Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area
dc.contributor.author | Millington, William | |
dc.contributor.author | Myer, Brian | |
dc.contributor.author | Cutrera, Rodolfo | |
dc.contributor.author | Feleder, Carlos | |
dc.contributor.buuauthor | Yılmaz, Mustafa Sertaç | |
dc.contributor.buuauthor | Göktalay, Gökhan | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-9496-1475 | tr_TR |
dc.contributor.researcherid | AAH-1571-2021 | tr_TR |
dc.contributor.researcherid | AAH-1448-2021 | tr_TR |
dc.contributor.scopusid | 8895544100 | tr_TR |
dc.contributor.scopusid | 6508023759 | tr_TR |
dc.date.accessioned | 2022-03-14T12:15:29Z | |
dc.date.available | 2022-03-14T12:15:29Z | |
dc.date.issued | 2008-10-15 | |
dc.description.abstract | We recently reported that the preoptic anterior hypothalamic area (POA) mediates the hypotensive response evoked by lipopolysaccharide (LPS). In this study, we investigated how the inflammatory signal induced by Lips reaches the POA. Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension. Microinjection of the alpha-adrenergic receptor antagonist phentolamine into the POA, blocked initiation of the hypotensive response and prevented the late decompensatory phase. These data suggest that LPS hypotension is mediated by the vagus nerve which conveys the signal to the NTS and, in turn, stimulates norepinephrine release within the POA. | tr_TR |
dc.description.sponsorship | Albany College of Pharmacy | en_US |
dc.identifier.citation | Yılmaz, M.S. vd. (2008). ''Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area''. Journal of Neuroimmunology, 203(1), 39-49. | en_US |
dc.identifier.endpage | 49 | tr_TR |
dc.identifier.issn | 0165-5728 | |
dc.identifier.issn | 1872-8421 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 18653249 | tr_TR |
dc.identifier.scopus | 2-s2.0-52949137864 | tr_TR |
dc.identifier.startpage | 39 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.jneuroim.2008.06.023 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S016557280800249X | |
dc.identifier.uri | http://hdl.handle.net/11452/24998 | |
dc.identifier.volume | 203 | tr_TR |
dc.identifier.wos | 000260695200006 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Journal of Neuroimmunology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Alpha-adrenergic receptors | en_US |
dc.subject | Endotoxic shock | en_US |
dc.subject | Hypotension | en_US |
dc.subject | Nucleus tractus solitarius | en_US |
dc.subject | Vagus nerve | en_US |
dc.subject | Tumor-necrosis-factor | en_US |
dc.subject | C-fos expression | en_US |
dc.subject | Subdiaphragmatic vagotomy | en_US |
dc.subject | Nitric-oxide | en_US |
dc.subject | Tnf-alpha | en_US |
dc.subject | Body-temperature | en_US |
dc.subject | Endotoxic fever | en_US |
dc.subject | Guinea-pigs | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Rat | en_US |
dc.subject.emtree | Alpha adrenergic receptor | en_US |
dc.subject.emtree | Lidocaine | en_US |
dc.subject.emtree | Lipopolysaccharide | en_US |
dc.subject.emtree | Noradrenalin | en_US |
dc.subject.emtree | Phentolamine | en_US |
dc.subject.emtree | Propranolol | en_US |
dc.subject.emtree | Adrenergic system | en_US |
dc.subject.emtree | Adrenergic transmission | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Anterior hypothalamus | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Hypotension | en_US |
dc.subject.emtree | Immune response | en_US |
dc.subject.emtree | Inflammation | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Neuropathology | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Noradrenalin release | en_US |
dc.subject.emtree | Pharmacological blocking | en_US |
dc.subject.emtree | Preoptic area | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Solitary tract nucleus | en_US |
dc.subject.emtree | Vagotomy | en_US |
dc.subject.emtree | Vagus nerve | en_US |
dc.subject.mesh | Acute disease | en_US |
dc.subject.mesh | Adrenergic alpha-antagonists | en_US |
dc.subject.mesh | Anesthetics, local | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Hypotension | en_US |
dc.subject.mesh | Lidocaine | en_US |
dc.subject.mesh | Lipopolysaccharides | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Phentolamine | en_US |
dc.subject.mesh | Preoptic -area | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-Dawled | en_US |
dc.subject.mesh | Receptors, adrenergic, alpha | en_US |
dc.subject.mesh | Shock, septic | en_US |
dc.subject.mesh | Signal transduction | en_US |
dc.subject.mesh | Solitary nucleus | en_US |
dc.subject.mesh | Vagotomy | en_US |
dc.subject.mesh | Vagus nerve | en_US |
dc.subject.scopus | Illness Behavior; Leukocyte Endogenous Mediator; Antipyretics | en_US |
dc.subject.wos | Immunology | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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