Person: COŞKUN, BELKIS NİHAN
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COŞKUN
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BELKIS NİHAN
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Publication Are there any clues to predict bamboo spine in axial spondyloarthritis?(Wiley, 2020-10-01) Atagündüz, Pamir; Kiraz, Sedat; Akar, Servet; Küçükşahin, Orhan; Erden, Abdulsamet; Beş, Cemal; Kılıç, Levent; Karadağ, Ömer; Kaşifoğlu, Timuçin; Emmüngil, Hakan; Çınar, Muhammet; Kimyon, Gezmis; Yazısız, Veli; Ateş, Aşkın; Ersözlü, Emine Duygu; Gonullu, Emel; Mercan, Rıdvan; Ertenli, İhsan; Kalyoncu, Umut; Yağız, Burcu; YAĞIZ, BURCU; Coşkun, Nihan; COŞKUN, BELKIS NİHAN; Tıp Fakültesi; CLH-7318-2022Publication Irritable bowel syndrome in patients on renal replacement treatment(Oxford Univ Press, 2015-05-01) Aktaş, Nimet; Oruç, Ayşegül; Ersoy, Alparslan; Coşkun, Belkıs Nihan; Gül, Bülent; Yıldız, Abdulmecit; Ayar, Yavuz; Sayılar, Emel Işıktaş; Aktaş, Nimet; ORUÇ, AYŞEGÜL; ERSOY, ALPARSLAN; COŞKUN, BELKIS NİHAN; GÜL, CUMA BÜLENT; YILDIZ, ABDULMECİT; Ayar, Yavuz; Sayılar, Emel Işıktaş; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0002-0710-0923; 0000-0003-0298-4157; AGF-0767-2022; AAH-4002-2021; AAH-5054-2021; O-9948-2015; AAG-7155-2021; GSE-0029-2022; W-2575-2017Publication Predictors for the risk and severity of post-thrombotic syndrome in vascular Behcet's disease(Elsevier, 2021-02-04) Aksoy, Aysun; Çolak, Seda; Yağız, Burcu; Coşkun, Belkıs Nihan; Omma, Ahmet; Yıldız, Yasin; Sarı, Alper; Ataş, Nuh; Ilgın, Can; Karadağ, Ömer; Erden, Abdulsamet; Dalkılıç, Ediz; Bolca, Naile; Ergelen, Rabia; Onur, Mehmet Ruhi; Direskeneli, Haner; Alibaz-Öner, Fatma; YAĞIZ, BURCU; COŞKUN, BELKIS NİHAN; BOLCA TOPAL, NAİLE; DALKILIÇ, HÜSEYİN EDİZ; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; Romatoloji Bilim Dalı; 0000-0003-0298-4157; JQW-5031-2023; AAG-7155-2021; CMF-4757-2022 ; EKW-9201-2022Objective: Deep vein thrombosis (DVT) of the lower extremities is the most common form of vascular involvement in Behcet disease (BD), frequently leading to post-thrombotic syndrome (PTS) as a disabling complication. We have described the clinical characteristics and predictors of PTS presence among patients with BD and lower extremity DVT. We also used venous Doppler ultrasound (US) examinations in our assessment. Methods: Patients with BD (n = 205; 166 men, 39 women; age 39 6 9.5 years) and a history of DVT were investigated. The Villalta scale was used to assess the presence and severity of PTS. Doppler US examinations were performed within 1 week of the clinical evaluation. The total number of vessels with reflux, thrombi, recanalization, and collateral vessels were calculated. Results: Of the 205 patients with BD, 62% had had PTS and 18% had had severe PTS. Patients with PTS had had greater reflux (P = .054) and thrombosis (P = .02) scores compared with patients without PTS. Treatment with anticoagulation (AC), immunosuppressive (IS) therapy, or AC combined with IS drugs did not affect the occurrence of PTS. However, patients treated with IS therapy, with or without AC drugs, had a decreased incidence of severe PTS compared with the AC-only group (P = .017). Patients treated with AC plus IS agents also had increased collateral scores compared with patients treated with only IS drugs. Interferon-a use seemed to provide better recanalization scores compared with azathioprine only (1.0 [range, 0-14] vs 2.5 [range, 0-10]; P = .010). Conclusions: Patients with BD and DVT have a high risk of developing severe PTS. IS treatment decreases the development of severe PTS. AC therapy might influence the course of PTS by increasing the collateral scores, and the use of interferon-a also increased recanalization scores. Routine assessment with Doppler US examinations could be helpful in the prediction of severe PTS.Publication Preferences of inflammatory arthritis patients for biological disease-modifying antirheumatic drugs in the first 100 days of the COVID-19 pandemic(TÜBİTAK, 2021-01-01) Kalyoncu, Umut; Pehlivan, Yavuz; Akar, Servet; Kaşifoğlu, Timuçin; Kimyon, Gezmiş; Karadağ, Ömer; Dalkılıç, Ediz; Ertenli, Ali