Person: YILMAZ, ZEKİ
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YILMAZ
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ZEKİ
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Publication Identification of serum proteins in dogs naturally infected with Anaplasma phagocytophilum and Borrelia burgdorferi: A pilot study(Hellenic Veterinary Medical Soc, 2021-10-01) Martinez, L. F.; Escribano, D.; Schanilec, P.; Martinez-Subiela, S.; Tvarijonaviciute, A.; Ceron, J. J.; Yilmaz, Z.; Kocatürk, M.; Levent, P.; Sarıl, A.; SARIL, AHMET; Cihan, H.; Yilmaz, Zeki; YILMAZ, ZEKİ; Yalcin, E.; YALÇIN, EBRU; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; 0000-0001-9836-0749; 0000-0002-6697-6079; ; ACP-9956-2022; A-9637-2008; ACP-9956-2022Serum proteomic analysis would aid in better understanding the pathophysiology of several diseases. The aim of this study was to identify the serum proteomes of dogs with anaplasmosis and Lyme disease using a pro-teomic approach. Diseases were diagnosed by a commercial rapid in-clinic ELISA. Borrelia antibodies were evaluated by IFAT. Four groups were designated: symptomatic dogs with anaplasmosis (n=5), dogs with Lyme disease (n=5), dual-positive dogs (n=5), and healthy control dogs (n=5). Serum samples were collected before treatment. Two-dimen-sional electrophoresis of pooled samples in each group were run in triplicate. Ten out of 57 differentially expressed spots between groups were evaluated for identification by mass spectrometry. Compared to those of controls, levels of vitamin D-binding protein (VDBP), glycoprotein-9 (GP9) and kininogen-1 (KGN-1) decreased, while haptoglobin (Hp) and immunoglobulin (Ig) heavy chain levels increased in dual infection group. Serum apolipoprotein-A1 (Apo-A1) levels decreased in dogs with anaplasmosis, Lyme disease and dual in-fections compared to those in control dogs. Serum clusterin levels decreased in dogs with anaplasmosis but were not differentially expressed in dogs with Lyme disease or dogs with dual infections compared to those in control dogs. Calpain-3 decreased in dogs with anaplasmosis and Lyme disease. This study showed that many protein levels might be changed in dogs with naturally acquired anaplasmosis and Lyme disease. Understanding the role of these proteins in different biological processes can provide information of interest for diagnostic and therapeutic approaches for these clinical conditions.Publication Effect of pimobendan in the treatment of pulmonary hypertension in a cat with giant right atrium(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020-09-01) Tanaka, Ryou; Levent, Pınar; Sarıl, Ahmet; SARIL, AHMET; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Yilmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-9836-0749; V-5578-2017; A-9637-2008Publication Estimation of pulmonary arterial wave reflection by echo-doppler: A preliminary study in dogs with experimentally-induced acute pulmonary embolism(Frontiers Media Sa, 2021-12-08) Yoshida, Tomohiko; Uejima, Tokuhisa; Komeda, Syunta; Matsuura, Katsuhiro; Uemura, Akiko; Hayama, Hiromasa; Yamashita, Takeshi; Tanaka, Ryou; Yilmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0003-4311-9311; 0000-0002-6047-2865; 0000-0003-2671-5074; 0000-0001-6702-7150; 0000-0002-2544-8464; 0000-0001-9836-0749; 0000-0001-9948-6490; HQY-9709-2023; CAH-7393-2022; AHB-6165-2022; A-9637-2008; M-3078-2019Background: Pulmonary arterial (PA) wave reflection provides additional information for assessing right ventricular afterload, but its applications is hampered by the need for invasive pressure and flow measurements. We tested the hypothesis that PA pressure and flow waveforms estimated by Doppler echocardiography could be used to quantify PA wave reflection.Methods: Doppler echocardiographic images of tricuspid regurgitation and right ventricular outflow tract flow used to estimate PA pressure and flow waveforms were acquired simultaneously with direct measurements with a dual sensor-tipped catheter under various hemodynamic conditions in a canine model of pulmonary hypertension (n = 8). Wave separation analysis was performed on echo-Doppler derived as well as catheter derived waveforms to separate PA pressure into forward (Pf) and backward (Pb) pressures and derive wave reflection coefficient (RC) defined as the ratio of peak Pb to peak Pf.Results: Wave reflection indices by echo-Doppler agreed well with corresponding indices by catheter (Pb: mean difference = 0.4 mmHg, 95% limits of agreement = -4.3 to 5.0 mmHg; RC: bias = 0.13, 95% limits of agreement = -0.25 to 0.26). RC correlated negatively with PA compliance.Conclusion: This echo-Doppler method yields reasonable measurement of reflected wave in the pulmonary circulation, paving the way to a more integrative assessment of pulmonary hemodynamics in the clinical setting.Publication Chylothorax associated with ebstein's