Anti-emetic efficacy of tropisetron and metoclopramide
dc.contributor.buuauthor | Yılmazlar, Aysun | |
dc.contributor.buuauthor | Yılmazlar, Tuncay | |
dc.contributor.buuauthor | Gürpınar, Ercan | |
dc.contributor.buuauthor | Korun, Nusret | |
dc.contributor.buuauthor | Kutlay, Oya | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | tr_TR |
dc.date.accessioned | 2021-09-08T06:13:11Z | |
dc.date.available | 2021-09-08T06:13:11Z | |
dc.date.issued | 1996 | |
dc.description.abstract | Post-operative vomiting, especially in ambulatory surgical patients, remains a troublesome problem. This placebo-controlled, randomized, prospective double-blind trial was designed to evaluate the efficacy of two prophylactic antiemetic regimens on post-operative vomiting in 1-day thyroid surgery. Altogether 60 elective surgical patients were followed for 4 h post-operatively. All patients were American Society of Anesthesiologists physical status of I or II and aged between 22 and 60 years: group 1 was saline control; in groups 2 and 3, metoclopramide (0.2 mg/kg) or tropisetron (5 mg) was administered, respectively, as an intravenous single dose during induction. Patients were pre-medicated. A standardized anaesthetic technique consisting of thiopentone-succinylcholine for induction and fentanyl-nitrous oxide-halothane-pancuronium for maintenance of anaesthesia was used. A 'rescue' anti-emetic was provided in case of continued vomiting or at the patient's request. Anti-emetic inefficacy was defined as request for rescue anti-emetic and/or vomiting episode during the first 4 h post-operation. The number of patients vomiting was 12/20 (60%), 10/20 (50%) and 1/20 (5%) within the first 2 h post-operation in groups 1, 2 and 3, respectively (P > 0.05 for groups 1 and 2; P < 0.01 for groups 2 and 3; P < 0.001 for groups 1 and 3). In group 2, three patients required rescue medication during the first 2 h post-operation, but no significant difference was observed between groups 2 and 3 (P > 0.05). None of the cases in any of the groups needed any rescue medication during postoperative 2 - 4 h. It is concluded that tropisetron is a highly effective anti-emetic drug in the prophylaxis of postoperative vomiting. | en_US |
dc.identifier.citation | Yılmazlar, A. vd. (1996). "Anti-emetic efficacy of tropisetron and metoclopramide". Journal of International Medical Research, 24(3), 266-270. | en_US |
dc.identifier.endpage | 270 | tr_TR |
dc.identifier.issn | 0300-0605 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 8725987 | tr_TR |
dc.identifier.scopus | 2-s2.0-0029937527 | tr_TR |
dc.identifier.startpage | 266 | tr_TR |
dc.identifier.uri | https://doi.org/10.1177/030006059602400305 | |
dc.identifier.uri | https://journals.sagepub.com/doi/10.1177/030006059602400305 | |
dc.identifier.uri | http://hdl.handle.net/11452/21755 | |
dc.identifier.volume | 24 | tr_TR |
dc.identifier.wos | A1996UN59100005 | |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Sage Publications | en_US |
dc.relation.journal | Journal of International Medical Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Research & experimental medicine | en_US |
dc.subject | Pharmacology & pharmacy | en_US |
dc.subject | Metoclopramide | en_US |
dc.subject | Tropisetron | en_US |
dc.subject | Post-operative vomiting | en_US |
dc.subject | Postoperative nausea | en_US |
dc.subject | Antagonists | en_US |
dc.subject | Prevention | en_US |
dc.subject | Droperidol | en_US |
dc.subject.scopus | Postoperative Nausea and Vomiting; Palonosetron; Antiemetics | en_US |
dc.subject.wos | Medicine, research & experimental | en_US |
dc.subject.wos | Pharmacology & pharmacy | en_US |
dc.title | Anti-emetic efficacy of tropisetron and metoclopramide | en_US |
dc.type | Article |
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