Person: KOCATÜRK, MERİÇ
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KOCATÜRK
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MERİÇ
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Publication Effect of pimobendan in the treatment of pulmonary hypertension in a cat with giant right atrium(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020-09-01) Tanaka, Ryou; Levent, Pınar; Sarıl, Ahmet; SARIL, AHMET; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Yilmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-9836-0749; V-5578-2017; A-9637-2008Publication Unilateral ovariohysterectomy due to incarcerated uterine horn in a pregnant ewe with ventral hernia(Mezogazda Kiado Kft, 2020-06-01) Intas, Kamil Seyrek; Kocaturk, Meric; KOCATÜRK, MERİÇ; Salci, Emsal Sinem Ozdemir; ÖZDEMİR SALCI, EMSAL SİNEM; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0002-2849-1222; V-5578-2017; AAH-5294-2021Background: Ventral hernias are commonly diagnosed is ewes and other animals, which are likely to occur during pregnancy, due to the increased abdominal content. Hernias in pregnant animals might contain the uterus with dead or live foetus inside. Caesarean section and ovariohysterectomy can be indicated to solve these cases. In case of unilateral ovariohysterectomy, fertility of the animal can be preserved.Objectives: The aim of this article is to present a case, where unilateral ovariohysterectomy was performed on a pregnant ewe which had ventral hernia containing one uterine horn and a dead foetus inside, however the other uterine horn had a viable foetus in the abdomen.Case presentation: A 5-year-old, curly-fleeced breed, pregnant (at 145th day) ewe was presented with the complaint of recumbency, anorexia and focal abdominal swelling. On physical examination the swelling was 30 cm in diameter on the ventral abdomen. Palpation of the swelling was painful and contained a herniated uterine horn with the incarcerated head and extremities of a foetus. Ultrasonography confirmed the dead foetus in the incarcerated uterine horn but the foetus in the other uterine horn was alive. Under general anaesthesia, caesarean section was performed with routine lateral abdominal approach. Appearance of the uterine horn in the hernial sac was ischemic and showed necrosis. Following uterine incision, a dead foetus, necrotic uterine content and placentomes were observed. Considering further fertility of the ewe, unilateral ovariohysterectomy was performed, because the other uterine horn contained a viable foetus inside. The ewe and its newborn lamb were discharged without any complication.Conclusion: Unilateral ovariohysterectomy can be a useful tool in the management of ventral hernias in ewe, when the aim is to preserve the animal's fertility.Publication A case of a complete atrioventricular canal defect in a ferret(Bmc, 2021-01-22) Agudelo, Carlos F.; Jekl, Vladimir; Hauptman, Karel; Crha, Michal; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-8320-1286; 0000-0002-2849-1222; V-5578-2017BackgroundAtrioventricular canal defect is a rare congenital disorder of the heart and describes the presence of an atrial septal defect, a variable presentation of ventricular septal alterations including ventricular septal defect malformations in the mitral and tricuspid valves. The defect has been described in human beings, dogs, cats, pigs, and horses.Case presentationThis paper describes the case of a complete atrioventricular canal defect in a four-year-old intact male pet ferret (Mustela putorius furo), which was presented due to posterior weakness, ataxia, and decreased appetite. A loud systolic murmur, dyspnea, and hind limb paraparesis were detected during the clinical examination. Thoracic radiographs showed generalized cardiomegaly and lung edema. ECG showed sinus rhythm with prolonged P waves and QRS complexes. Echocardiography showed a large atrial septal defect, atrioventricular dysplasia, and a ventricular septal defect. Palliative treatment with oxygen, furosemide, spironolactone, enalapril, diltiazem, and supportive care was chosen as the therapy of choice. The ferret recovered gradually during hospitalization. A follow-up examination at three and six months showed stabilization of cardiac function.ConclusionsTo the authors knowledge, this is the first time an atrioventricular canal defect has been described in a pet ferret.Publication Choline or cdp-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-induced endotoxic shock(Elsevier, 2021-10-27) Ozarda, Yesim; Ceron, Jose Joaquin; Buturak, Ali; Ulus, Ismail H.; Kocaturk, Meric; KOCATÜRK, MERİÇ; Yilmaz, Zeki; YILMAZ, ZEKİ; Cansev, Mehmet; CANSEV, MEHMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0002-2849-1222; 