anomaly in a golden retriever dog(Ankara Üniversitesi, 2015-01-01) Yılmaz, Zeki; Levent, Pınar; Kocatürk, Meriç; Cihan, Hüseyin; Pars, Elif; Sağ, Saim; YILMAZ, ZEKİ; Levent, Pınar; KOCATÜRK, MERİÇ; CİHAN, HÜSEYİN; Sağ, Saim; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji İç Hastalıkları Anabilim Dalı; 0000-0001-9836-0749; 0000-0002-2849-1222; 0000-0003-1544-6438; 0000-0001-8404-8252; ABH-3742-2020; V-5578-2017; AAW-9185-2020; A-9637-2008; DDR-1481-20222-year-old, intact female, a Golden Retriever Dog was presented with the signs of respiratory distress, exercise intolerance, and muscular weakness. A high-grade systolic murmur was auscultated over the tricuspid valvular area. Thoracic radiographs showed an enlarged D-shape heart and free fluid (chylothorax) in the pleural space. ECG revealed small QRS complexes. Doppler echocardiography disclosed severe tricuspid insufficiency with moderate pulmonary hypertension, and tricuspid leaflets also were displaced down into the right ventricle, substantiating Ebstein's anomaly. Five-weeks after the medical therapy, patient died at home. The owner of the patient refused the necropsy. This is the first case report of tricuspid dysplasia and Ebstein's anomaly along with chylothorax in dogs.Publication Clinical approach to etiology, diagnosis, and treatment in dogs with pericardial effusion - a retrospective study(Ankara Üniversitesi, 2016-01-01) Kocatürk, Meriç; Salcı, Hakan; İpek, Volkan; Çelimli, Nureddin; Yılmaz, Zeki; KOCATÜRK, MERİÇ; YILMAZ, ZEKİ; SALCI, HAKAN; İpek, Volkan; Çelimli, Nureddin; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-5874-7797; 0000-0001-9836-0749; A-9637-2008; ABZ-7197-2022; V-5578-2017; T-4623-2019; JIX-0056-2023In this study, signalement, presenting clinical signs, results of diagnostic investigations and therapeutic outcomes of 17 dogs with pericardial effusion (PE) were evaluated retrospectively. Common findings were exercise intolerance (70%), muffled heart sound (60%) and ascites (50%). ECG showed low voltage QRS (60%) and supraventricular tachycardia (40%). Radiological findings revealed enlarged and globoid cardiac silhouette in all dogs. PE was confirmed by echocardiographic examinations, which was due to intracardiac neoplasia (n=6) or non-neoplastic causes [dilated cardiomyopathy (n=5), right-sided heart failure (RSHF, n=2), and idiopathic (n=4)]. In dogs with RSHF, Doppler-derived pulmonary hypertension was also observed. Analysis of pericardial fluids that was collected by pericardiocentesis showed a hemorrhagic effusion in dogs with intracardiac neoplasia, and transudate in the rest. In 4 dogs with neoplastic PE, pericardiectomy and tumor resection were performed. Histopathological examinations revealed an aortic body adenoma (n=1), aortic body carcinoma (n=1), papillary mesothelioma (n=1) and malignant epitheloid mesothelioma (n=1). In 2 dogs, neoplastic PE could not be classified. Dogs were treated medically for heart failure and neoplasia, as well. Prognosis was better for the first 12 months in dogs with non-neoplastic PE. In conclusion, echocardiographic examination is the best means to diagnose PE. In practice, when added to physically examination findings echocardiography also provides solid information in determining prognosis of PE due to neoplasia versus non-neoplastic causes. Survival time may be extended by pericardiectomy in the case of neoplastic PE, as well.Publication Thromboelastographic evaluation of coagulation profile in dogs with subclinical and clinical ehrlichiosis(Kafkas Univ, Veteriner Fakultesi Dergisi, 2023-07-17) Tanaka, Ryou; Ceron, Jose Joaquin; Kocatürk, Merit; Yılmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı. ; 0000-0001-9836-0749; 0000-0001-9948-6490; 0000-0002-8654-1793; A-9637-2008Canine monocytic ehrlichiosis (CME), a vector-borne disease of worldwide distribution, causes coagulopathy in dogs. Thromboelastography-TEG measures the efficiency of coagulation. However, there is lack of knowledge about TEG evaluation in different stages of CME. Thus, this study aimed to evaluate the coagulation status and viscoelastic properties of blood using TEG parameters in dogs with naturally-occurring CME, and their potential to discriminate between subclinical and clinical forms of the disease. The relationship between TEG parameters and C-reactive protein (CRP) was also investigated. For these purposes, 29 E. canis-seropositive dogs were used (12 subclinical and 17 clinical forms), and 10 healthy dogs as controls. Kaolin-activated TEG was performed in all dogs. Platelets were lower (P<0.01), but CRP was higher (P<0.001) in clinical form than in subclinical form. TEG-reaction (R) and clot-formation times (K) decreased (P<0.01), whereas a-angle and coagulation index (CI) increased (P<0.01) in both forms of CME compared to controls. The magnitude of decreases in R- and K-times and increases in