Anti-emetic efficacy of tropisetron and metoclopramide

dc.contributor.buuauthorYılmazlar, Aysun
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.buuauthorGürpınar, Ercan
dc.contributor.buuauthorKorun, Nusret
dc.contributor.buuauthorKutlay, Oya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.date.accessioned2021-09-08T06:13:11Z
dc.date.available2021-09-08T06:13:11Z
dc.date.issued1996
dc.description.abstractPost-operative vomiting, especially in ambulatory surgical patients, remains a troublesome problem. This placebo-controlled, randomized, prospective double-blind trial was designed to evaluate the efficacy of two prophylactic antiemetic regimens on post-operative vomiting in 1-day thyroid surgery. Altogether 60 elective surgical patients were followed for 4 h post-operatively. All patients were American Society of Anesthesiologists physical status of I or II and aged between 22 and 60 years: group 1 was saline control; in groups 2 and 3, metoclopramide (0.2 mg/kg) or tropisetron (5 mg) was administered, respectively, as an intravenous single dose during induction. Patients were pre-medicated. A standardized anaesthetic technique consisting of thiopentone-succinylcholine for induction and fentanyl-nitrous oxide-halothane-pancuronium for maintenance of anaesthesia was used. A 'rescue' anti-emetic was provided in case of continued vomiting or at the patient's request. Anti-emetic inefficacy was defined as request for rescue anti-emetic and/or vomiting episode during the first 4 h post-operation. The number of patients vomiting was 12/20 (60%), 10/20 (50%) and 1/20 (5%) within the first 2 h post-operation in groups 1, 2 and 3, respectively (P > 0.05 for groups 1 and 2; P < 0.01 for groups 2 and 3; P < 0.001 for groups 1 and 3). In group 2, three patients required rescue medication during the first 2 h post-operation, but no significant difference was observed between groups 2 and 3 (P > 0.05). None of the cases in any of the groups needed any rescue medication during postoperative 2 - 4 h. It is concluded that tropisetron is a highly effective anti-emetic drug in the prophylaxis of postoperative vomiting.en_US
dc.identifier.citationYılmazlar, A. vd. (1996). "Anti-emetic efficacy of tropisetron and metoclopramide". Journal of International Medical Research, 24(3), 266-270.en_US
dc.identifier.endpage270tr_TR
dc.identifier.issn0300-0605
dc.identifier.issue3tr_TR
dc.identifier.pubmed8725987tr_TR
dc.identifier.scopus2-s2.0-0029937527tr_TR
dc.identifier.startpage266tr_TR
dc.identifier.urihttps://doi.org/10.1177/030006059602400305
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/030006059602400305
dc.identifier.urihttp://hdl.handle.net/11452/21755
dc.identifier.volume24tr_TR
dc.identifier.wosA1996UN59100005
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.journalJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectMetoclopramideen_US
dc.subjectTropisetronen_US
dc.subjectPost-operative vomitingen_US
dc.subjectPostoperative nauseaen_US
dc.subjectAntagonistsen_US
dc.subjectPreventionen_US
dc.subjectDroperidolen_US
dc.subject.scopusPostoperative Nausea and Vomiting; Palonosetron; Antiemeticsen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleAnti-emetic efficacy of tropisetron and metoclopramideen_US
dc.typeArticle

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