Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups

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dc.contributor.authorMarzloff, George
dc.contributor.authorSakamoto, Toshimasa
dc.contributor.authorWurtman, Richard J.
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.date.accessioned2021-11-29T10:49:00Z
dc.date.available2021-11-29T10:49:00Z
dc.date.issued2009-04
dc.description.abstractDeveloping neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5′-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses.tr_TR
dc.description.sponsorshipNational Institute of Mental Health (R37MH028783)tr_TR
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA (R01MH028783)tr_TR
dc.description.sponsorshipMetabolism Charitable Trusttr_TR
dc.description.sponsorshipCenter for Brain Sciencestr_TR
dc.identifier.citationCansev, M. vd. (2009). "Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups". Developmental Neuroscience, 31(3), 181-192.tr_TR
dc.identifier.endpage192tr_TR
dc.identifier.issn03785866
dc.identifier.issue3tr_TR
dc.identifier.pubmed19145070tr_TR
dc.identifier.scopus2-s2.0-67649111166tr_TR
dc.identifier.startpage181tr_TR
dc.identifier.urihttps://doi.org/10.1159/000193394
dc.identifier.urihttps://www.karger.com/Article/Abstract/193394
dc.identifier.urihttp://hdl.handle.net/11452/22851
dc.identifier.volume31tr_TR
dc.identifier.wos000265862500002tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherKargertr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalDevelopmental Neurosciencetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectDendritic spinestr_TR
dc.subjectDevelopmenttr_TR
dc.subjectDocosahexaenoic acidtr_TR
dc.subjectInfant nutritiontr_TR
dc.subjectMembrane phosphatidestr_TR
dc.subjectSynaptic proteinstr_TR
dc.subjectSynaptogenesistr_TR
dc.subjectUridinetr_TR
dc.subjectPolyunsaturated fatty-acidstr_TR
dc.subjectNucleoside transporter familytr_TR
dc.subjectCdp-cholinetr_TR
dc.subjectArachidonic-acidtr_TR
dc.subjectDendritic spinestr_TR
dc.subjectBreast-milktr_TR
dc.subjectPheochromocytoma cellstr_TR
dc.subjectNeurite outgrowthtr_TR
dc.subjectFetal-developmenttr_TR
dc.subjectDietary cholinetr_TR
dc.subjectDevelopmental biologytr_TR
dc.subjectNeurosciences & neurologytr_TR
dc.subject.emtreeDocosahexaenoic acidtr_TR
dc.subject.emtreePhospholipidtr_TR
dc.subject.emtreePostsynaptic density protein 95tr_TR
dc.subject.emtreeSynapsin Itr_TR
dc.subject.emtreeUridine phosphatetr_TR
dc.subject.emtreeAnimal experimenttr_TR
dc.subject.emtreeAnimal tissuetr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeBirthtr_TR
dc.subject.emtreeBraintr_TR
dc.subject.emtreeBrain developmenttr_TR
dc.subject.emtreeBreast feedingtr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeDendritic spinetr_TR
dc.subject.emtreeDrug effecttr_TR
dc.subject.emtreeDrug mechanismtr_TR
dc.subject.emtreeFemaletr_TR
dc.subject.emtreeFetustr_TR
dc.subject.emtreeHippocampustr_TR
dc.subject.emtreeLactationtr_TR
dc.subject.emtreeMaternal nutritiontr_TR
dc.subject.emtreeNewborntr_TR
dc.subject.emtreeNonhumantr_TR
dc.subject.emtreePregnancytr_TR
dc.subject.emtreePriority journaltr_TR
dc.subject.emtreeRattr_TR
dc.subject.emtreeSupplementationtr_TR
dc.subject.emtreeSynapsetr_TR
dc.subject.meshAdministration, oraltr_TR
dc.subject.meshAnimalstr_TR
dc.subject.meshAnimals, newborntr_TR
dc.subject.meshBlotting, westerntr_TR
dc.subject.meshBraintr_TR
dc.subject.meshBrain chemistrytr_TR
dc.subject.meshDendritestr_TR
dc.subject.meshDietary supplementstr_TR
dc.subject.meshDocosahexaenoic acidstr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshPhospholipidstr_TR
dc.subject.meshPregnancytr_TR
dc.subject.meshRatstr_TR
dc.subject.meshRats, sprague-dawleytr_TR
dc.subject.meshSynapsestr_TR
dc.subject.meshUridinetr_TR
dc.subject.scopusCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicolinetr_TR
dc.subject.wosDevelopmental biologytr_TR
dc.subject.wosNeurosciencestr_TR
dc.titleGiving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pupstr_TR
dc.typeArticle
dc.wos.quartileQ3tr_TR

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