0000-0001-9836-0749; 0000-0003-2918-5064; 0000-0002-8654-1793; H-9043-2015; D-5340-2015; V-5578-2017; A-9637-2008Endotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5 '-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study was to determine the effects of choline or CDPcholine on endotoxin-induced cardiovascular and respiratory dysfunctions. Dogs were treated intravenously (i.v.) with saline or endotoxin (LPS, 0.1 mg/kg) 5 min before i.v. infusion of saline, choline (20 mg/kg) or CDP-choline (70 mg/kg). Blood pressure, cardiac rate, myocardial and left ventricular functions, respiratory rate, blood gases, serum electrolytes and cardiac injury markers were determined before and at 0.5-48 h after endotoxin. Plasma tumor necrosis factor alpha (TNF-alpha), high mobility group box-1 (HMGB1), catecholamine and nitric oxide (NO) levels were measured 2 h and 24 h after the treatments. Endotoxin caused immediate and sustained reductions in blood pressure, cardiac output, pO2 and pH; changes in left ventricular functions, structure and volume parameters; and elevations in heart rate, respiratory rate, pCO2 and serum electrolytes (Na, K, Cl, Ca and P). Endotoxin also resulted in elevations in blood levels of cardiac injury markers, TNF-alpha, HMGB1, catecholamine and NO. In choline- or CDP-choline-treated dogs, all endotoxin effects were much smaller in magnitude and shorter in duration than observed values in controls. These data show that treatment with choline or CDP-choline improves functions of cardiovascular and respiratory systems in experimental endotoxemia and suggest that they may be useful in treatment of endotoxin shock in clinical setting.Publication Ventricular septal defect and pulmonic stenosis in a dog(Kafkas Univer, Veteriner Fakultesi Dergisi, 2019-09-01) Uemura, Akiko; Tanaka, Ryou; Yılmaz, Zeki; YILMAZ, ZEKİ; Levent, Pınar; Sarıl, Ahmet; SARIL, AHMET; Kocatürk, Meriç; KOCATÜRK, MERİÇ; 0000-0001-9836-0749; 0000-0003-2671-5074; 0000-0002-2849-1222; 0000-0001-9948-6490; V-5578-2017; M-3078-2019; T-1481-2019; A-9637-2008Publication Changes in choline and cholinesterase in saliva of dogs with parvovirus infection(Elsevier, 2021-01-01) Kocatürk, Meriç; Tecles, Fernando; Yalçın, Ebru; Cihan, Hüseyin; Tural, Merve; Levent, Pınar; Cansev, Mehmet; Ceron, Jose J.; Yılmaz, Zeki; KOCATÜRK, MERİÇ; YALÇIN, EBRU; CİHAN, HÜSEYİN; Tural, Merve; Levent, Pınar; CANSEV, MEHMET; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-6703-4908; 0000-0003-2918-5064; 0000-0001-9836-0749; M-9071-2019; GDR-9018-2022 ; V-5578-2017; ACP-9956-2022; A-9637-2008; ABH-3742-2020; DDR-1481-2022This study investigated the changes in choline (Ch) and butyrylcholinesterase (BChE) in saliva in canine parvovirosis (CP) as a model of sepsis, and their correlations with these analytes in serum and with other markers of inflammation such as white blood cell count (WBC) and serum C-reactive protein (CRP). A total of 30 dogs with CP were sampled for saliva and serum at presentation, and 10 healthy puppies were also sampled as controls. Salivary Ch was higher in dogs with CP (P < 0.001) showing a positive correlation with CRP, whereas no differences were observed in salivary BChE. This is the first report in which Ch is measured in saliva of dogs and based in the results of this study, salivary Ch could be potentially used as biomarker of the severity of CP.Publication Echocardiographic diagnosis and surgical correction of aortopulmonary window in a Belgian Shepherd Dog (Malinois)(Ankara Üniversitesi, 2015-01-01) Kocaturk-Ocal, Meric; Salcı, Hakan; Çetin, Melike; Karapınar, Tolga; Yılmaz, Zeki; KOCATÜRK, MERİÇ; SALCI, HAKAN; Çetin, Melike; YILMAZ, ZEKİ; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-9836-0749; A-9637-2008; V-5578-2017; T-4623-2019; AAB-1790-2022A 20-month-old, female Belgian Malinois Dog was referred for evaluation on exercise intolerance. A high-grade machinery murmur, tachycardia, and cardiomegaly were observed. An aortopulmonary window was diagnosed by a color-Doppler echocardiography showing a turbulent blood flow shunting from the proximal part of ascendance aorta to the main pulmonary artery. This cardiac anomaly was corrected by surgery. Dog was treated by furosemide, pimobendan, and enalapril during post-operative 7 days. 1-year after the surgery, life quality of the patient was perfectly good. This is the first report of this rare congenital heart disease and its successful outcome of surgically correction in Belgian Malinois Dogs.Publication Chylothorax associated with ebstein's anomaly in a golden retriever dog(Ankara