Publication: Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study
dc.contributor.author | Gajic, Ognien | |
dc.contributor.author | Dabbagh, Ousama | |
dc.contributor.author | Park, Pauline K. | |
dc.contributor.author | Adesanya, Adebola | |
dc.contributor.author | Chang, Steven Y. | |
dc.contributor.author | Hou, Peter | |
dc.contributor.author | Anderson, Harry, III | |
dc.contributor.author | Hoth, J. Jason | |
dc.contributor.author | Mikkelsen, Mark E. | |
dc.contributor.author | Gentile, Nina T. | |
dc.contributor.author | Gong, Michelle N. | |
dc.contributor.author | Talmor, Daniel | |
dc.contributor.author | Bajwa, Ednan | |
dc.contributor.author | Watkins, Timothy R. | |
dc.contributor.author | Festic, Emir | |
dc.contributor.author | Yılmaz, Murat | |
dc.contributor.author | Kaufman, David A. | |
dc.contributor.author | Esper, Annette M. | |
dc.contributor.author | Sadikot, Ruxana | |
dc.contributor.author | Douglas, Ivor | |
dc.contributor.author | Sevransky, Jonathan | |
dc.contributor.author | Malinchoc, Michael | |
dc.contributor.buuauthor | İşçimen, Remzi | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0001-8111-5958 | tr_TR |
dc.contributor.researcherid | AAI-8104-2021 | tr_TR |
dc.contributor.scopusid | 16645821200 | tr_TR |
dc.date.accessioned | 2022-11-08T11:50:07Z | |
dc.date.available | 2022-11-08T11:50:07Z | |
dc.date.issued | 2011-02 | |
dc.description.abstract | Rationale: Accurate, early identification of patients at risk for developing acute lung injury (ALI) provides the opportunity to test and implement secondary prevention strategies. Objectives: To determine the frequency and outcome of ALI development in patients at risk and validate a lung injury prediction score (LIPS). Methods: In this prospective multicenter observational cohort study, predisposing conditions and risk modifiers predictive of ALI development were identified from routine clinical data available during initial evaluation. The discrimination of the model was assessed with area under receiver operating curve (AUC). The risk of death from ALI was determined after adjustment for severity of illness and predisposing conditions. Measurements and Main Results: Twenty-two hospitals enrolled 5,584 patients at risk All developed a median of 2 (interquartile range 1-4) days after initial evaluation in 377 (6.8%; 148 ALI-only, 229 adult respiratory distress syndrome) patients. The frequency of ALI varied according to predisposing conditions (from 3% in pancreatitis to 26% after smoke inhalation). LIPS discriminated patients who developed ALI from those who did not with an AUC of 0.80(95% confidence interval, 0.78-0.82). When adjusted for severity of illness and predisposing conditions, development of ALI increased the risk of in-hospital death (odds ratio, 4.1; 95% confidence interval, 2.9-5.7). Conclusions: ALI occurrence varies according to predisposing conditions and carries an independently poor prognosis. Using routinely available clinical data, LIPS identifies patients at high risk for ALI early in the course of their illness. This model will alert clinicians about the risk of ALI and facilitate testing and implementation of ALI prevention strategies. | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA HL78743-01A1, 1 KL2 RR024151 | en_US |
dc.description.sponsorship | Mayo Clinic Critical Care Research Committee | en_US |
dc.description.sponsorship | Sanofi-Aventis | en_US |
dc.description.sponsorship | Pfizer | en_US |
dc.description.sponsorship | University of Missouri | en_US |
dc.description.sponsorship | Vital Therapies | en_US |
dc.description.sponsorship | Maquet Inc. | en_US |
dc.description.sponsorship | Eli Lilly | en_US |
dc.description.sponsorship | Artisan Pharma | en_US |
dc.description.sponsorship | Allen | en_US |
dc.description.sponsorship | Grice | en_US |
dc.description.sponsorship | Ammons | en_US |
dc.description.sponsorship | American Lung Association | en_US |
dc.description.sponsorship | American College of Surgeons | en_US |
dc.description.sponsorship | Vapotherm in industry | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Center for Advancing Translational Sciences (NCATS) | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Center for Research Resources (NCRR) - KL2RR024151 | en_US |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI) - K23HL087934 | en_US |