İhsan; Kılıç, Levent; Ersözlü, Duygu; Beş, Cemal; Emmungil, Hakan; Mercan, Rıdvan; Ediboğlu, Elif Durak; Kanıtez, Nilüfer; Bilgin, Emre; Çolak, Seda; Koca, Süleyman Serdar; Gönüllü, Emel; Küçükşahin, Orhan; Coşkun, Nihan; Yağız, Burcu; Kiraz, Sedat; PEHLİVAN, YAVUZ; DALKILIÇ, HÜSEYİN EDİZ; COŞKUN, BELKIS NİHAN; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0002-3734-1242; 0000-0003-1372-1555; 0000-0001-5184-4404; 0000-0003-1185-5816; 0000-0002-2260-4660; 0000-0003-4995-430X; 0000-0002-6990-4206; W-7332-2019; AAK-7851-2021; AAD-5448-2019; AAZ-5845-2021; AAG-8227-2021; C-8092-2015; JQW-5031-2023; GZA-3287-2022Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of COVID-19, the rate of continuation on bDMARDs, the reasons for treatment discontinuation, if any, and the current general disease activity (visual analog scale, [VAS]). Results: A total of 1394 patients (493 RA [47.3% on anti-TNF] patients and 901 SpA [90.0% on anti-TNF] patients) were included in the study. Overall, 2.8% of the patients had symptoms suggesting COVID-19, and 2 (0.15%) patients had PCR-confirmed COVID-19. Overall, 18.1% of all patients (13.8% of the RA and 20.5% of the SpA; p = 0.003) discontinued their bDMARDs. In the SpA group, the patients who discontinued bDMARDs were younger (40 [21-73] vs. 44 years [20-79]; p = 0.005) and had higher general disease activity; however, no difference was relevant for RA patients. Conclusion: Although the COVID-19 was quite uncommon in the first 100 days of the pandemic, nearly one-fifth of the patients discontinued bDMARDs within this period. The long-term effects of the pandemic should be monitored.Publication Isotretinoin-induced sacroiliitis in patients with hidradenitis suppurativa: A case-based review(Springer Heidelberg, 2019-12-01) Coşkun, Belkıs Nihan; COŞKUN, BELKIS NİHAN; Yağız, Burcu; YAĞIZ, BURCU; Pehlivan, Yavuz; PEHLİVAN, YAVUZ; Dalkılıç, Ediz; DALKILIÇ, HÜSEYİN EDİZ; Tıp Fakültesi; AAG-7155-2021; AAG-8227-2021; JQW-5031-2023Hidradenitis suppurativa (HS) is a chronic, suppurative skin disease characterized by painful nodules, particularly in the axillae and groin. Isotretinoin can be used in the treatment of HS; however, it may paradoxically lead to skin lesions or worsen the existing lesions. Isotretinoin, which is commonly used in the treatment of severe acne, is associated with several side effects, including rheumatic side effects and rarely sacroiliitis. In this study, we discussed two cases who presented with low back pain after isotretinoin was used for the treatment of acne vulgaris. The patients did not have low back pain before isotretinoin use and did not have enthesitis, dactylitis, uveitis, psoriasis, recent infection, trauma, and family history spondylitis. HLA-B27 was negative. Bone-marrow edema was detected at the sacroiliac joint on magnetic resonance imaging. Because of these findings, sacroiliitis related to the drug was considered in our patients and isotretinoin treatments were discontinued. Because the patients' low back pain continued when they administered non-steroidal anti-inflammatory drugs, biological drug treatments were started. Both cases presented had a simultaneous HS lesion. After the treatment, both low back pain and HS lesions regressed. Patients with isotretinoin therapy should be alerted for inflammatory low back pain and HS lesions that may develop. We should note that biologic agents should be considered in the treatment of resistant cases.Publication Characteristics of patients who received biological treatment after kidney transplantation and the incidence of serious infections: A multicenter study(Bmj Publishing Group, 2023-06-01) Yıldırım, T. Demirci; Kökoğlu, E. Oğuz; Coşkun, B. N.; Yıldırım, D.; Şenel, S.; Pehlivan, Y.; Küçük, H.; Kaşifoğlu, T.; Sarı, I.; COŞKUN, BELKIS NİHAN; PEHLİVAN, YAVUZ; Tıp Fakültesi; Romatoloji Ana Bilim Dalı; KIW-0794-2024; FQP-0451-2022Publication General characteristics of male breast cancer patients in Bursa region(Aves, 2012-07-01) Avcı, Nilüfer; Balcı, Mehmet