Epigenetic approach to early-onset Parkinson's disease: Low methylation status of SNCA and PARK2 promoter regions

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dc.contributor.authorElibol, Bülent
dc.contributor.authorBora, Ayşe Tokcaer
dc.contributor.authorSaka, Esen
dc.contributor.authorDemirkıran, Meltem
dc.contributor.authorAkbostancı, Cenk
dc.contributor.authorDoğu, Okan
dc.contributor.authorÇolakoğlu, Beril
dc.contributor.authorKenangil, Gülay
dc.contributor.authorKaleagası, Hakan
dc.contributor.buuauthorEryılmaz, Işıl Ezgi
dc.contributor.buuauthorÇeçener, Gulşah
dc.contributor.buuauthorErer, Sevda
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorZarifoğlu, Mehmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3316-316Xtr_TR
dc.contributor.orcid0000-0002-3820-424Xtr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-1619-6680tr_TR
dc.contributor.researcheridGWV-3548-2022tr_TR
dc.contributor.researcheridAAP-9988-2020tr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.contributor.researcheridABI-6078-2020tr_TR
dc.contributor.scopusid57189380840tr_TR
dc.contributor.scopusid6508156530tr_TR
dc.contributor.scopusid25635370800tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6603411305tr_TR
dc.contributor.scopusid6602965754tr_TR
dc.date.accessioned2023-01-02T12:49:56Z
dc.date.available2023-01-02T12:49:56Z
dc.date.issued2017-08-12
dc.description.abstractBackground and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD). Materials and methods: The promoter region methylation status of SNCA and PARK2 genes was evaluated by methylation specific-PCR (MSP) in 91 patients with EOPD and 52 healthy individuals. Results: The methylation of SNCA and PARK2 promoter regions were significantly lower in EOPD patients compared to the control group (P = 0.013 and P = 0.03, respectively). We also found that the methylation status of the SNCA might be associated with positive family history of PD (P = 0.042). Conclusion: Although it should be supported by further analysis, based on the results of the present study, the methylation status of SNCA and PARK2 genes might contribute to EOPD pathogenesis.en_US
dc.identifier.citationEryılmaz, I. E. vd. (2017). ''Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions''. Neurological Research, 39(11), 965-972.en_US
dc.identifier.endpage972tr_TR
dc.identifier.issn0161-6412
dc.identifier.issue11tr_TR
dc.identifier.pubmed28830306tr_TR
dc.identifier.scopus2-s2.0-85028553453tr_TR
dc.identifier.startpage965tr_TR
dc.identifier.urihttps://doi.org/10.1080/01616412.2017.1368141
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01616412.2017.1368141
dc.identifier.uri1743-1328
dc.identifier.urihttp://hdl.handle.net/11452/30224
dc.identifier.volume39tr_TR
dc.identifier.wos000414052900004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.bapKUAP(T)-2013/43en_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectEarly-onset parkinson’s diseaseen_US
dc.subjectEpigeneticen_US
dc.subjectMethylationen_US
dc.subjectPARK2en_US
dc.subjectSNCAen_US
dc.subjectAlpha-synucleinen_US
dc.subjectLeukocyte dnaen_US
dc.subjectGeneen_US
dc.subjectMutationsen_US
dc.subjectExpressionen_US
dc.subject.emtreeAlpha synucleinen_US
dc.subject.emtreeBisulfiteen_US
dc.subject.emtreeLevodopaen_US
dc.subject.emtreeParkin 2en_US
dc.subject.emtreeUbiquitin protein ligase E3en_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAlpha synucleinen_US
dc.subject.emtreeParkinen_US
dc.subject.emtreeSNCA protein, humanen_US
dc.subject.emtreeUbiquitin protein ligaseen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCpG islanden_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeDNA methylationen_US
dc.subject.emtreeDNA sequenceen_US
dc.subject.emtreeEpigeneticsen_US
dc.subject.emtreeExonen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMissense mutationen_US
dc.subject.emtreeNonsense mutationen_US
dc.subject.emtreePARK2 geneen_US
dc.subject.emtreeParkinson diseaseen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePromoter regionen_US
dc.subject.emtreeSNCA geneen_US
dc.subject.emtreeUnified parkinson disease rating scaleen_US
dc.subject.emtreeGenetic epigenesisen_US
dc.subject.emtreeGenetic predispositionen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeOnset ageen_US
dc.subject.emtreeParkinson diseaseen_US
dc.subject.emtreePedigreeen_US
dc.subject.meshAge of onseten_US
dc.subject.meshalpha-synucleinen_US
dc.subject.meshCpG islandsen_US
dc.subject.meshEpigenesis, geneticen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshParkinson diseaseen_US
dc.subject.meshPedigreeen_US
dc.subject.meshPromoter regionsen_US
dc.subject.meshGeneticen_US
dc.subject.meshUbiquitin-protein ligasesen_US
dc.subject.meshDNA methylationen_US
dc.subject.scopusPTEN-induced Putative Kinase; Parkin Protein; Protein Deglycase DJ-1en_US
dc.subject.wosClinical neurologyen_US
dc.subject.wosNeurosciencesen_US
dc.titleEpigenetic approach to early-onset Parkinson's disease: Low methylation status of SNCA and PARK2 promoter regionsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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