Publication: Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones
dc.contributor.buuauthor | Güvenç, Gökçen | |
dc.contributor.buuauthor | Altınbaş, Burçin | |
dc.contributor.buuauthor | Kaşıkçı, Esra | |
dc.contributor.buuauthor | Özyurt, Ebru | |
dc.contributor.buuauthor | Baş, Ayşenur | |
dc.contributor.buuauthor | Udum, Duygu | |
dc.contributor.buuauthor | Niaz, Nasir | |
dc.contributor.buuauthor | Yalçın, Murat | |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi | |
dc.contributor.orcid | 0000-0002-1413-3651 | |
dc.contributor.orcid | 000-0002-9534-736X | |
dc.contributor.orcid | 0000-0003-1591-510X | |
dc.contributor.orcid | 0000-0001-7052-1694 | |
dc.contributor.orcid | 0000-0002-5600-8162 | |
dc.contributor.researcherid | AAR-6815-2021 | |
dc.contributor.researcherid | IYS-2646-2023 | |
dc.contributor.researcherid | CZB-8484-2022 | |
dc.contributor.researcherid | GDW-7164-2022 | |
dc.contributor.researcherid | AAH-5167-2021 | |
dc.contributor.researcherid | AAC-4975-2022 | |
dc.contributor.researcherid | AAG-6956-2021 | |
dc.contributor.scopusid | 56529426800 | |
dc.contributor.scopusid | 55356919300 | |
dc.contributor.scopusid | 57209073902 | |
dc.contributor.scopusid | 57211540698 | |
dc.contributor.scopusid | 57211534062 | |
dc.contributor.scopusid | 31967936400 | |
dc.contributor.scopusid | 7060367600 | |
dc.contributor.scopusid | 57192959734 | |
dc.date.accessioned | 2024-05-28T13:42:04Z | |
dc.date.available | 2024-05-28T13:42:04Z | |
dc.date.issued | 2019-12 | |
dc.description.abstract | Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA. | |
dc.identifier.doi | https://doi.org/10.1111/and.13410 | |
dc.identifier.issn | 0303-4569 | |
dc.identifier.issue | 11 | |
dc.identifier.pubmed | 31637758 | |
dc.identifier.scopus | 2-s2.0-85074360824 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1111/and.13410 | |
dc.identifier.uri | https://hdl.handle.net/11452/41543 | |
dc.identifier.volume | 51 | |
dc.identifier.wos | 000491929400001 | |
dc.indexed.pubmed | PubMed | |
dc.indexed.scopus | Scopus | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.bap | OUAP(V)2015/26 | |
dc.relation.journal | Andrologia | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Hypothalamic-pituitary-gonadal axis | |
dc.subject | Intracerebroventricular | |
dc.subject | Male sex hormones | |
dc.subject | Nesfatin-1 | |
dc.subject | Phoenixin | |
dc.subject | Luteinizing-hormone | |
dc.subject | Gonadotropin-secretion | |
dc.subject | Food-intake | |
dc.subject | Peptide | |
dc.subject | Brain | |
dc.subject | Nucb2/nesfatin-1 | |
dc.subject | Testosterone | |
dc.subject | Neuropeptıde | |
dc.subject | Expressıon | |
dc.subject | Puberty | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Gonadotropin-Releasing Hormone | |
dc.subject.mesh | Gonadotropins | |
dc.subject.mesh | Pituitary | |
dc.subject.mesh | Hypothalamic Hormones | |
dc.subject.mesh | Male | |
dc.subject.mesh | Nucleobindins | |
dc.subject.mesh | Peptide hormones | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Wistar | |
dc.subject.mesh | Testosterone | |
dc.subject.scopus | Nesfatin-1; Calcium-Binding Protein; Hypothalamus | |
dc.subject.wos | Andrology | |
dc.title | Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones | |
dc.type | Article | |
dspace.entity.type | Publication |