 2022-04-01) KÖSE, HÜLYA; KARALI, ZUHAL; Çekiç, Şükrü; ÇEKİÇ, ŞÜKRÜ; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-9574-1842; 0000-0001-8571-2581; L-1933-2017; AAH-1658-2021