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ÖZEL, ŞAHİN

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ÖZEL

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ŞAHİN

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    Effects of some phenolic compounds on the inhibition of α-glycosidase enzyme-immobilized on Pluronic®F127 micelles: An in vitro and in silico study
    (Elsevier, 2021-10-28) Kassa, Solomon Bezabeh; Taslimi, Parham; Özel, Şahin; Gür, Bahri; Gülçin, İlhami; Önganer, Yavuz; ÖZEL, ŞAHİN; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; JHC-0846-2023
    This study aimed to consider the activity of immobilized alpha-glycosidase, significant enzyme defined in serum glucose adjustment, on Pluronic (R) F127 micelles and to compare the results with theoretical molecular docking studies. The phenolic molecules were used for the activity studies, which play a crucial role in the inhibition of alpha-glycosidase by providing conservation against pathogen factors. The immobilization of alpha-glycosidase on Pluronic (R) F127 micelles showed higher kinetic activity towards p-nitrophenyl-D-glucopyranoside (pNPG) than the free one. The inhibition profiles from some phenolic molecules were observed impressively with IC50 values between 20.47 and 1118.68 nM and K-i values between 18.51 and 1087.53 nM against immobilized alpha-glycosidase. In addition, the inhibition effects of the studied phenolic compounds have been tested with calculated negative binding energies from theoretical molecular docking studies. Negative binding energy values were as - 6.1 and - 8.3 kcalmol(-1) for p-coumaric acid and tetrakis compounds, respectively.
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    Synthesis, characterization, photophysical and surface properties of poly(amino naphthalene) and its poly(azomethine) compound
    (Wiley, 2023-05-01) Kaya, İsmet; Akyüz, Burçin; Özel, Şahin; ÖZEL, ŞAHİN; Uludağ Üniversite/Fen-Edebiyat Fakültesi/Kimya Bölümü; FRJ-8271-2022
    In this study, 8-((4-hydroxybenzylidene)amino)naphthalene-2-ol (ANAPSB) compound was synthesized from condensation reaction of 8-amino-2-naphthol (ANAP) with 4-hydroxybenzaldehyde and then ANAPSB and 8-amino-2-naphthol were polymerized via oxidative polycondensation alkaline medium by H2O2 (35% aqueous solution) as oxidant at 70? 14 h. The structures of compounds were confirmed by UV-Vis, H-1-C-13-NMR and FT-IR measurements. The surface morphologies of PANAP and PANAPSB were examined with SEM analyses. The electrochemical properties of 8-amino-2-naphthol, poly(8-amino-2-naphthol) (PANAP), ANAPSB and poly(8-((4-hydroxybenzylidene)amino)naphthalene-2-ol) (PANAPSB) were determined by cyclic voltammetry technique. The thermal properties of compounds were found by TG-DTA analysis. The glass transition temperatures (Tg) of PANAP and PANAPSB were determined from DSC measurements. The Tg values of PANAP and PANAPSB were found to be 159 and 150 degrees C, respectively. The Mn, Mw, Mp, Mz and PDI values of the PANAP and PANAPSB were calculated from gel permeation chromatography measurements. The optical and fluorescence properties of the compounds were determined by UV-Vis and fluorescence measurements, respectively. The optical band gap values of ANAP, PANAP, ANAPSB and PANAPSB were calculated as 3.12, 1.61, 2.79 and 1.57 eV, respectively.