Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer
dc.contributor.buuauthor | Tuncay, Berrin | |
dc.contributor.buuauthor | Cecener, Gülşah | |
dc.contributor.buuauthor | Engeli, U. | |
dc.contributor.buuauthor | Gözü, Oktay | |
dc.contributor.buuauthor | Karadağ, M. | |
dc.contributor.buuauthor | Özyardımcı, N. | |
dc.contributor.buuauthor | Edward, Ege | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Moleküler Biyoloji ve Genetik Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-1619-6680 | tr_TR |
dc.contributor.orcid | 0000-0002-3820-424X | tr_TR |
dc.contributor.researcherid | ABI-6078-2020 | tr_TR |
dc.contributor.researcherid | AAP-9988-2020 | tr_TR |
dc.contributor.scopusid | 23103142200 | tr_TR |
dc.contributor.scopusid | 6602965754 | tr_TR |
dc.contributor.scopusid | 6508156530 | tr_TR |
dc.contributor.scopusid | 6701760348 | tr_TR |
dc.contributor.scopusid | 6505942273 | tr_TR |
dc.contributor.scopusid | 6701341320 | tr_TR |
dc.contributor.scopusid | 8833423400 | tr_TR |
dc.date.accessioned | 2021-11-18T08:46:40Z | |
dc.date.available | 2021-11-18T08:46:40Z | |
dc.date.issued | 2002 | |
dc.description.abstract | Fragile sites are non-staining gaps and breaks on mammalian chromosomes. Several investigators have pointed out that these sites may act as factors that predispose to specific chromosomal rearrangements that are present in some cancer cases. The expression of common fragile sites induced by aphidicolin (Ape) was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 15 patients with lung cancer, 20 of their clinically healthy family members, and 20 age-matched normal controls. As a result of cytogenetic evaluation carried out by the High Resolution Banding (HRB) technique, 1q21, 2q33, 3p14, 7q32, 13q13, 16q23, 17q21, and 22q12 are defined as fragile sites in patients and relatives. The rate of total fragile sites and 2q33, 3p14, and 16q23 are statistically significant in both patients and relatives when compared with the control group. Therefore, our results showed that common fragile sites might be unstable factors in the human genome and they can be used as suitable markers for genetic predisposition to lung cancer. | en_US |
dc.identifier.citation | Karadağ, M. vd. (2002)."Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer". Teratogenesis Carcinogenesis and Mutagenesis, 22(1), 31-40. | en_US |
dc.identifier.endpage | 40 | tr_TR |
dc.identifier.issn | 0270-3211 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 11754385 | tr_TR |
dc.identifier.scopus | 2-s2.0-0036135197 | tr_TR |
dc.identifier.startpage | 31 | tr_TR |
dc.identifier.uri | https://doi.org/10.1002/tcm.1036 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/tcm.1036 | |
dc.identifier.uri | http://hdl.handle.net/11452/22722 | |
dc.identifier.volume | 22 | tr_TR |
dc.identifier.wos | 000172950200003 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Teratogenesis Carcinogenesis and Mutagenesis | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Nonrandom distribution | en_US |
dc.subject | Small cell lung cancer | en_US |
dc.subject | Chromosome aberration | en_US |
dc.subject | Chromosome aberration | en_US |
dc.subject | Common fragile sites | en_US |
dc.subject | Genetic pre-disposition | en_US |
dc.subject | Peripheric blood lymphocyte cultures | en_US |
dc.subject | Breast-cancershort arm | en_US |
dc.subject | Expression frequency | en_US |
dc.subject | Renal-cell | en_US |
dc.subject | Fhit gene | en_US |
dc.subject | Heterozygosity | en_US |
dc.subject | Aphidicolin | en_US |
dc.subject | Lymphocytes | en_US |
dc.subject | Susceptibility | en_US |
dc.subject | Oncology | en_US |
dc.subject | Genetics & heredity | en_US |
dc.subject | Toxicology | en_US |
dc.subject | Mammalia | en_US |
dc.subject.emtree | Chromosome 16q | en_US |
dc.subject.emtree | Aphidicolin | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Aged | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Chromosomal localization | en_US |
dc.subject.emtree | Chromosome 13q | en_US |
dc.subject.emtree | Chromosome 3p | en_US |
dc.subject.emtree | Chromosome 17q | en_US |
dc.subject.emtree | Chromosome 1q | en_US |
dc.subject.emtree | Chromosome 22q | en_US |
dc.subject.emtree | Chromosome 2q | en_US |
dc.subject.emtree | Chromosome 7q | en_US |
dc.subject.emtree | Chromosome breakage | en_US |
dc.subject.emtree | Chromosome fragility | en_US |
dc.subject.emtree | Chromosome high resolution banding analysis | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Cytogenetics | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Gene expression regulation | en_US |
dc.subject.emtree | Gene rearrangement | en_US |
dc.subject.emtree | Genetic marker | en_US |
dc.subject.emtree | Genetic predisposition | en_US |
dc.subject.emtree | Genetic stability | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Lung cancer | en_US |
dc.subject.emtree | Lung small cell cancer | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Metaphase | en_US |
dc.subject.emtree | Peripheral lymphocyte | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Relative | en_US |
dc.subject.mesh | Cytogenetics | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Carcinoma, small cell | en_US |
dc.subject.mesh | Chromosome aberrations | en_US |
dc.subject.mesh | Chromosome breakage | en_US |
dc.subject.mesh | Chromosome fragile sites | en_US |
dc.subject.mesh | Chromosome fragility | en_US |
dc.subject.mesh | Chromosomes, human | en_US |
dc.subject.mesh | Genetic markers | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Genetic predisposition to disease | en_US |
dc.subject.mesh | Lung neoplasms | en_US |
dc.subject.mesh | Lymphocytes | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Pedigree | en_US |
dc.subject.scopus | WW Domain Containing Oxidoreductase; Spinocerebellar Ataxia 12; Chromosome Fragile Sites | en_US |
dc.subject.wos | Oncology | en_US |
dc.subject.wos | Genetics & heredity | en_US |
dc.subject.wos | Toxicology | en_US |
dc.title | Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 (Toxicology) | en_US |
dc.wos.quartile | Q4 | en_US |