New insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs

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dc.contributor.authorFlood, Pamela
dc.contributor.authorPapke, Roger L.
dc.contributor.authorDamaj, M. Imad
dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAG-8716-2019
dc.contributor.researcheridEOB-5882-2022
dc.contributor.scopusid15062425700tr_TR
dc.contributor.scopusid55664349700tr_TR
dc.date.accessioned2024-03-28T10:54:20Z
dc.date.available2024-03-28T10:54:20Z
dc.date.issued2017-08-16
dc.description.abstractBackground: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this review is to introduce readers particularly to alpha 7 nAChRs in a perspective of pain and its modulation. Methods: Developments for alpha 7 nAChR modulators and recent animal studies related to pain are reviewed. Results: Accumulating evidences suggest that selective ligands for alpha 7 nAChRs hold promise in the treatment of chronic pain conditions as they lack many of side effects associated with other nicotinic receptor types. Conclusion: This review provides the reader recent insights on alpha 7 nAChRs from structure and function to the latest findings on the pharmacology and therapeutic targeting of these receptors for the treatment of pain and inflammation.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services - National Institutes of Health (NIH) - R01-CA206028 / R01GM057481en_US
dc.identifier.citationBağdaş, D. vd. (2018). ''New insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs''. Current Neuropharmacology, 16(4), 415-425.en_US
dc.identifier.doihttps://doi.org/10.2174/1570159X15666170818102108
dc.identifier.eissn1875-6190
dc.identifier.endpage425tr_TR
dc.identifier.issn1570-159X
dc.identifier.issue4tr_TR
dc.identifier.pubmed28820052tr_TR
dc.identifier.scopus2-s2.0-85048949626
dc.identifier.startpage415tr_TR
dc.identifier.urihttps://www.eurekaselect.com/article/85349en_US
dc.identifier.urihttps://hdl.handle.net/11452/40650
dc.identifier.volume16tr_TR
dc.identifier.wos000431914200007tr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.bap(KUAP (T) 2016/15)tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalCurrent Neuropharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha 7 nicotinic acetylcholine receptorsen_US
dc.subjectNicotineen_US
dc.subjectPainen_US
dc.subjectInflammationen_US
dc.subjectModulatorsen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAgonistsen_US
dc.subjectPositive allosteric modulatoren_US
dc.subjectCholinergic antiinflammatory pathwayen_US
dc.subjectGated ion-channelen_US
dc.subjectX-ray-structureen_US
dc.subjectNeuropathic painen_US
dc.subjectAnimal-modelsen_US
dc.subjectSpinal-corden_US
dc.subjectBinding-sitesen_US
dc.subjectHuman monocytesen_US
dc.subjectDrug discoveryen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.emtreeBungarotoxin receptoren_US
dc.subject.emtreeGelatinase Ben_US
dc.subject.emtreeGlial fibrillary acidic proteinen_US
dc.subject.emtreeHigh mobility group B1 proteinen_US
dc.subject.emtreeL kappa Ben_US
dc.subject.emtreeImmunoglobulin enhancer binding proteinen_US
dc.subject.emtreeInterleukin 1en_US
dc.subject.emtreeInterleukin 10en_US
dc.subject.emtreeInterleukin 18en_US
dc.subject.emtreeInterleukin 1betaen_US
dc.subject.emtreeInterleukin 6en_US
dc.subject.emtreeJanus kinase 2en_US
dc.subject.emtreeLigand gated ion channelen_US
dc.subject.emtreeMecamylamineen_US
dc.subject.emtreeMitogen activated protein kinase 1en_US
dc.subject.emtreeMitogen activated protein kinase 3en_US
dc.subject.emtreeMyeloid differentiation factor 88en_US
dc.subject.emtreeNicotinic receptoren_US
dc.subject.emtreePhosphatidylcholineen_US
dc.subject.emtreeSerotoninen_US
dc.subject.emtreeSTAT3 proteinen_US
dc.subject.emtreeSuppressor of cytokine signaling 3en_US
dc.subject.emtreeToll like receptor 4en_US
dc.subject.emtreeTumor necrosis factoren_US
dc.subject.emtreeAnalgesic agenten_US
dc.subject.emtreeCholinergic receptor stimulating agenten_US
dc.subject.emtreeNicotinic receptoren_US
dc.subject.emtreeNonsteroid antiinflammatory agenten_US
dc.subject.emtreeAntiinflammatory activityen_US
dc.subject.emtreeBinding siteen_US
dc.subject.emtreeChronic painen_US
dc.subject.emtreeConformational transitionen_US
dc.subject.emtreeCytokine productionen_US
dc.subject.emtreeCytokine releaseen_US
dc.subject.emtreeDesensitizationen_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeMacrophage migrationen_US
dc.subject.emtreeNeuropathic painen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePainen_US
dc.subject.emtreePhosphorylationen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeReviewen_US
dc.subject.emtreeSignal transductionen_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeInflammationen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNerve cellen_US
dc.subject.emtreePainen_US
dc.subject.meshAnalgesicsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-inflammatory agentsen_US
dc.subject.meshNon-steroidalen_US
dc.subject.meshCholinergic agentsen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammationen_US
dc.subject.meshNeuronsen_US
dc.subject.meshPainen_US
dc.subject.meshReceptors, nicotinicen_US
dc.subject.scopusInflammation; Methyllycaconitine; 3-(2,4-Dimethoxybenzylidene)Anabaseineen_US
dc.subject.wosNeurosciencesen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleNew insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRsen_US
dc.typeArticleen_US
dc.wos.quartileQ1en_US

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