Publication:
Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones

dc.contributor.buuauthorGüvenç, Gökçen
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorKaşıkçı, Esra
dc.contributor.buuauthorÖzyurt, Ebru
dc.contributor.buuauthorBaş, Ayşenur
dc.contributor.buuauthorUdum, Duygu
dc.contributor.buuauthorNiaz, Nasir
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi
dc.contributor.orcid0000-0002-1413-3651
dc.contributor.orcid000-0002-9534-736X
dc.contributor.orcid0000-0003-1591-510X
dc.contributor.orcid0000-0001-7052-1694
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.researcheridAAR-6815-2021
dc.contributor.researcheridIYS-2646-2023
dc.contributor.researcheridCZB-8484-2022
dc.contributor.researcheridGDW-7164-2022
dc.contributor.researcheridAAH-5167-2021
dc.contributor.researcheridAAC-4975-2022
dc.contributor.researcheridAAG-6956-2021
dc.contributor.scopusid56529426800
dc.contributor.scopusid55356919300
dc.contributor.scopusid57209073902
dc.contributor.scopusid57211540698
dc.contributor.scopusid57211534062
dc.contributor.scopusid31967936400
dc.contributor.scopusid7060367600
dc.contributor.scopusid57192959734
dc.date.accessioned2024-05-28T13:42:04Z
dc.date.available2024-05-28T13:42:04Z
dc.date.issued2019-12
dc.description.abstractPhoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.
dc.identifier.doihttps://doi.org/10.1111/and.13410
dc.identifier.issn0303-4569
dc.identifier.issue11
dc.identifier.pubmed31637758
dc.identifier.scopus2-s2.0-85074360824
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/and.13410
dc.identifier.urihttps://hdl.handle.net/11452/41543
dc.identifier.volume51
dc.identifier.wos000491929400001
dc.indexed.pubmedPubMed
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.bapOUAP(V)2015/26
dc.relation.journalAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHypothalamic-pituitary-gonadal axis
dc.subjectIntracerebroventricular
dc.subjectMale sex hormones
dc.subjectNesfatin-1
dc.subjectPhoenixin
dc.subjectLuteinizing-hormone
dc.subjectGonadotropin-secretion
dc.subjectFood-intake
dc.subjectPeptide
dc.subjectBrain
dc.subjectNucb2/nesfatin-1
dc.subjectTestosterone
dc.subjectNeuropeptıde
dc.subjectExpressıon
dc.subjectPuberty
dc.subject.meshAnimals
dc.subject.meshGonadotropin-Releasing Hormone
dc.subject.meshGonadotropins
dc.subject.meshPituitary
dc.subject.meshHypothalamic Hormones
dc.subject.meshMale
dc.subject.meshNucleobindins
dc.subject.meshPeptide hormones
dc.subject.meshRats
dc.subject.meshWistar
dc.subject.meshTestosterone
dc.subject.scopusNesfatin-1; Calcium-Binding Protein; Hypothalamus
dc.subject.wosAndrology
dc.titleContingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones
dc.typeArticle
dspace.entity.typePublication

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