Ali; Esen, İrfan; Tandoğan, Gülen; Merter, Mustafa; Çubukcu, Erdem; Ölmez, Fatih; Coşkun, Belkıs Nihan; Hartavi, Mustafa; Tolunay, Şahsine; Avcı, Nilüfer; Balcı, Mehmet Ali; Esen, İrfan; Tandoğan, Gülen; Merter, Mustafa; ÇUBUKÇU, ERDEM; Ölmez, Fatih; COŞKUN, BELKIS NİHAN; Hartavi, Mustafa; TOLUNAY, ŞAHSİNE; Tıp Fakültesi; Medikal Onkoloji Ana Bilim Dalı; 0000-0003-1465-7153; AAI-1612-2021; ABD-7124-2020; AAG-7155-2021; ABI-4413-2020; CCT-7946-2022; DYT-8587-2022; DFP-9003-2022; JGT-4101-2023; JGV-7746-2023; CUI-5353-2022Introduction: Male breast cancer constitutes less than 1% of all cases of breast cancer. In this study, we analyzed clinical and pathological features of male breast cancer cases, which had been followed up and treated at our institution.Material and Method: The data regarding the main clinicopathological features of the male breast cancer patients were retrieved from the patients' records retrospectively.Results: A total of 16 patients were included in the analysis with a median age of 60 (41-75). The most common cell type was infiltrating ductal carcinoma, comprising 81.3 % of all cases. Most patients were staged as locally advanced (50% - stage 3) at the time of diagnosis. Estrogen and/or progesterone receptor positivity were found in 13 patients (81.3%). HER2 status could be examined in 9 patients, and 4 patients (25%) found to be positive for HER2 overexpression. Overall survival was 3(1-12) years and disease-free survival was 2 (1-8) years.Discussion: Despite the increasing knowledge about breast cancer in women, little is known in case of male breast cancer management. Therefore, there is a strong need to perform randomized studies for the treatment of male breast cancer.Publication Evaluation of rheumatoid arthritis and connective tissue disease-related interstitial lung disease with pulmonary physiologic test, HRCT, and patient-based measures of dyspnea and functional disability(Springer London, 2021-03-11) Topcu, Atakan; Mursaloğlu, H. Hakan; Yalcınkaya, Yasemin; Karakurt, Sait; Yağız, Burcu; Alaca, Zeynep; Demir, Meryem; Coşkun, Belkıs Nihan; Dalkılıç, Ediz; İnanç, Nevsun; YAĞIZ, BURCU; COŞKUN, BELKIS NİHAN; DALKILIÇ, HÜSEYİN EDİZ; Tıp Fakültesi; Romatoloji Ana Bilim Dalı; 0000-0003-0298-4157; 0000-0002-0624-1986; 0000-0001-8645-2670; JQW-5031-2023; AAG-7155-2021; CMF-4757-2022Objectives We aim to investigate the relationship between pulmonary function and imaging parameters with symptom-related patient-reported outcome measures (PROs). Method We included 65 patients of rheumatoid arthritis (RA) and connective tissue disease (CTD) with and without interstitial lung disease (ILD) into this cross-sectional study. We evaluated the relationship between FVC, DLco, and PROs and compared to HRCT findings. PROs included visual analogue scale for breathing, modified Borg scale, medical research council dyspnea scale, St. George's respiratory questionnaire (SGRQ), Leicester cough questionnaire, and Short Form 36 quality of life (SF-36 QoL). Results The mean age was 57.4 +/- 9.7 and 61.9% (39/65) of patients had an established ILD. In RA-ILD group, SGRQ score was higher (p < 0.001) and SF-36 physical functioning score was lower (p = 0.02) than CTD-ILD group. In RA group, there was a significant correlation between FVC and SF-36 role functioning/physical score (r = 0.724, p = 0.012). In CTD group, SF-36 general health score was correlated with both FVC (r = 0.441, p = 0.045) and DLco (r = 0.485, p = 0.035), and also SF-36 physical functioning score was correlated with FVC (r = 0.441, p = 0.040). PROs were found to be similar between ILD and non-ILD patients. SF-36 QoL total and SGRQ outcomes were worse in non-ILD group. Conclusions We concluded that PROs could be used to evaluate health-related quality of life (HRQoL) in RA- or CTD-related ILD. The physical health determinants of HRQoL are measurably worse in RA-ILD patients than in CTD patients. But, PROs may not be very helpful in differentiating patients with cough and/or shortness of breath due to ILD or non-ILD causes in RA/CTD.Publication Clinical and laboratory factors associated with bamboo spine in patients with axial spondyloarthritis: Are there clues for bamboo spine?