Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique

dc.contributor.authorAcar, Hasan
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorDoygun, Muammer
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorOğul, Erhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Moleküler Biyoloji ve Genetik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.date.accessioned2021-09-29T05:44:11Z
dc.date.available2021-09-29T05:44:11Z
dc.date.issued2002
dc.description.abstractIn this study, we investigated the relationship between genetic alterations such as chromosome 22 aneuploidy and p53 gene deletion, and the pathological types of meningioma of typical and aggressive forms. Thirty-four meningiomas (23 typical and 11 aggressive) were examined by application of fluorescence in situ hybridization (FISH) with chromosome 22 specific alpha satellite probe and a combination of p53 locus specific and chromosome 17 centromere specific alpha satellite probes, to evaluate the chromosome 22 aneuploidy and gain or loss of p53 gene along with chromosome 17. The results showed that, although chromosome 22 aneuploidy was seen in 7 out of 23 typical (30.4%) and 4 out of 11 aggressive meningiomas (36.3%), no p53 deletion was detected in typical meningiomas, and p53 deletion was detected in 3 out of 11 aggressive meningiomas (1 atypical and 2 malignant), which had recurrence. There were no simultaneous occurrences of p53 gene deletions between typical and aggressive meningiomas. The present findings indicate that the loss of chromosome 22 may be involved with tumorogenesis of typical and aggressive meningiomas, while p53 gene deletions may be involved with malignant progression and recurrence in the aggressive meningiomas.en_US
dc.identifier.citationYakut, T. vd. (2002). "Evaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH technique". Teratogenesis Carcinogenesis and Mutagenesis, 22(3),217-225.en_US
dc.identifier.endpage225tr_TR
dc.identifier.issn0270-3211
dc.identifier.issue3tr_TR
dc.identifier.pubmed11948632tr_TR
dc.identifier.scopus2-s2.0-0036239486tr_TR
dc.identifier.startpage217tr_TR
dc.identifier.urihttps://doi.org/10.1002/tcm.10013
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/tcm.10013
dc.identifier.urihttp://hdl.handle.net/11452/22119
dc.identifier.volume22tr_TR
dc.identifier.wos000175234800006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosome 22en_US
dc.subjectFISHen_US
dc.subjectMeningiomaen_US
dc.subjectp53 geneen_US
dc.subjectStrand conformation polymorphısmen_US
dc.subjectFluorescence in-situen_US
dc.subjectHuman-brain-tumorsen_US
dc.subjectAllelic lossesen_US
dc.subjectPrognostic-significanceen_US
dc.subjectMalignant meningiomasen_US
dc.subjectHybridization fishen_US
dc.subjectProgressionen_US
dc.subjectDeletionsen_US
dc.subjectLeukemiaen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAneuploidyen_US
dc.subject.meshBrain neoplasmsen_US
dc.subject.meshChromosomes, human, pair 17en_US
dc.subject.meshChromosomes, human, pair 22en_US
dc.subject.meshFemaleen_US
dc.subject.meshGene deletionen_US
dc.subject.meshGenes, p53en_US
dc.subject.meshHumansen_US
dc.subject.meshIn situ hybridization, fluorescenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMeningiomaen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMonosomyen_US
dc.subject.meshMutationen_US
dc.subject.scopusMeningioma; Radiosurgery; Skull Baseen_US
dc.subject.wosOncologyen_US
dc.subject.wosToxicologyen_US
dc.subject.wosGenetics & heredityen_US
dc.titleEvaluation of relationship between chromosome 22 and p53 gene alterations and the subtype of meningiomas by the interphase-FISH techniqueen_US
dc.typeArticle
dc.wos.quartileQ4en_US
dc.wos.quartileQ3 (Toxicology)en_US

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