a-angle and CI were higher in dogs with subclinical form compared to clinical form. CRP was correlated negatively (P<0.05) with TEG-Ly30. In conclusion, among TEG parameters, R-time, K-time, a-angle, and CI values may be used to differentiate subclinical form of CME from clinical form. Hypercoagulability is especially frequent in dogs with subclinical CME and may be associated with systemic inflammation.Publication Hybrid balloon dilation treatment for cor triatriatum dexter in a small breed puppy(Korean Soc Veterinary Science, 2019-09-01) Uemura, Akiko; Yoshida, Tomohiko; Matsuura, Katsuhiro; Tanaka, Ryou; Yılmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0001-9836-0749The authors encountered a 4-month-old, female Shiba dog weighing 4.0 kg, who had been exhibiting abdominal distension and increasing ascites for 2 months. She was brought for further examination and treatment with the chief complaints of ascites and dyspnoea during sleep. The dog was diagnosed with ascites caused by cor triatriatum dexter based on the physical and imaging findings. Under general anaesthesia, she was treated with hybrid balloon dilation under transoesophageal echocardiography guidance. Her postoperative recovery was quite rapid and uneventful. This method appears to be a useful, new, and less-invasive treatment option for cor triatriatum dexter.Publication Serum leptin and ghrelin levels and their relationship with serum cortisol,thyroid hormones, lipids, homocysteine and folic acid in dogs with compulsive tail chasing(Cabi Publishing-c A B Int, 2017-01-01) Yalçın, Ebru; Yılmaz, Zeki; Özarda, Yeşim; Denenberg, S; YALÇIN, EBRU; YILMAZ, ZEKİ; ÖZARDA, YEŞİM; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Bölümü; Denenberg, S; 0000-0001-9836-0749; 0000-0002-6697-6079; AAL-8873-2021; ACP-9956-2022; A-9637-2008Publication Echocardiographic diagnosis and surgical correction of aortopulmonary window in a Belgian Shepherd Dog (Malinois)(Ankara Üniversitesi, 2015-01-01) Kocaturk-Ocal, Meric; Salcı, Hakan; Çetin, Melike; Karapınar, Tolga; Yılmaz, Zeki; KOCATÜRK, MERİÇ; SALCI, HAKAN; Çetin, Melike; YILMAZ, ZEKİ; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-9836-0749; A-9637-2008; V-5578-2017; T-4623-2019; AAB-1790-2022A 20-month-old, female Belgian Malinois Dog was referred for evaluation on exercise intolerance. A high-grade machinery murmur, tachycardia, and cardiomegaly were observed. An aortopulmonary window was diagnosed by a color-Doppler echocardiography showing a turbulent blood flow shunting from the proximal part of ascendance aorta to the main pulmonary artery. This cardiac anomaly was corrected by surgery. Dog was treated by furosemide, pimobendan, and enalapril during post-operative 7 days. 1-year after the surgery, life quality of the patient was perfectly good. This is the first report of this rare congenital heart disease and its successful outcome of surgically correction in Belgian Malinois Dogs.Publication Role of two-dimensional speckle-tracking echocardiography in early detection of left ventricular dysfunction in dogs(Mdpi, 2021-08-07) Hamabe, Lina; Mandour, Ahmed S.; Shimada, Kazumi; Uemura, Akiko; Yılmaz, Zeki; Nagaoka, Kentaro; Tanaka, Ryou; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-9836-0749; A-9637-2008Simple Summary Two-dimensional speckle-tracking echocardiography represents an advanced imaging technique that allows the analysis of global and regional myocardial function, cardiac rotation and synchronicity using deformation imaging. It has gained growing importance over the last decade, especially in human medicine as a method of evaluating myocardial function. This review aims to give an overview of the current understanding of this technique and its clinical applicability in the field of veterinary medicine with a focus on early detection of left ventricular dysfunction in dogs. Two-dimensional speckle-tracking echocardiography (2D-STE) is an advanced echocardiographic technique based on deformation imaging that allows comprehensive evaluation of the myocardial function. Clinical application of 2D-STE holds great potential for its ability to provide valuable information on both global and regional myocardial function and to quantify cardiac rotation and synchronicity, which are not readily possible with the conventional echocardiography. It has gained growing importance over the past decade, especially in human medicine, and its application includes assessment of myocardial function, detection of subclinical myocardial dysfunction and serving as a prognostic indicator. This review illustrates the fundamental concepts of deformation analysis and gives an overview of the current understanding and its clinical application of this technique in veterinary medicine, with a focus on early detection of left ventricular (LV) dysfunction in dogs.
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