(Clinical & Exper Rheumatology, 2023-03-01) Atagündüz, Mehmet Pamir; Kiraz, S.; Akar, S.; Küçükşahin, Ömer; Erden, Abdulsaniet; Aksoy, Aysun; Beş, Cemal; Kanıtez, Nilüfer Alpay; Kılıç, Levent; Karadağ, Ömer; Kaşifoğlu, Timuçin; Emmungil, H.; Çınar, M.; Kimyon, G.; Yazısız, V.; Ateş, Aşkın; Ersözlü, D.; Gönüllü, Emel; Mercan, R.; Ertenli, I.; Kalyoncu, Umu; Coskun, Belkıs Nihan; COŞKUN, BELKIS NİHAN; Yagiz, Burcu; YAĞIZ, BURCU; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; KIW-0794-2024; JSI-1958-2023Objective To analyse the clinical and laboratory factors associated with bamboo spine.Methods Data of patients fulfilling the 2009 ASAS classification criteria for axial spondyloarthritis, registered in the national, multicentre, longitudinal, and observational database of TReasure was analysed. Radiographs were assessed using the Bath Ankylosing Spondylitis Radiologic Index (BASRI). Data of patients with a bamboo spine (Group 1) was compared to data derived from patients with a longstanding disease of at least 15 years but no syndesmophytes (Group 2).Results Out of the 5060 patients, 1246 had eligible radiographs. There were 111 patients (8.9%) with a bamboo spine. Male sex was more common among patients with bamboo spine. The median BMI of 27.7 (25.8-31.1) in Group1 was higher than the BMI of 25.9 (22.9-29.2) in Group 2 (p<0.001). Hip arthritis, present or documented by a physician, was more common in Group 1 [(58/108 (53.7%) vs. 35/103 (34%), p=0.004]. There was a tendency towards a more prevalent enthesitis in these patients [29.1% (25/86) vs. 15.9%(11/69), p=0.054]. HLA-B27 status did not differ between groups. Smoking was more prevalent in Group 1. Multivariate logistic regression analysis revealed that male sex, body mass index, hip arthritis, and enthesitis are associated with bamboo spine in axSpA.Conclusion Bamboo spine was more common in the male sex and associated with a delay in diagnosis, high BMI, hip involvement, and enthesitis. The constellation of increased body weight, hip arthritis, and enthesitis may imply that mechanical stress contributes to radiographic damage in the presence of chronic inflammation.Publication Anti-cyclic citrullinated peptide and rheumatoid factor in patients with chronic hepatitis B and hepatitis B carriers(Aves, 2015-06-01) Dalkılıç, Ediz; Öksüz, Mustafa Ferhat; Tufan, Ayşe Nur; Özbek, Aysun; Nizamoğlu, Ali; Dölarslan, Mürşide Esra; Coşkun, Belkıs Nihan; Pehlivan, Yavuz; DALKILIÇ, HÜSEYİN EDİZ; Öksüz, Mustafa Ferhat; Tufan, Ayşe Nur; Özbek, Aysun; Nizamoğlu, Ali; Dölarslan, Mürşide Esra; COŞKUN, BELKIS NİHAN; PEHLİVAN, YAVUZ; Tıp Fakültesi; Romatoloji Ana Bilim Dalı; 0000-0002-8669-4212; 0000-0003-0298-4157; JHC-5173-2023; KQP-2558-2024; GHE-4236-2022; JHC-7868-2023; DKA-0061-2022; D-5535-2019; AAG-7155-2021; AAG-8227-2021Objective: Rheumatoid factor (RF) positivity that may occur in a number of patients with hepatitis B (HBV) infection poses challenges in terms of differential diagnosis with rheumatoid arthritis (RA). On the other hand, antibodies to cyclic citrullinated peptide (anti-CCP) may prove to be an important marker for differential diagnosis of the two conditions. This study aimed to assess anti-CCP and RF positivity among patients with hepatitis B and rheumatoid arthritis.Material and Methods: Anti-CCP and RF seropositivity was assessed in 61 patients with HBV infection (32 patients with chronic hepatitis, 29 patients with inactive HBV carrier status) and 40 patients with RA as the control group.Results: RF positivity was found in 18.7% and 34.4% of the patients with chronic hepatitis B and inactive HBV carrier status, respectively. On the other hand, only one patient with chronic HBV had low positive anti-CCP. RF was positive in 24 (60%) and anti-CCP was positive in 26 (65%) patients among the 40 patients with RA.Conclusion: Anti-CCP may be helpful in the differential diagnosis between RA and chronic HBV infection or inactive HBV carrier status.