dc.description.statementofresponsibility | Walker | en_US |
dc.identifier.citation | Gajic, O. vd. (2011). "Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study". American Journal of Respiratory and Critical Care Medicine, 183(4), 462-470. | en_US |
dc.identifier.endpage | 470 | tr_TR |
dc.identifier.issn | 1073-449X | |
dc.identifier.issn | 1535-4970 | |
dc.identifier.issue | 4 | tr_TR |
dc.identifier.pubmed | 20802164 | tr_TR |
dc.identifier.scopus | 2-s2.0-78650060535 | tr_TR |
dc.identifier.startpage | 462 | tr_TR |
dc.identifier.uri | https://doi.org/10.1164/rccm.201004-0549OC | |
dc.identifier.uri | https://www.atsjournals.org/doi/full/10.1164/rccm.201004-0549OC | |
dc.identifier.uri | http://hdl.handle.net/11452/29428 | |
dc.identifier.volume | 183 | tr_TR |
dc.identifier.wos | 000287568500010 | |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Thoracic Society | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | General & internal medicine | en_US |
dc.subject | Respiratory system | en_US |
dc.subject | Respiratory distress syndrome | en_US |
dc.subject | Adult | en_US |
dc.subject | Prevention | en_US |
dc.subject | Prediction model | en_US |
dc.subject | Acute respiratory failure | en_US |
dc.subject | Respiratory-distress-syndrome | en_US |
dc.subject | Community-acquired pneumonia | en_US |
dc.subject | Intensive-care-unit | en_US |
dc.subject | Consensus conference | en_US |
dc.subject | Clinical predictors | en_US |
dc.subject | Ventilator settings | en_US |
dc.subject | Acute-pancreatitis | en_US |
dc.subject | Relevant outcomes | en_US |
dc.subject | Severity scores | en_US |
dc.subject | Validation | en_US |
dc.subject.emtree | Abdominal surgery | en_US |
dc.subject.emtree | Acute lung injury | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Adult respiratory distress syndrome | en_US |
dc.subject.emtree | Area under the curve | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Aspiration | en_US |
dc.subject.emtree | Clinical trial | en_US |
dc.subject.emtree | Cohort analysis | en_US |
dc.subject.emtree | Death | en_US |
dc.subject.emtree | Disease course | en_US |
dc.subject.emtree | Disease predisposition | en_US |
dc.subject.emtree | Disease severity | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Fracture | en_US |
dc.subject.emtree | Heart surgery | en_US |
dc.subject.emtree | High risk patient | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Lung contusion | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Multicenter study | en_US |
dc.subject.emtree | Near drowning | en_US |
dc.subject.emtree | Outcome assessment | en_US |
dc.subject.emtree | Pancreatitis | en_US |
dc.subject.emtree | Patient identification | en_US |
dc.subject.emtree | Pneumonia | en_US |
dc.subject.emtree | Prediction | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Prognosis | en_US |
dc.subject.emtree | Prospective study | en_US |
dc.subject.emtree | Scoring system | en_US |
dc.subject.emtree | Sepsis | en_US |
dc.subject.emtree | Shock | en_US |
dc.subject.emtree | Smoke | en_US |
dc.subject.emtree | Spine surgery | en_US |
dc.subject.emtree | Thorax surgery | en_US |
dc.subject.emtree | Traumatic brain injury | en_US |
dc.subject.mesh | Acute lung injury | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Area under curve | en_US |
dc.subject.mesh | Cohort studies | en_US |
dc.subject.mesh | Disease progression | en_US |
dc.subject.mesh | Early diagnosis | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Follow-up studies | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Predictive value of tests | en_US |
dc.subject.mesh | Prospective studies | en_US |
dc.subject.mesh | Reproducibility of results | en_US |
dc.subject.mesh | Risk factors | en_US |
dc.subject.scopus | Adult Respiratory Distress Syndrome; Acute Lung Injury; Artificial Ventilation | en_US |
dc.subject.wos | Critical care medicine | en_US |
dc.subject.wos | Respiratory system | en_US |
dc.title | Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study | en_US |
dc.type | Article | |
dc.wos.quartile | Q1 | en_US |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | tr_TR |