Üniversitesi, 2015-01-01) Yılmaz, Zeki; Levent, Pınar; Kocatürk, Meriç; Cihan, Hüseyin; Pars, Elif; Sağ, Saim; YILMAZ, ZEKİ; Levent, Pınar; KOCATÜRK, MERİÇ; CİHAN, HÜSEYİN; Sağ, Saim; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji İç Hastalıkları Anabilim Dalı; 0000-0001-9836-0749; 0000-0002-2849-1222; 0000-0003-1544-6438; 0000-0001-8404-8252; ABH-3742-2020; V-5578-2017; AAW-9185-2020; A-9637-2008; DDR-1481-20222-year-old, intact female, a Golden Retriever Dog was presented with the signs of respiratory distress, exercise intolerance, and muscular weakness. A high-grade systolic murmur was auscultated over the tricuspid valvular area. Thoracic radiographs showed an enlarged D-shape heart and free fluid (chylothorax) in the pleural space. ECG revealed small QRS complexes. Doppler echocardiography disclosed severe tricuspid insufficiency with moderate pulmonary hypertension, and tricuspid leaflets also were displaced down into the right ventricle, substantiating Ebstein's anomaly. Five-weeks after the medical therapy, patient died at home. The owner of the patient refused the necropsy. This is the first case report of tricuspid dysplasia and Ebstein's anomaly along with chylothorax in dogs.Publication Clinical approach to etiology, diagnosis, and treatment in dogs with pericardial effusion - a retrospective study(Ankara Üniversitesi, 2016-01-01) Kocatürk, Meriç; Salcı, Hakan; İpek, Volkan; Çelimli, Nureddin; Yılmaz, Zeki; KOCATÜRK, MERİÇ; YILMAZ, ZEKİ; SALCI, HAKAN; İpek, Volkan; Çelimli, Nureddin; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-5874-7797; 0000-0001-9836-0749; A-9637-2008; ABZ-7197-2022; V-5578-2017; T-4623-2019; JIX-0056-2023In this study, signalement, presenting clinical signs, results of diagnostic investigations and therapeutic outcomes of 17 dogs with pericardial effusion (PE) were evaluated retrospectively. Common findings were exercise intolerance (70%), muffled heart sound (60%) and ascites (50%). ECG showed low voltage QRS (60%) and supraventricular tachycardia (40%). Radiological findings revealed enlarged and globoid cardiac silhouette in all dogs. PE was confirmed by echocardiographic examinations, which was due to intracardiac neoplasia (n=6) or non-neoplastic causes [dilated cardiomyopathy (n=5), right-sided heart failure (RSHF, n=2), and idiopathic (n=4)]. In dogs with RSHF, Doppler-derived pulmonary hypertension was also observed. Analysis of pericardial fluids that was collected by pericardiocentesis showed a hemorrhagic effusion in dogs with intracardiac neoplasia, and transudate in the rest. In 4 dogs with neoplastic PE, pericardiectomy and tumor resection were performed. Histopathological examinations revealed an aortic body adenoma (n=1), aortic body carcinoma (n=1), papillary mesothelioma (n=1) and malignant epitheloid mesothelioma (n=1). In 2 dogs, neoplastic PE could not be classified. Dogs were treated medically for heart failure and neoplasia, as well. Prognosis was better for the first 12 months in dogs with non-neoplastic PE. In conclusion, echocardiographic examination is the best means to diagnose PE. In practice, when added to physically examination findings echocardiography also provides solid information in determining prognosis of PE due to neoplasia versus non-neoplastic causes. Survival time may be extended by pericardiectomy in the case of neoplastic PE, as well.Publication Association between dilated cardiomyopathy and hypothyroidism in dogs(Veterinarni A Farmaceuticka Univerzita Brno, 2022-01-01) Koskova, Benicie; Ramirez, Carlos Fernando Agudelo; Filipejova, Zita; Crha, Michal; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.It is a known fact that thyroid hormones have an influence on the heart function. Opinions on hypothyroidism and its effect on dilated cardiomyopathy (DCM) development are controversial and often contradictory. This prospective study examined the potential association between hypothyroidism and DCM in dogs. A total of 35 dogs with DCM were included in the study. Preclinical DCM was diagnosed in 18 patients, and clinical DCM was diagnosed in 17 patients, four of which were also diagnosed with hypothyroidism. There was a positive correlation between the thyroid-stimulating hormone and body weight, left atrium size and the serum NT-proBNP concentration in patients with preclinical DCM. Euthyroid dogs with DCM had higher total thyroxine values and more ventricular premature complexes than hypothyroid dogs. Although our study did not confirm a direct relationship between hypothyroidism and DCM as a possible cause, other correlations were detected that had not yet been described in veterinary medicine.