Inflammatory response markers in rats undergoing abdominal surgical procedures

dc.contributor.authorUysal, Erdal
dc.contributor.authorSezgin, Efe
dc.contributor.buuauthorKirdak, Türkay
dc.contributor.buuauthorÇeçen, Gülce Sevdar
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.departmentUludağ Üniversites/Tıp Fakültes/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridCZX-7145-2022tr_TR
dc.contributor.researcheridJCN-7924-2023tr_TR
dc.contributor.researcheridEPN-2927-2022tr_TR
dc.contributor.scopusid8704181100tr_TR
dc.contributor.scopusid57218595192tr_TR
dc.contributor.scopusid6507468595tr_TR
dc.date.accessioned2023-10-20T06:38:22Z
dc.date.available2023-10-20T06:38:22Z
dc.date.issued2020
dc.description.abstractBackground The aim of this study was to determine the effectiveness of cortisol, interleukin (IL)-6, C-reactive protein (CRP), and white blood cell (WBC) count as inflammatory markers to evaluate the postoperative inflammatory response associated with various abdominal surgical procedures in rats. Methods Wistar albino rats (N=152) were randomly assigned to 7 groups: control, hepatectomy, splenectomy, nephrectomy, colectomy, gastrectomy, and sham. Apart from the control group, each group was then divided into 3 subgroups: 6th, 24th and 48th h. Thus, a total of 19 groups were defined, each including 8 rats. At the 6th, 24th and 48th h following the surgical procedures blood samples from each rat were collected. The plasma concentrations of IL- 6, cortisol, CRP, and WBC were measured. Results Both the surgery category and the elapsed time after the surgery had a significant effect on IL-6 levels (P<0.0001). Blood CRP levels were primarily determined by the surgery category (P<0.0001). Neither surgery nor the elapsed time had a significant effect on the cortisol levels. The elapsed time after surgery was the major factor that influenced the differences in WBC count among the surgery groups (P<0.0001). Conclusions Our results cumulatively indicate that the levels of IL-6, CRP, and cortisol and WBC count change at different time points after several abdominal surgical procedures. Cortisol level is not related to the type of surgical procedure or the elapsed time, while WBC count decreases with the elapsed time. None of the changes in the markers investigated in this study is specifically related to the category of abdominal surgical procedure.en_US
dc.identifier.citationKirdak, T. vd. (2020). "Inflammatory response markers in rats undergoing abdominal surgical procedures". Annals of Gastroenterology, 33(5), 528-535.en_US
dc.identifier.endpage535tr_TR
dc.identifier.issn1108-7471
dc.identifier.issn1792-7463
dc.identifier.issue5tr_TR
dc.identifier.pubmed32879601tr_TR
dc.identifier.scopus2-s2.0-85089713533tr_TR
dc.identifier.startpage528tr_TR
dc.identifier.urihttps://doi.org/10.20524/aog.2020.0511
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406820/pdf/AnnGastroenterol-33-528.pdf
dc.identifier.urihttp://hdl.handle.net/11452/34479
dc.identifier.volume33tr_TR
dc.identifier.wos000561139300013tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosESCIen_US
dc.language.isoenen_US
dc.publisherHellenic Soc Gastroenterologyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalAnnals of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subjectSurgicalen_US
dc.subjectProcedureen_US
dc.subjectInflammatoryen_US
dc.subjectResponseen_US
dc.subjectCortisolen_US
dc.subjectInterleukin-6en_US
dc.subjectC-reactive proteinen_US
dc.subjectStress-responseen_US
dc.subjectMetabolic responseen_US
dc.subjectGeneral-anesthesiaen_US
dc.subjectCytokineen_US
dc.subjectSurgeryen_US
dc.subjectTraumaen_US
dc.subjectLiveren_US
dc.subjectNephrectomyen_US
dc.subjectColectomyen_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeHydrocortisoneen_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeAbdominal surgeryen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeGastrectomyen_US
dc.subject.emtreeGeneral anesthesiaen_US
dc.subject.emtreeHemicolectomyen_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeLaparoscopyen_US
dc.subject.emtreeLaparotomyen_US
dc.subject.emtreeLeukocyte counten_US
dc.subject.emtreeLiver resectionen_US
dc.subject.emtreeNephrectomyen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSleeve gastrectomyen_US
dc.subject.emtreeSplenectomyen_US
dc.subject.emtreeStomach mucosaen_US
dc.subject.emtreeWistar raten_US
dc.subject.scopusPneumoperitoneum; Laparoscopy; Portsen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.titleInflammatory response markers in rats undergoing abdominal surgical proceduresen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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