Oral supplementation with docosahexaenoic acid and uridine-5 '-monophosphate increases dendritic spine density in adult gerbil hippocampus
dc.contributor.author | Sakamoto, Toshimasa | |
dc.contributor.author | Wurtman, Richard | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Darmakoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-2918-5064 | tr_TR |
dc.contributor.researcherid | M-9071-2019 | tr_TR |
dc.contributor.scopusid | 8872816100 | tr_TR |
dc.date.accessioned | 2021-09-15T13:45:24Z | |
dc.date.available | 2021-09-15T13:45:24Z | |
dc.date.issued | 2007-11-28 | |
dc.description.abstract | Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while laboratory animals, including animal models of AD, can exhibit improved cognitive ability with a diet enriched in DHA. Various cellular mechanisms have been proposed for DHA's behavioral effects, including increases in cellular membrane fluidity, promotion of neurite extension and inhibition of apoptosis. However, there is little direct evidence that DHA affects synaptic structure in living animals. Here we show that oral supplementation with DHA substantially increases the number of dendritic spines in adult gerbil hippocampus, particularly when animals are co-supplemented with a uridine source, uridine-S'-monophosphate (UMP), which increases brain levels of the rate-limiting phosphatide precursor CTP. The increase in dendritic spines (>30%) is accompanied by parallel increases in membrane phosphatides and in pre- and post-synaptic proteins within the hippocampus. Hence, oral DHA may promote neuronal membrane synthesis to increase the number of synapses, particularly when co-administered with UMP. Our findings provide a possible explanation for the effects of DHA on behavior and also suggest a strategy to treat cognitive disorders resulting from synapse loss. | en_US |
dc.identifier.citation | Sakamoto, T. vd. (2007). "Oral supplementation with docosahexaenoic acid and uridine-5 '-monophosphate increases dendritic spine density in adult gerbil hippocampus". Brain Research, 1182, 50-59. | en_US |
dc.identifier.endpage | 59 | tr_TR |
dc.identifier.issn | 00068993 | |
dc.identifier.pubmed | 17950710 | tr_TR |
dc.identifier.scopus | 2-s2.0-36049020643 | tr_TR |
dc.identifier.startpage | 50 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.brainres.2007.08.089 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006899307021385 | |
dc.identifier.uri | http://hdl.handle.net/11452/21976 | |
dc.identifier.volume | 1182 | tr_TR |
dc.identifier.wos | 000251702700005 | tr_TR |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Brain Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Uridine | en_US |
dc.subject | Docosahexaenoic acid | en_US |
dc.subject | Membrane synthesis | en_US |
dc.subject | Phosphatides | en_US |
dc.subject | Spine formation | en_US |
dc.subject | Synaptogenesis | en_US |
dc.subject | Animalia | en_US |
dc.subject | Gerbillinae | en_US |
dc.subject | Polyunsaturated fatty-acids | en_US |
dc.subject | Long-term potentiation | en_US |
dc.subject | Neurite outgrowth | en_US |
dc.subject | Alzheimers-disease | en_US |
dc.subject | Arachidonic-acid | en_US |
dc.subject | Synaptic-transmission | en_US |
dc.subject | Molecular-mechanisms | en_US |
dc.subject | Learning-ability | en_US |
dc.subject | Brain | en_US |
dc.subject | Uridine | en_US |
dc.subject.emtree | Gerbil | en_US |
dc.subject.emtree | Docosahexaenoic acid | en_US |
dc.subject.emtree | Uridine phosphate | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Cell density | en_US |
dc.subject.emtree | Cognitive defect | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dendritic spine | en_US |
dc.subject.emtree | Hippocampus | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nerve cell membrane | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Synapse | en_US |
dc.subject.mesh | Dose-response relationship, drug | en_US |
dc.subject.mesh | Actins | en_US |
dc.subject.mesh | Administration, oral | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dendritic spines | en_US |
dc.subject.mesh | Docosahexaenoic acids | en_US |
dc.subject.mesh | Drug interactions | en_US |
dc.subject.mesh | Gerbillinae | en_US |
dc.subject.mesh | Uridine monophosphate | en_US |
dc.subject.mesh | Glycerophospholipids | en_US |
dc.subject.mesh | Hippocampus | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Membrane proteins | en_US |
dc.subject.mesh | Models, biological | en_US |
dc.subject.mesh | Time factors | en_US |
dc.subject.scopus | Docosahexaenoic Acids; Omega 3 Fatty Acid; Fish Oils | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Oral supplementation with docosahexaenoic acid and uridine-5 '-monophosphate increases dendritic spine density in adult gerbil hippocampus | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |