Bioallethrin (tablet insektisid)'in sıçanların eritrositer parametreleri üzerine etkisinin araştırılması
Date
1994-10-13
Authors
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Publisher
Uludağ Üniversitesi
Abstract
Bu çalışmada, pyrethroid insektisidlerin bir üyesi olan bioallethrin içeren sivrisinek kovucu tabletlerin, sıçanların eritrositer parametreleri üzerine etkisi incelendi. Deney grupları 7, 15, 30 ve 60 günlük sürelerle günde 9 saat inhalasyon yolu ile bioallethrine maruz bırakıldı. Sürelerin bitiminde deney gruplarındaki ve ayrıca kontrol grubu sıçanlar anesteziye edildi ve direkt kalp ponksiyonu ile kanları alındı. Kanda eritrosit sayısı, Hgb, Hct, MCV, MCH, MCHC ölçüldü ve sonuçlar değerlendirildi. Eritrosit sayısında 7 günlük grupta azalma görüldü. Hgb sadece 30 günlük grupta artış gösterdi. Hct değerinde ise 7 ve 15 günlük gruplarda azalma görüldü. MCV'de hiçbir değişim görülmedi. MCH değeri 7 ve 15 günlük gruplarda artarken, MCHC değeri tüm gruplarda artış gösterdi. Bazı değişiklikler gözlenmesine karşın, bioallethrinin eritrositer parametreler üzerinde çok zararlı etkileri olmadığı sonucuna varıldı.
In this study, the effect of mosquito repellents, which contain bioallethrin a member of the pyrethroid insecticides, have been examined on erythroid parameters in rats. Experiment al groups were exposed to bioallethrin by inhalation for periods of 7, 15, 30, 60 days for nine hours in a day. At the end of the periods, the rats both in experimental and control groups were anaesthetized and blood samples were collected through heart puncture directly. Red blood cell count, Hgb, Hct, MCV, MCH, MCHC in blood were measured and data were evaluated. In the 7-day group a decrease in RBC count was observed. Hgb value was only increased in the 30-day group. In the 7-day and 15-day groups a decrease in Hct value was observed. MCV values were unchanged in all groups. While MCH values were increased in the 7-day and 15-day groups, MCHC values were increased in all groups. Although some changes were observed, we concluded that bioallethrin does not have so much harmful effects on erythroid parameters.
In this study, the effect of mosquito repellents, which contain bioallethrin a member of the pyrethroid insecticides, have been examined on erythroid parameters in rats. Experiment al groups were exposed to bioallethrin by inhalation for periods of 7, 15, 30, 60 days for nine hours in a day. At the end of the periods, the rats both in experimental and control groups were anaesthetized and blood samples were collected through heart puncture directly. Red blood cell count, Hgb, Hct, MCV, MCH, MCHC in blood were measured and data were evaluated. In the 7-day group a decrease in RBC count was observed. Hgb value was only increased in the 30-day group. In the 7-day and 15-day groups a decrease in Hct value was observed. MCV values were unchanged in all groups. While MCH values were increased in the 7-day and 15-day groups, MCHC values were increased in all groups. Although some changes were observed, we concluded that bioallethrin does not have so much harmful effects on erythroid parameters.
Description
Keywords
Bioallethrin, Eritrositer parametreler, Sıçan, Erythroid parameters, Rat
Citation
Noyan, S. vd. (1994). "Bioallethrin (tablet insektisid)'in sıçanların eritrositer parametreleri üzerine etkisinin araştırılması". Uludağ Üniversitesi Tıp Fakültesi Dergisi, 21(2-3), 115-119.